{"id":"https://openalex.org/W2074779331","doi":"https://doi.org/10.1074/jbc.m109.017608","title":"Exendin-4 Promotes Liver Cell Proliferation and Enhances the PDX-1-induced Liver to Pancreas Transdifferentiation Process","display_name":"Exendin-4 Promotes Liver Cell Proliferation and Enhances the PDX-1-induced Liver to Pancreas Transdifferentiation Process","publication_year":2009,"publication_date":"2009-09-16","ids":{"openalex":"https://openalex.org/W2074779331","doi":"https://doi.org/10.1074/jbc.m109.017608","mag":"2074779331","pmid":"https://pubmed.ncbi.nlm.nih.gov/19755420","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2785195"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m109.017608","doi":"https://doi.org/10.1074/jbc.m109.017608","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.017608","pdf_url":"http://www.jbc.org/article/S0021925820377899/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820377899/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043060552","display_name":"Vered Aviv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Vered Aviv","raw_affiliation_strings":["Endocrine Institute, Sheba Medical Center, Tel-Hashomer 52621, Israel","Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Institute, Sheba Medical Center, Tel-Hashomer 52621, Israel","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077873505","display_name":"Irit Meivar\u2010Levy","orcid":"https://orcid.org/0000-0002-4618-3653","observed_orcids":["https://orcid.org/0000-0002-4618-3653"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Irit Meivar-Levy","raw_affiliation_strings":["Endocrine Institute, Sheba Medical Center, Tel-Hashomer 52621, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Institute, Sheba Medical Center, Tel-Hashomer 52621, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042765513","display_name":"Itzhak H. Rachmut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Itzhak H. Rachmut","raw_affiliation_strings":["Endocrine Institute, Sheba Medical Center, Tel-Hashomer 52621, Israel","Life Science, Bar-Ilan University, Ramat-Gan 52900, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Institute, Sheba Medical Center, Tel-Hashomer 52621, Israel","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Life Science, Bar-Ilan University, Ramat-Gan 52900, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062850935","display_name":"Tamar Rubinek","orcid":"https://orcid.org/0000-0003-4731-8887","observed_orcids":["https://orcid.org/0000-0003-4731-8887"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Tamar Rubinek","raw_affiliation_strings":["Institute of Oncology, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Oncology, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112424809","display_name":"Eytan Mor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Eytan Mor","raw_affiliation_strings":["Rabin Medical Center, Beilinson Campus, Petah-Tiqva 49100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rabin Medical Center, Beilinson Campus, Petah-Tiqva 49100, Israel","institution_ids":["https://openalex.org/I2800389475"]}]},{"author_position":"last","author":{"id":null,"display_name":"Sarah Ferber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Sarah Ferber","raw_affiliation_strings":["Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel","Endocrine Institute, Sheba Medical Center, Tel-Hashomer 52621, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Endocrine Institute, Sheba Medical Center, Tel-Hashomer 52621, Israel","institution_ids":["https://openalex.org/I2799810450"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2799810450"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":10.1206,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.98415966,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"284","issue":"48","first_page":"33509","last_page":"33520"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exendin-4","display_name":"exendin-4","score":1.0},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.949999988079071},{"id":"https://openalex.org/keywords/pdx1","display_name":"PDX1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/liver-cell-proliferation","display_name":"liver cell proliferation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/islet-cells","display_name":"pancreatic endocrine cells","score":0.6470000147819519},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.7239999771118164},{"id":"https://openalex.org/keywords/insulin-producing-cells","display_name":"insulin-producing cells","score":0.5299999713897705},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C60870556","wikidata":"https://www.wikidata.org/wiki/Q2300675","display_name":"Transdifferentiation","level":3,"score":0.9757598638534546},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7096114158630371},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.6875853538513184},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.6173218488693237},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.596473753452301},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5465025305747986},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.478833943605423},{"id":"https://openalex.org/C2779050171","wikidata":"https://www.wikidata.org/wiki/Q18027973","display_name":"PDX1","level":4,"score":0.45522934198379517},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.43406978249549866},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42631155252456665},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3930177688598633},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.384330689907074},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3517678380012512},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3112489879131317},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.29479360580444336},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.10300332307815552},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09450986981391907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08751285076141357},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07058581709861755}],"mesh":[{"descriptor_ui":"D000067757","descriptor_name":"Glucagon-Like Peptide-1 Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077270","descriptor_name":"Exenatide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014688","descriptor_name":"Venoms","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D054338","descriptor_name":"Cell Transdifferentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m109.017608","doi":"https://doi.org/10.1074/jbc.m109.017608","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.017608","pdf_url":"http://www.jbc.org/article/S0021925820377899/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1781202","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2785195","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2785195","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2785195","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:19755420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19755420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m109.017608","doi":"https://doi.org/10.1074/jbc.m109.017608","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.017608","pdf_url":"http://www.jbc.org/article/S0021925820377899/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320309420","display_name":"Legacy Heritage Fund","ror":"https://ror.org/0370d4798"},{"id":"https://openalex.org/F4320320870","display_name":"European Foundation for the Study of Diabetes","ror":"https://ror.org/05tgz4m05"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2074779331.pdf","grobid_xml":"https://content.openalex.org/works/W2074779331.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1012070930","https://openalex.org/W1983987527","https://openalex.org/W1991834073","https://openalex.org/W2011065045","https://openalex.org/W2012133296","https://openalex.org/W2013330167","https://openalex.org/W2018646005","https://openalex.org/W2021555961","https://openalex.org/W2031631150","https://openalex.org/W2031942773","https://openalex.org/W2032524589","https://openalex.org/W2036472668","https://openalex.org/W2038463744","https://openalex.org/W2052868121","https://openalex.org/W2055486902","https://openalex.org/W2063561789","https://openalex.org/W2069914182","https://openalex.org/W2070577096","https://openalex.org/W2078201925","https://openalex.org/W2084948079","https://openalex.org/W2088927115","https://openalex.org/W2100614900","https://openalex.org/W2108394804","https://openalex.org/W2116818563","https://openalex.org/W2133916339","https://openalex.org/W2136760402","https://openalex.org/W2140004965","https://openalex.org/W2141880555","https://openalex.org/W2162418500","https://openalex.org/W2168048823","https://openalex.org/W2169938583","https://openalex.org/W2181615019","https://openalex.org/W4253422011"],"related_works":["https://openalex.org/W2036472668","https://openalex.org/W2098812327","https://openalex.org/W2133586331","https://openalex.org/W1978490164","https://openalex.org/W2893215169","https://openalex.org/W135140521","https://openalex.org/W7101101063","https://openalex.org/W2012133296","https://openalex.org/W1983719838","https://openalex.org/W4415324951"],"abstract_inverted_index":{"Over":[0],"the":[1,9,43,65,86,94,127,148,158,164,171,180,194,200,207,222,229,235,243,246],"last":[2],"few":[3],"years,":[4],"evidence":[5],"has":[6,73,212],"accumulated":[7],"revealing":[8],"unexpected":[10],"potential":[11],"of":[12,45,68,93,150,166,182,196,221,234,245],"committed":[13],"mammalian":[14],"cells":[15,69,80,184,198,225],"to":[16,18,83,85,119,133,152,186,190,241],"convert":[17],"a":[19,23,135,216],"different":[20],"phenotype":[21],"via":[22],"process":[24,40,173,237,248],"called":[25],"transdifferentiation":[26,172,236],"or":[27],"adult":[28,71,77],"cell":[29,140,204,210],"reprogramming.":[30],"These":[31],"findings":[32],"may":[33,41],"have":[34,123],"major":[35],"practical":[36],"implications":[37],"because":[38],"this":[39],"facilitate":[42],"generation":[44],"functional":[46,219],"autologous":[47],"tissues":[48,72],"that":[49,157],"can":[50,145],"be":[51],"used":[52],"for":[53,60,218],"replacing":[54],"malfunctioning":[55],"organs.":[56],"An":[57],"instructive":[58],"role":[59,136],"transcription":[61],"factors":[62],"in":[63,70,117,137,188,226],"diverting":[64],"developmental":[66,114],"fate":[67],"been":[74,213],"demonstrated":[75],"when":[76],"human":[78],"liver":[79,151,183],"were":[81],"induced":[82],"transdifferentiate":[84],"pancreatic":[87,95,138,201,208],"endocrine":[88],"lineage":[89,108,211],"upon":[90],"ectopic":[91],"expression":[92],"master":[96],"regulator":[97],"PDX-1":[98,191],"(pancreatic":[99],"and":[100,107,143,192,231,249],"duodenal":[101],"homeobox":[102],"gene":[103],"1).":[104],"Since":[105],"organogenesis":[106],"commitment":[109],"are":[110],"affected":[111],"also":[112,146],"by":[113],"signals":[115],"generated":[116],"response":[118,189],"environmental":[120],"triggers,":[121],"we":[122],"now":[124],"analyzed":[125],"whether":[126],"hormone":[128],"GLP-1":[129],"(glucogen-like":[130],"peptide-1)":[131],"documented":[132],"play":[134],"beta":[139,209],"differentiation,":[141],"maturation,":[142],"survival,":[144],"increase":[147,242],"efficiency":[149,165,244],"pancreas":[153],"transdifferentiation.":[154,168],"We":[155],"demonstrate":[156],"GLP-1R":[159],"agonist,":[160],"exendin-4,":[161],"significantly":[162],"improves":[163],"PDX-1-mediated":[167],"Exendin-4":[169],"affects":[170],"at":[174],"two":[175],"distinct":[176],"steps;":[177],"it":[178],"increases":[179],"proliferation":[181],"predisposed":[185],"transdifferentiated":[187,197],"promotes":[193],"maturation":[195],"along":[199],"lineage.":[202],"Liver":[203],"reprogramming":[205,247],"toward":[206],"suggested":[214],"as":[215],"strategy":[217],"replacement":[220],"ablated":[223],"insulin-producing":[224],"diabetics.":[227],"Understanding":[228],"cellular":[230],"molecular":[232],"basis":[233],"will":[238],"allow":[239],"us":[240],"optimize":[250],"its":[251],"therapeutic":[252],"merit.":[253]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":12}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
