{"id":"https://openalex.org/W2074973084","doi":"https://doi.org/10.1016/s0009-2797(98)00085-4","title":"Quantitative structure\u2013activity relationships (QSAR) for 9-anilinoacridines: a comparative analysis","display_name":"Quantitative structure\u2013activity relationships (QSAR) for 9-anilinoacridines: a comparative analysis","publication_year":1998,"publication_date":"1998-11-01","ids":{"openalex":"https://openalex.org/W2074973084","doi":"https://doi.org/10.1016/s0009-2797(98)00085-4","mag":"2074973084","pmid":"https://pubmed.ncbi.nlm.nih.gov/9920460"},"language":"en","primary_location":{"id":"doi:10.1016/s0009-2797(98)00085-4","doi":"https://doi.org/10.1016/s0009-2797(98)00085-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0009-2797(98)00085-4","pdf_url":null,"source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013444907","display_name":"Hua Gao","orcid":"https://orcid.org/0000-0002-1326-6946","observed_orcids":["https://orcid.org/0000-0002-1326-6946","https://orcid.org/0009-0008-2782-1745"]},"institutions":[{"id":"https://openalex.org/I177881444","display_name":"Pomona College","ror":"https://ror.org/0074grg94","country_code":"US","type":"education","lineage":["https://openalex.org/I177881444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Gao","raw_affiliation_strings":["Department of Chemistry, Pomona College, Claremont, CA 91711-6338, USA","Department of Chemistry, Pomona College, 645 N. College Avenue, Claremont, CA 91711-6338, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Pomona College, Claremont, CA 91711-6338, USA","institution_ids":["https://openalex.org/I177881444"]},{"raw_affiliation_string":"Department of Chemistry, Pomona College, 645 N. College Avenue, Claremont, CA 91711-6338, USA","institution_ids":["https://openalex.org/I177881444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023901201","display_name":"William Alexander Denny","orcid":"https://orcid.org/0000-0001-7997-1843","observed_orcids":["https://orcid.org/0000-0001-7997-1843"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"William A. Denny","raw_affiliation_strings":["Cancer Research Laboratory, Faculty of Medicine and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Laboratory, Faculty of Medicine and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022652844","display_name":"Rajni Garg","orcid":"https://orcid.org/0000-0002-9629-8141","observed_orcids":["https://orcid.org/0000-0002-9629-8141"]},"institutions":[{"id":"https://openalex.org/I177881444","display_name":"Pomona College","ror":"https://ror.org/0074grg94","country_code":"US","type":"education","lineage":["https://openalex.org/I177881444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajni Garg","raw_affiliation_strings":["Department of Chemistry, Pomona College, 645 N. College Avenue, Claremont, CA 91711-6338, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Pomona College, 645 N. College Avenue, Claremont, CA 91711-6338, USA","institution_ids":["https://openalex.org/I177881444"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034168601","display_name":"Corwin H. Hansch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177881444","display_name":"Pomona College","ror":"https://ror.org/0074grg94","country_code":"US","type":"education","lineage":["https://openalex.org/I177881444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corwin Hansch","raw_affiliation_strings":["Department of Chemistry, Pomona College, 645 N. College Avenue, Claremont, CA 91711-6338, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Pomona College, 645 N. College Avenue, Claremont, CA 91711-6338, USA","institution_ids":["https://openalex.org/I177881444"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":0.8637,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.71212121,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"116","issue":"3","first_page":"157","last_page":"180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/9-anilinoacridines","display_name":"9-anilinoacridines","score":0.9779999852180481},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8519999980926514},{"id":"https://openalex.org/keywords/l1210-cells","display_name":"L1210 leukemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mouse-toxicity","display_name":"mouse toxicity","score":0.6669999957084656},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.9120000004768372},{"id":"https://openalex.org/keywords/nucleophilicity","display_name":"nucleophilicity","score":0.8080000281333923},{"id":"https://openalex.org/keywords/hammett-substituent-constants","display_name":"Hammett substituent constants","score":0.847000002861023},{"id":"https://openalex.org/keywords/electron-donating-substituents","display_name":"electron-donating substituents","score":0.7239999771118164},{"id":"https://openalex.org/keywords/steric-effects","display_name":"steric effects","score":0.8109999895095825},{"id":"https://openalex.org/keywords/receptor-proteins","display_name":"receptor proteins","score":0.8119999766349792},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.9835520386695862},{"id":"https://openalex.org/C201194858","wikidata":"https://www.wikidata.org/wiki/Q898238","display_name":"Steric effects","level":2,"score":0.7832367420196533},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5898139476776123},{"id":"https://openalex.org/C178907741","wikidata":"https://www.wikidata.org/wiki/Q745930","display_name":"Nucleophile","level":3,"score":0.5113996863365173},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.48013803362846375},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4368012845516205},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.38237881660461426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27145251631736755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2440275251865387},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000677","descriptor_name":"Amsacrine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000677","descriptor_name":"Amsacrine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000677","descriptor_name":"Amsacrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000677","descriptor_name":"Amsacrine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007939","descriptor_name":"Leukemia L1210","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007939","descriptor_name":"Leukemia L1210","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0009-2797(98)00085-4","doi":"https://doi.org/10.1016/s0009-2797(98)00085-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0009-2797(98)00085-4","pdf_url":null,"source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},{"id":"pmid:9920460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9920460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-biological interactions","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7506872404","display_name":"TOWARD A PREDICTIVE TOXICOLOGY","funder_award_id":"R01ES007595","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1497508512","https://openalex.org/W1967912851","https://openalex.org/W1976406451","https://openalex.org/W1979764486","https://openalex.org/W1980017694","https://openalex.org/W1997074587","https://openalex.org/W1997573797","https://openalex.org/W1998329509","https://openalex.org/W1998582408","https://openalex.org/W2001115414","https://openalex.org/W2005831319","https://openalex.org/W2010511880","https://openalex.org/W2013980054","https://openalex.org/W2018466113","https://openalex.org/W2037438017","https://openalex.org/W2039568596","https://openalex.org/W2050302704","https://openalex.org/W2053985249","https://openalex.org/W2056367986","https://openalex.org/W2070834937","https://openalex.org/W2071012843","https://openalex.org/W2073081927","https://openalex.org/W2086106390","https://openalex.org/W2127163275","https://openalex.org/W2134289054","https://openalex.org/W2153177231","https://openalex.org/W2403069078","https://openalex.org/W2407981948","https://openalex.org/W2950049799","https://openalex.org/W2952725377","https://openalex.org/W6629627741","https://openalex.org/W6650071318"],"related_works":["https://openalex.org/W2050302704","https://openalex.org/W1991751589","https://openalex.org/W4280549065","https://openalex.org/W2334454885","https://openalex.org/W2112668533","https://openalex.org/W2072407420","https://openalex.org/W2065877713","https://openalex.org/W2417389452","https://openalex.org/W2988916186","https://openalex.org/W2897609477"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}