{"id":"https://openalex.org/W2075397172","doi":"https://doi.org/10.1139/y01-063","title":"Differential effects of phenobarbital on the constitutive and inducible expression of P450 2B and 3A subfamilies in sheep tissues","display_name":"Differential effects of phenobarbital on the constitutive and inducible expression of P450 2B and 3A subfamilies in sheep tissues","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2075397172","doi":"https://doi.org/10.1139/y01-063","mag":"2075397172","pmid":"https://pubmed.ncbi.nlm.nih.gov/11697743"},"language":"en","primary_location":{"id":"doi:10.1139/y01-063","doi":"https://doi.org/10.1139/y01-063","is_oa":false,"landing_page_url":"https://doi.org/10.1139/y01-063","pdf_url":null,"source":{"id":"https://openalex.org/S82722058","display_name":"Canadian Journal of Physiology and Pharmacology","issn_l":"0008-4212","issn":["0008-4212","1205-7541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Physiology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021525214","display_name":"Jacques Dupuy","orcid":"https://orcid.org/0000-0002-8144-154X","observed_orcids":["https://orcid.org/0000-0002-8144-154X"]},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jacques Dupuy","raw_affiliation_strings":["INRA, Laboratoire de Pharmacologie-Toxicologie, Toulouse, France. jdupuy@toulouse.inra.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRA, Laboratoire de Pharmacologie-Toxicologie, Toulouse, France. jdupuy@toulouse.inra.fr","institution_ids":["https://openalex.org/I4210088668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083370178","display_name":"G. Larrieu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gilberte Larrieu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039809075","display_name":"Jean Pierre Braun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean Pierre Braun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110223951","display_name":"M. Alvinerie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michel Alvinerie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035351503","display_name":"Pierre Galtier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre Galtier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1841,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.49549965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"79","issue":"10","first_page":"848","last_page":"853"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenobarbital","display_name":"phenobarbital","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyp2b","display_name":"CYP2B","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cyp3a","display_name":"CYP3A","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lacaune-sheep","display_name":"Lacaune sheep","score":0.8389999866485596},{"id":"https://openalex.org/keywords/duodenal-mucosa","display_name":"duodenal mucosa","score":0.7699999809265137},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C2777606763","wikidata":"https://www.wikidata.org/wiki/Q3322838","display_name":"Benzphetamine","level":4,"score":0.8246434926986694},{"id":"https://openalex.org/C2776809568","wikidata":"https://www.wikidata.org/wiki/Q134955","display_name":"Duodenum","level":2,"score":0.7721996307373047},{"id":"https://openalex.org/C2777226302","wikidata":"https://www.wikidata.org/wiki/Q233345","display_name":"Ileum","level":2,"score":0.7203202247619629},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6114755272865295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6012760400772095},{"id":"https://openalex.org/C2776366702","wikidata":"https://www.wikidata.org/wiki/Q185765","display_name":"Jejunum","level":2,"score":0.5761898756027222},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5631186962127686},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.5423331260681152},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.20248666405677795},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0753103494644165}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001189","descriptor_name":"Aryl Hydrocarbon Hydroxylases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010089","descriptor_name":"Oxidoreductases, N-Demethylating","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1139/y01-063","doi":"https://doi.org/10.1139/y01-063","is_oa":false,"landing_page_url":"https://doi.org/10.1139/y01-063","pdf_url":null,"source":{"id":"https://openalex.org/S82722058","display_name":"Canadian Journal of Physiology and Pharmacology","issn_l":"0008-4212","issn":["0008-4212","1205-7541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Physiology and Pharmacology","raw_type":"journal-article"},{"id":"doi:10.1139/cjpp-79-10-848","doi":"https://doi.org/10.1139/cjpp-79-10-848","is_oa":false,"landing_page_url":"https://doi.org/10.1139/cjpp-79-10-848","pdf_url":null,"source":{"id":"https://openalex.org/S82722058","display_name":"Canadian Journal of Physiology and Pharmacology","issn_l":"0008-4212","issn":["0008-4212","1205-7541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Physiology and Pharmacology","raw_type":"journal-article"},{"id":"pmid:11697743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11697743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian journal of physiology and pharmacology","raw_type":"Comparative Study"},{"id":"pmh:oai:HAL:hal-02674307v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.inrae.fr/hal-02674307","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Canadian Journal of Physiology and Pharmacology, 2001, 79, pp.848-853","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7150999903678894,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1528997672","https://openalex.org/W1532212858","https://openalex.org/W1586624031","https://openalex.org/W1589871776","https://openalex.org/W1650427240","https://openalex.org/W1892194801","https://openalex.org/W1951469402","https://openalex.org/W1973238763","https://openalex.org/W1977214082","https://openalex.org/W2003365117","https://openalex.org/W2020920370","https://openalex.org/W2041798311","https://openalex.org/W2045074190","https://openalex.org/W2047492040","https://openalex.org/W2063968553","https://openalex.org/W2068173377","https://openalex.org/W2090960267","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2132777822","https://openalex.org/W2163891284","https://openalex.org/W2170547669","https://openalex.org/W2213501008","https://openalex.org/W2290434193","https://openalex.org/W2408297839","https://openalex.org/W2410199846","https://openalex.org/W2411543957","https://openalex.org/W3202682947","https://openalex.org/W4232534952","https://openalex.org/W4245707418"],"related_works":["https://openalex.org/W934827347","https://openalex.org/W2048404837","https://openalex.org/W2050705924","https://openalex.org/W7099944071","https://openalex.org/W2442934122","https://openalex.org/W2083730360","https://openalex.org/W2131992712","https://openalex.org/W2006088867","https://openalex.org/W1938877388","https://openalex.org/W1586624031"],"abstract_inverted_index":{"The":[0],"activity":[1,105,133,150],"and":[2,16,28,32,43,47,70,88,101,109,127,134,151],"expression":[3,23,114,135,155],"of":[4,18,24,73,92,99,115,136,161],"cytochromes":[5],"P450":[6,33,62,91,118,138,152],"were":[7,41,122,143],"determined":[8],"in":[9,52,68,83,89,107,125,141,159],"liver,":[10],"kidneys,":[11,110],"lungs,":[12],"duodenum,":[13],"jejunum,":[14],"ileum,":[15],"caecum":[17],"adult":[19],"Lacaune":[20],"sheep.":[21,75,163],"High":[22],"total":[25,90],"P450,":[26],"benzphetamine":[27,131],"erythromycin":[29],"demethylase":[30,104,132],"activities,":[31],"2B":[34,119,139],"isoforms,":[35],"as":[36],"two":[37,117],"distinct":[38],"proteins":[39],"that":[40],"detected":[42],"called":[44],"P4502":[45,48],"Bm":[46],"Bx,":[49],"was":[50,65,156],"found":[51],"the":[53,61,97,113,116,137],"lungs":[54,142],"(in":[55],"addition":[56],"to":[57,80],"liver).":[58],"By":[59,129],"contrast,":[60,130],"3A":[63,153],"subfamily":[64,154],"only":[66,158],"expressed":[67],"liver":[69,108,160],"duodenal":[71],"mucosa":[72],"untreated":[74],"Phenobarbital":[76],"(PB)":[77],"treatment":[78],"led":[79],"significant":[81],"increases":[82],"all":[84],"measured":[85],"hepatic":[86],"parameters":[87],"each":[93],"investigated":[94],"organ":[95],"with":[96,112],"exception":[98],"ileum":[100],"caecum.":[102],"Benzphetamine":[103],"increased":[106,157],"correlating":[111],"proteins,":[120],"which":[121],"also":[123],"induced":[124],"duodenum":[126],"ileum.":[128],"isoforms":[140],"unchanged":[144],"by":[145],"PB":[146],"treatment.":[147],"Erythromycin":[148],"demethylation":[149],"PB-treated":[162]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}