{"id":"https://openalex.org/W2074767013","doi":"https://doi.org/10.1080/15257779908043069","title":"Synthesis and Biological Evaluation of a Carbocyclic Azanoraristeromycin Siderophore Conjugate","display_name":"Synthesis and Biological Evaluation of a Carbocyclic Azanoraristeromycin Siderophore Conjugate","publication_year":1999,"publication_date":"1999-02-01","ids":{"openalex":"https://openalex.org/W2074767013","doi":"https://doi.org/10.1080/15257779908043069","mag":"2074767013","pmid":"https://pubmed.ncbi.nlm.nih.gov/10067274"},"language":"en","primary_location":{"id":"doi:10.1080/15257779908043069","doi":"https://doi.org/10.1080/15257779908043069","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15257779908043069","pdf_url":null,"source":{"id":"https://openalex.org/S4210177795","display_name":"Nucleosides and Nucleotides","issn_l":"0732-8311","issn":["0732-8311","2332-3892"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides and Nucleotides","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041773055","display_name":"Arun Kumar Ghosh","orcid":"https://orcid.org/0000-0003-2472-1841","observed_orcids":["https://orcid.org/0000-0003-2472-1841"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arun Ghosh","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556, USA","Department of Chemistry and Biochemistry , University of Notre Dame , Notre Dame, IN, 46556, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556, USA","institution_ids":["https://openalex.org/I107639228"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry , University of Notre Dame , Notre Dame, IN, 46556, USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091265699","display_name":"Marvin J. Miller","orcid":"https://orcid.org/0000-0002-3704-8214","observed_orcids":["https://orcid.org/0000-0002-3704-8214"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marvin J. Miller","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040662398","display_name":"Erik De Clercq","orcid":"https://orcid.org/0000-0002-2985-8890","observed_orcids":["https://orcid.org/0000-0002-2985-8890"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Erik De Clercq","raw_affiliation_strings":["Rega Institute for Medical Research Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038319371","display_name":"Jan M. Balzarini","orcid":"https://orcid.org/0000-0003-2240-3321","observed_orcids":["https://orcid.org/0000-0003-2240-3321","https://orcid.org/0000-0003-1144-1808"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jan Balzarini","raw_affiliation_strings":["Rega Institute for Medical Research Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5743,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.63010306,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"18","issue":"2","first_page":"217","last_page":"225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.2003999948501587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.2003999948501587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.12349999696016312,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.09120000153779984,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.8500000238418579},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8700000047683716},{"id":"https://openalex.org/keywords/iron-binding","display_name":"iron binding","score":0.32199999690055847},{"id":"https://openalex.org/keywords/deprotection","display_name":"deprotection","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.9409140348434448},{"id":"https://openalex.org/C108319773","wikidata":"https://www.wikidata.org/wiki/Q424747","display_name":"Siderophore","level":3,"score":0.9285834431648254},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4742376208305359},{"id":"https://openalex.org/C167392928","wikidata":"https://www.wikidata.org/wiki/Q4820777","display_name":"Tripeptide","level":3,"score":0.46166497468948364},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.45914125442504883},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4241224527359009},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3983728587627411},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3552238345146179},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31283459067344666},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.20156919956207275},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005291","descriptor_name":"Ferrichrome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017262","descriptor_name":"Siderophores","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D017262","descriptor_name":"Siderophores","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/15257779908043069","doi":"https://doi.org/10.1080/15257779908043069","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15257779908043069","pdf_url":null,"source":{"id":"https://openalex.org/S4210177795","display_name":"Nucleosides and Nucleotides","issn_l":"0732-8311","issn":["0732-8311","2332-3892"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides and Nucleotides","raw_type":"journal-article"},{"id":"pmid:10067274","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10067274","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides & nucleotides","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5246208302","display_name":"DRUGS AND DELIVERY SYSTEMS FOR OPPORTUNISTIC INFECTIONS","funder_award_id":"R01AI030988","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G975140997","display_name":null,"funder_award_id":"AI30988","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W211640632","https://openalex.org/W244727067","https://openalex.org/W1985529995","https://openalex.org/W2044255679","https://openalex.org/W2045067913","https://openalex.org/W2048804047","https://openalex.org/W2053584811","https://openalex.org/W2072412711","https://openalex.org/W2078704343","https://openalex.org/W2949643490","https://openalex.org/W2953009601","https://openalex.org/W2953276816"],"related_works":["https://openalex.org/W2951780369","https://openalex.org/W4414742561","https://openalex.org/W2044255679","https://openalex.org/W2087464654","https://openalex.org/W2027930398","https://openalex.org/W2037291813","https://openalex.org/W2043007242","https://openalex.org/W2048804047","https://openalex.org/W2005747995","https://openalex.org/W1980798298"],"abstract_inverted_index":{"Synthesis":[0],"and":[1,45,53],"biological":[2],"evaluation":[3],"of":[4,14,28],"a":[5],"carbocyclic":[6],"azanoraristeromycin":[7,36],"siderophore":[8,37],"conjugate":[9,38,54],"22":[10,46],"is":[11],"reported.":[12],"Coupling":[13],"previously":[15],"prepared":[16],"L-alanyl-4'-azanoraristeromycin":[17],"19":[18,44],"with":[19,41],"protected":[20],"tripeptide":[21],"trihydroxamate":[22],"20,":[23],"followed":[24],"by":[25,75],"hydrogenolytic":[26],"removal":[27],"all":[29],"protecting":[30],"groups,":[31],"provided":[32],"the":[33],"first":[34],"carbocylic":[35],"(22,":[39],"8":[40],"iron).":[42],"Compounds":[43],"showed":[47],"inhibitory":[48],"activity":[49,60],"against":[50,61],"tumor":[51],"cells,":[52],"22,":[55],"in":[56],"particular,":[57],"displayed":[58],"significant":[59],"those":[62],"viruses":[63],"(i.e.":[64],"reo,":[65],"parainfluenza,":[66],"vaccinia,":[67],"cytomegalo)":[68],"that":[69],"are":[70],"known":[71],"to":[72],"be":[73],"inhibited":[74],"S-adenosylhomocysteine":[76],"hydrolase":[77],"inhibitors.":[78]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
