{"id":"https://openalex.org/W2075215849","doi":"https://doi.org/10.1073/pnas.87.22.8845","title":"Incorporation of marine lipids into mitochondrial membranes increases susceptibility to damage by calcium and reactive oxygen species: evidence for enhanced activation of phospholipase A2 in mitochondria enriched with n-3 fatty acids.","display_name":"Incorporation of marine lipids into mitochondrial membranes increases susceptibility to damage by calcium and reactive oxygen species: evidence for enhanced activation of phospholipase A2 in mitochondria enriched with n-3 fatty acids.","publication_year":1990,"publication_date":"1990-11-01","ids":{"openalex":"https://openalex.org/W2075215849","doi":"https://doi.org/10.1073/pnas.87.22.8845","mag":"2075215849","pmid":"https://pubmed.ncbi.nlm.nih.gov/2123344","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/55056"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.87.22.8845","doi":"https://doi.org/10.1073/pnas.87.22.8845","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.87.22.8845","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/55056","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038157219","display_name":"Charles D. Malis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C D Malis","raw_affiliation_strings":["Medical Services, Masschusetts General Hospital, Boston 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Services, Masschusetts General Hospital, Boston 02114","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P C Weber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P C Weber","raw_affiliation_strings":["Medical Services, Masschusetts General Hospital, Boston 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Services, Masschusetts General Hospital, Boston 02114","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079152086","display_name":"Alexander Leaf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Leaf","raw_affiliation_strings":["Medical Services, Masschusetts General Hospital, Boston 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Services, Masschusetts General Hospital, Boston 02114","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089781525","display_name":"Joseph Vincent Bonventre","orcid":"https://orcid.org/0000-0001-7144-386X","observed_orcids":["https://orcid.org/0000-0001-7144-386X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J V Bonventre","raw_affiliation_strings":["Medical Services, Masschusetts General Hospital, Boston 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Services, Masschusetts General Hospital, Boston 02114","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":4.6496,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.9522789,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"87","issue":"22","first_page":"8845","last_page":"8849"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.5957000255584717,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.5957000255584717,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.39579999446868896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-membrane","display_name":"mitochondrial membrane","score":0.6840000152587891},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9890000224113464},{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.8299999833106995},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mitochondrial-respiratory-function","display_name":"mitochondrial respiratory function","score":0.4880000054836273},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.777999997138977},{"id":"https://openalex.org/keywords/fish-oil-diet","display_name":"fish oil diet","score":0.6769999861717224},{"id":"https://openalex.org/keywords/dibucaine","display_name":"dibucaine","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7056418061256409},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6232219338417053},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6078298091888428},{"id":"https://openalex.org/C2776551241","wikidata":"https://www.wikidata.org/wiki/Q24768001","display_name":"Phospholipase A2","level":3,"score":0.6001885533332825},{"id":"https://openalex.org/C12927208","wikidata":"https://www.wikidata.org/wiki/Q210430","display_name":"Phospholipase","level":3,"score":0.5492581725120544},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.5019040107727051},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4947771430015564},{"id":"https://openalex.org/C2779946292","wikidata":"https://www.wikidata.org/wiki/Q1786125","display_name":"Fish oil","level":3,"score":0.49460265040397644},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.41544532775878906},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3593716323375702},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19206419587135315},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005395","descriptor_name":"Fish Oils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008293","descriptor_name":"Malates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008563","descriptor_name":"Membrane Lipids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011773","descriptor_name":"Pyruvates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011808","descriptor_name":"Quinone Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013386","descriptor_name":"Succinates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016660","descriptor_name":"NAD(P)H Dehydrogenase (Quinone)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054467","descriptor_name":"Phospholipases A2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.87.22.8845","doi":"https://doi.org/10.1073/pnas.87.22.8845","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.87.22.8845","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:55056","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/55056","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:2123344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2123344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:55056","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/55056","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2387889886","display_name":null,"funder_award_id":"DK-38452","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2485126375","display_name":null,"funder_award_id":"DK-38165","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3581889325","display_name":null,"funder_award_id":"DK-39773","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G755109007","display_name":"MECHANISM OF DISEASE PREVENTION BY N 3 FATTY ACIDS","funder_award_id":"R01DK038165","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8181590737","display_name":"CELLULAR BIOLOGY OF RENAL FUNCTION AND DISEASE","funder_award_id":"P01DK038452","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1541054247","https://openalex.org/W1557577469","https://openalex.org/W1571964755","https://openalex.org/W1581458636","https://openalex.org/W1612071344","https://openalex.org/W1860019662","https://openalex.org/W1870633384","https://openalex.org/W1970716386","https://openalex.org/W1973690450","https://openalex.org/W1981102657","https://openalex.org/W1984005711","https://openalex.org/W1996633032","https://openalex.org/W2008873477","https://openalex.org/W2013926474","https://openalex.org/W2037721549","https://openalex.org/W2042001734","https://openalex.org/W2060012951","https://openalex.org/W2064287942","https://openalex.org/W2081290499","https://openalex.org/W2083197521","https://openalex.org/W2087130195","https://openalex.org/W2087421641","https://openalex.org/W2090821389","https://openalex.org/W2153856379","https://openalex.org/W2163474013","https://openalex.org/W2277936759","https://openalex.org/W2281699676","https://openalex.org/W2297865043","https://openalex.org/W2321334948","https://openalex.org/W2395643266","https://openalex.org/W2403106544"],"related_works":["https://openalex.org/W2414646226","https://openalex.org/W7100105583","https://openalex.org/W1854722798","https://openalex.org/W2135437814","https://openalex.org/W1990447734","https://openalex.org/W2013446045","https://openalex.org/W2019264715","https://openalex.org/W2069062436","https://openalex.org/W2092921724","https://openalex.org/W2789292240"],"abstract_inverted_index":{"Experiments":[0],"were":[1,29,44],"designed":[2],"to":[3,15,52,100,114,167,190],"evaluate":[4],"the":[5,121,129,158,204],"susceptibility":[6],"of":[7,104,123,132,136,145,150,206],"mitochondrial":[8,48,213,218],"membranes":[9,219],"enriched":[10,59,127,221],"with":[11,83,141,173,222],"n-3":[12,61,223],"fatty":[13,62,125,151,224],"acids":[14,126,152],"damage":[16,171,214],"by":[17,156],"Ca2+":[18,53,115,174,191],"and":[19,26,38,54,64,67,78,102,109,116,175,192,196,212],"reactive":[20,55,117,176,193],"oxygen":[21,56,118,177,194],"species.":[22,178],"Fatty":[23],"acid":[24],"content":[25],"respiratory":[27,207],"function":[28],"assessed":[30],"in":[31,60,75,107,187,201],"renal":[32],"cortical":[33],"mitochondria":[34,58,84,135,144,169,188],"isolated":[35],"from":[36,85,134],"fish-oil-":[37,108],"beef-tallow-fed":[39,110,146],"rats.":[40,147],"Dietary":[41],"fish":[42],"oils":[43],"readily":[45],"incorporated":[46],"into":[47],"membranes.":[49],"After":[50],"exposure":[51],"species,":[57],"acids,":[63],"using":[65],"pyruvate":[66],"malate":[68],"as":[69],"substrates,":[70],"had":[71],"significantly":[72],"greater":[73],"changes":[74],"state":[76],"3":[77],"uncoupled":[79],"respirations,":[80],"when":[81,139,217],"compared":[82,140],"rats":[86,138],"fed":[87],"beef":[88],"tallow.":[89],"Mitochondrial":[90],"site":[91],"1":[92],"(NADH":[93],"coenzyme":[94],"Q":[95],"reductase)":[96],"activity":[97,211],"was":[98,153],"reduced":[99],"45":[101],"85%":[103],"control":[105],"values":[106],"groups,":[111],"respectively.":[112],"Exposure":[113],"species":[119,195],"enhance":[120],"release":[122,149],"polyunsaturated":[124],"at":[128,199],"sn-2":[130],"position":[131],"phospholipids":[133],"fish-oil-fed":[137],"similarly":[142],"treated":[143],"This":[148],"partially":[154],"inhibited":[155],"dibucaine,":[157],"phospholipase":[159,183],"A2":[160,184,210],"inhibitor,":[161],"which":[162],"we":[163],"have":[164],"previously":[165],"shown":[166],"protect":[168],"against":[170],"associated":[172],"The":[179],"results":[180],"indicate":[181],"that":[182],"is":[185,197],"activated":[186],"exposed":[189],"responsible,":[198],"least":[200],"part,":[202],"for":[203],"impairment":[205],"function.":[208],"Phospholipase":[209],"are":[215,220],"enhanced":[216],"acids.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}