{"id":"https://openalex.org/W2075213417","doi":"https://doi.org/10.1371/journal.pone.0117908","title":"TGF\u03b2 Signaling in Myeloid Cells Regulates Mammary Carcinoma Cell Invasion through Fibroblast Interactions","display_name":"TGF\u03b2 Signaling in Myeloid Cells Regulates Mammary Carcinoma Cell Invasion through Fibroblast Interactions","publication_year":2015,"publication_date":"2015-01-28","ids":{"openalex":"https://openalex.org/W2075213417","doi":"https://doi.org/10.1371/journal.pone.0117908","mag":"2075213417","pmid":"https://pubmed.ncbi.nlm.nih.gov/25629162","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4309578"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0117908","doi":"https://doi.org/10.1371/journal.pone.0117908","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0117908","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117908&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117908&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061352936","display_name":"Aubie K. Shaw","orcid":"https://orcid.org/0000-0002-5298-801X","observed_orcids":["https://orcid.org/0000-0002-5298-801X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aubie K. Shaw","raw_affiliation_strings":["Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, United States of America","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039938547","display_name":"Michael W. Pickup","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael W. Pickup","raw_affiliation_strings":["Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, United States of America","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035885878","display_name":"Anna M. Chytil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Chytil","raw_affiliation_strings":["Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, United States of America","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038498817","display_name":"Mary E. Aakre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Aakre","raw_affiliation_strings":["Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, United States of America","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003732631","display_name":"Philip Owens","orcid":"https://orcid.org/0000-0002-1452-9285","observed_orcids":["https://orcid.org/0000-0002-1452-9285"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Owens","raw_affiliation_strings":["Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, United States of America","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045030798","display_name":"Harold L. Moses","orcid":"https://orcid.org/0000-0002-0116-0140","observed_orcids":["https://orcid.org/0000-0002-0116-0140"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harold L. Moses","raw_affiliation_strings":["Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, United States of America","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074717453","display_name":"Sergey V. Novitskiy","orcid":"https://orcid.org/0000-0002-5051-0952","observed_orcids":["https://orcid.org/0000-0002-5051-0952"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sergey V. Novitskiy","raw_affiliation_strings":["Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, United States of America","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074717453"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.3128,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.79041473,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"10","issue":"1","first_page":"e0117908","last_page":"e0117908"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9020000100135803},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8069999814033508},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8889999985694885},{"id":"https://openalex.org/keywords/fibroblast-migration","display_name":"fibroblast migration","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6370000243186951},{"id":"https://openalex.org/keywords/cxcl11","display_name":"CXCL11","score":0.9150000214576721},{"id":"https://openalex.org/keywords/fgf2","display_name":"FGF2","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tgf-beta-receptor-ii","display_name":"TGFBR2","score":0.843999981880188},{"id":"https://openalex.org/keywords/akt1","display_name":"AKT1","score":0.5950000286102295},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.9100000262260437},{"id":"https://openalex.org/keywords/collective-cell-migration","display_name":"collective cell migration","score":0.6620000004768372},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6669999957084656},{"id":"https://openalex.org/keywords/secreted-factors","display_name":"secreted factors","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6445046067237854},{"id":"https://openalex.org/C171779818","wikidata":"https://www.wikidata.org/wiki/Q3799301","display_name":"Integrin alpha M","level":3,"score":0.6120700836181641},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.6077984571456909},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5154536366462708},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.5056273937225342},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4995238780975342},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4541432857513428},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.40239256620407104},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3854038119316101},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37802961468696594},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3077922761440277},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.30628910660743713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07152816653251648},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077294","descriptor_name":"Receptor, Transforming Growth Factor-beta Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pone.0117908","doi":"https://doi.org/10.1371/journal.pone.0117908","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0117908","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117908&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4309578","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4309578","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:25629162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25629162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:813a3107705a40b598ee4e39a7579bbf","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/813a3107705a40b598ee4e39a7579bbf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 1, p e0117908 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0117908","doi":"https://doi.org/10.1371/journal.pone.0117908","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0117908","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117908&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1195708112","display_name":null,"funder_award_id":"CA 085492","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1339403715","display_name":null,"funder_award_id":"P30 CA068485","funder_id":"https://openalex.org/F4320313998","funder_display_name":"Vanderbilt University Medical Center"},{"id":"https://openalex.org/G2748648653","display_name":"TGF-beta Suppression and Promotion of Mammary Carcinomas","funder_award_id":"R01CA085492","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3269002440","display_name":null,"funder_award_id":"P30 CA068485","funder_id":"https://openalex.org/F4320309601","funder_display_name":"Vanderbilt-Ingram Cancer Center"},{"id":"https://openalex.org/G3824155810","display_name":null,"funder_award_id":"CA102162","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5526428480","display_name":null,"funder_award_id":"P30 CA068485","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6360502121","display_name":null,"funder_award_id":"P30 CA068485","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G7327618739","display_name":"TGF-beta in Mammary Development and Tumorigenesis","funder_award_id":"R01CA102162","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8953775245","display_name":null,"funder_award_id":"CA068485","funder_id":"https://openalex.org/F4320309601","funder_display_name":"Vanderbilt-Ingram Cancer Center"},{"id":"https://openalex.org/G9000089795","display_name":null,"funder_award_id":"CA-068485","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000880732","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA068485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320309601","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/05dq2gs74"},{"id":"https://openalex.org/F4320313505","display_name":"Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation","ror":"https://ror.org/05r5zfp34"},{"id":"https://openalex.org/F4320313998","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2075213417.pdf","grobid_xml":"https://content.openalex.org/works/W2075213417.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1736395830","https://openalex.org/W1906804363","https://openalex.org/W1925817305","https://openalex.org/W1931315964","https://openalex.org/W1963968922","https://openalex.org/W1966636482","https://openalex.org/W1975191869","https://openalex.org/W1977381126","https://openalex.org/W1977983810","https://openalex.org/W1978580798","https://openalex.org/W1987361483","https://openalex.org/W1989288986","https://openalex.org/W1998299539","https://openalex.org/W1999700615","https://openalex.org/W2004150448","https://openalex.org/W2005435360","https://openalex.org/W2014434319","https://openalex.org/W2020815627","https://openalex.org/W2035571645","https://openalex.org/W2038918212","https://openalex.org/W2051672403","https://openalex.org/W2053277543","https://openalex.org/W2055061339","https://openalex.org/W2071867803","https://openalex.org/W2077594233","https://openalex.org/W2083932352","https://openalex.org/W2103165458","https://openalex.org/W2109199436","https://openalex.org/W2115369408","https://openalex.org/W2120093145","https://openalex.org/W2122929031","https://openalex.org/W2127421703","https://openalex.org/W2129115386","https://openalex.org/W2129146910","https://openalex.org/W2130870648","https://openalex.org/W2136000914","https://openalex.org/W2159520551","https://openalex.org/W2159587614","https://openalex.org/W2167341806","https://openalex.org/W2168336731","https://openalex.org/W2187214483"],"related_works":["https://openalex.org/W7097456512","https://openalex.org/W1976066810","https://openalex.org/W1996734758","https://openalex.org/W2130870648","https://openalex.org/W2017331339","https://openalex.org/W2083935789","https://openalex.org/W1990792892","https://openalex.org/W2090671602","https://openalex.org/W2105213327","https://openalex.org/W1969109645"],"abstract_inverted_index":{"Metastasis":[0],"is":[1,155],"the":[2,14,19,49,76,148,261],"most":[3],"devastating":[4],"aspect":[5],"of":[6,16,22,45,85,99,143,163,165,198,217],"cancer,":[7],"however":[8,215],"we":[9,91],"know":[10],"very":[11],"little":[12],"about":[13],"mechanisms":[15,63],"local":[17],"invasion,":[18],"earliest":[20],"step":[21],"metastasis.":[23,268],"During":[24],"tumor":[25,39],"growth":[26],"CD11b+":[27,57,68,94,116,123,166,171,186,195,212,222,243,255],"Gr1+":[28,58,69,95,117,124,167,187,196,213,223,244],"cells,":[29,214],"known":[30],"also":[31],"as":[32],"MDSCs,":[33],"have":[34,120],"been":[35],"shown":[36],"to":[37,55,267],"promote":[38,60,97,189],"progression":[40],"by":[41,62,103,111],"a":[42],"wide":[43],"spectrum":[44],"effects":[46],"that":[47,64,93,128,154,170,239,253],"suppress":[48],"anti-tumor":[50],"immune":[51],"response.":[52],"In":[53,88],"addition":[54],"immunosuppression,":[56],"cells":[59,70,96,102,168,174,188,197,224,245,258],"metastasis":[61],"are":[65],"currently":[66],"unknown.":[67],"localize":[71],"near":[72],"fibroblasts,":[73],"which":[74],"remodel":[75],"ECM":[77],"and":[78,139,145,159,229,251],"leave":[79],"tracks":[80],"for":[81,263],"collective":[82],"cell":[83,125,182],"migration":[84,153,177,191,210],"carcinoma":[86,101,249],"cells.":[87,118],"this":[89],"study":[90],"discovered":[92],"invasion":[98,250,265],"mammary":[100],"increasing":[104],"fibroblast":[105,130,152,176,190,234,247],"migration.":[106,235],"This":[107],"effect":[108,150],"was":[109],"directed":[110,248],"secreted":[112,126],"factors":[113],"derived":[114],"from":[115],"We":[119],"identified":[121,169],"several":[122],"proteins":[127],"activate":[129],"migration,":[131],"including":[132],"CXCL11,":[133,226],"CXCL15,":[134],"FGF2,":[135],"IGF-I,":[136],"IL1Ra,":[137],"Resistin,":[138],"Shh.":[140],"The":[141],"combination":[142],"CXCL11":[144],"FGF2":[146,230],"had":[147],"strongest":[149],"on":[151,221],"associated":[156],"with":[157],"Akt1":[158],"ERK1/2":[160],"phosphorylation.":[161],"Analysis":[162],"subsets":[164],"Ly6Chigh":[172,256],"Ly6Glow":[173,257],"increase":[175],"more":[178,192],"than":[179,193],"other":[180],"myeloid":[181],"populations.":[183],"Additionally,":[184],"tumor-derived":[185],"splenic":[194],"tumor-bearing":[199],"mice.":[200],"While":[201],"TGF\u03b2":[202,218,240],"signaling":[203,241],"in":[204,232,242],"fibroblasts":[205],"does":[206],"not":[207],"regulate":[208],"their":[209],"toward":[211],"deletion":[216],"receptor":[219],"II":[220],"downregulates":[225],"Shh,":[227],"IGF1":[228],"resulting":[231],"reduced":[233],"These":[236],"studies":[237],"show":[238],"promotes":[246],"suggests":[252],"perivascular":[254],"may":[259],"be":[260],"stimulus":[262],"localized":[264],"leading":[266]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
