{"id":"https://openalex.org/W2074560223","doi":"https://doi.org/10.1016/j.gde.2011.07.003","title":"Shedding light on the system: studying embryonic development with light sheet microscopy","display_name":"Shedding light on the system: studying embryonic development with light sheet microscopy","publication_year":2011,"publication_date":"2011-08-21","ids":{"openalex":"https://openalex.org/W2074560223","doi":"https://doi.org/10.1016/j.gde.2011.07.003","mag":"2074560223","pmid":"https://pubmed.ncbi.nlm.nih.gov/21862314"},"language":"en","primary_location":{"id":"doi:10.1016/j.gde.2011.07.003","doi":"https://doi.org/10.1016/j.gde.2011.07.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.gde.2011.07.003","pdf_url":null,"source":{"id":"https://openalex.org/S116174365","display_name":"Current Opinion in Genetics & Development","issn_l":"0959-437X","issn":["0959-437X","1879-0380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Genetics & Development","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085712951","display_name":"Raju Tomer","orcid":"https://orcid.org/0000-0002-4229-2860","observed_orcids":["https://orcid.org/0000-0002-4229-2860"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Raju Tomer","raw_affiliation_strings":["Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA. tomerr@janelia.hhmi.org","Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA. tomerr@janelia.hhmi.org","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]},{"raw_affiliation_string":"Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147 (USA)","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009717967","display_name":"Khaled A. Khairy","orcid":"https://orcid.org/0000-0002-9274-5928","observed_orcids":["https://orcid.org/0000-0002-9274-5928"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khaled Khairy","raw_affiliation_strings":["Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075656434","display_name":"Philipp Keller","orcid":"https://orcid.org/0000-0003-2896-4920","observed_orcids":["https://orcid.org/0000-0003-2896-4920"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Philipp J Keller","raw_affiliation_strings":["Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075656434","https://openalex.org/A5085712951"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.8891,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.60843373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"21","issue":"5","first_page":"558","last_page":"565"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/light-sheet-microscopy","display_name":"light-sheet microscopy","score":0.9470000267028809},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.9929999709129333},{"id":"https://openalex.org/keywords/live-imaging","display_name":"live imaging","score":0.9240000247955322},{"id":"https://openalex.org/keywords/quantitative-imaging","display_name":"quantitative imaging","score":0.6600000262260437},{"id":"https://openalex.org/keywords/photobleaching","display_name":"photobleaching","score":0.7519999742507935},{"id":"https://openalex.org/keywords/optical-penetration-depth","display_name":"optical penetration depth","score":0.9369999766349792},{"id":"https://openalex.org/keywords/imaging-speed","display_name":"imaging speed","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C113976765","wikidata":"https://www.wikidata.org/wiki/Q1823502","display_name":"Light sheet fluorescence microscopy","level":4,"score":0.7891536951065063},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.5555972456932068},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5224222540855408},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5172017812728882},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.46209943294525146},{"id":"https://openalex.org/C67649825","wikidata":"https://www.wikidata.org/wiki/Q196538","display_name":"Microscope","level":2,"score":0.44051414728164673},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.31310197710990906},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.21969273686408997},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09078711271286011},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.07079464197158813}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.gde.2011.07.003","doi":"https://doi.org/10.1016/j.gde.2011.07.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.gde.2011.07.003","pdf_url":null,"source":{"id":"https://openalex.org/S116174365","display_name":"Current Opinion in Genetics & Development","issn_l":"0959-437X","issn":["0959-437X","1879-0380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Genetics & Development","raw_type":"journal-article"},{"id":"pmid:21862314","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21862314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in genetics & development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1930341357","https://openalex.org/W1981124145","https://openalex.org/W1982917504","https://openalex.org/W1985406021","https://openalex.org/W1988546517","https://openalex.org/W1989643997","https://openalex.org/W1991315119","https://openalex.org/W1995311028","https://openalex.org/W2008199383","https://openalex.org/W2013741244","https://openalex.org/W2015357416","https://openalex.org/W2016899197","https://openalex.org/W2020556902","https://openalex.org/W2030224529","https://openalex.org/W2030700809","https://openalex.org/W2031312855","https://openalex.org/W2032714703","https://openalex.org/W2040870938","https://openalex.org/W2046896453","https://openalex.org/W2050721997","https://openalex.org/W2054823391","https://openalex.org/W2057132085","https://openalex.org/W2061229001","https://openalex.org/W2064259337","https://openalex.org/W2070585173","https://openalex.org/W2087451538","https://openalex.org/W2087975158","https://openalex.org/W2088186055","https://openalex.org/W2090440175","https://openalex.org/W2092022226","https://openalex.org/W2094643072","https://openalex.org/W2098681947","https://openalex.org/W2100976925","https://openalex.org/W2110021835","https://openalex.org/W2115401766","https://openalex.org/W2134100056","https://openalex.org/W2153126824","https://openalex.org/W2165777867","https://openalex.org/W2167390012","https://openalex.org/W2168283408","https://openalex.org/W4237173899"],"related_works":["https://openalex.org/W2331982492","https://openalex.org/W2017304976","https://openalex.org/W2017951283","https://openalex.org/W4410383409","https://openalex.org/W1970884399","https://openalex.org/W2090440175","https://openalex.org/W3210829547","https://openalex.org/W2415545601","https://openalex.org/W2145734069","https://openalex.org/W2888933155"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}