{"id":"https://openalex.org/W2074698353","doi":"https://doi.org/10.2967/jnumed.109.071977","title":"Development of a Universal Anti\u2013Polyethylene Glycol Reporter Gene for Noninvasive Imaging of PEGylated Probes","display_name":"Development of a Universal Anti\u2013Polyethylene Glycol Reporter Gene for Noninvasive Imaging of PEGylated Probes","publication_year":2010,"publication_date":"2010-05-19","ids":{"openalex":"https://openalex.org/W2074698353","doi":"https://doi.org/10.2967/jnumed.109.071977","mag":"2074698353","pmid":"https://pubmed.ncbi.nlm.nih.gov/20484433"},"language":"en","primary_location":{"id":"doi:10.2967/jnumed.109.071977","doi":"https://doi.org/10.2967/jnumed.109.071977","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.109.071977","pdf_url":"https://jnm.snmjournals.org/content/jnumed/51/6/933.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jnm.snmjournals.org/content/jnumed/51/6/933.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kuo-Hsiang Chuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuo-Hsiang Chuang","raw_affiliation_strings":["Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan","Kaohsiung Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Kaohsiung Medical University","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043751769","display_name":"Hsin-Ell Wang","orcid":"https://orcid.org/0000-0003-4818-4921","observed_orcids":["https://orcid.org/0000-0003-4818-4921"]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsin-Ell Wang","raw_affiliation_strings":["Institute of Radiological Science , National Yang-Ming University , Taipei , Taiwan;","National Yang Ming University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Radiological Science , National Yang-Ming University , Taipei , Taiwan;","institution_ids":["https://openalex.org/I4387156312"]},{"raw_affiliation_string":"National Yang Ming University","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109216241","display_name":"Ta-Chun Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ta-Chun Cheng","raw_affiliation_strings":["Department of Biomedical Science and Environmental Biology , Kaohsiung Medical University , Kaohsiung , Taiwan;","Faculty of Biomedical and Environmental Biology , Kaohsiung Medical University , 100 Shih-Chuan 1st Rd. , Kaohsiung , Taiwan","Graduate Institute of Medicine , Kaohsiung Medical University , Kaohsiung , Taiwan;","Institute of Biomedical Sciences , Academia Sinica , Academia Rd. , Section 2 , No. 128 , Taipei 11529 , Taiwan","National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center , Kaohsiung , Taiwan;","Kaohsiung Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science and Environmental Biology , Kaohsiung Medical University , Kaohsiung , Taiwan;","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Faculty of Biomedical and Environmental Biology , Kaohsiung Medical University , 100 Shih-Chuan 1st Rd. , Kaohsiung , Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Graduate Institute of Medicine , Kaohsiung Medical University , Kaohsiung , Taiwan;","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Institute of Biomedical Sciences , Academia Sinica , Academia Rd. , Section 2 , No. 128 , Taipei 11529 , Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"raw_affiliation_string":"National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center , Kaohsiung , Taiwan;","institution_ids":["https://openalex.org/I142974352","https://openalex.org/I152743029"]},{"raw_affiliation_string":"Kaohsiung Medical University","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110033870","display_name":"Shey\u2010Cherng Tzou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shey-Cherng Tzou","raw_affiliation_strings":["Department of Biomedical Science and Environmental Biology , Kaohsiung Medical University , Kaohsiung , Taiwan;","Kaohsiung Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science and Environmental Biology , Kaohsiung Medical University , Kaohsiung , Taiwan;","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Kaohsiung Medical University","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088921509","display_name":"Wei\u2010Lung Tseng","orcid":"https://orcid.org/0000-0001-9808-5863","observed_orcids":["https://orcid.org/0000-0001-9808-5863"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Lung Tseng","raw_affiliation_strings":["Department of Chemistry , National Sun Yat-sen University , Kaohsiung , Taiwan;","National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center , Kaohsiung , Taiwan;","National Sun Yat\u2010sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry , National Sun Yat-sen University , Kaohsiung , Taiwan;","institution_ids":["https://openalex.org/I142974352"]},{"raw_affiliation_string":"National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center , Kaohsiung , Taiwan;","institution_ids":["https://openalex.org/I142974352","https://openalex.org/I152743029"]},{"raw_affiliation_string":"National Sun Yat\u2010sen University","institution_ids":["https://openalex.org/I142974352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102328796","display_name":"Wen-Chun Hung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wen-Chun Hung","raw_affiliation_strings":["Institute of Biomedical Sciences , National Sun Yat-Sen University , Kaohsiung , Taiwan; and","National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center , Kaohsiung , Taiwan;","National Sun Yat\u2010sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences , National Sun Yat-Sen University , Kaohsiung , Taiwan; and","institution_ids":["https://openalex.org/I142974352"]},{"raw_affiliation_string":"National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center , Kaohsiung , Taiwan;","institution_ids":["https://openalex.org/I142974352","https://openalex.org/I152743029"]},{"raw_affiliation_string":"National Sun Yat\u2010sen University","institution_ids":["https://openalex.org/I142974352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108424910","display_name":"Ming-Hong Tai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Hong Tai","raw_affiliation_strings":["Institute of Biomedical Sciences , National Sun Yat-Sen University , Kaohsiung , Taiwan; and","National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center , Kaohsiung , Taiwan;","National Sun Yat\u2010sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences , National Sun Yat-Sen University , Kaohsiung , Taiwan; and","institution_ids":["https://openalex.org/I142974352"]},{"raw_affiliation_string":"National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center , Kaohsiung , Taiwan;","institution_ids":["https://openalex.org/I142974352","https://openalex.org/I152743029"]},{"raw_affiliation_string":"National Sun Yat\u2010sen University","institution_ids":["https://openalex.org/I142974352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034192038","display_name":"Tien-Kuei Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tien-Kuei Chang","raw_affiliation_strings":["Institute of Radiological Science , National Yang-Ming University , Taipei , Taiwan;","National Yang Ming University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Radiological Science , National Yang-Ming University , Taipei , Taiwan;","institution_ids":["https://openalex.org/I4387156312"]},{"raw_affiliation_string":"National Yang Ming University","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002537567","display_name":"Steve R. Roffler","orcid":"https://orcid.org/0000-0003-2543-7295","observed_orcids":["https://orcid.org/0000-0003-2543-7295"]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Steve R. Roffler","raw_affiliation_strings":["Institute of Biomedical Sciences , Academia Sinica , Taipei , Taiwan","Academia Sinica, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences , Academia Sinica , Taipei , Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"raw_affiliation_string":"Academia Sinica, Taiwan","institution_ids":["https://openalex.org/I84653119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026887457","display_name":"Tian\u2010Lu Cheng","orcid":"https://orcid.org/0000-0002-7263-2766","observed_orcids":["https://orcid.org/0000-0002-7263-2766","https://orcid.org/0000-0001-6424-4731"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tian-Lu Cheng","raw_affiliation_strings":["Department of Biomedical Science and Environmental Biology , Kaohsiung Medical University , Kaohsiung , Taiwan;","Faculty of Biomedical and Environmental Biology , Kaohsiung Medical University , 100 Shih-Chuan 1st Rd. , Kaohsiung , Taiwan","Graduate Institute of Medicine , Kaohsiung Medical University , Kaohsiung , Taiwan;","Institute of Biomedical Sciences , Academia Sinica , Academia Rd. , Section 2 , No. 128 , Taipei 11529 , Taiwan","National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center , Kaohsiung , Taiwan;","Kaohsiung Medical University","National Sun Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science and Environmental Biology , Kaohsiung Medical University , Kaohsiung , Taiwan;","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Faculty of Biomedical and Environmental Biology , Kaohsiung Medical University , 100 Shih-Chuan 1st Rd. , Kaohsiung , Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Graduate Institute of Medicine , Kaohsiung Medical University , Kaohsiung , Taiwan;","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Institute of Biomedical Sciences , Academia Sinica , Academia Rd. , Section 2 , No. 128 , Taipei 11529 , Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"raw_affiliation_string":"National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center , Kaohsiung , Taiwan;","institution_ids":["https://openalex.org/I142974352","https://openalex.org/I152743029"]},{"raw_affiliation_string":"Kaohsiung Medical University","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"National Sun Yat-Sen University","institution_ids":["https://openalex.org/I142974352"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4989,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.79556437,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"51","issue":"6","first_page":"933","last_page":"941"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.46480000019073486,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.46480000019073486,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.1941000074148178,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.058800000697374344,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyethylene-glycol","display_name":"polyethylene glycol","score":0.9049999713897705},{"id":"https://openalex.org/keywords/fab-fragment","display_name":"Fab fragment","score":0.5699999928474426},{"id":"https://openalex.org/keywords/optical-imaging","display_name":"optical imaging","score":0.5929999947547913},{"id":"https://openalex.org/keywords/mri-contrast-agents","display_name":"MRI contrast agents","score":0.7179999947547913},{"id":"https://openalex.org/keywords/small-animal-pet","display_name":"small animal PET","score":0.8849999904632568},{"id":"https://openalex.org/keywords/humanized-antibody","display_name":"humanized monoclonal antibody","score":0.6539999842643738},{"id":"https://openalex.org/keywords/gene-expression-imaging","display_name":"gene expression imaging","score":0.7009999752044678},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.4320000112056732},{"id":"https://openalex.org/keywords/metastatic-tumor-model","display_name":"metastatic tumor model","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.8222798109054565},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6089324951171875},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.5578210353851318},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.47677022218704224},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4645632803440094},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4448511600494385},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.43868985772132874},{"id":"https://openalex.org/C54400483","wikidata":"https://www.wikidata.org/wiki/Q1793202","display_name":"PEG ratio","level":2,"score":0.43427807092666626},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4305279850959778},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4264083504676819},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.4123101532459259},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29287290573120117},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25997090339660645},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2095349133014679},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1724798083305359},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013937","descriptor_name":"Thymidine Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015335","descriptor_name":"Molecular Probes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015335","descriptor_name":"Molecular Probes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015335","descriptor_name":"Molecular Probes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055620","descriptor_name":"Optical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057054","descriptor_name":"Molecular Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.2967/jnumed.109.071977","doi":"https://doi.org/10.2967/jnumed.109.071977","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.109.071977","pdf_url":"https://jnm.snmjournals.org/content/jnumed/51/6/933.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},{"id":"pmid:20484433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20484433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.817.1519","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.817.1519","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnm.snmjournals.org/content/51/6/933.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.2967/jnumed.109.071977","doi":"https://doi.org/10.2967/jnumed.109.071977","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.109.071977","pdf_url":"https://jnm.snmjournals.org/content/jnumed/51/6/933.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1633691972","display_name":null,"funder_award_id":"AS-98-TP-B09","funder_id":"https://openalex.org/F4320321041","funder_display_name":"Academia Sinica"}],"funders":[{"id":"https://openalex.org/F4320310118","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10"},{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320321041","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784"},{"id":"https://openalex.org/F4320321160","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71"},{"id":"https://openalex.org/F4320322811","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96"},{"id":"https://openalex.org/F4320322845","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29"},{"id":"https://openalex.org/F4320327176","display_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","ror":"https://ror.org/02xmkec90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2074698353.pdf","grobid_xml":"https://content.openalex.org/works/W2074698353.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1484092314","https://openalex.org/W1570000692","https://openalex.org/W1954112274","https://openalex.org/W1966490343","https://openalex.org/W1977701499","https://openalex.org/W1979058593","https://openalex.org/W1992628941","https://openalex.org/W2005523979","https://openalex.org/W2012395766","https://openalex.org/W2013557720","https://openalex.org/W2015032724","https://openalex.org/W2019465287","https://openalex.org/W2021721463","https://openalex.org/W2023565393","https://openalex.org/W2025244200","https://openalex.org/W2030087354","https://openalex.org/W2040056272","https://openalex.org/W2058438178","https://openalex.org/W2068041760","https://openalex.org/W2083709175","https://openalex.org/W2083940874","https://openalex.org/W2085411817","https://openalex.org/W2094704598","https://openalex.org/W2107418859","https://openalex.org/W2108712641","https://openalex.org/W2112041130","https://openalex.org/W2124409897","https://openalex.org/W2126012201","https://openalex.org/W2129883771","https://openalex.org/W2134725811","https://openalex.org/W2137663279","https://openalex.org/W2139882752","https://openalex.org/W2170944244","https://openalex.org/W2171882555","https://openalex.org/W2320749841"],"related_works":["https://openalex.org/W2129883771","https://openalex.org/W2170944244","https://openalex.org/W7095175557","https://openalex.org/W2065607834","https://openalex.org/W2130970481","https://openalex.org/W1987752674","https://openalex.org/W2013118610","https://openalex.org/W2108250239","https://openalex.org/W2054139564","https://openalex.org/W2388994215"],"abstract_inverted_index":{"UNLABELLED:":[0],"A":[1],"reporter":[2,19,34,59,86,149,154,170,216,225,242,256],"gene":[3,14,60,64,270],"can":[4,36],"provide":[5,264],"important":[6],"information":[7],"regarding":[8],"the":[9,90,102,107,140,147,151,214,223,236,239],"specificity":[10,220,246],"and":[11,26,39,57,73,79,124,133,143,171,180,202,210,253,277],"efficacy":[12],"of":[13,89,93,106,112,146],"or":[15,66,189,232,272],"cell":[16,67,273],"therapies.":[17],"Although":[18],"genes":[20,38],"are":[21],"increasingly":[22],"used":[23],"in":[24,41,131,134,176,184,247,275],"experimental":[25,276],"clinical":[27,278],"studies,":[28],"a":[29,55,81,94,167,265],"highly":[30,251],"specific":[31,252],"yet":[32],"nonimmunogenic":[33,58,254],"that":[35,87,191],"track":[37],"cells":[40,188],"vivo":[42,177],"by":[43,69,206],"multiple":[44],"imaging":[45,174,200,219,245],"technologies":[46],"still":[47],"awaits":[48],"development.":[49],"In":[50,136],"this":[51],"study,":[52],"we":[53,138,165],"constructed":[54],"versatile":[56],"to":[61,101,222,235,263,268],"noninvasively":[62],"image":[63,269],"expression":[65,271],"delivery":[68,274],"optical":[70,117,207],"imaging,":[71,118,208],"MRI,":[72,123,209],"small-animal":[74,127,211],"PET.":[75,212],"METHODS:":[76],"We":[77],"cloned":[78],"expressed":[80,193],"membrane-anchored":[82],"anti-polyethylene":[83],"glycol":[84],"(PEG)":[85],"consists":[88],"Fab":[91],"fragment":[92],"mouse":[95,108],"anti-PEG":[96,148,169,194,215,241,255],"monoclonal":[97],"antibody,":[98],"AGP3,":[99],"fused":[100],"C-like":[103],"extracellular-transmembrane-cytosolic":[104],"domains":[105],"B7-1":[109],"receptor.":[110],"Binding":[111],"PEGylated":[113,199,261],"probes":[114,201,262],"(PEG-NIR797":[115],"for":[116,122,126],"PEG-superparamagnetic":[119],"iron":[120],"oxide":[121],"(124)I-PEG":[125],"PET)":[128],"were":[129],"examined":[130],"vitro":[132],"vivo.":[135,248],"addition,":[137],"compared":[139],"specificity,":[141],"immunogenicity,":[142],"probe":[144],"toxicity":[145,234],"with":[150,178,260],"gold":[152],"standard":[153],"gene,":[155],"type":[156],"1":[157],"herpes":[158],"simplex":[159],"virus":[160],"thymidine":[161],"kinase":[162],"(HSV-tk).":[163],"Finally,":[164],"derived":[166],"humanized":[168,240],"evaluated":[172],"its":[173],"function":[175],"subcutaneous":[179],"metastatic":[181],"tumor":[182],"models":[183],"mice.":[185],"RESULTS:":[186],"The":[187,250],"tumors":[190],"stably":[192],"reporters":[195],"selectively":[196],"accumulated":[197],"various":[198],"could":[203],"be":[204,258],"detected":[205],"Importantly,":[213],"displayed":[217],"an":[218],"comparable":[221],"HSV-tk":[224],"but":[226],"did":[227],"not":[228],"provoke":[229],"immune":[230],"responses":[231],"cause":[233],"host.":[237],"Furthermore,":[238],"retained":[243],"high":[244],"CONCLUSION:":[249],"may":[257],"paired":[259],"valuable":[266],"system":[267],"studies.":[279]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
