{"id":"https://openalex.org/W2074083103","doi":"https://doi.org/10.1021/bi052313i","title":"Crystal Structures of the Short-Chain Flavin Reductase HpaC from Sulfolobus tokodaii Strain 7 in Its Three States: NAD(P)+-Free, NAD+-Bound, and NADP+-Bound,","display_name":"Crystal Structures of the Short-Chain Flavin Reductase HpaC from Sulfolobus tokodaii Strain 7 in Its Three States: NAD(P)+-Free, NAD+-Bound, and NADP+-Bound,","publication_year":2006,"publication_date":"2006-04-01","ids":{"openalex":"https://openalex.org/W2074083103","doi":"https://doi.org/10.1021/bi052313i","mag":"2074083103","pmid":"https://pubmed.ncbi.nlm.nih.gov/16618099"},"language":"en","primary_location":{"id":"doi:10.1021/bi052313i","doi":"https://doi.org/10.1021/bi052313i","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi052313i","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062050105","display_name":"Masahiko Okai","orcid":"https://orcid.org/0000-0001-7194-316X","observed_orcids":["https://orcid.org/0000-0001-7194-316X"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiko Okai","raw_affiliation_strings":["Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Norio Kudo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norio Kudo","raw_affiliation_strings":["Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065898639","display_name":"Woo Cheol Lee","orcid":"https://orcid.org/0000-0003-0353-9784","observed_orcids":["https://orcid.org/0000-0003-0353-9784"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Woo Cheol Lee","raw_affiliation_strings":["Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013962895","display_name":"Masayuki Kamo","orcid":"https://orcid.org/0009-0007-5163-7190","observed_orcids":["https://orcid.org/0009-0007-5163-7190"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Kamo","raw_affiliation_strings":["Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026362808","display_name":"Koji Nagata","orcid":"https://orcid.org/0000-0002-4704-0603","observed_orcids":["https://orcid.org/0000-0002-4704-0603"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Nagata","raw_affiliation_strings":["Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039444335","display_name":"Masaru Tanokura","orcid":"https://orcid.org/0000-0001-5072-2480","observed_orcids":["https://orcid.org/0000-0001-5072-2480"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Tanokura","raw_affiliation_strings":["Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.0436,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.69985518,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"45","issue":"16","first_page":"5103","last_page":"5110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hpac","display_name":"HPAC","score":0.972000002861023},{"id":"https://openalex.org/keywords/flavin-reductase","display_name":"flavin reductase","score":0.906000018119812},{"id":"https://openalex.org/keywords/sulfolobus-tokodaii","display_name":"Sulfolobus tokodaii","score":0.9559999704360962},{"id":"https://openalex.org/keywords/4-hydroxyphenylacetate","display_name":"4-hydroxyphenylacetate","score":0.8920000195503235},{"id":"https://openalex.org/keywords/nad-binding","display_name":"NAD+ binding","score":0.6830000281333923},{"id":"https://openalex.org/keywords/nadp-binding","display_name":"NADP+ binding","score":1.0},{"id":"https://openalex.org/keywords/flavin-mononucleotide","display_name":"flavin mononucleotide","score":0.8610000014305115},{"id":"https://openalex.org/keywords/flavin-binding-site","display_name":"flavin binding site","score":0.8019999861717224},{"id":"https://openalex.org/keywords/hydride-transfer","display_name":"hydride transfer","score":0.8980000019073486},{"id":"https://openalex.org/keywords/nadh","display_name":"NADH","score":0.5669999718666077},{"id":"https://openalex.org/keywords/two-component-systems","display_name":"two-component systems","score":0.5649999976158142},{"id":"https://openalex.org/keywords/enzyme-crystal-structure","display_name":"enzyme crystal structure","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.9050361514091492},{"id":"https://openalex.org/C33093398","wikidata":"https://www.wikidata.org/wiki/Q174337","display_name":"Flavin group","level":3,"score":0.7919380068778992},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6138025522232056},{"id":"https://openalex.org/C2779728014","wikidata":"https://www.wikidata.org/wiki/Q192423","display_name":"Nicotinamide","level":3,"score":0.5454646944999695},{"id":"https://openalex.org/C2779268744","wikidata":"https://www.wikidata.org/wiki/Q407479","display_name":"Oxidoreductase","level":3,"score":0.538981556892395},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5153931379318237},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.46178489923477173},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.4602119028568268},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.44883179664611816},{"id":"https://openalex.org/C45566312","wikidata":"https://www.wikidata.org/wiki/Q307765","display_name":"Glycerol-3-phosphate dehydrogenase","level":4,"score":0.42116352915763855},{"id":"https://openalex.org/C2776901170","wikidata":"https://www.wikidata.org/wiki/Q12499775","display_name":"Nicotinamide adenine dinucleotide","level":4,"score":0.41701412200927734},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3734872341156006},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2824166417121887},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2621880769729614}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016944","descriptor_name":"Sulfolobus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D016944","descriptor_name":"Sulfolobus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D038181","descriptor_name":"FMN Reductase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038181","descriptor_name":"FMN Reductase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D038181","descriptor_name":"FMN Reductase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi052313i","doi":"https://doi.org/10.1021/bi052313i","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi052313i","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:16618099","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16618099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1505834253","https://openalex.org/W1520730837","https://openalex.org/W1530476407","https://openalex.org/W1539796472","https://openalex.org/W1552471784","https://openalex.org/W1595604283","https://openalex.org/W1847611580","https://openalex.org/W1885317482","https://openalex.org/W1965277349","https://openalex.org/W1984803944","https://openalex.org/W1986191025","https://openalex.org/W1995017064","https://openalex.org/W1999200457","https://openalex.org/W2008264826","https://openalex.org/W2014694459","https://openalex.org/W2019212742","https://openalex.org/W2022058405","https://openalex.org/W2023578932","https://openalex.org/W2038840577","https://openalex.org/W2041803833","https://openalex.org/W2049543473","https://openalex.org/W2056418197","https://openalex.org/W2066855657","https://openalex.org/W2095353568","https://openalex.org/W2097493124","https://openalex.org/W2102095960","https://openalex.org/W2102977495","https://openalex.org/W2110861556","https://openalex.org/W2114999469","https://openalex.org/W2122044132","https://openalex.org/W2125764149","https://openalex.org/W2128635872","https://openalex.org/W2131174843","https://openalex.org/W2132168364","https://openalex.org/W2135839939","https://openalex.org/W2138694962","https://openalex.org/W2153921930","https://openalex.org/W2159702069","https://openalex.org/W2163510389","https://openalex.org/W2170186817"],"related_works":["https://openalex.org/W2085073354","https://openalex.org/W2038340006","https://openalex.org/W2027646269","https://openalex.org/W2125764149","https://openalex.org/W2131174843","https://openalex.org/W2809147781","https://openalex.org/W7097957231","https://openalex.org/W978244352","https://openalex.org/W1974238327","https://openalex.org/W2170186817"],"abstract_inverted_index":{"4-Hydroxyphenylacetate":[0],"(4-HPA)":[1],"is":[2,22],"oxidized":[3],"as":[4,62],"an":[5,72],"energy":[6],"source":[7],"by":[8,30],"two":[9],"component":[10,14,19],"enzymes,":[11],"the":[12,17,37,44,87,101,104,110,117,126,151],"large":[13],"(HpaB)":[15],"and":[16,58,65,103,144],"small":[18],"(HpaC).":[20],"HpaB":[21],"a":[23,31,63,133,168,175],"4-HPA":[24],"monooxygenase":[25],"that":[26,157],"utilizes":[27],"FADH(2)":[28],"supplied":[29],"flavin":[32],"reductase":[33],"HpaC.":[34],"We":[35],"determined":[36],"crystal":[38],"structure":[39],"of":[40,90,142,148,154],"HpaC":[41,60,74],"(ST0723)":[42],"from":[43],"aerobic":[45],"thermoacidophilic":[46],"crenarchaeon":[47],"Sulfolobus":[48],"tokodaii":[49],"strain":[50],"7":[51],"in":[52,92,109,116,174],"its":[53,93],"three":[54],"states":[55],"[NAD(P)(+)-free,":[56],"NAD(+)-bound,":[57],"NADP(+)-bound].":[59],"exists":[61],"homodimer,":[64],"each":[66],"monomer":[67],"was":[68,81,107,172,179],"found":[69],"to":[70,77,85,125],"contain":[71],"FMN.":[73],"preferred":[75],"FMN":[76,155],"FAD":[78,91],"because":[79],"there":[80],"not":[82,180],"enough":[83],"space":[84],"accommodate":[86],"AMP":[88],"moiety":[89],"flavin-binding":[94],"site.":[95],"The":[96,113,129,146,163],"most":[97],"striking":[98],"difference":[99],"between":[100],"NAD(P)(+)-free":[102,127],"NAD(+)/NADP(+)-bound":[105,118],"structures":[106,119],"observed":[108],"N-terminal":[111,114],"helix.":[112],"helices":[115],"rotated":[120],"ca.":[121],"20":[122],"degrees":[123],"relative":[124],"structure.":[128],"bound":[130,164,173],"NAD(+)":[131,149],"has":[132],"compact":[134,169],"folded":[135],"conformation":[136,170],"with":[137],"nearly":[138],"parallel":[139],"stacking":[140],"rings":[141],"nicotinamide":[143,147],"adenine.":[145],"stacked":[150],"isoalloxazine":[152],"ring":[153],"so":[156],"NADH":[158],"could":[159],"directly":[160],"transfer":[161],"hydride.":[162],"NADP(+)":[165],"also":[166],"had":[167],"but":[171],"reverse":[176],"direction,":[177],"which":[178],"suitable":[181],"for":[182],"hydride":[183],"transfer.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}