{"id":"https://openalex.org/W2074646860","doi":"https://doi.org/10.1111/j.1749-6632.1992.tb42590.x","title":"Three\u2010dimensional Cell Cultures Mimic Tissuesa","display_name":"Three\u2010dimensional Cell Cultures Mimic Tissuesa","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W2074646860","doi":"https://doi.org/10.1111/j.1749-6632.1992.tb42590.x","mag":"2074646860","pmid":"https://pubmed.ncbi.nlm.nih.gov/1416608"},"language":"en","primary_location":{"id":"doi:10.1111/j.1749-6632.1992.tb42590.x","doi":"https://doi.org/10.1111/j.1749-6632.1992.tb42590.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1992.tb42590.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012106344","display_name":"W. Mark Saltzman","orcid":"https://orcid.org/0000-0002-2163-549X","observed_orcids":["https://orcid.org/0000-0002-2163-549X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. M. SALTZMAN","raw_affiliation_strings":["Department of Chemical Engineering, Johns Hopkins University, Baltimore, Maryland 21218","Department of Chemical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218","W. M. Saltzman is a Camille and Henry Dreyfus Teacher-Scholar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Johns Hopkins University, Baltimore, Maryland 21218","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Chemical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"W. M. Saltzman is a Camille and Henry Dreyfus Teacher-Scholar","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058077037","display_name":"Maria R. Parkhurst","orcid":"https://orcid.org/0000-0001-7231-5069","observed_orcids":["https://orcid.org/0000-0001-7231-5069"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. R. PARKHURST","raw_affiliation_strings":["Department of Chemical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218","M. R. Parkhurst is a Howard Hughes Medical Institute Predoctoral Fellow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"M. R. Parkhurst is a Howard Hughes Medical Institute Predoctoral Fellow","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079950690","display_name":"Patricia A. Parsons\u2010Wingerter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. PARSONS\u2010WINGERTER","raw_affiliation_strings":["Department of Chemical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109187307","display_name":"W\u2010H. ZHU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W\u2010H. ZHU","raw_affiliation_strings":["Department of Chemical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.3978,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.5390463,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"665","issue":"1","first_page":"259","last_page":"273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.14319999516010284,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.11940000206232071,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.996999979019165},{"id":"https://openalex.org/keywords/type-i-collagen-gel","display_name":"type I collagen gel","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cell-encapsulation","display_name":"cell encapsulation","score":0.828000009059906},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.968999981880188},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":1.0},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":1.0},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9480000138282776},{"id":"https://openalex.org/keywords/protein-secretion","display_name":"protein secretion","score":0.9890000224113464},{"id":"https://openalex.org/keywords/growth-factor-induction","display_name":"growth factor induction","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.9240000247955322}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3982236087322235},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3768267035484314},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3479344844818115}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1749-6632.1992.tb42590.x","doi":"https://doi.org/10.1111/j.1749-6632.1992.tb42590.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1992.tb42590.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:1416608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1416608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5443484073","display_name":"MOLECULAR AND CELLULAR TRANSPORT IN MUCUS","funder_award_id":"R01GM043873","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W67276405","https://openalex.org/W194937791","https://openalex.org/W948550917","https://openalex.org/W1259106232","https://openalex.org/W1573141499","https://openalex.org/W1764690568","https://openalex.org/W1827306431","https://openalex.org/W1964736779","https://openalex.org/W1970130656","https://openalex.org/W1977779461","https://openalex.org/W1980745641","https://openalex.org/W1984061807","https://openalex.org/W1984729535","https://openalex.org/W1988300335","https://openalex.org/W2004344284","https://openalex.org/W2009892717","https://openalex.org/W2011892883","https://openalex.org/W2012874302","https://openalex.org/W2014731769","https://openalex.org/W2025357993","https://openalex.org/W2027186071","https://openalex.org/W2030957900","https://openalex.org/W2038362287","https://openalex.org/W2039442999","https://openalex.org/W2040720266","https://openalex.org/W2050088971","https://openalex.org/W2053654911","https://openalex.org/W2068180652","https://openalex.org/W2073611916","https://openalex.org/W2082032025","https://openalex.org/W2091281748","https://openalex.org/W2099435753","https://openalex.org/W2102622701","https://openalex.org/W2110586785","https://openalex.org/W2151170471","https://openalex.org/W2315439481","https://openalex.org/W2329843734","https://openalex.org/W2341523381","https://openalex.org/W2400235296","https://openalex.org/W2414822485"],"related_works":["https://openalex.org/W2500316243","https://openalex.org/W2063596220","https://openalex.org/W2717751940","https://openalex.org/W2748500819","https://openalex.org/W2123551029","https://openalex.org/W1488563510","https://openalex.org/W7118001106","https://openalex.org/W1589343672","https://openalex.org/W2035419826","https://openalex.org/W6988791956"],"abstract_inverted_index":{"Three-dimensional":[0],"cell":[1,15,68,72,74,77],"culture":[2],"using":[3,66],"gels":[4],"of":[5],"type":[6],"I":[7],"collagen":[8],"is":[9],"a":[10,18],"flexible":[11],"method":[12],"for":[13,44],"studying":[14],"behavior":[16],"in":[17,25,79],"tissuelike":[19,82],"environment.":[20],"With":[21],"only":[22],"small":[23],"changes":[24],"the":[26,52],"basic":[27],"protocol,":[28],"we":[29,62],"were":[30,55],"able":[31],"to":[32,70],"encapsulate":[33],"neutrophils,":[34],"hepatocytes,":[35],"and":[36,48,57,76],"PC12":[37],"cells.":[38],"As":[39],"demonstrated":[40],"by":[41],"cell-specific":[42],"assays":[43],"migration,":[45],"protein":[46],"secretion,":[47],"growth":[49],"factor":[50],"induction,":[51],"encapsulated":[53],"cells":[54],"viable":[56],"functional.":[58],"In":[59],"future":[60],"studies,":[61],"will":[63],"focus":[64],"on":[65],"these":[67],"cultures":[69],"study":[71],"movement,":[73],"growth,":[75],"function":[78],"carefully":[80],"controlled":[81],"environments.":[83]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
