{"id":"https://openalex.org/W2074731052","doi":"https://doi.org/10.1002/cbic.200700560","title":"Linear Analogues of Human \u03b2\u2010Defensin 3: Concepts for Design of Antimicrobial Peptides with Reduced Cytotoxicity to Mammalian Cells","display_name":"Linear Analogues of Human \u03b2\u2010Defensin 3: Concepts for Design of Antimicrobial Peptides with Reduced Cytotoxicity to Mammalian Cells","publication_year":2008,"publication_date":"2008-03-18","ids":{"openalex":"https://openalex.org/W2074731052","doi":"https://doi.org/10.1002/cbic.200700560","mag":"2074731052","pmid":"https://pubmed.ncbi.nlm.nih.gov/18350527"},"language":"en","primary_location":{"id":"doi:10.1002/cbic.200700560","doi":"https://doi.org/10.1002/cbic.200700560","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbic.200700560","pdf_url":null,"source":{"id":"https://openalex.org/S154285657","display_name":"ChemBioChem","issn_l":"1439-4227","issn":["1439-4227","1439-7633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemBioChem","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048275793","display_name":"Shouping Liu","orcid":"https://orcid.org/0000-0003-2415-076X","observed_orcids":["https://orcid.org/0000-0003-2415-076X"]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Shouping Liu","raw_affiliation_strings":["Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 16875, Singapore","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 16875, Singapore","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100674991","display_name":"Lei Zhou","orcid":"https://orcid.org/0000-0001-5893-6002","observed_orcids":["https://orcid.org/0000-0001-5893-6002","https://orcid.org/0000-0001-8251-3974","https://orcid.org/0009-0007-9394-309X"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Lei Zhou","raw_affiliation_strings":["Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 16875, Singapore","Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 16875, Singapore,","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 16875, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 16875, Singapore,","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336759","display_name":"Jing Li","orcid":"https://orcid.org/0000-0001-5860-0605","observed_orcids":["https://orcid.org/0000-0001-5860-0605"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":["Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 16875, Singapore","Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 16875, Singapore,","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 16875, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 16875, Singapore,","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066953701","display_name":"Anita Suresh","orcid":"https://orcid.org/0000-0003-2645-058X","observed_orcids":["https://orcid.org/0000-0003-2645-058X"]},"institutions":[{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Anita Suresh","raw_affiliation_strings":["Bioinformatics Institute, Singapore 16875, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Institute, Singapore 16875, Singapore","institution_ids":["https://openalex.org/I4210148498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045760818","display_name":"Chandra Shekhar Verma","orcid":"https://orcid.org/0000-0003-0733-9798","observed_orcids":["https://orcid.org/0000-0003-0733-9798","https://orcid.org/0000-0003-2319-9510"]},"institutions":[{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Chandra Verma","raw_affiliation_strings":["Bioinformatics Institute, Singapore 16875, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Institute, Singapore 16875, Singapore","institution_ids":["https://openalex.org/I4210148498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042926858","display_name":"Yong Hwee Foo","orcid":"https://orcid.org/0000-0003-2337-469X","observed_orcids":["https://orcid.org/0000-0003-2337-469X"]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yong Hwee Foo","raw_affiliation_strings":["Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 16875, Singapore,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 16875, Singapore,","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065480872","display_name":"P. H. Yap","orcid":"https://orcid.org/0000-0002-5376-5141","observed_orcids":["https://orcid.org/0000-0002-5376-5141"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric P. H. Yap","raw_affiliation_strings":["Defence Medical & Environmental Research Institute, Singapore 16875, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Defence Medical & Environmental Research Institute, Singapore 16875, Singapore","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103011509","display_name":"Donald T. H. Tan","orcid":"https://orcid.org/0000-0002-5269-9736","observed_orcids":["https://orcid.org/0000-0002-5269-9736"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I2799299286","display_name":"Singapore National Eye Center","ror":"https://ror.org/029nvrb94","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2799299286"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Donald T. H. Tan","raw_affiliation_strings":["Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 16875, Singapore","Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 16875, Singapore,","Singapore National Eye Center, Singapore 16875, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 16875, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 16875, Singapore,","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Singapore National Eye Center, Singapore 16875, Singapore","institution_ids":["https://openalex.org/I2799299286"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007551999","display_name":"Roger Wilmer Beuerman","orcid":"https://orcid.org/0000-0002-0725-9336","observed_orcids":["https://orcid.org/0000-0002-0725-9336"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Roger W. Beuerman","raw_affiliation_strings":["Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 16875, Singapore","Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 16875, Singapore,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 16875, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 16875, Singapore,","institution_ids":["https://openalex.org/I4210116917"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":6.0494,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.95847104,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":"6","first_page":"964","last_page":"973"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-beta-defensin-3","display_name":"human beta-defensin 3","score":0.9190000295639038},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hemolysis","display_name":"hemolysis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/conjunctival-epithelial-cells","display_name":"conjunctival epithelial cells","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hydrophobicity-tuning","display_name":"hydrophobicity tuning","score":0.8240000009536743},{"id":"https://openalex.org/keywords/peptide-secondary-structure","display_name":"peptide secondary structure","score":0.8389999866485596},{"id":"https://openalex.org/keywords/peptide-design","display_name":"peptide design","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.9632729291915894},{"id":"https://openalex.org/C2776498113","wikidata":"https://www.wikidata.org/wiki/Q412820","display_name":"Defensin","level":3,"score":0.8436800241470337},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.7799840569496155},{"id":"https://openalex.org/C129437159","wikidata":"https://www.wikidata.org/wiki/Q4897294","display_name":"Beta defensin","level":4,"score":0.712089478969574},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.6325388550758362},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.6235799193382263},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5862885117530823},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.4876938760280609},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.41154801845550537},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4054425358772278},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38211533427238464},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.29938217997550964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19251742959022522},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14836573600769043},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08248543739318848}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003228","descriptor_name":"Conjunctiva","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006094","descriptor_name":"Gram-Positive Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023083","descriptor_name":"beta-Defensins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D023083","descriptor_name":"beta-Defensins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D023083","descriptor_name":"beta-Defensins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/cbic.200700560","doi":"https://doi.org/10.1002/cbic.200700560","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbic.200700560","pdf_url":null,"source":{"id":"https://openalex.org/S154285657","display_name":"ChemBioChem","issn_l":"1439-4227","issn":["1439-4227","1439-7633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemBioChem","raw_type":"journal-article"},{"id":"pmid:18350527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18350527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chembiochem : a European journal of chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/26476","doi":null,"is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/26476","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W295484251","https://openalex.org/W1899856807","https://openalex.org/W1906070812","https://openalex.org/W1964611156","https://openalex.org/W1965135642","https://openalex.org/W1968931227","https://openalex.org/W1969711244","https://openalex.org/W1971891360","https://openalex.org/W1972027206","https://openalex.org/W1973881700","https://openalex.org/W1976301815","https://openalex.org/W1977842852","https://openalex.org/W1983066769","https://openalex.org/W1983521156","https://openalex.org/W1983628124","https://openalex.org/W1986286007","https://openalex.org/W1988930390","https://openalex.org/W1990519548","https://openalex.org/W1998721601","https://openalex.org/W2002066211","https://openalex.org/W2005929034","https://openalex.org/W2006731855","https://openalex.org/W2009756829","https://openalex.org/W2016333004","https://openalex.org/W2019275100","https://openalex.org/W2024136247","https://openalex.org/W2029667189","https://openalex.org/W2030106420","https://openalex.org/W2032368629","https://openalex.org/W2039095462","https://openalex.org/W2039276129","https://openalex.org/W2039694750","https://openalex.org/W2042490093","https://openalex.org/W2043930412","https://openalex.org/W2047730466","https://openalex.org/W2052300481","https://openalex.org/W2053418558","https://openalex.org/W2054421242","https://openalex.org/W2056013343","https://openalex.org/W2056222003","https://openalex.org/W2060306551","https://openalex.org/W2068221306","https://openalex.org/W2068434462","https://openalex.org/W2070981363","https://openalex.org/W2075014095","https://openalex.org/W2077814131","https://openalex.org/W2080044891","https://openalex.org/W2081277508","https://openalex.org/W2082237396","https://openalex.org/W2084175456","https://openalex.org/W2090042814","https://openalex.org/W2092539708","https://openalex.org/W2094788251","https://openalex.org/W2108792803","https://openalex.org/W2114711439","https://openalex.org/W2117364212","https://openalex.org/W2118233996","https://openalex.org/W2124508823","https://openalex.org/W2139394468","https://openalex.org/W2148067829","https://openalex.org/W2154794547","https://openalex.org/W2159633669","https://openalex.org/W2160171025","https://openalex.org/W2160780417","https://openalex.org/W2162819583","https://openalex.org/W2167776486","https://openalex.org/W2170792377","https://openalex.org/W4211175230"],"related_works":["https://openalex.org/W2170381215","https://openalex.org/W2046640332","https://openalex.org/W2077814131","https://openalex.org/W4388090319","https://openalex.org/W2031213053","https://openalex.org/W1508526764","https://openalex.org/W1041135800","https://openalex.org/W6981010728","https://openalex.org/W2121864792","https://openalex.org/W1982218254"],"abstract_inverted_index":{"A":[0],"series":[1],"of":[2,59,72,91,103,121,134,141,152,165,169],"engineered":[3],"linear":[4,78,104,123,143,167],"analogues":[5,62,79,124,168],"[coded":[6],"as":[7],"F6,":[8],"W6,":[9],"Y6,":[10,64],"A6,":[11,65],"S6":[12,66],"and":[13,19,29,41,67,109,137,176],"C(Acm)6]":[14,68],"were":[15,111],"modeled,":[16],"designed,":[17],"synthesized":[18],"structurally":[20,129],"characterized":[21],"by":[22],"mass":[23],"spectra,":[24],"circular":[25],"dichroism,":[26],"hydrophobicity":[27,102],"analysis":[28],"molecular":[30],"modeling.":[31],"We":[32],"have":[33,80],"screened":[34],"antimicrobial":[35,116],"activity,":[36],"hemolysis":[37,110],"to":[38,43,83,96,127,131,147,179],"rabbit":[39],"erythrocytes,":[40],"cytotoxicity":[42,82,108,120,178],"human":[44,84],"conjunctival":[45,85],"epithelial":[46,86],"cells.":[47,181],"No":[48],"significant":[49],"hemolytic":[50],"effect":[51],"was":[52],"observed":[53],"for":[54,161],"hBD3":[55,105],"or":[56],"from":[57],"five":[58],"the":[60,70,89,100,115,122,132,138,142,163],"six":[61,77],"[F6,":[63],"over":[69,88],"range":[71,90],"3-100":[73],"microg":[74,93],"mL(-1).":[75],"The":[76,118],"reduced":[81,107,177],"cells":[87],"6-100":[92],"mL(-1)":[94],"compared":[95],"hBD3.":[97],"By":[98],"tuning":[99],"overall":[101],"analogues,":[106],"obtained":[112],"while":[113],"preserving":[114],"properties.":[117],"decreased":[119],"is":[125],"suggested":[126],"be":[128,148],"related":[130],"removal":[133],"disulfide":[135],"bridges,":[136],"flexible":[139],"structure":[140],"forms,":[144],"which":[145],"seem":[146],"associated":[149],"with":[150,172],"loss":[151],"secondary":[153],"structure.":[154],"These":[155],"results":[156],"suggest":[157],"a":[158],"new":[159,166],"approach":[160],"guiding":[162],"design":[164],"defensin":[170],"peptides":[171],"strong":[173],"antibiotic":[174],"properties":[175],"mammalian":[180]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}