{"id":"https://openalex.org/W2074246760","doi":"https://doi.org/10.1002/jbm.a.30441","title":"Suppression of polyethylene particle\u2013induced osteolysis by exogenous osteoprotegerin","display_name":"Suppression of polyethylene particle\u2013induced osteolysis by exogenous osteoprotegerin","publication_year":2005,"publication_date":"2005-08-08","ids":{"openalex":"https://openalex.org/W2074246760","doi":"https://doi.org/10.1002/jbm.a.30441","mag":"2074246760","pmid":"https://pubmed.ncbi.nlm.nih.gov/16088891"},"language":"en","primary_location":{"id":"doi:10.1002/jbm.a.30441","doi":"https://doi.org/10.1002/jbm.a.30441","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.30441","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111675681","display_name":"Fabian von Knoch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148531","display_name":"Kantonsspital Graub\u00fcnden","ror":"https://ror.org/04wpn1218","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210148531"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Fabian von Knoch","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kantonsspital Chur, Loestrasse 170, 7000 Chur, Switzerland. fabianvonknoch@yahoo.com","Department of Orthopaedic Surgery, Kantonsspital Chur, Loestrasse 170, 7000 Chur, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kantonsspital Chur, Loestrasse 170, 7000 Chur, Switzerland. fabianvonknoch@yahoo.com","institution_ids":["https://openalex.org/I4210148531"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kantonsspital Chur, Loestrasse 170, 7000 Chur, Switzerland","institution_ids":["https://openalex.org/I4210148531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032004196","display_name":"Anja Heckelei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anja Heckelei","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086358349","display_name":"Christian Wedemeyer","orcid":"https://orcid.org/0000-0002-3914-0209","observed_orcids":["https://orcid.org/0000-0002-3914-0209"]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Wedemeyer","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067155393","display_name":"Guido Saxler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Guido Saxler","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009949474","display_name":"Gero Hilken","orcid":"https://orcid.org/0000-0002-3881-796X","observed_orcids":["https://orcid.org/0000-0002-3881-796X"]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gero Hilken","raw_affiliation_strings":["Central Animal Laboratory, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Animal Laboratory, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039524900","display_name":"Jochen Brankamp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jochen Brankamp","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071937533","display_name":"Thomas Sterner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Sterner","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051909001","display_name":"Stefan Landgraeber","orcid":"https://orcid.org/0000-0002-6472-4038","observed_orcids":["https://orcid.org/0000-0002-6472-4038"]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Landgraeber","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071662260","display_name":"Frank Henschke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Henschke","raw_affiliation_strings":["Pathologisches Institut am Johannisstift, Reumontstrasse 28, 33102 Paderborn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathologisches Institut am Johannisstift, Reumontstrasse 28, 33102 Paderborn, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108215977","display_name":"F. L\u00f6er","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Franz L\u00f6er","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072370851","display_name":"Marius von Knoch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marius von Knoch","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111675681"],"corresponding_institution_ids":["https://openalex.org/I4210148531"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":4.1489,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.93489909,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"75A","issue":"2","first_page":"288","last_page":"294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteolysis","display_name":"osteolysis","score":0.8309999704360962},{"id":"https://openalex.org/keywords/polyethylene-wear-particles","display_name":"polyethylene wear particles","score":0.7269999980926514},{"id":"https://openalex.org/keywords/ultra-high-molecular-weight-polyethylene","display_name":"ultra-high molecular weight polyethylene","score":0.9419999718666077},{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/rankl","display_name":"RANKL","score":0.703000009059906},{"id":"https://openalex.org/keywords/rank-signaling","display_name":"RANK signaling","score":0.9409999847412109},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.9929999709129333},{"id":"https://openalex.org/keywords/periprosthetic-osteolysis","display_name":"periprosthetic osteolysis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/total-joint-arthroplasty","display_name":"total joint arthroplasty","score":0.9800000190734863},{"id":"https://openalex.org/keywords/implant-failure","display_name":"implant failure","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C2781282405","wikidata":"https://www.wikidata.org/wiki/Q2035084","display_name":"Osteolysis","level":2,"score":0.9407551288604736},{"id":"https://openalex.org/C2780426850","wikidata":"https://www.wikidata.org/wiki/Q3357478","display_name":"Osteoprotegerin","level":4,"score":0.9050842523574829},{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.7586288452148438},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.6839666366577148},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.6705418825149536},{"id":"https://openalex.org/C2779918246","wikidata":"https://www.wikidata.org/wiki/Q613203","display_name":"Calvaria","level":3,"score":0.5112426280975342},{"id":"https://openalex.org/C146562846","wikidata":"https://www.wikidata.org/wiki/Q96649518","display_name":"Resorption","level":2,"score":0.48805487155914307},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46197736263275146},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.45721718668937683},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3554936647415161},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34474262595176697},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2916112542152405},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.2551591396331787},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.20283859968185425},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18919232487678528},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0709267258644104},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.057608455419540405}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008422","descriptor_name":"Materials Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010014","descriptor_name":"Osteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011095","descriptor_name":"Polyethylenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011475","descriptor_name":"Prosthesis Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053244","descriptor_name":"Osteoprotegerin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbm.a.30441","doi":"https://doi.org/10.1002/jbm.a.30441","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.30441","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},{"id":"pmid:16088891","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16088891","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical materials research. Part A","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W150117690","https://openalex.org/W180986551","https://openalex.org/W1831604303","https://openalex.org/W1957982496","https://openalex.org/W1963599627","https://openalex.org/W1978585175","https://openalex.org/W1979121126","https://openalex.org/W1985148995","https://openalex.org/W1986310612","https://openalex.org/W1992159640","https://openalex.org/W2000647744","https://openalex.org/W2010507314","https://openalex.org/W2018526774","https://openalex.org/W2033376594","https://openalex.org/W2041369768","https://openalex.org/W2045425607","https://openalex.org/W2048299560","https://openalex.org/W2048964423","https://openalex.org/W2050716165","https://openalex.org/W2053286399","https://openalex.org/W2057240308","https://openalex.org/W2072896716","https://openalex.org/W2083185600","https://openalex.org/W2089376561","https://openalex.org/W2093252878","https://openalex.org/W2118767606","https://openalex.org/W2142356861","https://openalex.org/W2157967983","https://openalex.org/W2160211410","https://openalex.org/W2169642737","https://openalex.org/W2245567567","https://openalex.org/W2466971790","https://openalex.org/W4233562142","https://openalex.org/W4292824376"],"related_works":["https://openalex.org/W2393081227","https://openalex.org/W2036555730","https://openalex.org/W2048964423","https://openalex.org/W2139510860","https://openalex.org/W2142356861","https://openalex.org/W2090111646","https://openalex.org/W6977004215","https://openalex.org/W2891867142","https://openalex.org/W2912254500","https://openalex.org/W2277416142"],"abstract_inverted_index":{"Alterations":[0],"of":[1,5,9,41,185],"the":[2,25,39,113,182,186],"key":[3],"regulators":[4],"osteoclastogenesis,":[6],"receptor":[7],"activator":[8],"NF-kappaB":[10],"(RANK),":[11],"RANK":[12],"ligand":[13],"(RANKL),":[14],"and":[15,76,79,82,106,119,135,140,153,159],"osteoprotegerin":[16],"(OPG)":[17],"have":[18],"been":[19],"implicated":[20],"in":[21,32,57,131,173,189],"wear":[22,190,202],"particle-induced":[23,48,147,171,191],"osteolysis,":[24],"most":[26],"common":[27],"cause":[28],"for":[29,104,201],"implant":[30],"failure":[31],"total":[33,207],"joint":[34,208],"replacements.":[35],"This":[36,178],"study":[37],"investigated":[38],"effect":[40],"exogenous":[42,166],"OPG":[43,84,144,167,194],"on":[44],"ultra-high-molecular-weight":[45],"polyethylene":[46],"(UHMWPE)":[47],"osteolysis.":[49,192],"The":[50],"murine":[51,175],"calvarial":[52,176],"osteolysis":[53,172,205],"model":[54],"was":[55,110],"utilized":[56],"28":[58],"C57BL/6J":[59],"mice":[60],"randomized":[61],"to":[62],"four":[63],"groups.":[64],"Group":[65],"I":[66],"underwent":[67],"sham":[68],"surgery":[69],"only,":[70],"group":[71,77],"II":[72],"received":[73],"UHMWPE":[74,127,170],"particles,":[75],"III":[78],"IV":[80],"particles":[81],"subcutaneous":[83],"starting":[85],"from":[86],"day":[87,92],"0":[88],"(group":[89,94],"III)":[90],"or":[91],"5":[93],"IV)":[95],"until":[96],"sacrifice.":[97],"After":[98],"2":[99],"weeks,":[100],"calvaria":[101],"were":[102,122],"prepared":[103],"histology":[105],"histomorphometry.":[107],"Bone":[108],"resorption":[109,155],"measured":[111],"within":[112],"midline":[114],"suture":[115],"using":[116,124],"Giemsa":[117],"staining":[118],"osteoclast":[120,151],"numbers":[121],"determined":[123],"TRAP":[125],"staining.":[126],"particle":[128],"implantation":[129],"resulted":[130],"grossly":[132],"pronounced":[133],"osteoclastogenesis":[134],"bone":[136,154],"resorption.":[137],"Both":[138],"immediate":[139],"delayed":[141],"treatment":[142,199],"with":[143],"counteracted":[145],"these":[146],"effects":[148],"significantly,":[149],"suppressing":[150],"formation":[152],"(p":[156],"<":[157,161],"0.001":[158],"p":[160],"0.001,":[162],"respectively).":[163],"In":[164],"conclusion,":[165],"markedly":[168],"suppressed":[169],"a":[174],"model.":[177],"important":[179],"finding":[180],"underscores":[181],"crucial":[183],"significance":[184],"OPG-RANKL-RANK":[187],"signaling":[188],"Exogenous":[193],"may":[195],"prove":[196],"an":[197],"effective":[198],"modality":[200],"debris-mediated":[203],"periprosthetic":[204],"after":[206],"arthroplasty.":[209]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
