{"id":"https://openalex.org/W2074950488","doi":"https://doi.org/10.1109/embc.2012.6346452","title":"Artificial tissue bioreactor (ATB) for biological and imaging applications","display_name":"Artificial tissue bioreactor (ATB) for biological and imaging applications","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W2074950488","doi":"https://doi.org/10.1109/embc.2012.6346452","mag":"2074950488","pmid":"https://pubmed.ncbi.nlm.nih.gov/23366413"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2012.6346452","doi":"https://doi.org/10.1109/embc.2012.6346452","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6346452","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102170483","display_name":"Timothy Whitehead","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. D. Whitehead","raw_affiliation_strings":["Mallinckrodt Institute of Radiology, Division of Radiological Sciences, Saint Louis, MO 63110, USA","Mallinckrodt Institute of Radiology (MIR), Division of Radiological Sciences, Saint Louis, MO, 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Division of Radiological Sciences, Saint Louis, MO 63110, USA","institution_ids":[]},{"raw_affiliation_string":"Mallinckrodt Institute of Radiology (MIR), Division of Radiological Sciences, Saint Louis, MO, 63110, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061937232","display_name":"Samuel T. Nemanich","orcid":"https://orcid.org/0000-0001-6093-7266","observed_orcids":["https://orcid.org/0000-0001-6093-7266"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. T. Nemanich","raw_affiliation_strings":["Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Saint Louis, MO, USA","Mallinckrodt Institute of Radiology (MIR), Division of Radiological Sciences, Saint Louis, MO, 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Saint Louis, MO, USA","institution_ids":[]},{"raw_affiliation_string":"Mallinckrodt Institute of Radiology (MIR), Division of Radiological Sciences, Saint Louis, MO, 63110, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030382209","display_name":"Kooresh Isaac Shoghi","orcid":"https://orcid.org/0000-0003-3204-457X","observed_orcids":["https://orcid.org/0000-0003-3204-457X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. I. Shoghi","raw_affiliation_strings":["Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Saint Louis, MO, USA","Mallinckrodt Institute of Radiology (MIR), Division of Radiological Sciences, Saint Louis, MO, 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Saint Louis, MO, USA","institution_ids":[]},{"raw_affiliation_string":"Mallinckrodt Institute of Radiology (MIR), Division of Radiological Sciences, Saint Louis, MO, 63110, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.22981328,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"2012","issue":null,"first_page":"2420","last_page":"2423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.15309999883174896,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.11800000071525574,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tissue-microenvironment","display_name":"tissue microenvironment","score":0.7459999918937683},{"id":"https://openalex.org/keywords/in-vivo-imaging","display_name":"in vivo imaging","score":0.6909999847412109},{"id":"https://openalex.org/keywords/small-animal-pet","display_name":"small animal PET","score":0.7860000133514404},{"id":"https://openalex.org/keywords/pioglitazone","display_name":"pioglitazone","score":0.7429999709129333},{"id":"https://openalex.org/keywords/ppargamma-agonists","display_name":"PPAR\u03b3 agonists","score":0.878000020980835},{"id":"https://openalex.org/keywords/glucose-utilization","display_name":"glucose utilization","score":0.5989999771118164},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.8410000205039978},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.5720000267028809},{"id":"https://openalex.org/keywords/glucose-tolerance-test","display_name":"glucose tolerance test","score":0.8809999823570251},{"id":"https://openalex.org/keywords/fatty-acid-uptake","display_name":"fatty acid uptake","score":0.9909999966621399},{"id":"https://openalex.org/keywords/radiopharmaceuticals","display_name":"radiopharmaceuticals","score":0.8700000047683716},{"id":"https://openalex.org/keywords/preclinical-translation","display_name":"preclinical translation","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.7205624580383301},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5011692047119141},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.40298303961753845},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3639949858188629},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3278625011444092},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2064439058303833},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.19497603178024292},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001187","descriptor_name":"Artificial Organs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001187","descriptor_name":"Artificial Organs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001187","descriptor_name":"Artificial Organs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D017753","descriptor_name":"Ecosystem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017753","descriptor_name":"Ecosystem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017753","descriptor_name":"Ecosystem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019544","descriptor_name":"Equipment Failure Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019544","descriptor_name":"Equipment Failure Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019544","descriptor_name":"Equipment Failure Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032701","descriptor_name":"Biomimetics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D032701","descriptor_name":"Biomimetics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D032701","descriptor_name":"Biomimetics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2012.6346452","doi":"https://doi.org/10.1109/embc.2012.6346452","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6346452","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:23366413","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23366413","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.5899999737739563}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4025836268","display_name":null,"funder_award_id":"5R01DK085298","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7066015164","display_name":"MULTI-TISSUE MULTI-TRACER METABOLIC PHENOTYPING OF DIABETES WITH PRE-CLINICAL PET","funder_award_id":"5r01dk085298-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2069283448","https://openalex.org/W2071539877","https://openalex.org/W2086269269"],"related_works":["https://openalex.org/W2058170566","https://openalex.org/W2755342338","https://openalex.org/W2772917594","https://openalex.org/W2775347418","https://openalex.org/W2166024367","https://openalex.org/W3116076068","https://openalex.org/W2229312674","https://openalex.org/W2951359407","https://openalex.org/W2079911747","https://openalex.org/W1969923398"],"abstract_inverted_index":{"Three-dimensional":[0],"(3D)":[1],"culture":[2],"systems":[3],"are":[4],"increasingly":[5],"applied":[6],"to":[7,26,103,154,158],"study":[8],"tissue":[9,22,44],"biology.":[10],"In":[11,92],"this":[12],"work,":[13],"we":[14,66],"report":[15],"on":[16,72,100],"the":[17,28,43,50,55,68,88,120,132,136],"development":[18],"of":[19,33,40,70,112,138,145],"an":[20],"artificial":[21],"bioreactor":[23],"(ATB)":[24],"designed":[25],"simulate":[27],"3D":[29],"structure":[30],"and":[31,83,140,147],"microenvironment":[32],"tissues":[34],"in":[35,119,143],"vivo,":[36],"with":[37,54,87,128],"multiple":[38],"avenues":[39],"sampling,":[41],"including":[42],"chamber,":[45],"for":[46,59],"downstream":[47],"analysis.":[48],"Additionally,":[49],"ATB":[51,78,121,133,152],"is":[52,98,124],"integrated":[53],"microPET":[56,129],"Focus":[57],"F220":[58],"in-vivo":[60],"imaging":[61],"applications.":[62],"As":[63],"a":[64,110],"proof-of-concept,":[65],"characterized":[67],"effects":[69],"lipids":[71],"glucose":[73,105],"utilization":[74],"using":[75,126],"HepG2":[76],"cells.":[77],"studies":[79,153],"were":[80],"performed":[81,99],"pre-":[82],"post-":[84],"therapeutic":[85],"intervention":[86],"PPAR-\u03b3":[89],"agonist":[90],"pioglitazone.":[91],"parallel,":[93],"Glucose":[94],"Tolerance":[95],"Test":[96],"(GTT)":[97],"media":[101],"samples":[102],"assess":[104],"uptake":[106,118],"by":[107],"cells":[108],"as":[109],"measures":[111],"insulin":[113],"signaling":[114],"sensitivity.":[115],"Fatty":[116],"acid":[117],"cell":[122],"chamber":[123],"measured":[125],"[(11)C]Palmitate":[127],"imaging.":[130],"Overall,":[131],"will":[134],"facilitate":[135],"use":[137],"existing":[139],"novel":[141],"radiopharmaceuticals":[142],"discovery":[144],"validating":[146],"translating":[148],"insights":[149],"derived":[150],"from":[151],"pre-clinical":[155],"animal":[156],"studies,":[157],"clinical":[159],"evaluation.":[160]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
