{"id":"https://openalex.org/W2074921900","doi":"https://doi.org/10.1016/s0006-8993(03)02720-3","title":"Expression of brain-derived neurotrophic factor (BDNF) and inducible nitric oxide synthase (iNOS) in rat astrocyte cultures treated with Levetiracetam","display_name":"Expression of brain-derived neurotrophic factor (BDNF) and inducible nitric oxide synthase (iNOS) in rat astrocyte cultures treated with Levetiracetam","publication_year":2003,"publication_date":"2003-05-19","ids":{"openalex":"https://openalex.org/W2074921900","doi":"https://doi.org/10.1016/s0006-8993(03)02720-3","mag":"2074921900","pmid":"https://pubmed.ncbi.nlm.nih.gov/12763257"},"language":"en","primary_location":{"id":"doi:10.1016/s0006-8993(03)02720-3","doi":"https://doi.org/10.1016/s0006-8993(03)02720-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-8993(03)02720-3","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010708987","display_name":"Venera Cardile","orcid":"https://orcid.org/0000-0001-9902-3736","observed_orcids":["https://orcid.org/0000-0001-9902-3736"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Venera Cardile","raw_affiliation_strings":["Department of Physiological Sciences, University of Catania, V.le Andrea Doria 6, 95125, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Sciences, University of Catania, V.le Andrea Doria 6, 95125, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110064816","display_name":"Antonino Pavone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105999","display_name":"Ospedale Garibaldi","ror":"https://ror.org/01q6hrg49","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210105999"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonino Pavone","raw_affiliation_strings":["Department of Neurology, Garibaldi Hospital, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Garibaldi Hospital, Catania, Italy","institution_ids":["https://openalex.org/I4210105999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002137674","display_name":"Rosario Gulino","orcid":"https://orcid.org/0000-0002-8067-697X","observed_orcids":["https://orcid.org/0000-0002-8067-697X"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosario Gulino","raw_affiliation_strings":["Department of Physiological Sciences, University of Catania, V.le Andrea Doria 6, 95125, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Sciences, University of Catania, V.le Andrea Doria 6, 95125, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042983104","display_name":"Marcella Renis","orcid":"https://orcid.org/0000-0002-9464-3087","observed_orcids":["https://orcid.org/0000-0002-9464-3087"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marcella Renis","raw_affiliation_strings":["Department of Biological Chemistry, Medical Chemistry and Molecular Biology, University of Catania, V. le A. Doria 6, 95125 Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Medical Chemistry and Molecular Biology, University of Catania, V. le A. Doria 6, 95125 Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041298151","display_name":"Christian Scifo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Christian Scifo","raw_affiliation_strings":["Department of Biological Chemistry, Medical Chemistry and Molecular Biology, University of Catania, V. le A. Doria 6, 95125 Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Medical Chemistry and Molecular Biology, University of Catania, V. le A. Doria 6, 95125 Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023280816","display_name":"Vincenzo Perciavalle","orcid":"https://orcid.org/0000-0003-0614-2969","observed_orcids":["https://orcid.org/0000-0003-0614-2969"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Vincenzo Perciavalle","raw_affiliation_strings":["Department of Physiological Sciences, University of Catania, V.le Andrea Doria 6, 95125, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Sciences, University of Catania, V.le Andrea Doria 6, 95125, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5023280816"],"corresponding_institution_ids":["https://openalex.org/I39063666"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":2.0994,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.86124951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"976","issue":"2","first_page":"227","last_page":"233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.188400000333786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.03819999843835831,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levetiracetam","display_name":"levetiracetam","score":0.9919999837875366},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":1.0},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cortical-astrocytes","display_name":"cortical astrocytes","score":0.8180000185966492},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.9290000200271606},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9789999723434448},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"neurotrophic factors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.6510000228881836},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.7059999704360962},{"id":"https://openalex.org/keywords/concentration-response-relationship","display_name":"concentration-dependent effects","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.7948046922683716},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.7590885162353516},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.7283676862716675},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.7016619443893433},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6974893808364868},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6230611205101013},{"id":"https://openalex.org/C2777332695","wikidata":"https://www.wikidata.org/wiki/Q417227","display_name":"Levetiracetam","level":3,"score":0.6118035316467285},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48274534940719604},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4317851662635803},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.43059295415878296},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.3225047290325165},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30779165029525757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29505693912506104},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.22045516967773438},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20284876227378845},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.14174127578735352},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08137339353561401}],"mesh":[{"descriptor_ui":"D000077287","descriptor_name":"Levetiracetam","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010889","descriptor_name":"Piracetam","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010889","descriptor_name":"Piracetam","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0006-8993(03)02720-3","doi":"https://doi.org/10.1016/s0006-8993(03)02720-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-8993(03)02720-3","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},{"id":"pmid:12763257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12763257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1502060777","https://openalex.org/W1591346556","https://openalex.org/W1829813323","https://openalex.org/W1969822555","https://openalex.org/W1970154519","https://openalex.org/W1978460142","https://openalex.org/W2001628666","https://openalex.org/W2005254595","https://openalex.org/W2007437940","https://openalex.org/W2018073322","https://openalex.org/W2024550853","https://openalex.org/W2025978099","https://openalex.org/W2029568994","https://openalex.org/W2031611126","https://openalex.org/W2031833127","https://openalex.org/W2048314677","https://openalex.org/W2068372391","https://openalex.org/W2070568755","https://openalex.org/W2073756883","https://openalex.org/W2084330376","https://openalex.org/W2094544368","https://openalex.org/W2097545500","https://openalex.org/W2100837269","https://openalex.org/W2101808673","https://openalex.org/W2115810166","https://openalex.org/W2128635872","https://openalex.org/W2151160854"],"related_works":["https://openalex.org/W1529718777","https://openalex.org/W3196784940","https://openalex.org/W2054113428","https://openalex.org/W1947276794","https://openalex.org/W2039290396","https://openalex.org/W2083183430","https://openalex.org/W1966573828","https://openalex.org/W7037747285","https://openalex.org/W2057108179","https://openalex.org/W2524473181"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
