{"id":"https://openalex.org/W2075340477","doi":"https://doi.org/10.1126/science.276.5319.1690","title":"Elementary Calcium-Release Units Induced by Inositol Trisphosphate","display_name":"Elementary Calcium-Release Units Induced by Inositol Trisphosphate","publication_year":1997,"publication_date":"1997-06-13","ids":{"openalex":"https://openalex.org/W2075340477","doi":"https://doi.org/10.1126/science.276.5319.1690","mag":"2075340477","pmid":"https://pubmed.ncbi.nlm.nih.gov/9180077"},"language":"en","primary_location":{"id":"doi:10.1126/science.276.5319.1690","doi":"https://doi.org/10.1126/science.276.5319.1690","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.276.5319.1690","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110074287","display_name":"John H. Horne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Horne","raw_affiliation_strings":["Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021268165","display_name":"Tobias Meyer","orcid":"https://orcid.org/0000-0003-4339-3804","observed_orcids":["https://orcid.org/0000-0003-4339-3804"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tobias Meyer","raw_affiliation_strings":["Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021268165"],"corresponding_institution_ids":["https://openalex.org/I4210126298"],"apc_list":null,"apc_paid":null,"fwci":6.9323,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.98076923,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"276","issue":"5319","first_page":"1690","last_page":"1693"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.6342999935150146,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.6342999935150146,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.2493000030517578,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.07890000194311142,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inositol-1-4-5-trisphosphate","display_name":"inositol 1,4,5-trisphosphate","score":0.9700000286102295},{"id":"https://openalex.org/keywords/calcium-release","display_name":"calcium release","score":0.6430000066757202},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.6359999775886536},{"id":"https://openalex.org/keywords/calcium-indicator","display_name":"calcium sensor","score":0.4020000100135803},{"id":"https://openalex.org/keywords/dextran","display_name":"dextran","score":0.7350000143051147},{"id":"https://openalex.org/keywords/geranylgeranylation","display_name":"geranylgeranylation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/egta","display_name":"EGTA","score":0.6200000047683716},{"id":"https://openalex.org/keywords/calcium-buffers","display_name":"calcium buffers","score":0.6610000133514404},{"id":"https://openalex.org/keywords/calcium-transients","display_name":"calcium transients","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.8038949370384216},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.7030388116836548},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5408004522323608},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3828449249267578},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31583303213119507},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24378183484077454},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17357105016708374},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0445730984210968}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004533","descriptor_name":"Egtazic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009930","descriptor_name":"Organic Chemicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015544","descriptor_name":"Inositol 1,4,5-Trisphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.276.5319.1690","doi":"https://doi.org/10.1126/science.276.5319.1690","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.276.5319.1690","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:9180077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9180077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2703554620","display_name":"DECODING OF CALCIUM SIGNALS BY CAM KINASE","funder_award_id":"R01GM048113","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8053588943","display_name":"SIGNAL TRANSDUCTION INTO THE CELL NUCLEUS","funder_award_id":"R01GM051457","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G848855720","display_name":"REGULATION OF CONTRACTION IN MYOCARDIUM","funder_award_id":"P01HL047053","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G992433554","display_name":null,"funder_award_id":"GM 51457","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1977201959","https://openalex.org/W1980166477","https://openalex.org/W1997778815","https://openalex.org/W2021647551","https://openalex.org/W2026222986","https://openalex.org/W2027943220","https://openalex.org/W2039597091","https://openalex.org/W2045106617","https://openalex.org/W2056768791","https://openalex.org/W2061235611","https://openalex.org/W2066030442","https://openalex.org/W2069892277","https://openalex.org/W2091368852","https://openalex.org/W2112324969","https://openalex.org/W2176744910","https://openalex.org/W4242572601","https://openalex.org/W6823223428"],"related_works":["https://openalex.org/W2077075036","https://openalex.org/W2043617261","https://openalex.org/W1991002565","https://openalex.org/W7097503381","https://openalex.org/W2080291012","https://openalex.org/W2100680004","https://openalex.org/W2031264199","https://openalex.org/W4243780288","https://openalex.org/W2549840196","https://openalex.org/W1973272354"],"abstract_inverted_index":{"The":[0,22],"extent":[1],"to":[2,37,85],"which":[3],"inositol":[4],"1,4,5-trisphosphate":[5],"(InsP3)-induced":[6],"calcium":[7,27,35,77,81,110],"signals":[8,28],"are":[9,83],"localized":[10],"is":[11],"a":[12,33,46],"critical":[13],"parameter":[14],"for":[15],"understanding":[16],"the":[17,41,76],"mechanism":[18],"of":[19,25,45,90,108],"effector":[20,98],"activation.":[21],"spatial":[23],"characteristics":[24],"InsP3-mediated":[26],"were":[29,70],"determined":[30],"by":[31,75,104],"targeting":[32],"dextran-based":[34],"indicator":[36,56],"intracellular":[38],"membranes":[39],"through":[40],"in":[42],"situ":[43],"addition":[44],"geranylgeranyl":[47],"lipid":[48],"group.":[49],"Elementary":[50],"calcium-release":[51],"events":[52],"observed":[53],"with":[54],"this":[55],"typically":[57],"lasted":[58],"less":[59,65],"than":[60,66],"33":[61],"milliseconds,":[62],"had":[63],"diameters":[64],"2":[67],"micrometers,":[68],"and":[69],"uncoupled":[71],"from":[72,87],"each":[73],"other":[74],"buffer":[78],"EGTA.":[79],"Cellwide":[80],"transients":[82],"likely":[84],"result":[86],"synchronized":[88],"triggering":[89],"such":[91],"local":[92,109],"release":[93],"events,":[94],"suggesting":[95],"that":[96],"calcium-dependent":[97],"proteins":[99],"could":[100],"be":[101],"selectively":[102],"activated":[103],"localization":[105],"near":[106],"sites":[107],"release.":[111]},"counts_by_year":[{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}