{"id":"https://openalex.org/W2074855428","doi":"https://doi.org/10.1161/01.cir.0000131764.62242.96","title":"Gene Transfer of Parvalbumin Improves Diastolic Dysfunction in Senescent Myocytes","display_name":"Gene Transfer of Parvalbumin Improves Diastolic Dysfunction in Senescent Myocytes","publication_year":2004,"publication_date":"2004-06-07","ids":{"openalex":"https://openalex.org/W2074855428","doi":"https://doi.org/10.1161/01.cir.0000131764.62242.96","mag":"2074855428","pmid":"https://pubmed.ncbi.nlm.nih.gov/15173024"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.0000131764.62242.96","doi":"https://doi.org/10.1161/01.cir.0000131764.62242.96","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.0000131764.62242.96","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.0000131764.62242.96","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.0000131764.62242.96","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066533706","display_name":"Fawzia Huq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fawzia Huq","raw_affiliation_strings":["From the Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown (F.H., D.L., V.I., R.J.H.), and the Cardiac Muscle Research Laboratory, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston (R.L.), Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown (F.H., D.L., V.I., R.J.H.), and the Cardiac Muscle Research Laboratory, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston (R.L.), Mass","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059058710","display_name":"Djamel Lebeche","orcid":"https://orcid.org/0000-0002-7911-2923","observed_orcids":["https://orcid.org/0000-0002-7911-2923"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Djamel Lebeche","raw_affiliation_strings":["From the Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown (F.H., D.L., V.I., R.J.H.), and the Cardiac Muscle Research Laboratory, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston (R.L.), Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown (F.H., D.L., V.I., R.J.H.), and the Cardiac Muscle Research Laboratory, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston (R.L.), Mass","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103072904","display_name":"Vivek Iyer","orcid":"https://orcid.org/0000-0003-4451-8293","observed_orcids":["https://orcid.org/0000-0003-4451-8293"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivek Iyer","raw_affiliation_strings":["From the Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown (F.H., D.L., V.I., R.J.H.), and the Cardiac Muscle Research Laboratory, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston (R.L.), Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown (F.H., D.L., V.I., R.J.H.), and the Cardiac Muscle Research Laboratory, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston (R.L.), Mass","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052626419","display_name":"Ronglih Liao","orcid":"https://orcid.org/0000-0002-9598-9020","observed_orcids":["https://orcid.org/0000-0002-9598-9020"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronglih Liao","raw_affiliation_strings":["From the Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown (F.H., D.L., V.I., R.J.H.), and the Cardiac Muscle Research Laboratory, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston (R.L.), Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown (F.H., D.L., V.I., R.J.H.), and the Cardiac Muscle Research Laboratory, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston (R.L.), Mass","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032209826","display_name":"Roger J. Hajjar","orcid":"https://orcid.org/0000-0003-2522-1507","observed_orcids":["https://orcid.org/0000-0003-2522-1507"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger J. Hajjar","raw_affiliation_strings":["From the Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown (F.H., D.L., V.I., R.J.H.), and the Cardiac Muscle Research Laboratory, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston (R.L.), Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown (F.H., D.L., V.I., R.J.H.), and the Cardiac Muscle Research Laboratory, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston (R.L.), Mass","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.58,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.89784181,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"109","issue":"22","first_page":"2780","last_page":"2785"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.33469998836517334,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.33469998836517334,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.23170000314712524,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.13490000367164612,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parvalbumin","display_name":"parvalbumin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diastolic-dysfunction","display_name":"diastolic dysfunction","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cardiomyocyte-senescence","display_name":"cardiomyocyte senescence","score":0.8949999809265137},{"id":"https://openalex.org/keywords/adenoviral-gene-transfer","display_name":"adenoviral gene transfer","score":0.871999979019165},{"id":"https://openalex.org/keywords/calcium-buffering","display_name":"calcium buffering","score":0.6200000047683716},{"id":"https://openalex.org/keywords/calcium-transients","display_name":"calcium transients","score":0.7680000066757202},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.5360000133514404},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8812112808227539},{"id":"https://openalex.org/C141547260","wikidata":"https://www.wikidata.org/wiki/Q2720322","display_name":"Parvalbumin","level":2,"score":0.7007224559783936},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.6176925897598267},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.615524411201477},{"id":"https://openalex.org/C3018928802","wikidata":"https://www.wikidata.org/wiki/Q83185","display_name":"Gene transfer","level":3,"score":0.5863683223724365},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5218095779418945},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5095348954200745},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4589551091194153},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3534301817417145},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2095022201538086},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20908036828041077},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.10317999124526978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07317286729812622}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010320","descriptor_name":"Parvalbumins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010320","descriptor_name":"Parvalbumins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010320","descriptor_name":"Parvalbumins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010320","descriptor_name":"Parvalbumins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010320","descriptor_name":"Parvalbumins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010320","descriptor_name":"Parvalbumins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010320","descriptor_name":"Parvalbumins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010320","descriptor_name":"Parvalbumins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010320","descriptor_name":"Parvalbumins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010320","descriptor_name":"Parvalbumins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010320","descriptor_name":"Parvalbumins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010320","descriptor_name":"Parvalbumins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.cir.0000131764.62242.96","doi":"https://doi.org/10.1161/01.cir.0000131764.62242.96","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.0000131764.62242.96","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.0000131764.62242.96","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:15173024","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15173024","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1161/01.cir.0000131764.62242.96","doi":"https://doi.org/10.1161/01.cir.0000131764.62242.96","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.0000131764.62242.96","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.0000131764.62242.96","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7799999713897705}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1762127498","display_name":"K and Ca Channels in Cardiac Hypertrophy and Failure","funder_award_id":"R01HL071763","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1941377621","display_name":"Tracking Stem Cells: Viability and Function in the Heart","funder_award_id":"5r01hl073756-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2311557989","display_name":null,"funder_award_id":"HL057623","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4393796485","display_name":null,"funder_award_id":"HL 071763","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4539683967","display_name":null,"funder_award_id":"HLK0176659","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G511980200","display_name":null,"funder_award_id":"HL-067297","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6537265355","display_name":null,"funder_award_id":"HL-073756","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6617589049","display_name":"Regulation of Ca-signaling in Myofilaments by Troponin C","funder_award_id":"R01HL067297","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320323874","display_name":"Universit\u00e4t Z\u00fcrich","ror":"https://ror.org/02crff812"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2074855428.pdf","grobid_xml":"https://content.openalex.org/works/W2074855428.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W89282647","https://openalex.org/W1525577992","https://openalex.org/W1951805102","https://openalex.org/W1974214480","https://openalex.org/W1994348876","https://openalex.org/W1996141717","https://openalex.org/W1999021161","https://openalex.org/W2005624606","https://openalex.org/W2042145151","https://openalex.org/W2049547138","https://openalex.org/W2065503803","https://openalex.org/W2070813187","https://openalex.org/W2073892964","https://openalex.org/W2079286233","https://openalex.org/W2093688245","https://openalex.org/W2127926880","https://openalex.org/W2131892916","https://openalex.org/W2132912862","https://openalex.org/W2133916339","https://openalex.org/W2149136975","https://openalex.org/W2156265674","https://openalex.org/W2157581901","https://openalex.org/W2977097895","https://openalex.org/W4253422011","https://openalex.org/W4293179290"],"related_works":["https://openalex.org/W2033107022","https://openalex.org/W2038444503","https://openalex.org/W2065503803","https://openalex.org/W2167504654","https://openalex.org/W1996141717","https://openalex.org/W2072600439","https://openalex.org/W2131271123","https://openalex.org/W2913212950","https://openalex.org/W7096258439","https://openalex.org/W2096447726"],"abstract_inverted_index":{"BACKGROUND:":[0],"Impaired":[1],"relaxation":[2,34,136,181,190],"is":[3,84],"a":[4,17,91,111,195,211],"cardinal":[5],"feature":[6],"of":[7,15,38,43,93,95,113,144,151,188,198,206],"senescent":[8,58,67,101,139,158,219],"myocardial":[9],"dysfunction.":[10,40],"Recently,":[11],"adenoviral":[12],"gene":[13,51,204],"transfer":[14,52,205],"parvalbumin,":[16],"small":[18],"calcium-buffering":[19],"protein":[20],"found":[21],"exclusively":[22],"in":[23,35,57,138,157,182,194,218],"skeletal":[24],"muscle":[25],"and":[26,70,77,102,119,128,148,167],"neurons,":[27],"has":[28],"been":[29],"shown":[30],"to":[31,47,214],"improve":[32],"cardiomyocyte":[33],"disease":[36],"models":[37],"diastolic":[39,55,192,216],"The":[41],"goal":[42],"this":[44],"study":[45],"was":[46],"investigate":[48],"whether":[49],"parvalbumin":[50,163,207],"could":[53],"reverse":[54],"dysfunction":[56,193,217],"cardiomyocytes.":[59],"METHODS":[60],"AND":[61],"RESULTS:":[62],"Myocytes":[63],"were":[64,78,122,154],"isolated":[65],"from":[66],"(26":[68],"months)":[69,73],"adult":[71,103],"(6":[72],"F344/BN":[74],"hybrid":[75],"rats":[76],"infected":[79],"with":[80,162,165,170,201],"Ad.Parv.GFP":[81],"(where":[82],"GFP":[83],"green":[85],"fluorescent":[86],"protein)":[87],"or":[88],"Ad.betagal.GFP":[89],"at":[90,110],"multiplicity":[92],"infection":[94],"250":[96],"for":[97],"48":[98],"hours.":[99],"Uninfected":[100],"myocytes":[104,160],"served":[105],"as":[106],"controls.":[107],"After":[108],"stimulation":[109],"frequency":[112],"0.5":[114],"Hz,":[115],"intracellular":[116],"calcium":[117,145],"transients":[118],"myocyte":[120,152,174,189],"contractility":[121],"measured":[123],"using":[124],"dual":[125],"excitation":[126],"spectrofluorometry":[127],"video-edge":[129],"detection":[130],"system":[131],"(Ionoptix).":[132],"Parvalbumin":[133,177],"significantly":[134],"improved":[135],"parameters":[137],"myocytes:":[140],"Both":[141],"the":[142,149],"rate":[143,150],"transient":[146],"decay":[147],"relengthening":[153],"dramatically":[155],"increased":[156],"cardiac":[159],"transduced":[161],"compared":[164],"nontransduced":[166],"GFP-expressing":[168],"controls,":[169],"no":[171],"effect":[172],"on":[173],"shortening.":[175],"CONCLUSIONS:":[176],"expression":[178],"corrects":[179],"impaired":[180],"aging":[183],"myocytes.":[184],"Given":[185],"that":[186],"abnormalities":[187],"underlie":[191],"large":[196],"proportion":[197],"elderly":[199],"patients":[200],"heart":[202],"failure,":[203],"may":[208],"thus":[209],"be":[210],"novel":[212],"approach":[213],"target":[215],"myocardium.":[220]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}