{"id":"https://openalex.org/W2074366191","doi":"https://doi.org/10.4161/cam.4.4.12427","title":"Sweet cues","display_name":"Sweet cues","publication_year":2010,"publication_date":"2010-10-01","ids":{"openalex":"https://openalex.org/W2074366191","doi":"https://doi.org/10.4161/cam.4.4.12427","mag":"2074366191","pmid":"https://pubmed.ncbi.nlm.nih.gov/20562530","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3011263"},"language":"en","primary_location":{"id":"doi:10.4161/cam.4.4.12427","doi":"https://doi.org/10.4161/cam.4.4.12427","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cam.4.4.12427","pdf_url":null,"source":{"id":"https://openalex.org/S179222606","display_name":"Cell Adhesion & Migration","issn_l":"1933-6918","issn":["1933-6918","1933-6926"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Adhesion &amp; Migration","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.4161/cam.4.4.12427","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089700192","display_name":"Karen Symes","orcid":"https://orcid.org/0000-0002-1435-9618","observed_orcids":["https://orcid.org/0000-0002-1435-9618"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Karen Symes","raw_affiliation_strings":["Department of Biochemistry, Boston University School of Medicine; Boston, MA, USA. symes@bu.edu","Boston University School of Medicine","Boston, MA USA","Department of Biochemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Boston University School of Medicine; Boston, MA, USA. symes@bu.edu","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Boston University School of Medicine","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Boston, MA USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070127770","display_name":"Erin Marie Smith","orcid":"https://orcid.org/0000-0002-6726-628X","observed_orcids":["https://orcid.org/0000-0002-6726-628X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin M. Smith","raw_affiliation_strings":["Department of Biochemistry; Boston University School of Medicine; Boston, MA USA","Boston University School of Medicine","Boston, MA USA","Department of Biochemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry; Boston University School of Medicine; Boston, MA USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Boston University School of Medicine","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Boston, MA USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062386392","display_name":"Maria Mitsi","orcid":"https://orcid.org/0000-0001-8983-1983","observed_orcids":["https://orcid.org/0000-0001-8983-1983"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Maria Mitsi","raw_affiliation_strings":["Institute of Biologically Oriented Materials; ETH Zurich; Z\u00fcrich","ETH Zurich","Institute of Biologically Oriented Materials","Z\u00fcrich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biologically Oriented Materials; ETH Zurich; Z\u00fcrich","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"ETH Zurich","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Institute of Biologically Oriented Materials","institution_ids":[]},{"raw_affiliation_string":"Z\u00fcrich","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074638151","display_name":"Matthew A. Nugent","orcid":"https://orcid.org/0000-0001-7290-5616","observed_orcids":["https://orcid.org/0000-0001-7290-5616"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew A. Nugent","raw_affiliation_strings":["Department of Biochemistry; Boston University School of Medicine; Boston, MA USA","Boston University School of Medicine","Boston, MA USA","Department of Biochemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry; Boston University School of Medicine; Boston, MA USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Boston University School of Medicine","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Boston, MA USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089700192"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":{"value":1880,"currency":"GBP","value_usd":2306},"apc_paid":{"value":1880,"currency":"GBP","value_usd":2306},"fwci":0.6989,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.6750949,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"4","issue":"4","first_page":"507","last_page":"510"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heparan-sulfate-proteoglycans","display_name":"heparan sulfate proteoglycans","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.8500000238418579},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8230000138282776},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7910000085830688},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.9210000038146973},{"id":"https://openalex.org/keywords/morphogens","display_name":"morphogens","score":0.5139999985694885},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.8887713551521301},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7471470832824707},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7352959513664246},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5755728483200073},{"id":"https://openalex.org/C2778041096","wikidata":"https://www.wikidata.org/wiki/Q424668","display_name":"Heparan sulfate","level":3,"score":0.5058515071868896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47877776622772217},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4386083781719208},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4120592176914215},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29070568084716797},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.20799756050109863}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019812","descriptor_name":"Heparan Sulfate Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.4161/cam.4.4.12427","doi":"https://doi.org/10.4161/cam.4.4.12427","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cam.4.4.12427","pdf_url":null,"source":{"id":"https://openalex.org/S179222606","display_name":"Cell Adhesion & Migration","issn_l":"1933-6918","issn":["1933-6918","1933-6926"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Adhesion &amp; Migration","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3011263","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3011263","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Adh Migr","raw_type":"Text"},{"id":"pmid:20562530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20562530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell adhesion & migration","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/cam.4.4.12427","doi":"https://doi.org/10.4161/cam.4.4.12427","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cam.4.4.12427","pdf_url":null,"source":{"id":"https://openalex.org/S179222606","display_name":"Cell Adhesion & Migration","issn_l":"1933-6918","issn":["1933-6918","1933-6926"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Adhesion &amp; Migration","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3764317081","display_name":"Growth Factors in Vascular Biology","funder_award_id":"R01HL056200","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3895287106","display_name":null,"funder_award_id":"HL088572","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4092779142","display_name":"CELL MOVEMENT DURING XENOPUS DEVELOPMENT--METASTASIS","funder_award_id":"R01CA087375","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G599513662","display_name":"Elastase Injury of Pulmonary Extracellular Matrix","funder_award_id":"R01HL088572","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7005907507","display_name":null,"funder_award_id":"HL056200","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8907505791","display_name":null,"funder_award_id":"CA87375","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1499411251","https://openalex.org/W1525431775","https://openalex.org/W1534461206","https://openalex.org/W1547402512","https://openalex.org/W1904915544","https://openalex.org/W1927705072","https://openalex.org/W1974637644","https://openalex.org/W1975971309","https://openalex.org/W1981850046","https://openalex.org/W1985034953","https://openalex.org/W2002708941","https://openalex.org/W2008143849","https://openalex.org/W2010402705","https://openalex.org/W2012793556","https://openalex.org/W2023185970","https://openalex.org/W2032231544","https://openalex.org/W2032656834","https://openalex.org/W2038279507","https://openalex.org/W2046268574","https://openalex.org/W2051744951","https://openalex.org/W2067363890","https://openalex.org/W2070782703","https://openalex.org/W2080156358","https://openalex.org/W2092340517","https://openalex.org/W2095065858","https://openalex.org/W2102803142","https://openalex.org/W2112067413","https://openalex.org/W2126438501","https://openalex.org/W2140715727","https://openalex.org/W2155159489","https://openalex.org/W2155214429","https://openalex.org/W2163223977","https://openalex.org/W4211037427"],"related_works":["https://openalex.org/W2145948214","https://openalex.org/W2006458534","https://openalex.org/W2483951663","https://openalex.org/W1978974209","https://openalex.org/W2087276951","https://openalex.org/W2427759438","https://openalex.org/W1966081523","https://openalex.org/W2219065345","https://openalex.org/W80580632","https://openalex.org/W50320970"],"abstract_inverted_index":{"Growth":[0],"factors":[1,67],"regulate":[2],"a":[3,56],"diverse":[4],"array":[5],"of":[6,65,98,106],"cellular":[7],"functions":[8],"including":[9],"proliferation,":[10],"survival,":[11],"movement,":[12],"and":[13,27,41],"the":[14,23,63,69,96,131],"ability":[15],"to":[16,37,42,77,81,94],"do":[17],"this":[18,91,117,123],"often":[19],"involves":[20],"interactions":[21,64,114],"with":[22,68],"extracellular":[24],"matrix":[25],"(ECM)":[26],"particularly":[28],"heparan":[29,72],"sulfate":[30,73],"proteoglycans":[31],"(HSPGs).":[32],"HSPGs":[33,60],"have":[34,54],"been":[35,75],"shown":[36,76],"sequester":[38],"growth":[39,45,66,85,112,135],"factors,":[40],"act":[43],"as":[44,104,128,130],"factor":[46,86],"co-receptors":[47],"or":[48,142],"receptors":[49],"themselves.":[50],"Recent":[51],"studies,":[52],"however,":[53],"revealed":[55],"new":[57],"role":[58],"for":[59,116],"in":[61],"mediating":[62],"ECM.":[70],"Specifically,":[71],"has":[74],"modulate":[78],"fibronectin":[79,107,141],"structure":[80],"reveal":[82],"previously":[83],"masked":[84],"binding":[87],"sites.":[88],"In":[89],"vivo,":[90],"mechanism":[92],"appears":[93],"control":[95],"guidance":[97],"migrating":[99],"cells":[100],"during":[101],"embryonic":[102],"development":[103],"HSPG-modification":[105],"enables":[108],"direct":[109],"platelet":[110],"derived":[111],"factor-fibronectin":[113],"necessary":[115],"process.":[118],"A":[119],"model":[120],"based":[121],"on":[122],"observation":[124],"is":[125],"discussed":[126],"here":[127],"well":[129],"possibility":[132],"that":[133],"other":[134],"factors/morphogens":[136],"utilize":[137],"similar":[138],"mechanisms":[139],"involving":[140],"additional":[143],"ECM":[144],"proteins.":[145]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
