{"id":"https://openalex.org/W2074772243","doi":"https://doi.org/10.1021/mp050032z","title":"Enhanced Antiproliferative Activity of Transferrin-Conjugated Paclitaxel-Loaded Nanoparticles Is Mediated via Sustained Intracellular Drug Retention","display_name":"Enhanced Antiproliferative Activity of Transferrin-Conjugated Paclitaxel-Loaded Nanoparticles Is Mediated via Sustained Intracellular Drug Retention","publication_year":2005,"publication_date":"2005-06-21","ids":{"openalex":"https://openalex.org/W2074772243","doi":"https://doi.org/10.1021/mp050032z","mag":"2074772243","pmid":"https://pubmed.ncbi.nlm.nih.gov/16196490"},"language":"en","primary_location":{"id":"doi:10.1021/mp050032z","doi":"https://doi.org/10.1021/mp050032z","is_oa":false,"landing_page_url":"https://doi.org/10.1021/mp050032z","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061368317","display_name":"Sanjeeb Kumar Sahoo","orcid":"https://orcid.org/0000-0002-9096-6954","observed_orcids":["https://orcid.org/0000-0002-9096-6954"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjeeb K. Sahoo","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198-6025, and Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198-4525"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198-6025, and Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198-4525","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071677506","display_name":"Vinod D. Labhasetwar","orcid":"https://orcid.org/0000-0001-7950-1542","observed_orcids":["https://orcid.org/0000-0001-7950-1542"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vinod Labhasetwar","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198-6025, and Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198-4525"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198-6025, and Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198-4525","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071677506"],"corresponding_institution_ids":["https://openalex.org/I59130452"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.2956,"has_fulltext":false,"cited_by_count":342,"citation_normalized_percentile":{"value":0.94784079,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"2","issue":"5","first_page":"373","last_page":"383"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9200000166893005},{"id":"https://openalex.org/keywords/plga-nanoparticles","display_name":"PLGA nanoparticles","score":0.8980000019073486},{"id":"https://openalex.org/keywords/intracellular-drug-retention","display_name":"intracellular drug retention","score":0.7519999742507935},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.5889999866485596},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/mcf-7-adr-cells","display_name":"MCF-7/ADR cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8399999737739563},{"id":"https://openalex.org/keywords/transferrin-receptor","display_name":"transferrin receptor","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.7599999904632568},{"id":"https://openalex.org/keywords/exocytosis","display_name":"exocytosis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.8627117872238159},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7105190753936768},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6999324560165405},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6323695182800293},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.5684455037117004},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5398054122924805},{"id":"https://openalex.org/C112613896","wikidata":"https://www.wikidata.org/wiki/Q898370","display_name":"Conjugated system","level":3,"score":0.44247135519981384},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.4277164936065674},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3222001791000366},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1973036527633667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18397659063339233},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1822965443134308},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.150953471660614},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11859014630317688},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0883534848690033},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014168","descriptor_name":"Transferrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014168","descriptor_name":"Transferrin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014168","descriptor_name":"Transferrin","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014168","descriptor_name":"Transferrin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/mp050032z","doi":"https://doi.org/10.1021/mp050032z","is_oa":false,"landing_page_url":"https://doi.org/10.1021/mp050032z","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:16196490","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16196490","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmaceutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1552589960","https://openalex.org/W1601203296","https://openalex.org/W1664986234","https://openalex.org/W1971579914","https://openalex.org/W1983260096","https://openalex.org/W1988723846","https://openalex.org/W1996863476","https://openalex.org/W1998985130","https://openalex.org/W1999204999","https://openalex.org/W2005557567","https://openalex.org/W2012657157","https://openalex.org/W2043935611","https://openalex.org/W2046606679","https://openalex.org/W2053026268","https://openalex.org/W2053619773","https://openalex.org/W2055918793","https://openalex.org/W2061672022","https://openalex.org/W2063509123","https://openalex.org/W2063723183","https://openalex.org/W2078080940","https://openalex.org/W2078683291","https://openalex.org/W2079793032","https://openalex.org/W2087020662","https://openalex.org/W2089633391","https://openalex.org/W2089773350","https://openalex.org/W2090127461","https://openalex.org/W2094690600","https://openalex.org/W2095512576","https://openalex.org/W2097878215","https://openalex.org/W2098899609","https://openalex.org/W2110651692","https://openalex.org/W2127685088","https://openalex.org/W2138213276","https://openalex.org/W2156368993","https://openalex.org/W2424811722","https://openalex.org/W4248409326"],"related_works":["https://openalex.org/W1999204999","https://openalex.org/W2990297243","https://openalex.org/W2436094648","https://openalex.org/W2735316179","https://openalex.org/W2617797208","https://openalex.org/W2088893076","https://openalex.org/W2033433109","https://openalex.org/W2516099104","https://openalex.org/W2596215976","https://openalex.org/W4220983031"],"abstract_inverted_index":{"We":[0],"studied":[1],"the":[2,52,81,120,133,173,181,185],"molecular":[3],"mechanism":[4,75],"of":[5,8,51,76,80,102,119,148,164,184],"greater":[6,46,77,93],"efficacy":[7,183],"paclitaxel-loaded":[9],"nanoparticles":[10],"(Tx-NPs)":[11],"following":[12,151],"conjugation":[13],"to":[14,36,60,88,91,100,107],"transferrin":[15],"(Tf)":[16],"ligand":[17,38],"in":[18,54,64,69,116,125],"breast":[19],"cancer":[20],"cell":[21],"line.":[22],"NPs":[23,44,68,85,130,150,166],"were":[24],"formulated":[25],"using":[26],"biodegradable":[27],"polymer,":[28],"poly(lactic-co-glycolide)":[29],"(PLGA),":[30],"with":[31,62,83,122,128],"encapsulated":[32,186],"Tx":[33],"and":[34,47,56,71,96,109,179],"conjugated":[35,84],"Tf":[37,156],"via":[39,155,167],"an":[40],"epoxy":[41],"linker.":[42],"Tf-conjugated":[43,129,149],"demonstrated":[45],"sustained":[48,110],"antiproliferative":[49,78,117],"activity":[50,79,118],"drug":[53,63,82,112,121,134,142],"dose-":[55],"time-dependent":[57],"studies":[58],"compared":[59,99],"that":[61,101,132,163],"solution":[65],"or":[66],"unconjugated":[67,103,165],"MCF-7":[70],"MCF-7/Adr":[72,126],"cells.":[73],"The":[74,114,144],"was":[86],"determined":[87],"be":[89,137],"due":[90],"their":[92,152,176],"cellular":[94,153],"uptake":[95,154],"reduced":[97],"exocytosis":[98],"NPs,":[104],"thus":[105,171],"leading":[106],"higher":[108],"intracellular":[111,141,145,177],"levels.":[113],"increase":[115],"incubation":[123],"time":[124],"cells":[127],"suggests":[131],"resistance":[135],"can":[136],"overcome":[138],"by":[139],"sustaining":[140],"retention.":[143],"disposition":[146],"characteristics":[147],"receptors":[157],"could":[158],"have":[159],"been":[160],"different":[161],"from":[162],"nonspecific":[168],"endocytic":[169],"pathway,":[170],"influencing":[172],"NP":[174],"uptake,":[175],"retention,":[178],"hence":[180],"therapeutic":[182],"drug.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":28},{"year":2012,"cited_by_count":27}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
