{"id":"https://openalex.org/W2074549997","doi":"https://doi.org/10.1117/12.728607","title":"Automatic segmentation of cell nuclei in bladder and skin tissue for karyometric analysis","display_name":"Automatic segmentation of cell nuclei in bladder and skin tissue for karyometric analysis","publication_year":2007,"publication_date":"2007-07-05","ids":{"openalex":"https://openalex.org/W2074549997","doi":"https://doi.org/10.1117/12.728607","mag":"2074549997"},"language":"en","primary_location":{"id":"doi:10.1117/12.728607","doi":"https://doi.org/10.1117/12.728607","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.728607","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071942503","display_name":"Vrushali R. Korde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vrushali R. Korde","raw_affiliation_strings":["College of Optical Sciences, The Univ. of Arizona (United States)","College of Optical Sciences, The University of Arizona, Tucson, AZ, USA 85721\u20130094"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Optical Sciences, The Univ. of Arizona (United States)","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"College of Optical Sciences, The University of Arizona, Tucson, AZ, USA 85721\u20130094","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002551852","display_name":"Hubert G. Bartels","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hubert Bartels","raw_affiliation_strings":["Arizona Cancer Ctr. (United States)","Arizona Cancer Center, Tucson, AZ, USA 85716"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona Cancer Ctr. (United States)","institution_ids":[]},{"raw_affiliation_string":"Arizona Cancer Center, Tucson, AZ, USA 85716","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067090865","display_name":"James Ranger\u2010Moore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Ranger-Moore","raw_affiliation_strings":["Arizona Cancer Ctr. (United States)","Arizona Cancer Center, Tucson, AZ, USA 85716"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona Cancer Ctr. (United States)","institution_ids":[]},{"raw_affiliation_string":"Arizona Cancer Center, Tucson, AZ, USA 85716","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021337936","display_name":"Jennifer K. Barton","orcid":"https://orcid.org/0000-0003-4897-9361","observed_orcids":["https://orcid.org/0000-0003-4897-9361"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Barton","raw_affiliation_strings":["The Univ. of Arizona (United States)","Department of Biomedical Engineering, The University of Arizona, Tucson, AZ, USA 85724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Arizona (United States)","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Biomedical Engineering, The University of Arizona, Tucson, AZ, USA 85724","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.6423,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.94112769,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"6633","issue":null,"first_page":"66330V","last_page":"66330V"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.6083999872207642,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.6083999872207642,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.22609999775886536,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.14309999346733093,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclei-segmentation","display_name":"nuclei segmentation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/karyometry","display_name":"karyometry","score":0.7829999923706055},{"id":"https://openalex.org/keywords/bladder-histology","display_name":"bladder histology","score":0.8989999890327454},{"id":"https://openalex.org/keywords/skin-histology","display_name":"skin histology","score":0.9959999918937683},{"id":"https://openalex.org/keywords/automatic-image-segmentation","display_name":"automated image segmentation","score":0.609000027179718},{"id":"https://openalex.org/keywords/thresholding","display_name":"thresholding","score":0.5809999704360962},{"id":"https://openalex.org/keywords/dilation-and-erosion","display_name":"erosion and dilation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/segmentation-quality-assessment","display_name":"segmentation quality assessment","score":0.5600000023841858},{"id":"https://openalex.org/keywords/histopathological-image-analysis","display_name":"histopathology image analysis","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.8356620073318481},{"id":"https://openalex.org/C191178318","wikidata":"https://www.wikidata.org/wiki/Q2256906","display_name":"Thresholding","level":3,"score":0.687220573425293},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.6632937788963318},{"id":"https://openalex.org/C53533937","wikidata":"https://www.wikidata.org/wiki/Q185020","display_name":"Histogram","level":3,"score":0.5944316983222961},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.5868937373161316},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.564445972442627},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48280084133148193},{"id":"https://openalex.org/C2780757906","wikidata":"https://www.wikidata.org/wiki/Q5276676","display_name":"Dilation (metric space)","level":2,"score":0.4160427451133728},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4124656915664673},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3933263123035431},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3884100317955017},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2731729745864868},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2721751034259796},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19677752256393433},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.18184152245521545},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.728607","doi":"https://doi.org/10.1117/12.728607","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.728607","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2142332605","https://openalex.org/W53864427","https://openalex.org/W2018060626","https://openalex.org/W2564705774","https://openalex.org/W2305684009","https://openalex.org/W2440432263","https://openalex.org/W2062600280","https://openalex.org/W1972181364","https://openalex.org/W2061554822","https://openalex.org/W2921801068"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"automatically":[2],"segment":[3],"cell":[4,65],"nuclei":[5,62,106,186],"in":[6,22,83,130,154,201,231],"histology":[7,113,175,220,233],"images":[8,114,176,234,237],"of":[9,47,76,85,133,149,165,180,195,216,245],"bladder":[10,112,217,232],"and":[11,31,37,56,100,120,140,160,190,218,226,241],"skin":[12,174,219],"tissue":[13],"for":[14,147,214],"karyometric":[15,155,202,247],"analysis.":[16],"Materials/Methods:":[17],"The":[18,126,135,167,198],"four":[19],"main":[20],"steps":[21],"the":[23,48,86,150,243,246],"program":[24],"were":[25,102,115,229],"as":[26,70],"follows:":[27],"1)":[28],"median":[29],"filtering":[30],"thresholding,":[32],"2)":[33],"segmentation,":[34],"3)":[35],"categorizing,":[36],"4)":[38],"cusp":[39],"correction.":[40],"This":[41],"robust":[42],"segmentation":[43,67,77,80,128,206,210],"technique":[44],"used":[45,153,213],"properties":[46,75],"image":[49],"histogram":[50],"to":[51,107],"optimally":[52],"select":[53],"a":[54,131,178],"threshold":[55],"create":[57],"closed":[58],"four-way":[59],"chain":[60],"code":[61],"segmentations.":[63],"Each":[64],"nucleus":[66],"was":[68,81,170,250],"treated":[69],"an":[71,163,193],"individual":[72],"object":[73],"with":[74,162,177,192,204],"quality.":[78],"A":[79],"placed":[82],"one":[84],"following":[87],"three":[88],"categories":[89],"based":[90],"on":[91,104,172],"its":[92],"properties:":[93],"throw":[94],"away,":[95],"salvageable,":[96],"or":[97],"good.":[98],"Erosion/dilation":[99],"rethresholding":[101],"performed":[103,171],"salvageable":[105],"correct":[108],"cusps.":[109],"Results:":[110],"Ten":[111],"segmented":[116],"both":[117],"by":[118],"hand":[119,139,205,225],"using":[121],"this":[122],"automatic":[123,127,141,227],"segmention":[124],"algorithm.":[125],"resulted":[129],"sensitivity":[132,179],"76.4%.":[134],"average":[136,164,194],"difference":[137],"between":[138,158,188,224],"segmentations":[142,228],"over":[143,184],"42":[144],"nuclei,":[145],"calculated":[146],"each":[148],"95":[151],"features":[152,203],"analysis,":[156],"ranged":[157,187],"0":[159,189],"48.3%,":[161],"2.8%.":[166],"same":[168],"procedure":[169],"10":[173],"83.0%.":[181],"Average":[182,222],"differences":[183,223],"44":[185],"200%,":[191],"10.0%.":[196],"Conclusion:":[197],"close":[199],"agreement":[200],"shows":[207],"that":[208],"automated":[209],"can":[211],"be":[212],"analysis":[215],"images.":[221],"smaller":[230],"because":[235],"these":[236],"contained":[238],"less":[239],"contrast,":[240],"therefore":[242],"range":[244],"feature":[248],"values":[249],"smaller.":[251]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}