{"id":"https://openalex.org/W207444448","doi":null,"title":"Molecular and somatic-cell genetic analysis of metal-resistance mechanisms in mammalian cells","display_name":"Molecular and somatic-cell genetic analysis of metal-resistance mechanisms in mammalian cells","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W207444448","mag":"207444448"},"language":"en","primary_location":{"id":"pmh:oai:osti.gov:5518883","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/5518883","pdf_url":"https://www.osti.gov/servlets/purl/5518883","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.osti.gov/servlets/purl/5518883","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088752831","display_name":"Enger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Enger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113571455","display_name":"Carl E. Hildebrand","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C.E. Hildebrand","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113483522","display_name":"R.A. Walters","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.A. Walters","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110056694","display_name":"JeanClare Seagrave","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JeanClare Seagrave","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108628518","display_name":"S.S. Barham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S.S. Barham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063026441","display_name":"H.C. Hoagland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H.C. Hoagland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4858,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.53854674,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.4968000054359436,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.4968000054359436,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.4916999936103821,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12780","display_name":"Heavy Metal Pollution Remediation","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2312","display_name":"Water Science and Technology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metal-resistance","display_name":"metal resistance","score":0.878000020980835},{"id":"https://openalex.org/keywords/cadmium-detoxification","display_name":"cadmium detoxification","score":0.8220000267028809},{"id":"https://openalex.org/keywords/metallothionein","display_name":"metallothionein","score":0.9539999961853027},{"id":"https://openalex.org/keywords/heavy-metal-binding-proteins","display_name":"heavy metal binding proteins","score":0.8870000243186951},{"id":"https://openalex.org/keywords/metal-metabolism","display_name":"metal metabolism","score":0.7440000176429749},{"id":"https://openalex.org/keywords/human-cancer-cell-lines","display_name":"human cancer cell lines","score":0.7059999704360962},{"id":"https://openalex.org/keywords/granulocytes","display_name":"granulocytes","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cadmium-uptake","display_name":"cadmium uptake","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7570000290870667},{"id":"https://openalex.org/keywords/metal-resistance-genes","display_name":"metal resistance genes","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.8461912274360657},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.5479595065116882},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4552347958087921},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44289037585258484},{"id":"https://openalex.org/C23085057","wikidata":"https://www.wikidata.org/wiki/Q5532877","display_name":"Genetic analysis","level":3,"score":0.4194846749305725},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39698511362075806},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24746474623680115},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.05940285325050354}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:osti.gov:5518883","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/5518883","pdf_url":"https://www.osti.gov/servlets/purl/5518883","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:info:ark/67531/metadc1091628","doi":null,"is_oa":false,"landing_page_url":"https://digital.library.unt.edu/ark:/67531/metadc1091628/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400792","display_name":"University of North Texas Digital Library (University of North Texas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123534392","host_organization_name":"University of North Texas","host_organization_lineage":["https://openalex.org/I123534392"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular and cellular approaches to understanding mechanisms of toxicity conference, Boston, MA, USA, 1 Sep 1983","raw_type":"Article"},{"id":"mag:207444448","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/5518883","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:osti.gov:5518883","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/5518883","pdf_url":"https://www.osti.gov/servlets/purl/5518883","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W207444448.pdf","grobid_xml":"https://content.openalex.org/works/W207444448.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1986473207","https://openalex.org/W2230992387","https://openalex.org/W2010510766","https://openalex.org/W2102726114","https://openalex.org/W2023464226","https://openalex.org/W2052580459","https://openalex.org/W146954182","https://openalex.org/W7099828106","https://openalex.org/W1582846107","https://openalex.org/W2065865511"],"abstract_inverted_index":{"Combined":[0],"molecular":[1,63],"genetic":[2],"analyses":[3],"and":[4,72,96,183,249,255],"somatic":[5],"cell":[6,40,97,127,151],"systems":[7,250],"were":[8,27],"utilized":[9],"to":[10,29,65,103,186,223],"delineate":[11],"factors":[12,32,248],"involved":[13,33,48],"in":[14,34,49,90,114,123,135,140,190],"metal":[15,37,52,82,91,241],"metabolism.":[16],"Somatic":[17],"cells":[18],"derived":[19,99,126],"by":[20,230],"selection":[21],"procedures":[22],"using":[23],"toxic":[24,224],"heavy":[25,51],"metals":[26,225],"used":[28,93],"define":[30],"primary":[31],"acquisition":[35],"of":[36,44,70,74,78,88,132,147,169,179,220,232,235],"resistance.":[38,83],"Such":[39],"variants":[41,95],"permitted":[42],"isolation":[43],"the":[45,55,62,67,86,155,162,233],"specific":[46],"genes":[47,60,79],"conferring":[50],"binding":[53,242],"proteins,":[54],"metallothioneins.":[56],"(MT).":[57],"These":[58],"isolated":[59],"provided":[61,229],"probes":[64],"dissect":[66],"multiple":[68],"levels":[69],"control":[71],"organization":[73],"this":[75],"one":[76,236],"set":[77],"responsible":[80],"for":[81],"Studies":[84,117],"on":[85,118],"roles":[87],"MT":[89,144,182],"resistance":[92],"these":[94],"lines":[98,128,141],"from":[100],"human":[101,124,193],"tumors":[102],"illustrate":[104],"that":[105,154,216,251],"MTs":[106],"play":[107],"an":[108,217],"important":[109],"but":[110],"not":[111,165,227],"exclusive":[112],"role":[113],"cadmium":[115],"detoxification.":[116],"Cd/sup":[119,136,157,187,201],"+":[120,137,158,188,202],"+/":[121,138,159,189,203],"responses":[122,152,185,222],"tumor":[125],"showed":[129,153],"several":[130],"orders":[131],"magnitude":[133],"differences":[134],"sensitivity":[139,256],"having":[142],"similar":[143],"responses.":[145],"Analysis":[146],"cultured":[148,192],"normal":[149],"blood":[150,196],"most":[156],"resistant":[160],"population,":[161],"granulocytes,":[163],"did":[164],"produce":[166],"significant":[167],"quantities":[168],"MT.":[170,246],"The":[171],"results":[172,213],"presented":[173],"here":[174],"further":[175],"show":[176],"a":[177,207,238],"lack":[178],"correlation":[180],"between":[181],"cytotoxic":[184],"freshly":[191],"leukemic":[194],"peripheral":[195],"cells.":[197],"In":[198],"these,":[199],"enhanced":[200,210],"uptake":[204,254],"may":[205],"be":[206,228,259],"factor":[208],"determining":[209],"sensitivity.":[211],"Theses":[212],"together":[214],"indicate":[215],"adequate":[218],"understanding":[219],"cellular":[221,253],"will":[226],"elucidation":[231],"role(s)":[234],"or":[237],"few":[239],"known":[240],"proteins":[243],"such":[244],"as":[245],"Other":[247],"modulate":[252],"must":[257],"first":[258],"defined.":[260]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}