{"id":"https://openalex.org/W2075089366","doi":"https://doi.org/10.3109/10799893.2013.765466","title":"Signaling pathways of apoE and its role of gene expression in glomerulus diseases","display_name":"Signaling pathways of apoE and its role of gene expression in glomerulus diseases","publication_year":2013,"publication_date":"2013-02-06","ids":{"openalex":"https://openalex.org/W2075089366","doi":"https://doi.org/10.3109/10799893.2013.765466","mag":"2075089366","pmid":"https://pubmed.ncbi.nlm.nih.gov/23384034"},"language":"en","primary_location":{"id":"doi:10.3109/10799893.2013.765466","doi":"https://doi.org/10.3109/10799893.2013.765466","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10799893.2013.765466","pdf_url":null,"source":{"id":"https://openalex.org/S116485566","display_name":"Journal of Receptors and Signal Transduction","issn_l":"1079-9893","issn":["1079-9893","1532-4281"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Receptors and Signal Transduction","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028738648","display_name":"Tian\u2010Biao Zhou","orcid":"https://orcid.org/0000-0001-8065-1644","observed_orcids":["https://orcid.org/0000-0001-8065-1644"]},"institutions":[{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tian-Biao Zhou","raw_affiliation_strings":["Department of Pediatric Nephrology, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China. a126tianbiao@126.com","Department of Pediatric Nephrology, The First Affiliated Hospital of Guangxi Medical University GuangxiChina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Nephrology, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China. a126tianbiao@126.com","institution_ids":["https://openalex.org/I4210126060"]},{"raw_affiliation_string":"Department of Pediatric Nephrology, The First Affiliated Hospital of Guangxi Medical University GuangxiChina","institution_ids":["https://openalex.org/I4210126060"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028738648"],"corresponding_institution_ids":["https://openalex.org/I4210126060"],"apc_list":null,"apc_paid":null,"fwci":0.6874,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.59549229,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"33","issue":"2","first_page":"73","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":1.0},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.8140000104904175},{"id":"https://openalex.org/keywords/glomerular-disease","display_name":"glomerular disease","score":0.8880000114440918},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7590000033378601},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.9210000038146973},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.5120000243186951},{"id":"https://openalex.org/keywords/lipoprotein-metabolism","display_name":"lipoprotein metabolism","score":0.6880000233650208},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.8627485036849976},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6268231272697449},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5661124587059021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.564675509929657},{"id":"https://openalex.org/C2778305430","wikidata":"https://www.wikidata.org/wiki/Q26261754","display_name":"Glomerulus","level":3,"score":0.48684972524642944},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3451380729675293},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3273467421531677},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24314439296722412},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21223586797714233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19110378623008728},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.170506089925766},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.08983606100082397}],"mesh":[{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/10799893.2013.765466","doi":"https://doi.org/10.3109/10799893.2013.765466","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10799893.2013.765466","pdf_url":null,"source":{"id":"https://openalex.org/S116485566","display_name":"Journal of Receptors and Signal Transduction","issn_l":"1079-9893","issn":["1079-9893","1532-4281"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Receptors and Signal Transduction","raw_type":"journal-article"},{"id":"pmid:23384034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23384034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of receptor and signal transduction research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W148977389","https://openalex.org/W1486975043","https://openalex.org/W1557744319","https://openalex.org/W1613083159","https://openalex.org/W1700325307","https://openalex.org/W1916092740","https://openalex.org/W1963926156","https://openalex.org/W1968006244","https://openalex.org/W1969612969","https://openalex.org/W1969627037","https://openalex.org/W1969939676","https://openalex.org/W1973065853","https://openalex.org/W1983763717","https://openalex.org/W1985255315","https://openalex.org/W1985991637","https://openalex.org/W1990591737","https://openalex.org/W1990817626","https://openalex.org/W1991473040","https://openalex.org/W1998007306","https://openalex.org/W1998242696","https://openalex.org/W2006374768","https://openalex.org/W2009745059","https://openalex.org/W2010139788","https://openalex.org/W2010230585","https://openalex.org/W2011664363","https://openalex.org/W2016837245","https://openalex.org/W2022453693","https://openalex.org/W2024626536","https://openalex.org/W2025715668","https://openalex.org/W2029383045","https://openalex.org/W2034968148","https://openalex.org/W2036431179","https://openalex.org/W2041378352","https://openalex.org/W2042635917","https://openalex.org/W2043459401","https://openalex.org/W2043548367","https://openalex.org/W2050830833","https://openalex.org/W2053244527","https://openalex.org/W2055831169","https://openalex.org/W2058131196","https://openalex.org/W2058786449","https://openalex.org/W2067113880","https://openalex.org/W2067926907","https://openalex.org/W2068031853","https://openalex.org/W2069410066","https://openalex.org/W2071290036","https://openalex.org/W2072237349","https://openalex.org/W2074802841","https://openalex.org/W2075755300","https://openalex.org/W2076131392","https://openalex.org/W2080590043","https://openalex.org/W2089567032","https://openalex.org/W2089823710","https://openalex.org/W2091430270","https://openalex.org/W2094467938","https://openalex.org/W2097096146","https://openalex.org/W2103777275","https://openalex.org/W2108188894","https://openalex.org/W2111658016","https://openalex.org/W2113916200","https://openalex.org/W2115131332","https://openalex.org/W2121978743","https://openalex.org/W2123627479","https://openalex.org/W2123842685","https://openalex.org/W2126484541","https://openalex.org/W2128526521","https://openalex.org/W2133057324","https://openalex.org/W2136097616","https://openalex.org/W2137465937","https://openalex.org/W2142306178","https://openalex.org/W2144347168","https://openalex.org/W2147537511","https://openalex.org/W2151963542","https://openalex.org/W2152560964","https://openalex.org/W2154464807","https://openalex.org/W2155549757","https://openalex.org/W2156178535","https://openalex.org/W2156476693","https://openalex.org/W2164747847","https://openalex.org/W2166904607","https://openalex.org/W2170097739","https://openalex.org/W2264777867","https://openalex.org/W2286184612","https://openalex.org/W2308783719","https://openalex.org/W2324719726","https://openalex.org/W2463067607","https://openalex.org/W2465433189"],"related_works":["https://openalex.org/W2108779769","https://openalex.org/W2022453693","https://openalex.org/W2139181813","https://openalex.org/W2382067936","https://openalex.org/W2383395311","https://openalex.org/W2224840532","https://openalex.org/W2030561654","https://openalex.org/W2080590043","https://openalex.org/W2040856405","https://openalex.org/W4396990496"],"abstract_inverted_index":{"The":[0],"roles":[1,136],"of":[2,26,57,71,82,109,137,142,158,165,171,176,186,191,197],"apolipoprotein":[3],"E":[4],"(apoE)":[5],"in":[6,21,111,134,139,173,194],"regulating":[7],"plasma":[8],"lipids":[9],"and":[10,97,188],"lipoproteins":[11],"levels":[12],"have":[13],"been":[14],"investigated":[15],"for":[16,38,50,69,95,126],"over":[17],"several":[18],"decades.":[19],"However,":[20,168],"different":[22],"tissues/cells,":[23],"the":[24,54,58,92,106,129,135,140,146,156,163,169,174,182,195],"role":[25,170,190],"apoE":[27,45,62,110,127,138,159,172,187],"was":[28,34,46,86,99,116,179],"different,":[29],"such":[30],"as":[31,66,76],"that":[32,44,61],"it":[33],"a":[35,47,67,77,120],"risk":[36,164],"factor":[37,49,78],"cancer,":[39],"but":[40,73],"some":[41,149],"reports":[42],"stated":[43],"protective":[48],"renal":[51],"diseases.":[52,113,144,167],"At":[53],"moment,":[55],"most":[56],"studies":[59,150],"find":[60],"not":[63],"only":[64],"acts":[65],"ligand":[68],"metabolism":[70],"lipids,":[72],"also":[74,100,152],"plays":[75],"to":[79,89,103,118,128,154],"regulate":[80],"lots":[81],"signaling":[83,93,123],"pathways.":[84],"There":[85],"rare":[87,101],"review":[88,102,105,115],"sum":[90],"up":[91],"pathways":[94,124,185],"apoE,":[96],"there":[98],"widely":[104],"gene":[107,160,192],"expression":[108,161,193],"glomerulus":[112,143,166,177,198],"This":[114],"performed":[117,153],"provide":[119],"relatively":[121],"complete":[122],"flowchart":[125],"investigators":[130],"who":[131],"were":[132,151,200],"interested":[133],"pathogenesis":[141,175,196],"In":[145],"past":[147],"decades,":[148],"explore":[155],"association":[157],"with":[162],"diseases":[178,199],"controversial.":[180],"Here,":[181],"signal":[183],"transduction":[184],"its":[189],"reviewed.":[201]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}