{"id":"https://openalex.org/W2074698792","doi":"https://doi.org/10.1158/1538-7445.am2011-5168","title":"Abstract 5168: Unraveling the molecular signature that drives breast cancer-induced brain metastasis in a mouse xenograft model","display_name":"Abstract 5168: Unraveling the molecular signature that drives breast cancer-induced brain metastasis in a mouse xenograft model","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2074698792","doi":"https://doi.org/10.1158/1538-7445.am2011-5168","mag":"2074698792"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-5168","doi":"https://doi.org/10.1158/1538-7445.am2011-5168","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-5168","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112090511","display_name":"Keya De Mukhopadhyay","orcid":"https://orcid.org/0000-0002-0816-841X","observed_orcids":["https://orcid.org/0000-0002-0816-841X"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keya De Mukhopadhyay","raw_affiliation_strings":["1UT Health Science Ctr., San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health Science Ctr., San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045793356","display_name":"Abhik M. Bandyopadhyay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhik Bandyopadhyay","raw_affiliation_strings":["1UT Health Science Ctr., San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health Science Ctr., San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053091431","display_name":"ABDEL G. ELKAHLOUN","orcid":"https://orcid.org/0000-0002-1749-740X","observed_orcids":["https://orcid.org/0000-0002-1749-740X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdel G. Elkahloun","raw_affiliation_strings":["2National Human Genome Research Institute- NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2National Human Genome Research Institute- NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024810268","display_name":"John E. Cornell","orcid":"https://orcid.org/0000-0003-1648-7549","observed_orcids":["https://orcid.org/0000-0003-1648-7549"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Cornell","raw_affiliation_strings":["1UT Health Science Ctr., San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health Science Ctr., San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027911001","display_name":"Junhua Yang","orcid":"https://orcid.org/0000-0003-4117-7569","observed_orcids":["https://orcid.org/0000-0003-4117-7569"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junhua Yang","raw_affiliation_strings":["1UT Health Science Ctr., San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health Science Ctr., San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056931880","display_name":"Lu\u2010Zhe Sun","orcid":"https://orcid.org/0000-0001-7117-4559","observed_orcids":["https://orcid.org/0000-0001-7117-4559"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LuZhe Sun","raw_affiliation_strings":["1UT Health Science Ctr., San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health Science Ctr., San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"5168","last_page":"5168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.06199999898672104,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-brain-metastases","display_name":"breast cancer brain metastasis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mouse-xenograft-model","display_name":"xenograft mouse model","score":0.8830000162124634},{"id":"https://openalex.org/keywords/zeb2","display_name":"ZEB2","score":0.640999972820282},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9869999885559082},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8849999904632568},{"id":"https://openalex.org/keywords/metastatic-gene-signature","display_name":"metastatic gene signature","score":0.6470000147819519},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.6949999928474426},{"id":"https://openalex.org/keywords/hb-egf","display_name":"HB-EGF","score":0.9440000057220459},{"id":"https://openalex.org/keywords/st3gal1","display_name":"ST3GAL1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9409999847412109},{"id":"https://openalex.org/keywords/itga3","display_name":"ITGA3","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":1.0},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.6700000166893005},{"id":"https://openalex.org/keywords/aldehyde-dehydrogenase","display_name":"aldehyde dehydrogenase","score":0.9150000214576721},{"id":"https://openalex.org/keywords/mammospheres","display_name":"mammospheres","score":0.7799999713897705},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.8185114860534668},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.6904679536819458},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6302741169929504},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5988885164260864},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5915448665618896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45728394389152527},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45289745926856995},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4400365948677063},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.43256261944770813},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36110246181488037},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25338172912597656},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23346123099327087},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20530211925506592},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1308009922504425},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-5168","doi":"https://doi.org/10.1158/1538-7445.am2011-5168","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-5168","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2329084463","https://openalex.org/W2060813120","https://openalex.org/W2321520892","https://openalex.org/W2330995375","https://openalex.org/W4411291134","https://openalex.org/W4416140164","https://openalex.org/W4392370008","https://openalex.org/W7141519772","https://openalex.org/W2621893672","https://openalex.org/W1546856515"],"abstract_inverted_index":{"Abstract":[0],"Brain":[1],"metastases":[2,49],"are":[3,18,40,191,342],"most":[4],"feared":[5],"complication":[6],"in":[7,34,69,127,142,194,232,249,353,362],"breast":[8,25],"cancer":[9],"(BCa).":[10],"Nearly":[11],"20%":[12],"of":[13,30,43,86,98,123,206,268,287,303,328,349,382,398,406,429,434],"patients":[14],"with":[15,21,260,273],"advanced":[16],"BCa":[17,70,415],"eventually":[19],"diagnosed":[20],"brain":[22,32,48,58,67,76,108,141,179,262,275,296,309,351,367,384,399],"lesions,":[23],"making":[24],"tumors":[26],"the":[27,46,56,72,119,202,211,389,404,430,435],"main":[28],"source":[29],"metastatic":[31,213,263,276,297,310],"disease":[33],"women.":[35],"Presently":[36],"available":[37],"treatment":[38],"regimens":[39],"not":[41,374],"capable":[42],"significantly":[44,93,192],"treating":[45],"BCa-induced":[47,178,350,383],"due":[50],"to":[51,54,107,138,140,144,148,154,185,210,252,282,292,344,391,403,411],"their":[52],"inability":[53],"penetrate":[55],"blood":[57],"barrier.":[59],"Rodent":[60],"model":[61,89,175,356],"systems":[62],"have":[63,78,168],"been":[64],"reported":[65],"for":[66,75,176,323,370,438],"metastasis":[68,77,233,352,368,385,416],"but":[71,386],"current":[73],"models":[74],"limitations.":[79],"As":[80],"such,":[81],"there":[82],"is":[83,360],"a":[84,238,254,284,320,326,346],"need":[85],"an":[87,170,317],"efficient":[88,171],"system":[90],"that":[91,363],"can":[92],"contribute":[94],"towards":[95],"our":[96,354],"understanding":[97],"different":[99],"factors":[100],"from":[101,118,307],"both":[102],"host":[103],"and":[104,113,125,146,151,153,172,229,243,278,289,325,395,413,419],"tumor":[105],"leading":[106,401],"metastasis.":[109,180],"Previously":[110],"we":[111,167,220,236,314],"isolated":[112],"characterized":[114],"B6TC":[115,135,195,241,280],"cells,":[116],"derived":[117,237],"stable":[120],"spontaneous":[121],"fusion":[122],"MDA-MB-231/GFP/Neo":[124],"ZR-75-1/GFP/puro":[126],"mouse":[128,174],"bone":[129],"marrow":[130],"microenvironment.":[131],"The":[132],"low":[133],"ER-expressing":[134],"has":[136],"propensity":[137],"metastasize":[139],"addition":[143],"lung":[145],"bone,":[147],"express":[149],"CD44":[150],"ALDH,":[152],"form":[155],"mammospheres":[156],"indicating":[157],"its":[158],"stem":[159],"cell-like":[160],"features.":[161],"In":[162],"this":[163],"study":[164,359],"using":[165],"B6TC,":[166],"developed":[169],"novel":[173,355,393,407],"studying":[177],"We":[181],"performed":[182,272],"RNA":[183,189,269],"microarray":[184,270,304],"identify":[186,392],"genes":[187,222,291,298,311,369],"whose":[188],"levels":[190],"altered":[193],"cells":[196,281],"by":[197,246,299],"greater":[198],"than":[199],"2-fold":[200],"at":[201],"false":[203],"discovery":[204,405],"rate":[205],"0.001,":[207],"when":[208],"compared":[209],"parental":[212,279],"MDA-MB-231":[214],"or":[215],"non-aggressive":[216],"ZR-75-1":[217],"cells.":[218],"Interestingly":[219],"identified":[221,315],"like":[223],"MMP1,":[224],"HB-EGF,":[225],"ST3GAL1,":[226],"PTGS2,":[227],"ITGA3,":[228],"CXCR4":[230],"implicated":[231],"regulation.":[234],"Then":[235],"Luc-GFP":[239],"transfected":[240],"line":[242,259],"enriched":[244],"it":[245],"4":[247],"successive":[248,337],"vivo":[250],"passages":[251],"obtain":[253],"highly":[255,274],"aggressive":[256],"B6TC/Luc-GFP":[257,277],"cell":[258],"100%":[261],"frequency.":[264],"A":[265],"second":[266],"round":[267],"was":[271],"derive":[283],"core":[285],"signature":[286,348],"up-":[288],"down-regulated":[290],"select":[293],"unique":[294],"potential":[295,366],"comparing":[300],"two":[301],"sets":[302],"data.":[305],"Apart":[306],"potent":[308],"detected":[312],"earlier,":[313],"ZEB2,":[316],"EMT":[318],"activator,":[319],"crucial":[321],"promoter":[322],"metastasis,":[324],"modulator":[327],"TGF":[329],"beta":[330],"signaling":[331],"pathway,":[332],"which":[333],"shows":[334],"up-regulation":[335],"over":[336],"in-vivo":[338],"passages.":[339],"Further":[340],"analyses":[341],"underway":[343],"establish":[345],"refined":[347],"system.":[357],"Our":[358],"significant":[361],"they":[364],"suggest":[365],"BCa.":[371],"This":[372],"will":[373],"only":[375],"provide":[376],"valuable":[377],"insight":[378],"into":[379],"molecular":[380],"mechanism":[381],"also":[387],"lay":[388],"foundation":[390],"prognostic":[394],"therapeutic":[396],"markers":[397],"metastases,":[400],"ultimately":[402],"molecularly":[408],"targeted":[409],"drugs":[410],"prevent":[412],"eradicate":[414],"initiation,":[417],"progression":[418],"recurrence.":[420],"Citation":[421],"Format:":[422],"{Authors}.":[423],"{Abstract":[424],"title}":[425],"[abstract].":[426],"In:":[427],"Proceedings":[428],"102nd":[431],"Annual":[432],"Meeting":[433],"American":[436],"Association":[437],"Cancer":[439,449],"Research;":[440],"2011":[441],"Apr":[442],"2-6;":[443],"Orlando,":[444],"FL.":[445],"Philadelphia":[446],"(PA):":[447],"AACR;":[448],"Res":[450],"2011;71(8":[451],"Suppl):Abstract":[452],"nr":[453],"5168.":[454],"doi:10.1158/1538-7445.AM2011-5168":[455]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
