{"id":"https://openalex.org/W2074548655","doi":"https://doi.org/10.1002/bmc.1130060410","title":"Liquid chromatographic determination of hyoscine (scopolamine) in urine using solid phase extraction","display_name":"Liquid chromatographic determination of hyoscine (scopolamine) in urine using solid phase extraction","publication_year":1992,"publication_date":"1992-07-01","ids":{"openalex":"https://openalex.org/W2074548655","doi":"https://doi.org/10.1002/bmc.1130060410","mag":"2074548655","pmid":"https://pubmed.ncbi.nlm.nih.gov/1643390"},"language":"en","primary_location":{"id":"doi:10.1002/bmc.1130060410","doi":"https://doi.org/10.1002/bmc.1130060410","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bmc.1130060410","pdf_url":null,"source":{"id":"https://openalex.org/S123979729","display_name":"Biomedical Chromatography","issn_l":"0269-3879","issn":["0269-3879","1099-0801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Chromatography","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000952775","display_name":"Robin Whelpton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Robin Whelpton","raw_affiliation_strings":["Department of Pharmacology, Queen Mary and Westfield College, London, UK","Dept. of Pharmacology, Queen Mary & Westfield College, Mile End Road, London E1 4NS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Queen Mary and Westfield College, London, UK","institution_ids":["https://openalex.org/I166337079"]},{"raw_affiliation_string":"Dept. of Pharmacology, Queen Mary & Westfield College, Mile End Road, London E1 4NS, UK","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112261711","display_name":"Peter R. Hurst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter R. Hurst","raw_affiliation_strings":["Department of Pharmacology, Queen Mary and Westfield College, Mile End Road, London E1 4NS, UK","Dept. of Pharmacology, Queen Mary & Westfield College, Mile End Road, London E1 4NS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Queen Mary and Westfield College, Mile End Road, London E1 4NS, UK","institution_ids":["https://openalex.org/I166337079"]},{"raw_affiliation_string":"Dept. of Pharmacology, Queen Mary & Westfield College, Mile End Road, London E1 4NS, UK","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040097484","display_name":"Roger F. Metcalfe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1339065421","display_name":"Defence Science and Technology Laboratory","ror":"https://ror.org/04jswqb94","country_code":"GB","type":"government","lineage":["https://openalex.org/I1306956679","https://openalex.org/I1339065421","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roger F. Metcalfe","raw_affiliation_strings":["Chemical and Biological Defence Establishment, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Biological Defence Establishment, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK","institution_ids":["https://openalex.org/I1339065421"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058170685","display_name":"Sally A. Saunders","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1339065421","display_name":"Defence Science and Technology Laboratory","ror":"https://ror.org/04jswqb94","country_code":"GB","type":"government","lineage":["https://openalex.org/I1306956679","https://openalex.org/I1339065421","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sally A. Saunders","raw_affiliation_strings":["Chemical and Biological Defence Establishment, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Biological Defence Establishment, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK","institution_ids":["https://openalex.org/I1339065421"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000952775"],"corresponding_institution_ids":["https://openalex.org/I166337079"],"apc_list":{"value":3710,"currency":"USD","value_usd":3710},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"6","issue":"4","first_page":"198","last_page":"204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.6880000233650208,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.6880000233650208,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.2660999894142151,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scopolamine","display_name":"scopolamine","score":0.9890000224113464},{"id":"https://openalex.org/keywords/urine-drug-testing","display_name":"urine drug testing","score":0.6359999775886536},{"id":"https://openalex.org/keywords/solid-phase-extraction","display_name":"solid-phase extraction","score":0.9330000281333923},{"id":"https://openalex.org/keywords/coulometric-detection","display_name":"coulometric detection","score":0.9559999704360962},{"id":"https://openalex.org/keywords/transdermal-patch","display_name":"transdermal patch","score":0.7689999938011169},{"id":"https://openalex.org/keywords/urinary-metabolites","display_name":"urinary metabolites","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.9138269424438477},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8890268802642822},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.8308134078979492},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7678552865982056},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.6516902446746826},{"id":"https://openalex.org/C2778576352","wikidata":"https://www.wikidata.org/wiki/Q337188","display_name":"Scopolamine","level":2,"score":0.6093019247055054},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.5655543804168701},{"id":"https://openalex.org/C81426234","wikidata":"https://www.wikidata.org/wiki/Q1408763","display_name":"Solid phase extraction","level":3,"score":0.5511221885681152},{"id":"https://openalex.org/C109379892","wikidata":"https://www.wikidata.org/wiki/Q1136979","display_name":"Coulometry","level":4,"score":0.47100725769996643},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.44902265071868896},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.13993793725967407},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05122634768486023},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.03702348470687866},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C52859227","wikidata":"https://www.wikidata.org/wiki/Q7877","display_name":"Electrochemistry","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002855","descriptor_name":"Chromatography, Thin Layer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004563","descriptor_name":"Electrochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012601","descriptor_name":"Scopolamine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/bmc.1130060410","doi":"https://doi.org/10.1002/bmc.1130060410","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bmc.1130060410","pdf_url":null,"source":{"id":"https://openalex.org/S123979729","display_name":"Biomedical Chromatography","issn_l":"0269-3879","issn":["0269-3879","1099-0801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Chromatography","raw_type":"journal-article"},{"id":"pmid:1643390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1643390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical chromatography : BMC","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1964494413","https://openalex.org/W1987611354","https://openalex.org/W1993733653","https://openalex.org/W2002868033","https://openalex.org/W2055551089","https://openalex.org/W2065444040","https://openalex.org/W2078293327","https://openalex.org/W2083936837","https://openalex.org/W2091727364","https://openalex.org/W2106917585","https://openalex.org/W2134749646"],"related_works":["https://openalex.org/W2005533574","https://openalex.org/W2091195409","https://openalex.org/W2130201105","https://openalex.org/W1987611354","https://openalex.org/W2134749646","https://openalex.org/W1965239262","https://openalex.org/W1969940333","https://openalex.org/W2011459565","https://openalex.org/W2159168598","https://openalex.org/W2078814816"],"abstract_inverted_index":{"A":[0],"sensitive":[1],"method":[2,62],"for":[3,52],"the":[4,50,89],"determination":[5],"of":[6,42,80,88,106],"hyoscine":[7,25,82,91,111],"(scopolamine)":[8],"in":[9],"urine":[10,66],"is":[11,113],"described.":[12],"After":[13],"concentration":[14],"and":[15,19,49,86],"\"clean-up\"":[16],"on":[17],"C18":[18],"CN":[20],"solid":[21],"phase":[22],"extraction":[23],"columns,":[24],"was":[26,44,59,63,83,92,98],"quantified":[27],"by":[28],"high":[29],"performance":[30],"liquid":[31],"chromatography":[32],"with":[33,108],"coulometric":[34],"detection":[35,43],"(oxidation":[36],"at":[37],"+0.9":[38],"V).":[39],"The":[40,61,76,104],"limit":[41],"5":[45,53],"ng":[46],"per":[47],"sample":[48],"precision":[51],"mL":[54],"samples":[55,67],"containing":[56],"2":[57],"ng/mL":[58],"12.3%.":[60],"applied":[64],"to":[65,110],"collected":[68],"from":[69],"12":[70],"volunteers":[71],"wearing":[72],"Scopoderm":[73],"TTS":[74],"patches.":[75],"mean":[77],"excretion":[78],"rate":[79],"unmetabolized":[81],"0.45":[84],"micrograms/h":[85],"87%":[87],"total":[90],"present":[93],"as":[94,100],"conjugates.":[95],"Apohyoscine":[96],"(aposcopolamine)":[97],"identified":[99],"a":[101],"urinary":[102],"metabolite.":[103],"significance":[105],"this":[107],"regard":[109],"assays":[112],"discussed.":[114]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
