{"id":"https://openalex.org/W2074885567","doi":"https://doi.org/10.1111/j.1399-3011.1973.tb03457.x","title":"CALORIMETRIC INVESTIGATION OF RIBONUCLEASE THERMAL DENATURATION","display_name":"CALORIMETRIC INVESTIGATION OF RIBONUCLEASE THERMAL DENATURATION","publication_year":1973,"publication_date":"1973-07-01","ids":{"openalex":"https://openalex.org/W2074885567","doi":"https://doi.org/10.1111/j.1399-3011.1973.tb03457.x","mag":"2074885567","pmid":"https://pubmed.ncbi.nlm.nih.gov/4796696"},"language":"en","primary_location":{"id":"doi:10.1111/j.1399-3011.1973.tb03457.x","doi":"https://doi.org/10.1111/j.1399-3011.1973.tb03457.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-3011.1973.tb03457.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210190181","display_name":"International journal of peptide & protein research","issn_l":"0367-8377","issn":["0367-8377"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Peptide and Protein Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112756627","display_name":"Peter L. Privalov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137602","display_name":"Institute of Protein Research","ror":"https://ror.org/0489f0s93","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210137602"]},{"id":"https://openalex.org/I4405285364","display_name":"Academy of Sciences of the Soviet Union","ror":"https://ror.org/059mhqh10","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4405285364"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"P. L. Privalov","raw_affiliation_strings":["Institute of Protein Research, Academy of Sciences of the USSR, Poustchino, Moscow Region, USSR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Protein Research, Academy of Sciences of the USSR, Poustchino, Moscow Region, USSR","institution_ids":["https://openalex.org/I4210137602","https://openalex.org/I4405285364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108363702","display_name":"E. I. Tiktopulo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137602","display_name":"Institute of Protein Research","ror":"https://ror.org/0489f0s93","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210137602"]},{"id":"https://openalex.org/I4405285364","display_name":"Academy of Sciences of the Soviet Union","ror":"https://ror.org/059mhqh10","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4405285364"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. I. Tiktopulo","raw_affiliation_strings":["Institute of Protein Research, Academy of Sciences of the USSR, Poustchino, Moscow Region, USSR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Protein Research, Academy of Sciences of the USSR, Poustchino, Moscow Region, USSR","institution_ids":["https://openalex.org/I4210137602","https://openalex.org/I4405285364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111594291","display_name":"\u041d. \u041d. \u0425\u0435\u0447\u0438\u043d\u0430\u0448\u0432\u0438\u043b\u0438","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137602","display_name":"Institute of Protein Research","ror":"https://ror.org/0489f0s93","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210137602"]},{"id":"https://openalex.org/I4405285364","display_name":"Academy of Sciences of the Soviet Union","ror":"https://ror.org/059mhqh10","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4405285364"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. N. Khechinashvili","raw_affiliation_strings":["Institute of Protein Research, Academy of Sciences of the USSR, Poustchino, Moscow Region, USSR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Protein Research, Academy of Sciences of the USSR, Poustchino, Moscow Region, USSR","institution_ids":["https://openalex.org/I4210137602","https://openalex.org/I4405285364"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112756627"],"corresponding_institution_ids":["https://openalex.org/I4210137602","https://openalex.org/I4405285364"],"apc_list":null,"apc_paid":null,"fwci":2.4181,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.88541667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"5","issue":"4","first_page":"229","last_page":"237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribonuclease","display_name":"ribonuclease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thermal-denaturation","display_name":"thermal denaturation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/protein-denaturation","display_name":"protein denaturation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/heat-capacity-change","display_name":"heat capacity change","score":0.7699999809265137},{"id":"https://openalex.org/keywords/denaturation-enthalpy","display_name":"denaturation enthalpy","score":0.8989999890327454},{"id":"https://openalex.org/keywords/denaturation-temperature","display_name":"denaturation temperature","score":0.7850000262260437},{"id":"https://openalex.org/keywords/ph-dependence","display_name":"pH dependence","score":0.8109999895095825},{"id":"https://openalex.org/keywords/protein-thermodynamics","display_name":"protein thermodynamics","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C3288061","wikidata":"https://www.wikidata.org/wiki/Q161064","display_name":"Enthalpy","level":2,"score":0.7690707445144653},{"id":"https://openalex.org/C2776923230","wikidata":"https://www.wikidata.org/wiki/Q16955798","display_name":"Denaturation (fissile materials)","level":2,"score":0.7560343742370605},{"id":"https://openalex.org/C2778976237","wikidata":"https://www.wikidata.org/wiki/Q422523","display_name":"Ribonuclease","level":4,"score":0.7453920245170593},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6303554177284241},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.6269232630729675},{"id":"https://openalex.org/C60205243","wikidata":"https://www.wikidata.org/wiki/Q179388","display_name":"Heat capacity","level":2,"score":0.5591821670532227},{"id":"https://openalex.org/C202270520","wikidata":"https://www.wikidata.org/wiki/Q634314","display_name":"Calorimetry","level":2,"score":0.4936595857143402},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.4432760775089264},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.24109360575675964},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1285654902458191},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.09592661261558533},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002151","descriptor_name":"Calorimetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002621","descriptor_name":"Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003720","descriptor_name":"Densitometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009904","descriptor_name":"Optical Rotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1399-3011.1973.tb03457.x","doi":"https://doi.org/10.1111/j.1399-3011.1973.tb03457.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-3011.1973.tb03457.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210190181","display_name":"International journal of peptide & protein research","issn_l":"0367-8377","issn":["0367-8377"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Peptide and Protein Research","raw_type":"journal-article"},{"id":"pmid:4796696","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4796696","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of peptide and protein research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1955101318","https://openalex.org/W2016924802","https://openalex.org/W2049881751","https://openalex.org/W2093122332","https://openalex.org/W2110222046","https://openalex.org/W2110536097","https://openalex.org/W2314836559","https://openalex.org/W2327694135","https://openalex.org/W2442776015","https://openalex.org/W4246774493"],"related_works":["https://openalex.org/W2110536097","https://openalex.org/W7024720786","https://openalex.org/W7097952192","https://openalex.org/W2162613266","https://openalex.org/W4242670535","https://openalex.org/W2590075174","https://openalex.org/W2015510077","https://openalex.org/W1991068163","https://openalex.org/W2063164023","https://openalex.org/W2075238973"],"abstract_inverted_index":{"Thermal":[0],"denaturation":[1,117],"of":[2,21,24,89,113,116,121],"ribonuclease":[3,22],"has":[4],"been":[5],"investigated":[6],"by":[7,32,73,86],"scanning":[8],"microcalorimetric,":[9],"spectrophotometric":[10],"and":[11,28,92,118],"polarimetric":[12],"techniques.":[13],"It":[14],"is":[15,71,96],"shown":[16],"that":[17],"the":[18,33,42,59,67,78,87,90,103,122],"temperature":[19,34,115],"changes":[20,49,120],"are":[23,129],"a":[25,97],"complicated":[26],"character":[27],"may":[29],"be":[30],"subdivided":[31],"region":[35],"into":[36],"two":[37,104],"qualitatively":[38],"different":[39],"stages:":[40],"(a)":[41],"predenaturational":[43],"stage,":[44],"at":[45,99,125],"which":[46,70],"neither":[47],"abrupt":[48,79],"in":[50,81],"physico\u2010chemical":[51,83],"properties":[52],"nor":[53],"heat":[54,62,75,123],"absorption":[55,76],"occur,":[56],"but":[57],"where":[58],"protein":[60],"partial":[61],"capacity":[63,124],"considerably":[64],"grows;":[65],"(b)":[66],"denaturational":[68,119],"stage":[69,101],"accompanied":[72],"intensive":[74],"with":[77],"change":[80],"all":[82],"properties.":[84],"Judging":[85],"coincidence":[88],"calorimetric":[91],"effective":[93],"enthalpies,":[94],"there":[95],"transition":[98],"this":[100],"between":[102],"states":[105],"without":[106],"intermediate":[107],"thermodynamically":[108],"stable":[109],"forms.":[110],"Enthalpy":[111],"values":[112,128],"denaturation,":[114],"various":[126],"pH":[127],"given.":[130]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
