{"id":"https://openalex.org/W2074043387","doi":"https://doi.org/10.1371/journal.pone.0087086","title":"Frozen Cord Blood Hematopoietic Stem Cells Differentiate into Higher Numbers of Functional Natural Killer Cells In Vitro than Mobilized Hematopoietic Stem Cells or Freshly Isolated Cord Blood Hematopoietic Stem Cells","display_name":"Frozen Cord Blood Hematopoietic Stem Cells Differentiate into Higher Numbers of Functional Natural Killer Cells In Vitro than Mobilized Hematopoietic Stem Cells or Freshly Isolated Cord Blood Hematopoietic Stem Cells","publication_year":2014,"publication_date":"2014-01-29","ids":{"openalex":"https://openalex.org/W2074043387","doi":"https://doi.org/10.1371/journal.pone.0087086","mag":"2074043387","pmid":"https://pubmed.ncbi.nlm.nih.gov/24489840","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3906137"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0087086","doi":"https://doi.org/10.1371/journal.pone.0087086","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0087086","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087086&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087086&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046608175","display_name":"Martha Luevano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800598996","display_name":"Anthony Nolan","ror":"https://ror.org/043bfms20","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800598996"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martha Luevano","raw_affiliation_strings":["University College London, Cancer Institute, London, United Kingdom ; Anthony Nolan Research Institute, London, United Kingdom","Anthony Nolan Research Institute, London, United Kingdom","University College London, Cancer Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, Cancer Institute, London, United Kingdom ; Anthony Nolan Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2800598996","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Anthony Nolan Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2800598996"]},{"raw_affiliation_string":"University College London, Cancer Institute, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079600194","display_name":"Anna Domogala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800598996","display_name":"Anthony Nolan","ror":"https://ror.org/043bfms20","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800598996"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna Domogala","raw_affiliation_strings":["University College London, Cancer Institute, London, United Kingdom ; Anthony Nolan Research Institute, London, United Kingdom","Anthony Nolan Research Institute, London, United Kingdom","University College London, Cancer Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, Cancer Institute, London, United Kingdom ; Anthony Nolan Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2800598996","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Anthony Nolan Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2800598996"]},{"raw_affiliation_string":"University College London, Cancer Institute, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068119200","display_name":"Michael P. Blundell","orcid":"https://orcid.org/0000-0002-9179-6870","observed_orcids":["https://orcid.org/0000-0002-9179-6870"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Blundell","raw_affiliation_strings":["Centre for Immunodeficiency, Molecular Immunology Unit, UCL Institute of Child Health, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunodeficiency, Molecular Immunology Unit, UCL Institute of Child Health, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112056335","display_name":"Nicola Jackson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicola Jackson","raw_affiliation_strings":["University College London, Cancer Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, Cancer Institute, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044647468","display_name":"Isabela Pedroza\u2010Pacheco","orcid":"https://orcid.org/0000-0003-4921-7940","observed_orcids":["https://orcid.org/0000-0003-4921-7940"]},"institutions":[{"id":"https://openalex.org/I2800598996","display_name":"Anthony Nolan","ror":"https://ror.org/043bfms20","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800598996"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Isabela Pedroza-Pacheco","raw_affiliation_strings":["University College London, Cancer Institute, London, United Kingdom ; Anthony Nolan Research Institute, London, United Kingdom","Anthony Nolan Research Institute, London, United Kingdom","University College London, Cancer Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, Cancer Institute, London, United Kingdom ; Anthony Nolan Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2800598996","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Anthony Nolan Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2800598996"]},{"raw_affiliation_string":"University College London, Cancer Institute, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047847027","display_name":"Sophie Derniame","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800598996","display_name":"Anthony Nolan","ror":"https://ror.org/043bfms20","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800598996"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sophie Derniame","raw_affiliation_strings":["University College London, Cancer Institute, London, United Kingdom ; Anthony Nolan Research Institute, London, United Kingdom","Anthony Nolan Research Institute, London, United Kingdom","University College London, Cancer Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, Cancer Institute, London, United Kingdom ; Anthony Nolan Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2800598996","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Anthony Nolan Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2800598996"]},{"raw_affiliation_string":"University College London, Cancer Institute, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111836466","display_name":"Escobedo-Cousin Michelle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800598996","display_name":"Anthony Nolan","ror":"https://ror.org/043bfms20","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800598996"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michelle Escobedo-Cousin","raw_affiliation_strings":["University College London, Cancer Institute, London, United Kingdom ; Anthony Nolan Research Institute, London, United Kingdom","Anthony Nolan Research Institute, London, United Kingdom","University College London, Cancer Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, Cancer Institute, London, United Kingdom ; Anthony Nolan Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2800598996","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Anthony Nolan Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2800598996"]},{"raw_affiliation_string":"University College London, Cancer Institute, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016251660","display_name":"Sergi Querol","orcid":"https://orcid.org/0000-0002-1105-8633","observed_orcids":["https://orcid.org/0000-0002-1105-8633"]},"institutions":[{"id":"https://openalex.org/I4210151792","display_name":"Banc de Sang i Teixits","ror":"https://ror.org/053d4n634","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210151792"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sergio Querol","raw_affiliation_strings":["Programa Concordia Banc de Sang i Teixits, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa Concordia Banc de Sang i Teixits, Barcelona, Spain","institution_ids":["https://openalex.org/I4210151792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015856478","display_name":"Adrian James Thrasher","orcid":"https://orcid.org/0000-0002-6097-6115","observed_orcids":["https://orcid.org/0000-0002-6097-6115"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adrian Thrasher","raw_affiliation_strings":["Centre for Immunodeficiency, Molecular Immunology Unit, UCL Institute of Child Health, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunodeficiency, Molecular Immunology Unit, UCL Institute of Child Health, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020482451","display_name":"J. Alejandro Madrigal","orcid":"https://orcid.org/0000-0001-8359-9917","observed_orcids":["https://orcid.org/0000-0001-8359-9917"]},"institutions":[{"id":"https://openalex.org/I2800598996","display_name":"Anthony Nolan","ror":"https://ror.org/043bfms20","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800598996"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alejandro Madrigal","raw_affiliation_strings":["University College London, Cancer Institute, London, United Kingdom ; Anthony Nolan Research Institute, London, United Kingdom","Anthony Nolan Research Institute, London, United Kingdom","University College London, Cancer Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, Cancer Institute, London, United Kingdom ; Anthony Nolan Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2800598996","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Anthony Nolan Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2800598996"]},{"raw_affiliation_string":"University College London, Cancer Institute, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055175093","display_name":"Aurore Saudemont","orcid":"https://orcid.org/0000-0002-9376-8339","observed_orcids":["https://orcid.org/0000-0002-9376-8339"]},"institutions":[{"id":"https://openalex.org/I2800598996","display_name":"Anthony Nolan","ror":"https://ror.org/043bfms20","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800598996"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Aurore Saudemont","raw_affiliation_strings":["University College London, Cancer Institute, London, United Kingdom ; Anthony Nolan Research Institute, London, United Kingdom","Anthony Nolan Research Institute, London, United Kingdom","University College London, Cancer Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, Cancer Institute, London, United Kingdom ; Anthony Nolan Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2800598996","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Anthony Nolan Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2800598996"]},{"raw_affiliation_string":"University College London, Cancer Institute, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055175093"],"corresponding_institution_ids":["https://openalex.org/I2800598996","https://openalex.org/I45129253"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.3342,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.88556697,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"e87086","last_page":"e87086"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.906000018119812},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.781000018119812},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/nk-cell-differentiation","display_name":"NK cell differentiation","score":0.6079999804496765},{"id":"https://openalex.org/keywords/nk-cell-therapy","display_name":"NK cell therapy","score":0.7279999852180481},{"id":"https://openalex.org/keywords/cd33","display_name":"CD33","score":0.7139999866485596},{"id":"https://openalex.org/keywords/killer-cell-immunoglobulin-like-receptors","display_name":"killer cell immunoglobulin-like receptors","score":0.4189999997615814},{"id":"https://openalex.org/keywords/activating-receptors","display_name":"activating receptors","score":0.6340000033378601},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8240000009536743},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9919999837875366},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.6869999766349792},{"id":"https://openalex.org/keywords/peripheral-blood-stem-cells","display_name":"peripheral blood stem cells","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6351925730705261},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5736620426177979},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5577641129493713},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.5225067734718323},{"id":"https://openalex.org/C183315844","wikidata":"https://www.wikidata.org/wiki/Q6155969","display_name":"Janus kinase 3","level":5,"score":0.5139267444610596},{"id":"https://openalex.org/C28651165","wikidata":"https://www.wikidata.org/wiki/Q4259786","display_name":"Lymphokine-activated killer cell","level":5,"score":0.5056502819061279},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5037550330162048},{"id":"https://openalex.org/C2780914630","wikidata":"https://www.wikidata.org/wiki/Q914952","display_name":"Cord blood","level":2,"score":0.49470826983451843},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.48505276441574097},{"id":"https://openalex.org/C206191192","wikidata":"https://www.wikidata.org/wiki/Q17149636","display_name":"NK-92","level":5,"score":0.4784836173057556},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44173768162727356},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4304615557193756},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3289225697517395},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2504337728023529},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23918288946151733},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.23371198773384094},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015925","descriptor_name":"Cryopreservation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019650","descriptor_name":"Hematopoietic Stem Cell Mobilization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063268","descriptor_name":"Sialic Acid Binding Ig-like Lectin 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063268","descriptor_name":"Sialic Acid Binding Ig-like Lectin 3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0087086","doi":"https://doi.org/10.1371/journal.pone.0087086","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0087086","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087086&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2896131","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3906137","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3906137","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3906137","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24489840","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24489840","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.787.2999","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.787.2999","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ce/dc/pone.0087086.PMC3906137.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:1901303d936645e3a52cf1c962129a8a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1901303d936645e3a52cf1c962129a8a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 1, p e87086 (2014)","raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1421190","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1421190/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS ONE , 9 (1) (2014)","raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/917389","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Frozen_Cord_Blood_Hematopoietic_Stem_Cells_Differentiate_into_Higher_Numbers_of_Functional_Natural_Killer_Cells_In_Vitro_than_Mobilized_Hematopoietic_Stem_Cells_or_Freshly_Isolated_Cord_Blood_Hematopoietic_Stem_Cells/917389","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0087086","doi":"https://doi.org/10.1371/journal.pone.0087086","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0087086","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087086&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320315793","display_name":"Anthony Nolan","ror":"https://ror.org/043bfms20"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2074043387.pdf","grobid_xml":"https://content.openalex.org/works/W2074043387.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W15273747","https://openalex.org/W201942322","https://openalex.org/W253073608","https://openalex.org/W1538655073","https://openalex.org/W1545349676","https://openalex.org/W1549867593","https://openalex.org/W1750987015","https://openalex.org/W1879871130","https://openalex.org/W1964990642","https://openalex.org/W1966426962","https://openalex.org/W1970789291","https://openalex.org/W1974517970","https://openalex.org/W1974562505","https://openalex.org/W1989135726","https://openalex.org/W1991366046","https://openalex.org/W1993565885","https://openalex.org/W2003150683","https://openalex.org/W2003339708","https://openalex.org/W2006120252","https://openalex.org/W2010957709","https://openalex.org/W2017277626","https://openalex.org/W2017634609","https://openalex.org/W2020199063","https://openalex.org/W2037230358","https://openalex.org/W2042295185","https://openalex.org/W2045664257","https://openalex.org/W2053865431","https://openalex.org/W2056036165","https://openalex.org/W2057527696","https://openalex.org/W2062870385","https://openalex.org/W2063022052","https://openalex.org/W2072015736","https://openalex.org/W2081047303","https://openalex.org/W2083148270","https://openalex.org/W2097050852","https://openalex.org/W2097169249","https://openalex.org/W2102156468","https://openalex.org/W2105910944","https://openalex.org/W2106209530","https://openalex.org/W2121936992","https://openalex.org/W2127944870","https://openalex.org/W2130860049","https://openalex.org/W2137835860","https://openalex.org/W2138992037","https://openalex.org/W2141352299","https://openalex.org/W2144318755","https://openalex.org/W2147448501","https://openalex.org/W2160835020","https://openalex.org/W2161629874","https://openalex.org/W2165155867","https://openalex.org/W2168489363","https://openalex.org/W2171431469","https://openalex.org/W2276328619","https://openalex.org/W2472378881"],"related_works":["https://openalex.org/W7096900320","https://openalex.org/W647180678","https://openalex.org/W2767654912","https://openalex.org/W2732143399","https://openalex.org/W2336688854","https://openalex.org/W4401326726","https://openalex.org/W2138708037","https://openalex.org/W2606741483","https://openalex.org/W7128004213","https://openalex.org/W4409909581"],"abstract_inverted_index":{"Adoptive":[0],"natural":[1],"killer":[2],"(NK)":[3],"cell":[4,23,37,102,212,225],"therapy":[5],"relies":[6],"on":[7,149],"the":[8,50,66,135,150,153,181,196,202],"acquisition":[9],"of":[10,13,68,106,123,130,134,152,198,204,253],"large":[11],"numbers":[12,103,213],"NK":[14,22,36,83,101,113,183,205,224,237],"cells":[15,28,76,84,114,157,184,206,238],"that":[16,95,143,195,243],"are":[17,58],"cytotoxic":[18],"but":[19,127],"not":[20,147],"exhausted.":[21],"differentiation":[24],"from":[25,116],"hematopoietic":[26,74],"stem":[27,75],"(HSC)":[29],"has":[30],"become":[31],"an":[32,232],"alluring":[33],"option":[34],"for":[35,201,223,241],"therapy,":[38],"with":[39],"umbilical":[40],"cord":[41],"blood":[42,47],"(UCB)":[43],"and":[44,78,118,133,164,169],"mobilized":[45],"peripheral":[46],"(PBCD34(+))":[48],"being":[49],"most":[51],"accessible":[52],"HSC":[53],"sources":[54,252],"as":[55,172],"collection":[56],"procedures":[57],"less":[59],"invasive.":[60],"In":[61],"this":[62],"study":[63],"we":[64,93],"compared":[65,108,173,249],"capacity":[67,160],"frozen":[69,79,96,199],"or":[70],"freshly":[71],"isolated":[72],"UCB":[73],"(CBCD34(+))":[77],"PBCD34(+)":[80,119],"to":[81,109,161,174,235,250],"generate":[82,236],"in":[85,167,170,207,210,239],"vitro.":[86],"By":[87],"modifying":[88],"a":[89],"previously":[90],"published":[91],"protocol,":[92],"showed":[94,142],"CBCD34(+)":[97,111,117,200],"cultures":[98],"generated":[99,115,154,182],"higher":[100,211],"without":[104,216],"loss":[105],"function":[107,247],"fresh":[110],"cultures.":[112],"expressed":[120],"low":[121],"levels":[122,129],"killer-cell":[124],"immunoglobulin-like":[125],"receptors":[126,132],"high":[128],"activating":[131],"myeloid":[136],"marker":[137],"CD33.":[138],"However,":[139],"blocking":[140],"studies":[141],"CD33":[144],"expression":[145],"did":[146],"impact":[148],"functions":[151],"cells.":[155,176],"CBCD34(+)-NK":[156],"exhibited":[158],"increased":[159],"secrete":[162],"IFN-\u03b3":[163],"kill":[165],"K562":[166,178],"vitro":[168,208,240],"vivo":[171],"PBCD34(+)-NK":[175],"Moreover,":[177],"killing":[179],"by":[180,189],"could":[185],"be":[186],"further":[187],"enhanced":[188,245],"IL-12":[190],"stimulation.":[191],"Our":[192],"data":[193],"indicate":[194],"use":[197],"production":[203],"results":[209,228],"than":[214],"PBCD34(+),":[215],"jeopardizing":[217],"their":[218],"functionality,":[219],"rendering":[220],"them":[221],"suitable":[222],"immunotherapy.":[226],"The":[227],"presented":[229],"here":[230],"provide":[231],"optimal":[233],"strategy":[234],"immunotherapy":[242],"exhibit":[244],"effector":[246],"when":[248],"alternate":[251],"HSC.":[254]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
