{"id":"https://openalex.org/W2075225519","doi":"https://doi.org/10.1111/j.1528-1157.1984.tb04171.x","title":"Intensive Follow\u2010up Monitoring in Patients with Once Daily Evening Administration of Sodium Valproate","display_name":"Intensive Follow\u2010up Monitoring in Patients with Once Daily Evening Administration of Sodium Valproate","publication_year":1984,"publication_date":"1984-04-01","ids":{"openalex":"https://openalex.org/W2075225519","doi":"https://doi.org/10.1111/j.1528-1157.1984.tb04171.x","mag":"2075225519","pmid":"https://pubmed.ncbi.nlm.nih.gov/6423376"},"language":"en","primary_location":{"id":"doi:10.1111/j.1528-1157.1984.tb04171.x","doi":"https://doi.org/10.1111/j.1528-1157.1984.tb04171.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1528-1157.1984.tb04171.x","pdf_url":null,"source":{"id":"https://openalex.org/S203153751","display_name":"Epilepsia","issn_l":"0013-9580","issn":["0013-9580","1528-1157","1528-1167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068808056","display_name":"Hermann Stefan","orcid":"https://orcid.org/0000-0002-6506-6292","observed_orcids":["https://orcid.org/0000-0002-6506-6292"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"H. Stefan","raw_affiliation_strings":["*Universitiits-Nervenklinik und Poliklinik/Epileptologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Universitiits-Nervenklinik und Poliklinik/Epileptologie","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024986438","display_name":"Wieland Burr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Burr","raw_affiliation_strings":["*Universitiits-Nervenklinik und Poliklinik/Epileptologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Universitiits-Nervenklinik und Poliklinik/Epileptologie","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009642377","display_name":"Helmut Fichsel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. Fichsel","raw_affiliation_strings":["\u2020Universita\u0308ts-Kinderklinik, Bonn, Federal Republic of Germany","\u2020Universit\u00e4ts\u2010Kinderklinik, Bonn, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Universita\u0308ts-Kinderklinik, Bonn, Federal Republic of Germany","institution_ids":["https://openalex.org/I2799391451"]},{"raw_affiliation_string":"\u2020Universit\u00e4ts\u2010Kinderklinik, Bonn, Federal Republic of Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064464261","display_name":"W. Fr\u00f6scher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Fr\u00f6scher","raw_affiliation_strings":["*Universitiits-Nervenklinik und Poliklinik/Epileptologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Universitiits-Nervenklinik und Poliklinik/Epileptologie","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020437624","display_name":"Heinz Penin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Penin","raw_affiliation_strings":["*Universitiits-Nervenklinik und Poliklinik/Epileptologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Universitiits-Nervenklinik und Poliklinik/Epileptologie","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068808056"],"corresponding_institution_ids":[],"apc_list":{"value":4360,"currency":"USD","value_usd":4360},"apc_paid":null,"fwci":2.7024,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.89321728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"25","issue":"2","first_page":"152","last_page":"160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/seizure-frequency-reduction","display_name":"seizure frequency reduction","score":0.6370000243186951},{"id":"https://openalex.org/keywords/primary-generalized-epilepsy","display_name":"primary generalized epilepsy","score":0.7179999947547913},{"id":"https://openalex.org/keywords/absence-seizures","display_name":"absence seizures","score":0.9760000109672546},{"id":"https://openalex.org/keywords/myoclonic-seizures","display_name":"myoclonic seizures","score":0.9900000095367432},{"id":"https://openalex.org/keywords/generalized-tonic-clonic-seizures","display_name":"generalized tonic-clonic seizures","score":0.9559999704360962},{"id":"https://openalex.org/keywords/dose-reduction","display_name":"dose reduction","score":0.5669999718666077},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7089999914169312},{"id":"https://openalex.org/keywords/sleepiness","display_name":"sleepiness","score":0.6620000004768372},{"id":"https://openalex.org/keywords/alopecia","display_name":"hair loss","score":0.9010000228881836},{"id":"https://openalex.org/keywords/antiepileptic-efficacy","display_name":"antiepileptic efficacy","score":0.5230000019073486},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C2776476923","wikidata":"https://www.wikidata.org/wiki/Q7725","display_name":"Evening","level":2,"score":0.9189354181289673},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6298995614051819},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5990524888038635},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.45868754386901855},{"id":"https://openalex.org/C2777172819","wikidata":"https://www.wikidata.org/wiki/Q240642","display_name":"Valproic Acid","level":3,"score":0.4360448122024536},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.42483747005462646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2389814853668213},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1528-1157.1984.tb04171.x","doi":"https://doi.org/10.1111/j.1528-1157.1984.tb04171.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1528-1157.1984.tb04171.x","pdf_url":null,"source":{"id":"https://openalex.org/S203153751","display_name":"Epilepsia","issn_l":"0013-9580","issn":["0013-9580","1528-1157","1528-1167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsia","raw_type":"journal-article"},{"id":"pmid:6423376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6423376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W257027439","https://openalex.org/W1973237800","https://openalex.org/W1978173138","https://openalex.org/W1988203082","https://openalex.org/W2002561110","https://openalex.org/W2002746772","https://openalex.org/W2002921724","https://openalex.org/W2020253297","https://openalex.org/W2037755761","https://openalex.org/W2053157428","https://openalex.org/W2058665976","https://openalex.org/W2109210017","https://openalex.org/W2158587532","https://openalex.org/W2394671532","https://openalex.org/W3021162679"],"related_works":["https://openalex.org/W2053157428","https://openalex.org/W2043160457","https://openalex.org/W2403498120","https://openalex.org/W2008805752","https://openalex.org/W2157251966","https://openalex.org/W3029786756","https://openalex.org/W1906001636","https://openalex.org/W1988765602","https://openalex.org/W120789868","https://openalex.org/W2413156289"],"abstract_inverted_index":{"Summary:":[0],"For":[1],"18":[2,271],"previously":[3],"untreated":[4],"patients":[5,220],"with":[6,152],"absence,":[7],"myoclonic,":[8],"or":[9],"grand":[10],"mal":[11],"seizures\u2013or":[12],"combinations\u2013results":[13],"of":[14,57,63,78,117,129,136,167,199,215,222,229,232,259],"clinical":[15],"and":[16,37,114,174,191,207,242],"electroenceph\u2010alographical":[17],"monitoring":[18],"are":[19],"reported.":[20],"Sodium":[21],"valproate":[22,82,261],"was":[23,88,213],"given":[24],"once":[25,255],"daily":[26,256],"in":[27,126,155,165,294,320],"the":[28,44,61,73,93,103,130,133,200,216,233,236,243,266],"evening.":[29],"Monitoring":[30],"included":[31],"repeated":[32],"24\u201348":[33],"h":[34,185],"EEG":[35,94],"recordings":[36],"drug":[38,74,104],"blood":[39,105],"level":[40,106,181],"measurements.":[41],"Results":[42],"indicated":[43],"evening":[45,257],"monodose":[46],"to":[47,70,98],"be":[48,99],"an":[49,344],"adequate":[50],"therapeutic":[51],"schedule":[52],"for":[53,251],"a":[54,65],"considerable":[55],"number":[56],"patients.":[58,157],"Apart":[59],"from":[60],"aspect":[62],"simplification,":[64],"further":[66],"important":[67],"aim":[68],"is":[69,262],"individually":[71],"minimize":[72],"dose.":[75],"An":[76],"average":[77],"15.6":[79],"mg/kg":[80,354],"sodium":[81,260],"(range,":[83],"10.0\u201325.5":[84],"mg/kg)":[85,360],"per":[86,240],"day":[87],"administered.":[89],"In":[90],"some":[91],"cases":[92,166],"discharge":[95],"activity":[96,138],"continued":[97],"lowered":[100,121],"even":[101],"after":[102],"had":[107],"reached":[108],"steady":[109],"state.":[110],"With":[111],"medication,":[112],"frequency":[113],"total":[115],"duration":[116,135],"paroxysms":[118,146,162],"were":[119,149,172,202],"significantly":[120],"(by":[122],"more":[123],"than":[124],"90%)":[125],"over":[127,183],"80%":[128,457],"patients,":[131],"whereas":[132],"mean":[134],"paroxysmal":[137],"did":[139],"not":[140,175],"change":[141],"uniformly.":[142],"Before":[143],"treatment,":[144],"short":[145,173],"(1\u20135":[147,405],"s)":[148],"seen":[150],"together":[151],"longer":[153],"ones":[154],"11":[156,401],"During":[158],"treatment":[159],"either":[160],"all":[161],"disappeared":[163],"or,":[164],"remaining":[168],"activity,":[169],"most":[170],"discharges":[171],"accompanied":[176],"by":[177],"seizure":[178],"manifestations.":[179],"Blood":[180],"profiles":[182],"24":[184,307,431],"showed":[186],"maximal":[187],"values":[188,196],"between":[189,204],"midnight":[190],"2":[192],"a.m.":[193,211],"The":[194,209],"minimal":[195],"(about":[197],"half":[198],"maximum)":[201],"found":[203],"10":[205],"p.m.":[206],"midnight.":[208],"8":[210],"value":[212],"70\u201380%":[214],"maximum.":[217],"Only":[218],"three":[219],"complained":[221],"slight":[223],"side":[224,245],"effects":[225],"(temporary":[226],"drowsiness,":[227],"loss":[228],"hair).":[230],"Because":[231],"simplified":[234],"handling,":[235],"relatively":[237],"low":[238],"dose":[239],"day,":[241],"few":[244],"effects,":[246],"it":[247],"seems":[248],"possible":[249],"that":[250],"primary":[252],"generalized":[253],"epilepsies":[254],"administration":[258],"appropriate":[263],"without":[264],"diminishing":[265],"antiepileptic":[267],"effect.":[268],"ZUSAMMENFASSUNG":[269],"Von":[270],"bisher":[272],"unbehandelten":[273],"Patienten":[274,330,376,402,462],"mit":[275],"Absencen.":[276],"myoklonischen":[277],"oder":[278,418],"Grand":[279],"Mai":[280],"Anf\u00e4llen":[281,427],"und":[282,286,311,342,368,423,437,448],"Kombinationen,":[283],"werden":[284,341],"klinischer":[285,472],"EEG\u2010Verlauf":[287],"berichtet.":[288],"Die":[289,299,313],"Tagesmenge":[290],"Natrium":[291,355,479],"Valproat":[292,356,480],"wurde":[293],"einer":[295,321],"Dosis":[296],"abends":[297,323,492],"verabreicht.":[298,362],"Beobachtung":[300],"geschah":[301],"durch":[302],"wiederholte":[303],"EEG\u2010Ableitungen":[304],"f\u00fcr":[305,325,506],"jeweils":[306],"bis":[308,358,456],"48":[309],"Stunden":[310,432],"Blutspiegelunlersuchungen.":[312],"Ergebnisse":[314],"lassen":[315],"vermuten.":[316],"Da\u00df":[317],"die":[318,338,345,387,419,442,477,499],"Valproat\u2010Therapie,":[319],"Tagesdosis":[322,478],"gegeben,":[324],"eine":[326],"betr\u00e4chtliche":[327],"Anzahl":[328],"von":[329,426],"ein":[331],"ad\u00e4quales":[332],"therapeutisches":[333],"Vorgehen":[334,484],"darstellt.":[335],"Damit":[336],"kann":[337],"Medikamenteneinnahme":[339],"vereinfacht":[340],"leichter":[343],"individuell":[346],"erforderliche":[347],"Minimaldosis":[348],"angepasst":[349],"werden.":[350],"Durchschnittlich":[351],"wurden":[352,424],"15,6":[353],"(10,0":[357],"25,5":[359],"t\u00e4glich":[361],"Unter":[363],"der":[364,370,373,375,390,397,412,444,503,509],"Behandlung":[365,398,413,504],"nahmen":[366],"H\u00e4ufigkeit":[367],"Gesamtdauer":[369],"Paroxysmen":[371,391,404,417],"bei":[372,400],"Mehrzahl":[374],"(\u00fcber":[377],"80%)":[378],"signifikant":[379],"ab":[380],"(Verminderung":[381],"um":[382],"mehr":[383],"als":[384,489],"90%),":[385],"w\u00e4hrend":[386],"mittlere":[388],"Dauer":[389],"sich":[392,497],"nicht":[393,425],"einheitlich":[394],"ver\u00e4nderte.":[395],"Vor":[396],"waren":[399,421],"kurze":[403],"Sek.)":[406],"neben":[407],"l\u00e4ngeren":[408],"zu":[409,485],"sehen.":[410],"W\u00e4hrend":[411],"verschwanden":[414],"entweder":[415],"alle":[416,507],"Ausbr\u00fcche":[420],"kurz":[422],"begleitet.":[428],"Blutspiegeltagesprofile":[429],"\u00fcber":[430,464],"zeigten":[433],"Maxima":[434],"zwischen":[435,446],"24.00":[436,449],"2.00":[438],"h.":[439,450],"Minima":[440],"(etwa":[441],"H\u00e4lfte":[443],"Maximalwerte)":[445],"22.00":[447],"Der":[451],"Morgenwert":[452],"(8.00)":[453],"erreichte":[454],"70":[455],"des":[458],"Maximalwertes.":[459],"Nur":[460],"3":[461],"klagten":[463],"leichte":[465],"Nebenwirkungen":[466],"(vor\u00fcbergehende":[467],"Schl\u00e4frigkeit,":[468],"Haarausfall).":[469],"Bei":[470],"guter":[471],"Wirksamkeit":[473],"ist":[474],"es":[475],"m\u00f6glich.":[476],"gegen\u2010\u00fcber":[481],"dem":[482],"fr\u00fcheren":[483],"vermindern,":[486],"wenn":[487],"sie":[488],"t\u00e4gliche":[490],"Einmaldosis":[491],"verabfolgt":[493],"wird.":[494],"Dabei":[495],"vermindern":[496],"auch":[498],"Nebenwirkungen.":[500],"Diese":[501],"Art":[502],"wird":[505],"Typen":[508],"prim\u00e4r":[510],"generalisierten":[511],"Epilepsien":[512],"empfohlen.":[513]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}