{"id":"https://openalex.org/W2074247654","doi":"https://doi.org/10.1073/pnas.83.7.2105","title":"Ethanol regulation of adenosine receptor-stimulated cAMP levels in a clonal neural cell line: an in vitro model of cellular tolerance to ethanol.","display_name":"Ethanol regulation of adenosine receptor-stimulated cAMP levels in a clonal neural cell line: an in vitro model of cellular tolerance to ethanol.","publication_year":1986,"publication_date":"1986-04-01","ids":{"openalex":"https://openalex.org/W2074247654","doi":"https://doi.org/10.1073/pnas.83.7.2105","mag":"2074247654","pmid":"https://pubmed.ncbi.nlm.nih.gov/3008152","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/323239"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.83.7.2105","doi":"https://doi.org/10.1073/pnas.83.7.2105","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.83.7.2105","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC323239","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036365076","display_name":"Adrienne S. Gordon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A S Gordon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112147822","display_name":"K. Collier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Collier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109328135","display_name":"I Diamond","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Diamond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1129,"has_fulltext":false,"cited_by_count":182,"citation_normalized_percentile":{"value":0.92626728,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"83","issue":"7","first_page":"2105","last_page":"2108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.45559999346733093,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.45559999346733093,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.33980000019073486,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.15109999477863312,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol-tolerance","display_name":"ethanol tolerance","score":0.8600000143051147},{"id":"https://openalex.org/keywords/ethanol-dependence","display_name":"ethanol dependence","score":0.8370000123977661},{"id":"https://openalex.org/keywords/adenosine-receptors","display_name":"adenosine receptors","score":0.8669999837875366},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.7770000100135803},{"id":"https://openalex.org/keywords/ng108-15-cells","display_name":"NG108-15 cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/neuroblastoma-glioma-hybrid-cells","display_name":"neuroblastoma-glioma hybrid cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/chronic-alcohol-exposure","display_name":"chronic ethanol exposure","score":0.7599999904632568},{"id":"https://openalex.org/keywords/acute-ethanol-intoxication","display_name":"acute ethanol intoxication","score":0.8619999885559082},{"id":"https://openalex.org/keywords/ethanol-withdrawal","display_name":"ethanol withdrawal","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.7778509259223938},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.7129694819450378},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5525937080383301},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5229895114898682},{"id":"https://openalex.org/C67907053","wikidata":"https://www.wikidata.org/wiki/Q356147","display_name":"Adenosine receptor","level":4,"score":0.5001428127288818},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4722920060157776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46120327711105347},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4029153287410736},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37008732557296753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3678032159805298},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36684292554855347},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3570905327796936},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33889883756637573},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16637995839118958},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.07906574010848999},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.056800663471221924}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010660","descriptor_name":"Phenylisopropyladenosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011983","descriptor_name":"Receptors, Purinergic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.83.7.2105","doi":"https://doi.org/10.1073/pnas.83.7.2105","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.83.7.2105","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:56823","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC323239","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:3008152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3008152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:323239","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC323239/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"mag:2499792434","doi":null,"is_oa":false,"landing_page_url":"https://www.jstor.org/stable/27147","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:56823","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC323239","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W575798123","https://openalex.org/W1549106650","https://openalex.org/W1775749144","https://openalex.org/W1966461945","https://openalex.org/W1975079592","https://openalex.org/W1980387958","https://openalex.org/W1981943570","https://openalex.org/W2006428817","https://openalex.org/W2013117701","https://openalex.org/W2020601722","https://openalex.org/W2035783270","https://openalex.org/W2050687568","https://openalex.org/W2067267825","https://openalex.org/W2072709970","https://openalex.org/W2088645830","https://openalex.org/W2107303243","https://openalex.org/W2128624418","https://openalex.org/W2131767630","https://openalex.org/W2301918850","https://openalex.org/W2417983195","https://openalex.org/W2418227465","https://openalex.org/W2461361399","https://openalex.org/W4406985669"],"related_works":["https://openalex.org/W2499792434","https://openalex.org/W1916797351","https://openalex.org/W2122480465","https://openalex.org/W75122881","https://openalex.org/W2285708558","https://openalex.org/W1992282357","https://openalex.org/W2409635862","https://openalex.org/W2072709970","https://openalex.org/W2043083570","https://openalex.org/W206044939"],"abstract_inverted_index":{"The":[0],"acute":[1,81,141],"and":[2,145],"chronic":[3],"neurologic":[4],"effects":[5,34],"of":[6,35,123,140],"ethanol":[7,22,47,97,128,142],"appear":[8,134],"to":[9,12,21,30,32,46,64,68,83,90,98,108,135],"be":[10,109],"due":[11],"its":[13],"interaction":[14],"with":[15],"neural":[16],"cell":[17,56],"membranes.":[18],"Chronic":[19],"exposure":[20,82],"induces":[23],"changes":[24,41,133],"in":[25,120],"the":[26,33,38,86,105,121,137],"membrane":[27,40],"that":[28,42,73],"lead":[29],"tolerance":[31,45,67],"ethanol.":[36,69,84,124],"However,":[37,85],"actual":[39],"account":[43],"for":[44],"are":[48],"not":[49],"understood.":[50],"We":[51,70],"have":[52,71],"developed":[53],"a":[54],"model":[55],"culture":[57],"system,":[58],"using":[59],"NG108-15":[60],"neuroblastoma-glioma":[61],"hybrid":[62],"cells,":[63],"study":[65],"cellular":[66,132],"found":[72],"adenosine":[74],"receptor-stimulated":[75],"cAMP":[76,102,118],"levels":[77,119],"increased":[78],"markedly":[79],"upon":[80],"cells":[87,95,106],"became":[88],"tolerant":[89],"ethanol,":[91,112],"since":[92],"chronically":[93],"treated":[94],"required":[96],"maintain":[99],"normal":[100],"adenosine-stimulated":[101,117],"levels.":[103],"Moreover,":[104],"appeared":[107],"dependent":[110],"on":[111],"as":[113],"evidenced":[114],"by":[115],"reduced":[116],"absence":[122],"Recovery":[125],"occurred":[126],"after":[127],"was":[129],"withdrawn.":[130],"These":[131],"parallel":[136],"clinical":[138],"events":[139],"intoxication,":[143],"tolerance,":[144],"dependence.":[146]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
