{"id":"https://openalex.org/W2074416005","doi":"https://doi.org/10.1016/0006-3223(94)00305-m","title":"Regional 133Xenon cerebral blood flow and cerebral 99mTc-HMPAO uptake in patients with obsessive-compulsive disorder before and during treatment","display_name":"Regional 133Xenon cerebral blood flow and cerebral 99mTc-HMPAO uptake in patients with obsessive-compulsive disorder before and during treatment","publication_year":1995,"publication_date":"1995-10-01","ids":{"openalex":"https://openalex.org/W2074416005","doi":"https://doi.org/10.1016/0006-3223(94)00305-m","mag":"2074416005","pmid":"https://pubmed.ncbi.nlm.nih.gov/8672603"},"language":"en","primary_location":{"id":"doi:10.1016/0006-3223(94)00305-m","doi":"https://doi.org/10.1016/0006-3223(94)00305-m","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-3223(94)00305-m","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004369157","display_name":"Robert T. Rub\u00edn","orcid":"https://orcid.org/0000-0002-0304-4303","observed_orcids":["https://orcid.org/0000-0002-0304-4303"]},"institutions":[{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert T. Rubin","raw_affiliation_strings":["Neurosciences Research Center, Medical College of Pennsylvania, Pittsburgh, USA","Department of Psychiatry, Harbor-UCLA Medical Center, Torrance, CA 90509, USA","Neurosciences Research Center and Department of Psychiatry, Allegheny Campus of the Medical College of Pennsylvania and Hahnemann University, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosciences Research Center, Medical College of Pennsylvania, Pittsburgh, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Psychiatry, Harbor-UCLA Medical Center, Torrance, CA 90509, USA","institution_ids":["https://openalex.org/I4210165985"]},{"raw_affiliation_string":"Neurosciences Research Center and Department of Psychiatry, Allegheny Campus of the Medical College of Pennsylvania and Hahnemann University, Pittsburgh, PA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111689041","display_name":"Jambur Ananth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jambur Ananth","raw_affiliation_strings":["Department of Psychiatry, Harbor-UCLA Medical Center, Torrance, CA 90509, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harbor-UCLA Medical Center, Torrance, CA 90509, USA","institution_ids":["https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050968882","display_name":"Javier Villanueva\u2010Meyer","orcid":"https://orcid.org/0000-0002-1212-4233","observed_orcids":["https://orcid.org/0000-0002-1212-4233"]},"institutions":[{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javier Villanueva-Meyer","raw_affiliation_strings":["Department of Radiology (Division of Nuclear Medicine), Harbor-UCLA Medical Center, Torrance, CA 90509, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology (Division of Nuclear Medicine), Harbor-UCLA Medical Center, Torrance, CA 90509, USA","institution_ids":["https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070961109","display_name":"Peter G. Trajmar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter G. Trajmar","raw_affiliation_strings":["Department of Computer Science, University of California at Los Angeles, Los Angeles, CA 90024, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of California at Los Angeles, Los Angeles, CA 90024, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113731850","display_name":"Ismael Mena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ismael Mena","raw_affiliation_strings":["Department of Radiology (Division of Nuclear Medicine), Harbor-UCLA Medical Center, Torrance, CA 90509, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology (Division of Nuclear Medicine), Harbor-UCLA Medical Center, Torrance, CA 90509, USA","institution_ids":["https://openalex.org/I4210165985"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004369157"],"corresponding_institution_ids":["https://openalex.org/I4210165985"],"apc_list":{"value":5489,"currency":"USD","value_usd":5489},"apc_paid":null,"fwci":5.49,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.9574736,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"38","issue":"7","first_page":"429","last_page":"437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obsessive-compulsive-disorder","display_name":"obsessive-compulsive disorder","score":1.0},{"id":"https://openalex.org/keywords/regional-cerebral-blood-flow","display_name":"regional cerebral blood flow","score":0.9480000138282776},{"id":"https://openalex.org/keywords/99mtc-hmpao","display_name":"99mTc-HMPAO","score":0.9160000085830688},{"id":"https://openalex.org/keywords/133xe-inhalation","display_name":"133Xe inhalation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/orbitofrontal-cortex","display_name":"orbitofrontal cortex","score":0.8539999723434448},{"id":"https://openalex.org/keywords/caudate-nucleus","display_name":"caudate nucleus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cerebral-perfusion","display_name":"cerebral perfusion","score":0.4569999873638153},{"id":"https://openalex.org/keywords/ocd-pathophysiology","display_name":"OCD pathophysiology","score":0.7409999966621399},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C2781423529","wikidata":"https://www.wikidata.org/wiki/Q1132309","display_name":"Caudate nucleus","level":2,"score":0.8083713054656982},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.745650053024292},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.6440982818603516},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.5833934545516968},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5098680257797241},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4313367009162903},{"id":"https://openalex.org/C2779305415","wikidata":"https://www.wikidata.org/wiki/Q58713","display_name":"Clomipramine","level":2,"score":0.4110206067562103},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.39272433519363403},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3523012399673462}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D002421","descriptor_name":"Caudate Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002421","descriptor_name":"Caudate Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D002997","descriptor_name":"Clomipramine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002997","descriptor_name":"Clomipramine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004292","descriptor_name":"Dominance, Cerebral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004292","descriptor_name":"Dominance, Cerebral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D010091","descriptor_name":"Oximes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014980","descriptor_name":"Xenon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015609","descriptor_name":"Organotechnetium Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019690","descriptor_name":"Technetium Tc 99m Exametazime","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-3223(94)00305-m","doi":"https://doi.org/10.1016/0006-3223(94)00305-m","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-3223(94)00305-m","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},{"id":"pmid:8672603","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8672603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1483128446","display_name":"HORMONE RHYTHMS: METABOLIC SIGNIFICANCE IN PSYCHIATRY","funder_award_id":"5k05mh047363-14","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G521520193","display_name":null,"funder_award_id":"MH 47363","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W26958550","https://openalex.org/W1554976072","https://openalex.org/W1579276202","https://openalex.org/W1870024585","https://openalex.org/W1964156722","https://openalex.org/W1973457656","https://openalex.org/W1979132524","https://openalex.org/W1982012645","https://openalex.org/W1984000803","https://openalex.org/W1994971749","https://openalex.org/W2004543507","https://openalex.org/W2006001020","https://openalex.org/W2013041188","https://openalex.org/W2014506084","https://openalex.org/W2021499386","https://openalex.org/W2029742491","https://openalex.org/W2030313712","https://openalex.org/W2033437752","https://openalex.org/W2038460348","https://openalex.org/W2042305653","https://openalex.org/W2045983513","https://openalex.org/W2050528138","https://openalex.org/W2061265043","https://openalex.org/W2064498482","https://openalex.org/W2095851596","https://openalex.org/W2106566798","https://openalex.org/W2123822033","https://openalex.org/W2146600977","https://openalex.org/W2152962921","https://openalex.org/W2159011576","https://openalex.org/W2242029336","https://openalex.org/W2326250746","https://openalex.org/W2395864704","https://openalex.org/W2414277680","https://openalex.org/W2416778302","https://openalex.org/W2428372331","https://openalex.org/W2440259129","https://openalex.org/W2443491582","https://openalex.org/W4230461619","https://openalex.org/W4256698101","https://openalex.org/W6639160720"],"related_works":["https://openalex.org/W1973457656","https://openalex.org/W1991684222","https://openalex.org/W2053872721","https://openalex.org/W1979686712","https://openalex.org/W2001252141","https://openalex.org/W2089183450","https://openalex.org/W1966139177","https://openalex.org/W2166371058","https://openalex.org/W1983710662","https://openalex.org/W2116292828"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}