{"id":"https://openalex.org/W2074583717","doi":"https://doi.org/10.1016/j.anai.2011.04.008","title":"Economic burden of impairment in children with severe or difficult-to-treat asthma","display_name":"Economic burden of impairment in children with severe or difficult-to-treat asthma","publication_year":2011,"publication_date":"2011-06-19","ids":{"openalex":"https://openalex.org/W2074583717","doi":"https://doi.org/10.1016/j.anai.2011.04.008","mag":"2074583717","pmid":"https://pubmed.ncbi.nlm.nih.gov/21802018"},"language":"en","primary_location":{"id":"doi:10.1016/j.anai.2011.04.008","doi":"https://doi.org/10.1016/j.anai.2011.04.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.anai.2011.04.008","pdf_url":null,"source":{"id":"https://openalex.org/S153558830","display_name":"Annals of Allergy Asthma & Immunology","issn_l":"1081-1206","issn":["1081-1206","1534-4436"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Allergy, Asthma & Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033765434","display_name":"Stanley James Szefler","orcid":"https://orcid.org/0000-0002-6911-3199","observed_orcids":["https://orcid.org/0000-0002-6911-3199"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley J. Szefler","raw_affiliation_strings":["National Jewish Health, Denver, Colorado, USA","National Jewish Health, Denver, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Jewish Health, Denver, Colorado, USA","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"National Jewish Health, Denver, Colorado","institution_ids":["https://openalex.org/I3019586173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035441456","display_name":"Robert S. Zeiger","orcid":"https://orcid.org/0000-0001-5788-5063","observed_orcids":["https://orcid.org/0000-0001-5788-5063"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I4210091210","display_name":"Kaiser Permanente San Diego Medical Center","ror":"https://ror.org/00fg98b82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210091210"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert S. Zeiger","raw_affiliation_strings":["Kaiser-Permanente Medical Center, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaiser-Permanente Medical Center, San Diego, California","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I4210091210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025601511","display_name":"Tmirah Haselkorn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tmirah Haselkorn","raw_affiliation_strings":["Genentech, Inc., South San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112368407","display_name":"David R. Mink","orcid":"https://orcid.org/0009-0001-0000-1885","observed_orcids":["https://orcid.org/0009-0001-0000-1885"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David R. Mink","raw_affiliation_strings":["ICON Clinical Research, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICON Clinical Research, San Francisco, California","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110828889","display_name":"Tripthi V Kamath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tripthi V. Kamath","raw_affiliation_strings":["Genentech, Inc., South San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008654275","display_name":"James E. Fish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]},{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James E. Fish","raw_affiliation_strings":["Genentech, Inc., South San Francisco, California","Merck Research Laboratories, North Wales, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Merck Research Laboratories, North Wales, Pennsylvania","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090310464","display_name":"Bradley E. Chipps","orcid":"https://orcid.org/0009-0000-7857-9225","observed_orcids":["https://orcid.org/0009-0000-7857-9225"]},"institutions":[{"id":"https://openalex.org/I4210089976","display_name":"Capital Allergy and Respiratory Disease Center","ror":"https://ror.org/00ah4xn57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210089976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley E. Chipps","raw_affiliation_strings":["Capital Allergy & Respiratory Disease Center, Sacramento, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Capital Allergy & Respiratory Disease Center, Sacramento, California","institution_ids":["https://openalex.org/I4210089976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5025601511"],"corresponding_institution_ids":["https://openalex.org/I183934855"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":6.1883,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.96972427,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"107","issue":"2","first_page":"110","last_page":"119.e1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-asthma","display_name":"childhood asthma","score":0.8569999933242798},{"id":"https://openalex.org/keywords/severe-asthma","display_name":"severe asthma","score":0.9710000157356262},{"id":"https://openalex.org/keywords/difficult-to-treat-asthma","display_name":"difficult-to-treat asthma","score":0.949999988079071},{"id":"https://openalex.org/keywords/asthma-control","display_name":"asthma control","score":0.8119999766349792},{"id":"https://openalex.org/keywords/direct-medical-costs","display_name":"direct medical costs","score":0.652999997138977},{"id":"https://openalex.org/keywords/indirect-costs","display_name":"indirect costs","score":0.9599999785423279},{"id":"https://openalex.org/keywords/school-absenteeism","display_name":"school absenteeism","score":0.7440000176429749},{"id":"https://openalex.org/keywords/emergency-department-visits","display_name":"emergency department visits","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.9208099246025085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8531473875045776},{"id":"https://openalex.org/C6964187","wikidata":"https://www.wikidata.org/wiki/Q659256","display_name":"Indirect costs","level":2,"score":0.6189284324645996},{"id":"https://openalex.org/C2780724011","wikidata":"https://www.wikidata.org/wiki/Q1295316","display_name":"Emergency department","level":2,"score":0.5281714797019958},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5156247019767761},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.45252174139022827},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.35541802644729614},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23540660738945007},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.09706729650497437},{"id":"https://openalex.org/C121955636","wikidata":"https://www.wikidata.org/wiki/Q4116214","display_name":"Accounting","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004632","descriptor_name":"Emergency Medical Services","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017281","descriptor_name":"Cost of Illness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.anai.2011.04.008","doi":"https://doi.org/10.1016/j.anai.2011.04.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.anai.2011.04.008","pdf_url":null,"source":{"id":"https://openalex.org/S153558830","display_name":"Annals of Allergy Asthma & Immunology","issn_l":"1081-1206","issn":["1081-1206","1534-4436"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Allergy, Asthma & Immunology","raw_type":"journal-article"},{"id":"pmid:21802018","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21802018","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W44874218","https://openalex.org/W1964852367","https://openalex.org/W1993774561","https://openalex.org/W2008909342","https://openalex.org/W2010681958","https://openalex.org/W2016687680","https://openalex.org/W2019505326","https://openalex.org/W2036547724","https://openalex.org/W2037001176","https://openalex.org/W2042820847","https://openalex.org/W2057621677","https://openalex.org/W2068198910","https://openalex.org/W2079452627","https://openalex.org/W2087760311","https://openalex.org/W2094389104","https://openalex.org/W2094829202","https://openalex.org/W2111324648","https://openalex.org/W2117701206","https://openalex.org/W2125589299","https://openalex.org/W2135265003","https://openalex.org/W2143057253","https://openalex.org/W2149503411","https://openalex.org/W2152753523","https://openalex.org/W2157354669","https://openalex.org/W2163779250","https://openalex.org/W2171124333","https://openalex.org/W2171548074","https://openalex.org/W2288873333","https://openalex.org/W2604596332","https://openalex.org/W2616424562","https://openalex.org/W3178585699","https://openalex.org/W4388366699","https://openalex.org/W6601876111","https://openalex.org/W6682795252"],"related_works":["https://openalex.org/W2749868996","https://openalex.org/W1974042832","https://openalex.org/W6977250916","https://openalex.org/W7220277368","https://openalex.org/W2810202931","https://openalex.org/W4399113682","https://openalex.org/W2089283773","https://openalex.org/W4221100773","https://openalex.org/W2087746927","https://openalex.org/W2110579070"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}