{"id":"https://openalex.org/W2074469580","doi":"https://doi.org/10.1002/ijc.24356","title":"Increased expression of fatty acid synthase in human aberrant crypt foci: Possible target for colorectal cancer prevention","display_name":"Increased expression of fatty acid synthase in human aberrant crypt foci: Possible target for colorectal cancer prevention","publication_year":2009,"publication_date":"2009-02-17","ids":{"openalex":"https://openalex.org/W2074469580","doi":"https://doi.org/10.1002/ijc.24356","mag":"2074469580","pmid":"https://pubmed.ncbi.nlm.nih.gov/19358283","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2761610"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.24356","doi":"https://doi.org/10.1002/ijc.24356","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.24356","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.24356","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.24356","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065475517","display_name":"Kathleen E. Kearney","orcid":"https://orcid.org/0000-0002-1360-9216","observed_orcids":["https://orcid.org/0000-0002-1360-9216"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen E. Kearney","raw_affiliation_strings":["Department of Pathology and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106-7288, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106-7288, USA","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111649130","display_name":"Thomas G. Pretlow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas G. Pretlow","raw_affiliation_strings":["","Department of Pathology and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":null,"display_name":"Theresa P. Pretlow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Theresa P. Pretlow","raw_affiliation_strings":["","Department of Pathology and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH","Department of Pathology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106\u20107288, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Pathology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106\u20107288, USA","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":1.326,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.81546663,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"125","issue":"1","first_page":"249","last_page":"252"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fatty-acid-synthase","display_name":"fatty acid synthase","score":0.996999979019165},{"id":"https://openalex.org/keywords/aberrant-crypt-foci","display_name":"aberrant crypt foci","score":1.0},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8820000290870667},{"id":"https://openalex.org/keywords/colorectal-carcinogenesis","display_name":"colorectal carcinogenesis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/de-novo-lipogenesis","display_name":"de novo lipogenesis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8119999766349792},{"id":"https://openalex.org/keywords/colonic-mucosa","display_name":"colonic mucosa","score":0.7250000238418579},{"id":"https://openalex.org/keywords/dysplasia","display_name":"dysplasia","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C2780669762","wikidata":"https://www.wikidata.org/wiki/Q4667164","display_name":"Aberrant crypt foci","level":5,"score":0.886234700679779},{"id":"https://openalex.org/C48289651","wikidata":"https://www.wikidata.org/wiki/Q106916817","display_name":"Fatty acid synthase","level":3,"score":0.7751955986022949},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7739132642745972},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7021697759628296},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.5734010338783264},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5587639212608337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5065544843673706},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5055656433105469},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5046082735061646},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.4835474193096161},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4692147970199585},{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.45960405468940735},{"id":"https://openalex.org/C2993273003","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Neoplastic transformation","level":4,"score":0.4200572669506073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33188414573669434},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.314200758934021},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22884362936019897},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.1921921670436859},{"id":"https://openalex.org/C3018440083","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Colonic disease","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D054890","descriptor_name":"Fatty Acid Synthase, Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/ijc.24356","doi":"https://doi.org/10.1002/ijc.24356","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.24356","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.24356","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:19358283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19358283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2761610","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2761610","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int J Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/ijc.24356","doi":"https://doi.org/10.1002/ijc.24356","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.24356","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.24356","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1125725899","display_name":"HUMAN ABERRANT CRYPT FOCI--BIOMARKERS FOR COLON CANCER","funder_award_id":"R01CA066725","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1526051034","display_name":null,"funder_award_id":"CA66725","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2250051986","display_name":null,"funder_award_id":"P30 CA43703","funder_id":"https://openalex.org/F4320310281","funder_display_name":"Case Western Reserve University"},{"id":"https://openalex.org/G288394484","display_name":null,"funder_award_id":"CA 43703","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000862237","display_name":"Case Comprehensive Cancer Center Support Grant","funder_award_id":"P30CA043703","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310281","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2074469580.pdf","grobid_xml":"https://content.openalex.org/works/W2074469580.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1608714568","https://openalex.org/W1898639226","https://openalex.org/W1902678347","https://openalex.org/W1963769095","https://openalex.org/W1967482096","https://openalex.org/W1995571423","https://openalex.org/W1999339869","https://openalex.org/W2037071441","https://openalex.org/W2039163595","https://openalex.org/W2049274220","https://openalex.org/W2070675405","https://openalex.org/W2081608359","https://openalex.org/W2093265805","https://openalex.org/W2123037292","https://openalex.org/W2137642531","https://openalex.org/W2146607058","https://openalex.org/W2148456506","https://openalex.org/W2149159751","https://openalex.org/W2154722774","https://openalex.org/W2154746629","https://openalex.org/W2161020200","https://openalex.org/W2169555816","https://openalex.org/W2186483613","https://openalex.org/W2321435933","https://openalex.org/W2414481435"],"related_works":["https://openalex.org/W2015051582","https://openalex.org/W1898639226","https://openalex.org/W3208243458","https://openalex.org/W2031448936","https://openalex.org/W7132927784","https://openalex.org/W1996448526","https://openalex.org/W2104903589","https://openalex.org/W1999687409","https://openalex.org/W1970452751","https://openalex.org/W4403215955"],"abstract_inverted_index":{"Aberrant":[0],"crypt":[1],"foci":[2],"(ACF),":[3],"the":[4,10,20,34,87,139,145,150],"earliest":[5],"identified":[6],"monoclonal":[7],"lesions":[8],"in":[9,38,49,57,75,117,124,133,149,157,173],"colon,":[11],"provide":[12],"insights":[13],"into":[14],"changes":[15],"that":[16,123,164],"promote":[17],"and/or":[18],"accompany":[19],"transformation":[21],"of":[22,90,93,131,141,147,155,161],"normal":[23,51,101,126],"colonic":[24,102,127],"epithelial":[25],"cells":[26],"to":[27,138,144],"colorectal":[28,62,76,174],"cancer.":[29],"Fatty":[30],"acid":[31],"synthase":[32],"(FAS),":[33],"primary":[35],"enzyme":[36,166],"involved":[37],"de":[39],"novo":[40],"lipogenesis":[41],"from":[42,81,105],"carbohydrates,":[43],"is":[44,55,71],"expressed":[45],"at":[46],"low":[47],"levels":[48],"most":[50],"human":[52,59,79],"tissues":[53],"but":[54],"elevated":[56],"several":[58],"neoplasms":[60],"including":[61],"adenomas":[63],"and":[64,100,176],"carcinomas.":[65],"To":[66],"determine":[67],"if":[68],"this":[69,165],"pathway":[70],"altered":[72],"even":[73],"earlier":[74],"tumorigenesis,":[77],"35":[78],"ACF":[80,108,120,134,162],"21":[82],"patients":[83],"were":[84],"evaluated":[85],"for":[86,181],"immunohistochemical":[88],"expression":[89,114,130,154],"FAS.":[91],"Sections":[92],"colon":[94],"cancer":[95,106],"served":[96,109],"as":[97,110],"positive":[98],"controls,":[99],"mucosa":[103],"distant":[104],"or":[107,143],"negative":[111],"controls.":[112],"FAS":[113,132,156],"was":[115,135],"increased":[116],"30":[118],"(86%)":[119],"compared":[121],"with":[122],"adjacent":[125],"mucosa.":[128],"The":[129,152],"not":[136],"related":[137],"degree":[140],"dysplasia":[142],"number":[146],"crypts":[148],"ACF.":[151],"over":[153],"a":[158,179],"high":[159],"proportion":[160],"suggests":[163],"plays":[167],"an":[168],"important":[169],"role":[170],"very":[171],"early":[172],"tumorigenesis":[175],"may":[177],"be":[178],"target":[180],"chemoprevention.":[182]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}