{"id":"https://openalex.org/W2074375283","doi":"https://doi.org/10.1002/chem.200701102","title":"A Nanoporous Reactor for Efficient Proteolysis","display_name":"A Nanoporous Reactor for Efficient Proteolysis","publication_year":2007,"publication_date":"2007-10-24","ids":{"openalex":"https://openalex.org/W2074375283","doi":"https://doi.org/10.1002/chem.200701102","mag":"2074375283","pmid":"https://pubmed.ncbi.nlm.nih.gov/17960551"},"language":"en","primary_location":{"id":"doi:10.1002/chem.200701102","doi":"https://doi.org/10.1002/chem.200701102","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chem.200701102","pdf_url":null,"source":{"id":"https://openalex.org/S68911691","display_name":"Chemistry - A European Journal","issn_l":"0947-6539","issn":["0947-6539","1521-3765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 A European Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://infoscience.epfl.ch/record/175348","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021874293","display_name":"Liang Qiao","orcid":"https://orcid.org/0000-0002-6233-8459","observed_orcids":["https://orcid.org/0000-0002-6233-8459"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Qiao","raw_affiliation_strings":["Department of Chemistry, Institute of Biomedical Sciences, Fudan University, Shanghai 200433, China","Department of Chemistry, Institute of Biomedical Sciences, Fudan University, Shanghai 200433, China, Fax: (+86)\u200921\u20106564\u20101740"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Institute of Biomedical Sciences, Fudan University, Shanghai 200433, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of Chemistry, Institute of Biomedical Sciences, Fudan University, Shanghai 200433, China, Fax: (+86)\u200921\u20106564\u20101740","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008799889","display_name":"Yun Liu","orcid":"https://orcid.org/0000-0002-8947-3482","observed_orcids":["https://orcid.org/0000-0002-8947-3482","https://orcid.org/0009-0007-1688-8859"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Liu","raw_affiliation_strings":["Department of Chemistry, Institute of Biomedical Sciences, Fudan University, Shanghai 200433, China,","Department of Chemistry, Institute of Biomedical Sciences, Fudan University, Shanghai 200433, China, Fax: (+86)\u200921\u20106564\u20101740"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Institute of Biomedical Sciences, Fudan University, Shanghai 200433, China,","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of Chemistry, Institute of Biomedical Sciences, Fudan University, Shanghai 200433, China, Fax: (+86)\u200921\u20106564\u20101740","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064278171","display_name":"Sarah P. Hudson","orcid":"https://orcid.org/0000-0002-6718-2190","observed_orcids":["https://orcid.org/0000-0002-6718-2190"]},"institutions":[{"id":"https://openalex.org/I230495080","display_name":"University of Limerick","ror":"https://ror.org/00a0n9e72","country_code":"IE","type":"education","lineage":["https://openalex.org/I230495080"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Sarah\u2005P. Hudson","raw_affiliation_strings":["Department of Chemical and Environmental Sciences, Materials and Surface Science Institute, University of Limerick, Limerick, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Environmental Sciences, Materials and Surface Science Institute, University of Limerick, Limerick, Ireland","institution_ids":["https://openalex.org/I230495080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057539657","display_name":"Pengyuan Yang","orcid":"https://orcid.org/0000-0001-5779-1008","observed_orcids":["https://orcid.org/0000-0001-5779-1008"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengyuan Yang","raw_affiliation_strings":["Department of Chemistry, Institute of Biomedical Sciences, Fudan University, Shanghai 200433, China, Fax: (+86)\u200921\u20106564\u20101740"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Institute of Biomedical Sciences, Fudan University, Shanghai 200433, China, Fax: (+86)\u200921\u20106564\u20101740","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018893421","display_name":"Edmond Magner","orcid":"https://orcid.org/0000-0003-2042-556X","observed_orcids":["https://orcid.org/0000-0003-2042-556X"]},"institutions":[{"id":"https://openalex.org/I230495080","display_name":"University of Limerick","ror":"https://ror.org/00a0n9e72","country_code":"IE","type":"education","lineage":["https://openalex.org/I230495080"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Edmond Magner","raw_affiliation_strings":["Department of Chemical and Environmental Sciences, Materials and Surface Science Institute, University of Limerick, Limerick, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Environmental Sciences, Materials and Surface Science Institute, University of Limerick, Limerick, Ireland","institution_ids":["https://openalex.org/I230495080"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060480074","display_name":"Baohong Liu","orcid":"https://orcid.org/0000-0002-0660-8610","observed_orcids":["https://orcid.org/0000-0002-0660-8610"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baohong Liu","raw_affiliation_strings":["Department of Chemistry, Institute of Biomedical Sciences, Fudan University, Shanghai 200433, China, Fax: (+86)\u200921\u20106564\u20101740"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Institute of Biomedical Sciences, Fudan University, Shanghai 200433, China, Fax: (+86)\u200921\u20106564\u20101740","institution_ids":["https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":2.7682,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.9081386,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"151","last_page":"157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10735","display_name":"Mesoporous Materials and Catalysis","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesoporous-silicates","display_name":"mesoporous silicates","score":0.9139999747276306},{"id":"https://openalex.org/keywords/trypsin","display_name":"trypsin","score":0.8209999799728394},{"id":"https://openalex.org/keywords/protein-digestion","display_name":"protein digestion","score":0.6150000095367432},{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"cytochrome c","score":0.7319999933242798},{"id":"https://openalex.org/keywords/myoglobin","display_name":"myoglobin","score":1.0},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.6389999985694885},{"id":"https://openalex.org/keywords/maldi-tof-mass-spectrometry","display_name":"MALDI-TOF mass spectrometry","score":0.8159999847412109},{"id":"https://openalex.org/keywords/peptide-identification","display_name":"peptide identification","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7191723585128784},{"id":"https://openalex.org/C190818770","wikidata":"https://www.wikidata.org/wiki/Q6964123","display_name":"Nanoreactor","level":3,"score":0.699783205986023},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.6698232889175415},{"id":"https://openalex.org/C48940184","wikidata":"https://www.wikidata.org/wiki/Q17623309","display_name":"Nanoporous","level":2,"score":0.665262758731842},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.6601105332374573},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5824304819107056},{"id":"https://openalex.org/C82776694","wikidata":"https://www.wikidata.org/wiki/Q380049","display_name":"Mesoporous material","level":3,"score":0.5575145483016968},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5412819385528564},{"id":"https://openalex.org/C2781357212","wikidata":"https://www.wikidata.org/wiki/Q5275608","display_name":"Digestion (alchemy)","level":2,"score":0.53288733959198},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5314204692840576},{"id":"https://openalex.org/C75280812","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Matrix-assisted laser desorption/ionization","level":4,"score":0.46404901146888733},{"id":"https://openalex.org/C2778576202","wikidata":"https://www.wikidata.org/wiki/Q2540164","display_name":"Sample preparation","level":2,"score":0.44265180826187134},{"id":"https://openalex.org/C162711632","wikidata":"https://www.wikidata.org/wiki/Q905514","display_name":"Desorption","level":3,"score":0.34477558732032776},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2934143841266632},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1723904013633728},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.0952141284942627},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016062","descriptor_name":"Porosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/chem.200701102","doi":"https://doi.org/10.1002/chem.200701102","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chem.200701102","pdf_url":null,"source":{"id":"https://openalex.org/S68911691","display_name":"Chemistry - A European Journal","issn_l":"0947-6539","issn":["0947-6539","1521-3765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 A European Journal","raw_type":"journal-article"},{"id":"pmid:17960551","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17960551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry (Weinheim an der Bergstrasse, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:infoscience.epfl.ch:175348","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/175348","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:infoscience.tind.io:175348","doi":null,"is_oa":true,"landing_page_url":"https://infoscience.epfl.ch/handle/20.500.14299/78309","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"pmh:oai:infoscience.epfl.ch:175348","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/175348","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W21403231","https://openalex.org/W1976471602","https://openalex.org/W1978268245","https://openalex.org/W1985329640","https://openalex.org/W1985470384","https://openalex.org/W1987330726","https://openalex.org/W1991004406","https://openalex.org/W1996705260","https://openalex.org/W2014699872","https://openalex.org/W2028065252","https://openalex.org/W2030564203","https://openalex.org/W2037167319","https://openalex.org/W2043251453","https://openalex.org/W2049710608","https://openalex.org/W2050682768","https://openalex.org/W2052714460","https://openalex.org/W2054397184","https://openalex.org/W2058412674","https://openalex.org/W2068445841","https://openalex.org/W2077833889","https://openalex.org/W2081436856","https://openalex.org/W2088653576","https://openalex.org/W2109758733","https://openalex.org/W2112031925","https://openalex.org/W2118368153","https://openalex.org/W2120842722","https://openalex.org/W2122730212","https://openalex.org/W2128235529","https://openalex.org/W2143993735","https://openalex.org/W2161408389","https://openalex.org/W2167839880","https://openalex.org/W4253387058","https://openalex.org/W4256506417"],"related_works":["https://openalex.org/W2058412674","https://openalex.org/W2161015505","https://openalex.org/W2011304677","https://openalex.org/W1968947207","https://openalex.org/W2132915027","https://openalex.org/W2054167821","https://openalex.org/W1989317879","https://openalex.org/W2168695794","https://openalex.org/W2081436856","https://openalex.org/W2049710608"],"abstract_inverted_index":{"A":[0,104],"nanoreactor":[1,140],"based":[2],"on":[3],"mesoporous":[4,18],"silicates":[5],"is":[6,29,66],"described":[7],"for":[8,33,101],"efficient":[9,69],"tryptic":[10],"digestion":[11,39,100,146],"of":[12,26,40,83,92,112,144,150,161],"proteins":[13,131],"within":[14,86],"the":[15,41,84,87,110,120,142,159],"mesochannels.":[16],"Cyano-functionalized":[17],"silicate":[19],"(CNS),":[20],"with":[21,35,124,148],"an":[22],"average":[23],"pore":[24],"diameter":[25],"18":[27],"nm,":[28],"a":[30,154],"good":[31],"support":[32],"trypsin,":[34],"rapid":[36],"in":[37],"situ":[38],"model":[42],"proteins,":[43],"cytochrome":[44],"c":[45],"and":[46,80,127],"myoglobin.":[47],"The":[48],"generated":[49],"peptides":[50],"were":[51,96,132],"analyzed":[52],"by":[53,64,118],"matrix-assisted":[54],"laser":[55],"desorption":[56],"ionization":[57],"time-of-flight":[58],"mass":[59],"spectrometry":[60],"(MALDI-TOF":[61],"MS).":[62],"Proteolysis":[63],"trypsin-CNS":[65],"much":[67],"more":[68],"than":[70],"in-solution":[71],"digestion,":[72],"which":[73],"can":[74],"be":[75],"attributed":[76],"to":[77,157],"nanoscopic":[78],"confinement":[79],"concentration":[81],"enrichment":[82],"substrate":[85],"mesopores.":[88],"Proteins":[89],"at":[90],"concentrations":[91],"2":[93],"ng":[94],"muL(-1)":[95],"successfully":[97],"identified":[98,133],"after":[99,134],"20":[102],"min.":[103],"biological":[105],"complex":[106],"sample":[107],"extracted":[108],"from":[109],"cytoplasm":[111],"human":[113],"liver":[114],"tissue":[115],"was":[116],"digested":[117],"using":[119],"CNS-based":[121],"reactor.":[122],"Coupled":[123],"reverse-phase":[125],"HPLC":[126],"MALDI-TOF":[128],"MS/MS,":[129],"165":[130],"standard":[135],"protein":[136],"data":[137],"searching.":[138],"This":[139],"combines":[141],"advantages":[143],"short":[145],"time":[147],"retention":[149],"enzymatic":[151],"activity,":[152],"providing":[153],"promising":[155],"way":[156],"advance":[158],"development":[160],"proteomics.":[162]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}