{"id":"https://openalex.org/W2074710283","doi":"https://doi.org/10.1002/jcp.1041000315","title":"Rapid changes in poly (A)(+) mRNA content in growth stimulated fibroblasts following perturbations in protein synthesis","display_name":"Rapid changes in poly (A)(+) mRNA content in growth stimulated fibroblasts following perturbations in protein synthesis","publication_year":1979,"publication_date":"1979-09-01","ids":{"openalex":"https://openalex.org/W2074710283","doi":"https://doi.org/10.1002/jcp.1041000315","mag":"2074710283","pmid":"https://pubmed.ncbi.nlm.nih.gov/489672"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.1041000315","doi":"https://doi.org/10.1002/jcp.1041000315","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.1041000315","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046309858","display_name":"Richard K. Meister","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard K. Meister","raw_affiliation_strings":["Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017268557","display_name":"Sonia E. Hulman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonia E. Hulman","raw_affiliation_strings":["Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110529913","display_name":"Lee F. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lee F. Johnson","raw_affiliation_strings":["Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110529913"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":0.888,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.70338167,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"100","issue":"3","first_page":"531","last_page":"538"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.057999998331069946,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/poly-a-mrna","display_name":"poly(A)+ mRNA","score":0.8339999914169312},{"id":"https://openalex.org/keywords/mrna-turnover","display_name":"mRNA turnover","score":0.7110000252723694},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.996999979019165},{"id":"https://openalex.org/keywords/serum-stimulation","display_name":"serum stimulation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/3t6-fibroblasts","display_name":"3T6 fibroblasts","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.9337131381034851},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.7999743223190308},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.6843109726905823},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6272281408309937},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43147820234298706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3780459761619568},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3565567135810852},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.32436832785606384},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26364365220069885},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2502557039260864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1756211817264557},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08465829491615295}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001769","descriptor_name":"Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011061","descriptor_name":"Poly A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcp.1041000315","doi":"https://doi.org/10.1002/jcp.1041000315","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.1041000315","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:489672","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/489672","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W93662334","https://openalex.org/W588080209","https://openalex.org/W1968330498","https://openalex.org/W1985437709","https://openalex.org/W1987077239","https://openalex.org/W1994441429","https://openalex.org/W2003370287","https://openalex.org/W2009723923","https://openalex.org/W2010031182","https://openalex.org/W2025514540","https://openalex.org/W2029412662","https://openalex.org/W2036614693","https://openalex.org/W2043687408","https://openalex.org/W2059480944","https://openalex.org/W2066540780","https://openalex.org/W2071970069","https://openalex.org/W2081714384","https://openalex.org/W2083428182","https://openalex.org/W2090549460","https://openalex.org/W2092502122","https://openalex.org/W2093892992","https://openalex.org/W2116526157","https://openalex.org/W2136156520","https://openalex.org/W2161444009","https://openalex.org/W2169413646","https://openalex.org/W3194402442","https://openalex.org/W4245666356"],"related_works":["https://openalex.org/W2092502122","https://openalex.org/W2067624460","https://openalex.org/W2072261615","https://openalex.org/W2071970069","https://openalex.org/W1981018360","https://openalex.org/W2043687408","https://openalex.org/W2093892992","https://openalex.org/W2115566899","https://openalex.org/W2081714384","https://openalex.org/W2011980318"],"abstract_inverted_index":{"Abstract":[0],"We":[1],"have":[2],"previously":[3],"shown":[4],"that":[5,62,125,139,174,206],"when":[6],"resting":[7,142],"3T6":[8],"cells":[9,29,143],"are":[10,70],"serum":[11,67,102,154],"stimulated":[12,30,179],"in":[13,31,87,104,141,161,177,180,223,229,237],"the":[14,32,105,108,111,118,148,153,158,181,188,196,201,207,230,250,254],"presence":[15,106],"of":[16,18,34,79,107,117,120,183,198,200,220,232],"inhibitors":[17],"protein":[19,121,233],"synthesis,":[20,122],"poly(A)(+)":[21,88,126,162,221,238],"mRNA":[22,37,76,89,127,163,222,239],"content":[23,38,128,164,219,240],"increases":[24],"extremely":[25,242],"rapidly":[26,243],"relative":[27],"to":[28,65,72,82,133,138,145,173,195,212,225,252],"absence":[33,182],"drug.":[35,202],"Poly(A)(+)":[36],"nearly":[39,136],"doubles":[40],"within":[41,130],"two":[42,97,131],"hours,":[43],"but":[44,152,185],"then":[45],"remains":[46],"constant":[47],"for":[48],"at":[49,95],"least":[50],"ten":[51,99],"hours":[52,100,132],"(Johnson":[53],"and":[54,68,244],"Meister,":[55],"'77).":[56],"In":[57],"this":[58,74],"report":[59],"we":[60,123],"show":[61,205],"continuous":[63],"exposure":[64,199],"both":[66],"cycloheximide":[69,92],"required":[71],"maintain":[73],"elevated":[75],"level.":[77],"Removal":[78],"either":[80,96],"leads":[81],"an":[83,168,191,247],"equally":[84],"rapid":[85,112,159],"decrease":[86,160,213],"content.":[90],"If":[91,147],"is":[93,150,156,165,171,210],"withdrawn":[94,151],"or":[98],"following":[101],"stimulation":[103],"drug,":[109,184],"allowing":[110],"(<":[113],"30":[114],"minutes)":[115],"restoration":[116],"rate":[119,231],"observe":[124],"decreases":[129],"a":[134],"level":[135],"equal":[137,194],"found":[140],"prior":[144],"stimulation.":[146],"drug":[149,226],"stimulus":[155],"not,":[157],"followed":[166],"by":[167,190,249],"increase":[169,217],"which":[170,175],"parallel":[172],"occurs":[176],"cultures":[178],"displaced":[186],"from":[187],"latter":[189],"interval":[192],"approximately":[193],"length":[197],"These":[203],"results":[204],"mammalian":[208],"cell":[209,251],"able":[211],"as":[214,216],"well":[215],"its":[218],"response":[224],"induced":[227],"perturbations":[228],"synthesis.":[234],"The":[235],"changes":[236],"occur":[241],"may":[245],"represent":[246],"attempt":[248],"correct":[253],"perturbation.":[255]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
