{"id":"https://openalex.org/W2074529345","doi":"https://doi.org/10.1089/1076327042500319","title":"Engineering an Improved Acellular Nerve Graft via Optimized Chemical Processing","display_name":"Engineering an Improved Acellular Nerve Graft via Optimized Chemical Processing","publication_year":2004,"publication_date":"2004-09-01","ids":{"openalex":"https://openalex.org/W2074529345","doi":"https://doi.org/10.1089/1076327042500319","mag":"2074529345"},"language":"en","primary_location":{"id":"doi:10.1089/1076327042500319","doi":"https://doi.org/10.1089/1076327042500319","is_oa":false,"landing_page_url":"https://doi.org/10.1089/1076327042500319","pdf_url":null,"source":{"id":"https://openalex.org/S164177214","display_name":"Tissue Engineering","issn_l":"1076-3279","issn":["1076-3279","1557-8690"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032197949","display_name":"Terry W. Hudson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terry W. Hudson","raw_affiliation_strings":["Department of Chemical Engineering, University of Texas at Austin, Austin, Texas 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Texas at Austin, Austin, Texas 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040798707","display_name":"Stephen Y. Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Y. Liu","raw_affiliation_strings":["Department of Chemical Engineering, University of Texas at Austin, Austin, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Texas at Austin, Austin, Texas","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082475434","display_name":"Christine E. Schmidt","orcid":"https://orcid.org/0000-0002-5865-6016","observed_orcids":["https://orcid.org/0000-0002-5865-6016"]},"institutions":[{"id":"https://openalex.org/I4405271599","display_name":"Texas Materials Institute","ror":"https://ror.org/02q1tb011","country_code":"US","type":"education","lineage":["https://openalex.org/I4405271599"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine E. Schmidt","raw_affiliation_strings":["Department of Chemical Engineering, Department of Biomedical Engineering, and Texas Materials Institute, University of Texas at Austin, Austin, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Department of Biomedical Engineering, and Texas Materials Institute, University of Texas at Austin, Austin, Texas","institution_ids":["https://openalex.org/I4405271599","https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4971,"has_fulltext":false,"cited_by_count":323,"citation_normalized_percentile":{"value":0.87488313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"10","issue":"9","first_page":"1346","last_page":"1358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.03519999980926514,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acellular-nerve-graft","display_name":"acellular nerve graft","score":1.0},{"id":"https://openalex.org/keywords/peripheral-nerve-regeneration","display_name":"peripheral nerve regeneration","score":0.6650000214576721},{"id":"https://openalex.org/keywords/nerve-repair","display_name":"nerve repair","score":0.7080000042915344},{"id":"https://openalex.org/keywords/detergents","display_name":"detergents","score":0.9449999928474426},{"id":"https://openalex.org/keywords/sulfobetaine","display_name":"sulfobetaine","score":0.8769999742507935},{"id":"https://openalex.org/keywords/extracellular-matrix-preservation","display_name":"extracellular matrix preservation","score":0.8939999938011169}],"concepts":[{"id":"https://openalex.org/C190672674","wikidata":"https://www.wikidata.org/wiki/Q3866591","display_name":"Decellularization","level":3,"score":0.963190495967865},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.8178907632827759},{"id":"https://openalex.org/C3018498973","wikidata":"https://www.wikidata.org/wiki/Q9620","display_name":"Peripheral nerve","level":2,"score":0.7288291454315186},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6919443011283875},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.6481390595436096},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6141930818557739},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5233960747718811},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5191097259521484},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.34551578760147095},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2343597412109375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21915468573570251},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13199985027313232},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10950490832328796}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1089/1076327042500319","doi":"https://doi.org/10.1089/1076327042500319","is_oa":false,"landing_page_url":"https://doi.org/10.1089/1076327042500319","pdf_url":null,"source":{"id":"https://openalex.org/S164177214","display_name":"Tissue Engineering","issn_l":"1076-3279","issn":["1076-3279","1557-8690"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering","raw_type":"journal-article"},{"id":"doi:10.1089/ten.2004.10.1346","doi":"https://doi.org/10.1089/ten.2004.10.1346","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.2004.10.1346","pdf_url":null,"source":{"id":"https://openalex.org/S164177214","display_name":"Tissue Engineering","issn_l":"1076-3279","issn":["1076-3279","1557-8690"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1889634498","https://openalex.org/W1962850894","https://openalex.org/W1965310412","https://openalex.org/W1970233865","https://openalex.org/W1985207954","https://openalex.org/W1990067710","https://openalex.org/W2002526841","https://openalex.org/W2005600057","https://openalex.org/W2007125044","https://openalex.org/W2016552387","https://openalex.org/W2020005163","https://openalex.org/W2020378650","https://openalex.org/W2020453274","https://openalex.org/W2024708666","https://openalex.org/W2028470524","https://openalex.org/W2031955116","https://openalex.org/W2038049125","https://openalex.org/W2038236689","https://openalex.org/W2042549125","https://openalex.org/W2046116111","https://openalex.org/W2053016017","https://openalex.org/W2057447151","https://openalex.org/W2069599319","https://openalex.org/W2071949681","https://openalex.org/W2087627039","https://openalex.org/W2089640591","https://openalex.org/W2139154500","https://openalex.org/W2147124111","https://openalex.org/W2149845828","https://openalex.org/W2165475742","https://openalex.org/W2166253131","https://openalex.org/W4255908433"],"related_works":["https://openalex.org/W1774339690","https://openalex.org/W2869282709","https://openalex.org/W2372332888","https://openalex.org/W2943634150","https://openalex.org/W2557106892","https://openalex.org/W2788454970","https://openalex.org/W3108617902","https://openalex.org/W2320852923","https://openalex.org/W2520233475","https://openalex.org/W2988947717"],"abstract_inverted_index":{"The":[0],"long-term":[1],"goal":[2],"of":[3,46,63,77,110,113,136],"our":[4],"research":[5],"is":[6,125],"to":[7,26,57,108],"engineer":[8],"an":[9,126],"acellular":[10,38],"nerve":[11,15,32,39,50,60,117,138],"graft":[12,40,61],"for":[13,18],"clinical":[14],"repair":[16],"and":[17,52,72,82,99,120],"use":[19],"as":[20],"a":[21,59,66],"model":[22,37],"system":[23],"with":[24,65,93],"which":[25],"study":[27,102],"nerve\u2013extracellular":[28],"matrix":[29],"interactions":[30],"during":[31],"regeneration.":[33],"To":[34],"develop":[35],"this":[36],"we":[41],"(1)":[42],"examined":[43],"the":[44,75,94,104,111,133,141],"effects":[45,112],"detergents":[47,95,114],"on":[48,80,115],"peripheral":[49,116],"tissue,":[51],"(2)":[53],"used":[54],"that":[55,131],"knowledge":[56],"create":[58],"devoid":[62],"cells":[64],"well-preserved":[67],"extracellular":[68,83],"matrix.":[69],"Using":[70],"histochemistry":[71],"Western":[73],"analysis,":[74],"impact":[76],"each":[78],"detergent":[79],"cellular":[81],"tissue":[84,118],"components":[85],"was":[86,91],"determined.":[87],"An":[88],"optimized":[89],"protocol":[90,130],"created":[92],"Triton":[96],"X-200,":[97],"sulfobetaine-16,":[98],"sulfobetaine-10.":[100],"This":[101],"represents":[103],"most":[105],"comprehensive":[106],"examination":[107],"date":[109],"morphology":[119],"protein":[121],"composition.":[122],"Also":[123],"presented":[124],"improved":[127],"chemical":[128],"decellularization":[129],"preserves":[132],"internal":[134],"structure":[135],"native":[137],"more":[139],"than":[140],"predominant":[142],"current":[143],"protocol.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":29},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":29},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":28},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
