{"id":"https://openalex.org/W2074220249","doi":"https://doi.org/10.1111/j.1601-183x.2009.00518.x","title":"Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects","display_name":"Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects","publication_year":2009,"publication_date":"2009-06-26","ids":{"openalex":"https://openalex.org/W2074220249","doi":"https://doi.org/10.1111/j.1601-183x.2009.00518.x","mag":"2074220249","pmid":"https://pubmed.ncbi.nlm.nih.gov/19659925"},"language":"en","primary_location":{"id":"doi:10.1111/j.1601-183x.2009.00518.x","doi":"https://doi.org/10.1111/j.1601-183x.2009.00518.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1601-183x.2009.00518.x","pdf_url":null,"source":{"id":"https://openalex.org/S134433296","display_name":"Genes Brain & Behavior","issn_l":"1601-183X","issn":["1601-183X","1601-1848"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, Brain and Behavior","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041866909","display_name":"Palmiero Monteleone","orcid":"https://orcid.org/0000-0002-5287-3829","observed_orcids":["https://orcid.org/0000-0002-5287-3829","https://orcid.org/0000-0002-6786-4458"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"P. Monteleone","raw_affiliation_strings":["Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy. monteri@tin.it","Department of Psychiatry; University of Naples SUN; Largo Madonna delle Grazie 80138 Naples Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy. monteri@tin.it","institution_ids":[]},{"raw_affiliation_string":"Department of Psychiatry; University of Naples SUN; Largo Madonna delle Grazie 80138 Naples Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023657474","display_name":"Maurizio Bifulco","orcid":"https://orcid.org/0000-0002-1771-4531","observed_orcids":["https://orcid.org/0000-0002-1771-4531"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Bifulco","raw_affiliation_strings":["Department of Pharmacological Sciences, University of Salerno, Fisciano (Salerno), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, University of Salerno, Fisciano (Salerno), Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109114513","display_name":"C. Di Filippo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Di Filippo","raw_affiliation_strings":["Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044789260","display_name":"Patrizia Gazzerro","orcid":"https://orcid.org/0000-0003-0576-2955","observed_orcids":["https://orcid.org/0000-0003-0576-2955"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Gazzerro","raw_affiliation_strings":["Department of Pharmacological Sciences, University of Salerno, Fisciano (Salerno), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, University of Salerno, Fisciano (Salerno), Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025349798","display_name":"Benedetta Canestrelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Canestrelli","raw_affiliation_strings":["Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102861527","display_name":"Francesco Monteleone","orcid":"https://orcid.org/0000-0001-6813-6789","observed_orcids":["https://orcid.org/0000-0001-6813-6789"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Monteleone","raw_affiliation_strings":["Department of Pharmacological Sciences, University of Salerno, Fisciano (Salerno), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, University of Salerno, Fisciano (Salerno), Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026142881","display_name":"Maria Proto","orcid":"https://orcid.org/0000-0002-7066-174X","observed_orcids":["https://orcid.org/0000-0002-7066-174X"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. C. Proto","raw_affiliation_strings":["Department of Pharmacological Sciences, University of Salerno, Fisciano (Salerno), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, University of Salerno, Fisciano (Salerno), Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007779407","display_name":"Monica Di Genio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Di Genio","raw_affiliation_strings":["Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088738955","display_name":"Claudia Grimaldi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Grimaldi","raw_affiliation_strings":["Department of Pharmacological Sciences, University of Salerno, Fisciano (Salerno), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, University of Salerno, Fisciano (Salerno), Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020615555","display_name":"Mario Maj","orcid":"https://orcid.org/0000-0001-8408-0711","observed_orcids":["https://orcid.org/0000-0001-8408-0711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Maj","raw_affiliation_strings":["Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041866909"],"corresponding_institution_ids":[],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":5.2959,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.94805101,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"8","issue":"7","first_page":"728","last_page":"732"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anorexia-nervosa","display_name":"anorexia nervosa","score":0.9179999828338623},{"id":"https://openalex.org/keywords/bulimia-nervosa","display_name":"bulimia nervosa","score":1.0},{"id":"https://openalex.org/keywords/endocannabinoid-system","display_name":"endocannabinoid system","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cnr1","display_name":"CNR1","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cb1-receptor","display_name":"CB1 receptor","score":0.8309999704360962},{"id":"https://openalex.org/keywords/fatty-acid-amide-hydrolase","display_name":"fatty acid amide hydrolase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9509999752044678},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9319999814033508},{"id":"https://openalex.org/keywords/eating-disorders","display_name":"eating disorders","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7983159422874451},{"id":"https://openalex.org/C2777556793","wikidata":"https://www.wikidata.org/wiki/Q64513386","display_name":"Bulimia nervosa","level":3,"score":0.7728833556175232},{"id":"https://openalex.org/C2777031586","wikidata":"https://www.wikidata.org/wiki/Q131749","display_name":"Anorexia nervosa","level":3,"score":0.7521237134933472},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.6142826080322266},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4529688060283661},{"id":"https://openalex.org/C2781144285","wikidata":"https://www.wikidata.org/wiki/Q21113274","display_name":"Fatty acid amide hydrolase","level":5,"score":0.43903273344039917},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4248616695404053},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3898395895957947},{"id":"https://openalex.org/C2776394216","wikidata":"https://www.wikidata.org/wiki/Q373822","display_name":"Eating disorders","level":2,"score":0.3825646638870239},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34246009588241577},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33055585622787476},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.259105920791626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.254841148853302},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22051125764846802},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19375595450401306},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.15835490822792053},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09143215417861938},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000099252","descriptor_name":"Fatty Acid Amide Hydrolases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000856","descriptor_name":"Anorexia Nervosa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000856","descriptor_name":"Anorexia Nervosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000856","descriptor_name":"Anorexia Nervosa","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D052018","descriptor_name":"Bulimia Nervosa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D052018","descriptor_name":"Bulimia Nervosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052018","descriptor_name":"Bulimia Nervosa","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063385","descriptor_name":"Cannabinoid Receptor Modulators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D063388","descriptor_name":"Endocannabinoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1601-183x.2009.00518.x","doi":"https://doi.org/10.1111/j.1601-183x.2009.00518.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1601-183x.2009.00518.x","pdf_url":null,"source":{"id":"https://openalex.org/S134433296","display_name":"Genes Brain & Behavior","issn_l":"1601-183X","issn":["1601-183X","1601-1848"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, Brain and Behavior","raw_type":"journal-article"},{"id":"pmid:19659925","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19659925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, brain, and behavior","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4300000071525574}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W368475356","https://openalex.org/W1491109154","https://openalex.org/W1974332952","https://openalex.org/W1981067823","https://openalex.org/W1989542650","https://openalex.org/W1991778481","https://openalex.org/W2019238908","https://openalex.org/W2027352187","https://openalex.org/W2037412847","https://openalex.org/W2043356587","https://openalex.org/W2051741667","https://openalex.org/W2054936982","https://openalex.org/W2056611518","https://openalex.org/W2081850459","https://openalex.org/W2103659596","https://openalex.org/W2113502034","https://openalex.org/W2116750865","https://openalex.org/W2118091961","https://openalex.org/W2121528879","https://openalex.org/W2122487138","https://openalex.org/W2128919016","https://openalex.org/W2134410122","https://openalex.org/W2157501942","https://openalex.org/W2397982235","https://openalex.org/W2735928575"],"related_works":["https://openalex.org/W2128919016","https://openalex.org/W3126168522","https://openalex.org/W1996419360","https://openalex.org/W1978232246","https://openalex.org/W1981067823","https://openalex.org/W4416736889","https://openalex.org/W1983611759","https://openalex.org/W2086495784","https://openalex.org/W7217014113","https://openalex.org/W3217497580"],"abstract_inverted_index":{"Endocannabinoids":[0],"modulate":[1],"eating":[2,14],"behavior;":[3],"hence,":[4],"endocannabinoid":[5,29],"genes":[6],"may":[7],"contribute":[8],"to":[9,13,38,59,76,96,128,139,177,224,230],"the":[10,25,28,34,42,50,69,85,92,121,125,151,155,159,165,169,173,193,210,214,220,242],"biological":[11],"vulnerability":[12],"disorders.":[15],"The":[16,82],"rs1049353":[17],"(1359":[18],"G/A)":[19],"single":[20],"nucleotide":[21],"polymorphism":[22],"(SNP)":[23],"of":[24,41,54,84,91,120,150,158,172,192,241],"gene":[26,43],"coding":[27,44],"CB1":[30],"receptor":[31],"(CNR1)":[32],"and":[33,90,112,131,143,154,168,186,219,233,236],"rs324420":[35],"(cDNA":[36],"385C":[37,95,176,223],"A)":[39],"SNP":[40,89,98,179,218,226],"fatty":[45],"acid":[46],"amide":[47],"hydrolase":[48],"(FAAH),":[49],"major":[51],"degrading":[52],"enzyme":[53],"endocannabinoids,":[55],"have":[56,60],"been":[57],"suggested":[58],"functional":[61],"effects":[62,119],"on":[63],"mature":[64],"proteins.":[65],"Therefore,":[66],"we":[67],"explored":[68],"possibility":[70],"that":[71,213],"those":[72],"SNPs":[73,123,195,244],"were":[74,99,134,180],"associated":[75,229],"anorexia":[77,105,129,199,231,246],"nervosa":[78,111,130,133,200,232],"and/or":[79],"bulimia":[80,110,132,204,234],"nervosa.":[81,205,247],"distributions":[83],"CNR1":[86,160,215],"1359":[87,161,216],"G/A":[88,162,217],"FAAH":[93,174,221],"cDNA":[94,175,222],"A":[97,156,170,178,189,225],"investigated":[100],"in":[101,124,184,198,203,245],"134":[102],"patients":[103,108,145],"with":[104,109],"nervosa,":[106,235],"180":[107],"148":[113],"normal":[114],"weight":[115],"healthy":[116,140],"controls.":[117],"Additive":[118],"two":[122,194,243],"genetic":[126],"susceptibility":[127],"also":[135],"tested.":[136],"As":[137],"compared":[138],"controls,":[141],"anorexic":[142,185],"bulimic":[144,187],"showed":[146],"significantly":[147,181,228],"higher":[148],"frequencies":[149],"AG":[152],"genotype":[153,167],"allele":[157,171],"SNP.":[163],"Similarly,":[164],"AC":[166],"more":[182],"frequent":[183],"individuals.":[188],"synergistic":[190,239],"effect":[191,240],"was":[196],"evident":[197],"but":[201],"not":[202],"Present":[206],"findings":[207],"show":[208],"for":[209],"first":[211],"time":[212],"are":[227],"demonstrate":[237],"a":[238]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}