{"id":"https://openalex.org/W2074119331","doi":"https://doi.org/10.1002/(sici)1099-081x(199712)18:9<779::aid-bdd64>3.0.co;2-5","title":"Absolute bioavailability of letrozole in healthy postmenopausal women","display_name":"Absolute bioavailability of letrozole in healthy postmenopausal women","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W2074119331","doi":"https://doi.org/10.1002/(sici)1099-081x(199712)18:9<779::aid-bdd64>3.0.co;2-5","mag":"2074119331","pmid":"https://pubmed.ncbi.nlm.nih.gov/9429742"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1099-081x(199712)18:9<779::aid-bdd64>3.0.co;2-5","doi":"https://doi.org/10.1002/(sici)1099-081x(199712)18:9<779::aid-bdd64>3.0.co;2-5","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1099-081x(199712)18:9<779::aid-bdd64>3.0.co;2-5","pdf_url":null,"source":{"id":"https://openalex.org/S57691945","display_name":"Biopharmaceutics & Drug Disposition","issn_l":"0142-2782","issn":["0142-2782","1099-081X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopharmaceutics &amp; Drug Disposition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012164701","display_name":"Antoine Sioufi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"A. Sioufi","raw_affiliation_strings":["Laboratoires Ciba-Geigy, Bioanalytics and Pharmacokinetics, Rueil-Malmaison, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires Ciba-Geigy, Bioanalytics and Pharmacokinetics, Rueil-Malmaison, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027128221","display_name":"N. Gauducheau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Gauducheau","raw_affiliation_strings":["Laboratoires Ciba\u2013Geigy, Bioanalytics and Pharmacokinetics, B. P. 308, 92506 Rueil-Malmaison, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires Ciba\u2013Geigy, Bioanalytics and Pharmacokinetics, B. P. 308, 92506 Rueil-Malmaison, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089670329","display_name":"V. Pineau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Pineau","raw_affiliation_strings":["Laboratoires Ciba\u2013Geigy, Bioanalytics and Pharmacokinetics, B. P. 308, 92506 Rueil-Malmaison, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires Ciba\u2013Geigy, Bioanalytics and Pharmacokinetics, B. P. 308, 92506 Rueil-Malmaison, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042835180","display_name":"Fran\u00e7oise Marfil","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Marfil","raw_affiliation_strings":["Laboratoires Ciba\u2013Geigy, Bioanalytics and Pharmacokinetics, B. P. 308, 92506 Rueil-Malmaison, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires Ciba\u2013Geigy, Bioanalytics and Pharmacokinetics, B. P. 308, 92506 Rueil-Malmaison, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086833236","display_name":"A. Jaouen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Jaouen","raw_affiliation_strings":["Laboratoires Ciba\u2013Geigy, Bioanalytics and Pharmacokinetics, B. P. 308, 92506 Rueil-Malmaison, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires Ciba\u2013Geigy, Bioanalytics and Pharmacokinetics, B. P. 308, 92506 Rueil-Malmaison, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. M. Cardot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. M. Cardot","raw_affiliation_strings":["Laboratoires Ciba\u2013Geigy, Bioanalytics and Pharmacokinetics, B. P. 308, 92506 Rueil-Malmaison, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires Ciba\u2013Geigy, Bioanalytics and Pharmacokinetics, B. P. 308, 92506 Rueil-Malmaison, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087409115","display_name":"J. Godbillon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Godbillon","raw_affiliation_strings":["Laboratoires Ciba\u2013Geigy, Bioanalytics and Pharmacokinetics, B. P. 308, 92506 Rueil-Malmaison, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires Ciba\u2013Geigy, Bioanalytics and Pharmacokinetics, B. P. 308, 92506 Rueil-Malmaison, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081056394","display_name":"C. Czendlik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Czendlik","raw_affiliation_strings":["Ciba\u2013Geigy Limited, Human Pharmacology and Bioanalytics and Pharmacokinetics, CH-4002, Basle, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ciba\u2013Geigy Limited, Human Pharmacology and Bioanalytics and Pharmacokinetics, CH-4002, Basle, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110877211","display_name":"HANS HOWALD","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Howald","raw_affiliation_strings":["Ciba\u2013Geigy Limited, Human Pharmacology and Bioanalytics and Pharmacokinetics, CH-4002, Basle, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ciba\u2013Geigy Limited, Human Pharmacology and Bioanalytics and Pharmacokinetics, CH-4002, Basle, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"CH. Pfister","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CH. Pfister","raw_affiliation_strings":["Ciba\u2013Geigy Limited, Human Pharmacology and Bioanalytics and Pharmacokinetics, CH-4002, Basle, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ciba\u2013Geigy Limited, Human Pharmacology and Bioanalytics and Pharmacokinetics, CH-4002, Basle, Switzerland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049308444","display_name":"Franzanne Vreeland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Vreeland","raw_affiliation_strings":["Ciba Pharmaceuticals, Clinical Development, Summit, NJ 07901-1398, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ciba Pharmaceuticals, Clinical Development, Summit, NJ 07901-1398, U.S.A","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5012164701"],"corresponding_institution_ids":[],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":1.3137,"has_fulltext":false,"cited_by_count":102,"citation_normalized_percentile":{"value":0.80006379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"18","issue":"9","first_page":"779","last_page":"789"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.4717000126838684,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.4717000126838684,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.3296000063419342,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.03750000149011612,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/letrozole","display_name":"letrozole","score":1.0},{"id":"https://openalex.org/keywords/absolute-bioavailability","display_name":"absolute bioavailability","score":0.984000027179718},{"id":"https://openalex.org/keywords/aromatase-inhibitors","display_name":"aromatase inhibitors","score":0.8130000233650208},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.9639999866485596},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.5950000286102295},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.9120000004768372},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.765999972820282},{"id":"https://openalex.org/keywords/total-body-clearance","display_name":"body clearance","score":0.6460000276565552},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.7039999961853027},{"id":"https://openalex.org/keywords/glucuronidation","display_name":"glucuronidation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.6899999976158142},{"id":"https://openalex.org/keywords/advanced-breast-cancer","display_name":"advanced breast cancer","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2778812593","wikidata":"https://www.wikidata.org/wiki/Q194974","display_name":"Letrozole","level":5,"score":0.9303492307662964},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.7575740814208984},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6903301477432251},{"id":"https://openalex.org/C139254425","wikidata":"https://www.wikidata.org/wiki/Q1332167","display_name":"Volume of distribution","level":3,"score":0.5988605618476868},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5827396512031555},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5352414846420288},{"id":"https://openalex.org/C2779186261","wikidata":"https://www.wikidata.org/wiki/Q137786","display_name":"Glucuronide","level":3,"score":0.5305248498916626},{"id":"https://openalex.org/C2778504769","wikidata":"https://www.wikidata.org/wiki/Q3040305","display_name":"Aromatase inhibitor","level":5,"score":0.5051761269569397},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47637054324150085},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.4467134475708008},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4308955669403076},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.42142415046691895},{"id":"https://openalex.org/C149151106","wikidata":"https://www.wikidata.org/wiki/Q4677569","display_name":"Active metabolite","level":3,"score":0.4179561734199524},{"id":"https://openalex.org/C2776166826","wikidata":"https://www.wikidata.org/wiki/Q415287","display_name":"Aromatase","level":4,"score":0.40620118379592896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32235056161880493},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1743483543395996}],"mesh":[{"descriptor_ui":"D000077289","descriptor_name":"Letrozole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047072","descriptor_name":"Aromatase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1099-081x(199712)18:9<779::aid-bdd64>3.0.co;2-5","doi":"https://doi.org/10.1002/(sici)1099-081x(199712)18:9<779::aid-bdd64>3.0.co;2-5","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1099-081x(199712)18:9<779::aid-bdd64>3.0.co;2-5","pdf_url":null,"source":{"id":"https://openalex.org/S57691945","display_name":"Biopharmaceutics & Drug Disposition","issn_l":"0142-2782","issn":["0142-2782","1099-081X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopharmaceutics &amp; Drug Disposition","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1099-081x(199712)18:9<779::aid-bdd64>3.3.co;2-x","doi":"https://doi.org/10.1002/(sici)1099-081x(199712)18:9<779::aid-bdd64>3.3.co;2-x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1099-081x(199712)18:9<779::aid-bdd64>3.3.co;2-x","pdf_url":null,"source":{"id":"https://openalex.org/S57691945","display_name":"Biopharmaceutics & Drug Disposition","issn_l":"0142-2782","issn":["0142-2782","1099-081X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopharmaceutics &amp; Drug Disposition","raw_type":"journal-article"},{"id":"pmid:9429742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9429742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopharmaceutics & drug disposition","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2077305666","https://openalex.org/W7206295306","https://openalex.org/W2184879529","https://openalex.org/W1843214647","https://openalex.org/W2011467915","https://openalex.org/W2136912434","https://openalex.org/W3192809827","https://openalex.org/W2005636231","https://openalex.org/W2167514715","https://openalex.org/W2384116334"],"abstract_inverted_index":{"Letrozole":[0,58],"is":[1,12,107],"a":[2,48,99],"new":[3],"non-steroidal":[4],"inhibitor":[5],"of":[6,19,28,70,76,105,116],"the":[7,17,42,108,113,117,122],"aromatase":[8],"enzyme":[9],"system.":[10],"It":[11],"currently":[13],"under":[14],"development":[15],"for":[16],"treatment":[18],"postmenopausal":[20,56],"women":[21],"with":[22,112],"advanced":[23],"breast":[24],"cancer.":[25],"Absolute":[26],"bioavailability":[27,61],"letrozole":[29,71,77,106],"when":[30],"given":[31,45],"orally":[32],"as":[33,47],"one":[34],"2.5":[35],"mg":[36],"film-coated":[37],"tablet":[38],"in":[39,53,126],"comparison":[40],"to":[41],"same":[43],"dose":[44],"intravenously":[46],"bolus":[49],"injection":[50],"was":[51,65,72,83],"studied":[52],"12":[54],"healthy":[55],"women.":[57],"absolute":[59],"systemic":[60],"after":[62,80],"p.o.":[63],"administration":[64,82],"99.9":[66],"+/-":[67],"16.3%.":[68],"Elimination":[69],"slow.":[73],"Total-body":[74],"clearance":[75],"from":[78],"plasma":[79],"i.v.":[81],"low":[84],"(2.21":[85],"L":[86,96],"h-1).":[87],"The":[88,128],"calculated":[89],"distribution":[90],"volume":[91],"at":[92],"steady":[93],"state":[94],"(1.87":[95],"kg-1)":[97],"suggests":[98],"rather":[100],"high":[101],"tissue":[102],"distribution.":[103],"Biotransformation":[104],"main":[109],"elimination":[110],"mechanism":[111],"glucuronide":[114],"conjugate":[115],"secondary":[118],"alcohol":[119],"metabolite":[120],"being":[121],"predominant":[123],"species":[124],"found":[125],"urine.":[127],"two":[129],"study":[130],"treatments":[131],"were":[132],"tolerated":[133],"equally":[134],"well.":[135]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
