{"id":"https://openalex.org/W2074765331","doi":"https://doi.org/10.1115/sbc2008-192145","title":"Effect of Pathological and Physiological Loads on Interleukin-1\u03b1 Protein Production in Porcine Menisci","display_name":"Effect of Pathological and Physiological Loads on Interleukin-1\u03b1 Protein Production in Porcine Menisci","publication_year":2008,"publication_date":"2008-06-25","ids":{"openalex":"https://openalex.org/W2074765331","doi":"https://doi.org/10.1115/sbc2008-192145","mag":"2074765331"},"language":"en","primary_location":{"id":"doi:10.1115/sbc2008-192145","doi":"https://doi.org/10.1115/sbc2008-192145","is_oa":false,"landing_page_url":"https://doi.org/10.1115/sbc2008-192145","pdf_url":null,"source":{"id":"https://openalex.org/S4306503435","display_name":"ASME Summer Bioengineering Conference (SBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASME 2008 Summer Bioengineering Conference, Parts A and B","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017760564","display_name":"Megan Leigh Killian","orcid":"https://orcid.org/0000-0001-6868-5550","observed_orcids":["https://orcid.org/0000-0001-6868-5550"]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan L. Killian","raw_affiliation_strings":["Michigan Technological University, Houghton, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michigan Technological University, Houghton, MI","institution_ids":["https://openalex.org/I11957088"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039534172","display_name":"Tammy L. Haut Donahue","orcid":"https://orcid.org/0000-0001-7129-9503","observed_orcids":["https://orcid.org/0000-0001-7129-9503"]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tammy L. Haut Donahue","raw_affiliation_strings":["Michigan Technological University, Houghton, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michigan Technological University, Houghton, MI","institution_ids":["https://openalex.org/I11957088"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I11957088"],"apc_list":null,"apc_paid":null,"fwci":8.6102,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.95463511,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"209","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10442","display_name":"Knee injuries and reconstruction techniques","score":0.2150000035762787,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1-alpha","display_name":"interleukin-1 alpha","score":0.9620000123977661},{"id":"https://openalex.org/keywords/meniscus","display_name":"meniscus","score":0.968999981880188},{"id":"https://openalex.org/keywords/compressive-strain","display_name":"compressive strain","score":0.7039999961853027},{"id":"https://openalex.org/keywords/meniscal-implant","display_name":"meniscal implant","score":0.5820000171661377},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.734000027179718},{"id":"https://openalex.org/keywords/meniscal-degeneration","display_name":"meniscal degeneration","score":0.746999979019165},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/meniscectomy","display_name":"meniscectomy","score":0.8140000104904175},{"id":"https://openalex.org/keywords/porcine-meniscus","display_name":"porcine meniscus","score":0.7179999947547913},{"id":"https://openalex.org/keywords/dynamic-loading","display_name":"dynamic loading","score":0.35899999737739563},{"id":"https://openalex.org/keywords/knee-joint","display_name":"knee joint","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C189178095","wikidata":"https://www.wikidata.org/wiki/Q15834833","display_name":"Meniscus","level":3,"score":0.7908775210380554},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7163920402526855},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.6803848147392273},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.5497782230377197},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.5492692589759827},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.5338253974914551},{"id":"https://openalex.org/C2908736133","wikidata":"https://www.wikidata.org/wiki/Q37425","display_name":"Knee Joint","level":2,"score":0.438256174325943},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4380720853805542},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.43523144721984863},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4245089292526245},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35981106758117676},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3597065210342407},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35522687435150146},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3210197985172272},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31597834825515747},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2536681294441223},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.18179214000701904},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.09173274040222168},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1115/sbc2008-192145","doi":"https://doi.org/10.1115/sbc2008-192145","is_oa":false,"landing_page_url":"https://doi.org/10.1115/sbc2008-192145","pdf_url":null,"source":{"id":"https://openalex.org/S4306503435","display_name":"ASME Summer Bioengineering Conference (SBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASME 2008 Summer Bioengineering Conference, Parts A and B","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2079968413","https://openalex.org/W2075191937","https://openalex.org/W2069485500","https://openalex.org/W2051822687","https://openalex.org/W2012966860","https://openalex.org/W2245165785","https://openalex.org/W2009895803","https://openalex.org/W1492431918","https://openalex.org/W1969684172","https://openalex.org/W4214688390"],"abstract_inverted_index":{"The":[0],"meniscus":[1,75],"performs":[2],"several":[3],"functions":[4],"for":[5,190],"the":[6,28,41,45,73,160],"maintenance":[7],"of":[8,30,40,44,84,113,120,162,170],"knee":[9],"joint":[10,17],"health,":[11],"such":[12],"as":[13,24],"load":[14],"transmission":[15],"and":[16,62,68,76,95,133,146],"stability.":[18],"Meniscal":[19],"lesions":[20,34],"have":[21,55,88,104],"been":[22,56,89,129],"suggested":[23],"a":[25],"precursor":[26],"to":[27,37,49,64,66,91,117,131,166,185,205],"onset":[29],"osteoarthritis":[31],"(OA)[1].":[32],"Such":[33],"often":[35],"lead":[36,65],"surgical":[38],"removal":[39],"torn":[42],"portion":[43],"meniscus,":[46],"increasing":[47],"cartilage":[48,50],"contact":[51],"area.":[52],"Partial":[53],"meniscectomies":[54],"shown":[57,90],"using":[58],"finite":[59],"element":[60],"analysis":[61],"histology":[63],"altered":[67],"increased":[69],"mechanical":[70],"loading":[71],"on":[72],"remaining":[74],"underlying":[77],"articular":[78],"cartilage[2,3].":[79],"Consequently,":[80],"pathological":[81,118],"compressive":[82,122,177],"strains":[83],"more":[85],"than":[86,202],"15%":[87],"increase":[92,107],"proteoglycan":[93],"breakdown":[94],"meniscal":[96,114,174],"matrix":[97,134,143,156],"degradation[4].":[98],"Preliminary":[99],"investigations":[100],"in":[101,108,151,172],"our":[102],"laboratory":[103],"demonstrated":[105],"an":[106],"interleukin-1\u03b1":[109],"(IL-1\u03b1)":[110],"gene":[111,137],"expression":[112,138],"explants":[115],"subjected":[116],"levels":[119,207],"dynamic":[121,196],"strain":[123,178],"[6,7].":[124],"This":[125],"inflammatory":[126],"cytokine":[127],"has":[128],"attributed":[130],"apoptosis":[132],"degradation[5].":[135],"However,":[136],"measurements":[139],"merely":[140],"suggest":[141],"possible":[142],"remodeling":[144],"mechanisms":[145],"do":[147],"not":[148],"necessarily":[149],"result":[150],"protein":[152,168,188],"syntheses":[153],"from":[154],"which":[155],"changes":[157],"occur.":[158],"Therefore,":[159],"purpose":[161],"this":[163],"study":[164],"was":[165,181],"quantify":[167],"synthesis":[169,189],"IL-1\u03b1":[171],"porcine":[173],"implants":[175],"after":[176],"exercises.":[179],"It":[180],"hypothesized":[182],"that,":[183],"similar":[184],"mRNA":[186],"expression,":[187],"pathologically":[191],"loaded":[192,204],"(0":[193],"or":[194],"20%":[195],"strain)":[197],"samples":[198,203],"would":[199],"be":[200],"greater":[201],"physiological":[206],"(10%":[208],"strain).":[209]},"counts_by_year":[],"updated_date":"2026-10-05T09:50:58.205359","created_date":"2016-06-24T00:00:00"}
