{"id":"https://openalex.org/W2074807178","doi":"https://doi.org/10.1016/j.neuint.2007.10.006","title":"Programmed cell death and differential JNK, p38 and ERK response in a prenatal acute hypoxic hypoxia model","display_name":"Programmed cell death and differential JNK, p38 and ERK response in a prenatal acute hypoxic hypoxia model","publication_year":2007,"publication_date":"2007-12-05","ids":{"openalex":"https://openalex.org/W2074807178","doi":"https://doi.org/10.1016/j.neuint.2007.10.006","mag":"2074807178","pmid":"https://pubmed.ncbi.nlm.nih.gov/18077057"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuint.2007.10.006","doi":"https://doi.org/10.1016/j.neuint.2007.10.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuint.2007.10.006","pdf_url":null,"source":{"id":"https://openalex.org/S53315755","display_name":"Neurochemistry International","issn_l":"0197-0186","issn":["0197-0186","1872-9754"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemistry International","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004572824","display_name":"Marina Vacotto","orcid":"https://orcid.org/0000-0001-5026-7545","observed_orcids":["https://orcid.org/0000-0001-5026-7545"]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Marina Vacotto","raw_affiliation_strings":["Instituto de Biolog\u00eda Celular y Neurociencias, Prof. E. De Robertis, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biolog\u00eda Celular y Neurociencias, Prof. E. De Robertis, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036745399","display_name":"Omar A. Coso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Omar Coso","raw_affiliation_strings":["Laboratorio de Fisiologia y Biologia Molecular, FCEyN, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Fisiologia y Biologia Molecular, FCEyN, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032080281","display_name":"Sara Fiszer de Plazas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Sara Fiszer de Plazas","raw_affiliation_strings":["Instituto de Biolog\u00eda Celular y Neurociencias, Prof. E. De Robertis, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biolog\u00eda Celular y Neurociencias, Prof. E. De Robertis, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5032080281"],"corresponding_institution_ids":["https://openalex.org/I24354313"],"apc_list":{"value":4170,"currency":"USD","value_usd":4170},"apc_paid":null,"fwci":0.9508,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.77884293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"52","issue":"4-5","first_page":"857","last_page":"863"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.5282999873161316,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.5282999873161316,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.3743000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prenatal-hypoxia","display_name":"prenatal hypoxia","score":0.871999979019165},{"id":"https://openalex.org/keywords/acute-hypoxia","display_name":"acute hypoxia","score":0.878000020980835},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.9330000281333923},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/jnk-signaling","display_name":"JNK signaling","score":0.6499999761581421},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9890000224113464},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.8550000190734863},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mapk-inhibitors","display_name":"MAPK inhibitors","score":0.8149999976158142},{"id":"https://openalex.org/keywords/sp600125","display_name":"SP600125","score":0.9769999980926514},{"id":"https://openalex.org/keywords/sb203580","display_name":"SB203580","score":1.0},{"id":"https://openalex.org/keywords/atf2-phosphorylation","display_name":"ATF2 phosphorylation","score":0.890999972820282},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.6650000214576721},{"id":"https://openalex.org/keywords/tunel-positive-cells","display_name":"TUNEL-positive cells","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.8082919716835022},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7175958752632141},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.6860116720199585},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6233065128326416},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5847010612487793},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5458869934082031},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.49761489033699036},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.42470067739486694},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4229200482368469},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41629067063331604},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.36210352182388306},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3501036465167999},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3416091203689575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2445698082447052},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1743236482143402},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.06398844718933105},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005311","descriptor_name":"Fetal Hypoxia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005311","descriptor_name":"Fetal Hypoxia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005311","descriptor_name":"Fetal Hypoxia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neuint.2007.10.006","doi":"https://doi.org/10.1016/j.neuint.2007.10.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuint.2007.10.006","pdf_url":null,"source":{"id":"https://openalex.org/S53315755","display_name":"Neurochemistry International","issn_l":"0197-0186","issn":["0197-0186","1872-9754"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemistry International","raw_type":"journal-article"},{"id":"pmid:18077057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18077057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemistry international","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W148135683","https://openalex.org/W172990362","https://openalex.org/W1524544406","https://openalex.org/W1530284699","https://openalex.org/W1775749144","https://openalex.org/W1793531678","https://openalex.org/W1896626713","https://openalex.org/W1966569555","https://openalex.org/W1968590447","https://openalex.org/W1975411977","https://openalex.org/W1976385326","https://openalex.org/W1982031776","https://openalex.org/W1982390204","https://openalex.org/W1982499214","https://openalex.org/W1984715375","https://openalex.org/W1984903682","https://openalex.org/W1986559713","https://openalex.org/W1992420595","https://openalex.org/W1998487776","https://openalex.org/W1999199122","https://openalex.org/W2011982813","https://openalex.org/W2015592781","https://openalex.org/W2015779123","https://openalex.org/W2023849102","https://openalex.org/W2025850775","https://openalex.org/W2026951979","https://openalex.org/W2028644532","https://openalex.org/W2030664517","https://openalex.org/W2034784191","https://openalex.org/W2051448083","https://openalex.org/W2051663577","https://openalex.org/W2052428304","https://openalex.org/W2054013683","https://openalex.org/W2058342631","https://openalex.org/W2061447912","https://openalex.org/W2067113295","https://openalex.org/W2070508570","https://openalex.org/W2073730363","https://openalex.org/W2074169536","https://openalex.org/W2075104267","https://openalex.org/W2089880838","https://openalex.org/W2096305112","https://openalex.org/W2097779408","https://openalex.org/W2109159083","https://openalex.org/W2125331084","https://openalex.org/W2137979644","https://openalex.org/W2138302361","https://openalex.org/W2142638534","https://openalex.org/W2142848667","https://openalex.org/W2154473315","https://openalex.org/W2155124532","https://openalex.org/W6674893821"],"related_works":["https://openalex.org/W2067009526","https://openalex.org/W2136276833","https://openalex.org/W2062628662","https://openalex.org/W1982031776","https://openalex.org/W2070508570","https://openalex.org/W2015779123","https://openalex.org/W1974896352","https://openalex.org/W2037695401","https://openalex.org/W1992723989","https://openalex.org/W71702394"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}