{"id":"https://openalex.org/W2074009302","doi":"https://doi.org/10.1128/aac.45.12.3531-3537.2001","title":"Evidence of Less Severe Aortic Valve Destruction after Treatment of Experimental Staphylococcal Endocarditis with Vancomycin and Dexamethasone","display_name":"Evidence of Less Severe Aortic Valve Destruction after Treatment of Experimental Staphylococcal Endocarditis with Vancomycin and Dexamethasone","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2074009302","doi":"https://doi.org/10.1128/aac.45.12.3531-3537.2001","mag":"2074009302","pmid":"https://pubmed.ncbi.nlm.nih.gov/11709335","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/90864"},"language":"en","primary_location":{"id":"doi:10.1128/aac.45.12.3531-3537.2001","doi":"https://doi.org/10.1128/aac.45.12.3531-3537.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.45.12.3531-3537.2001","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC90864","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108451773","display_name":"Peter Siaperas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800888565","display_name":"Sismanoglio General Hospital","ror":"https://ror.org/057cm0m66","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800888565"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Peter Siaperas","raw_affiliation_strings":["<!--label omitted: 1-->Fourth Department of Medicine, Sismanoglion General Hospital,1","Fourth Department of Medicine, Sismanoglion General Hospital,1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Fourth Department of Medicine, Sismanoglion General Hospital,1","institution_ids":["https://openalex.org/I2800888565"]},{"raw_affiliation_string":"Fourth Department of Medicine, Sismanoglion General Hospital,1","institution_ids":["https://openalex.org/I2800888565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082092826","display_name":"Angelos V. Pefanis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166756","display_name":"Sotiria General Hospital","ror":"https://ror.org/05gbdc474","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166756"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Angelos Pefanis","raw_affiliation_strings":["<!--label omitted: 2-->Third Department of Medicine, Sotiria General Hospital,2","Third Department of Medicine, Sotiria General Hospital,2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 2-->Third Department of Medicine, Sotiria General Hospital,2","institution_ids":["https://openalex.org/I4210166756"]},{"raw_affiliation_string":"Third Department of Medicine, Sotiria General Hospital,2","institution_ids":["https://openalex.org/I4210166756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064972382","display_name":"Dimitrios Iliopoulos","orcid":"https://orcid.org/0000-0003-2780-2372","observed_orcids":["https://orcid.org/0000-0003-2780-2372"]},"institutions":[{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios Iliopoulos","raw_affiliation_strings":["<!--label omitted: 3-->Laboratory of Experimental Surgery and Surgical Research, Second Department of Propaedeutic Surgery, Laikon General Hospital,3 and","Laboratory of Experimental Surgery and Surgical Research, Second Department of Propaedeutic Surgery, Laikon General Hospital,3 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 3-->Laboratory of Experimental Surgery and Surgical Research, Second Department of Propaedeutic Surgery, Laikon General Hospital,3 and","institution_ids":["https://openalex.org/I4210114623"]},{"raw_affiliation_string":"Laboratory of Experimental Surgery and Surgical Research, Second Department of Propaedeutic Surgery, Laikon General Hospital,3 and","institution_ids":["https://openalex.org/I4210114623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029884274","display_name":"Ioannis Katsarolis","orcid":"https://orcid.org/0000-0002-5710-1545","observed_orcids":["https://orcid.org/0000-0002-5710-1545"]},"institutions":[{"id":"https://openalex.org/I2800888565","display_name":"Sismanoglio General Hospital","ror":"https://ror.org/057cm0m66","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800888565"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis Katsarolis","raw_affiliation_strings":["<!--label omitted: 1-->Fourth Department of Medicine, Sismanoglion General Hospital,1","Fourth Department of Medicine, Sismanoglion General Hospital,1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Fourth Department of Medicine, Sismanoglion General Hospital,1","institution_ids":["https://openalex.org/I2800888565"]},{"raw_affiliation_string":"Fourth Department of Medicine, Sismanoglion General Hospital,1","institution_ids":["https://openalex.org/I2800888565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014902243","display_name":"Aspassia Kyroudi-Voulgari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Aspassia Kyroudi-Voulgari","raw_affiliation_strings":["<!--label omitted: 4-->Department of Histology and Embryology,4 Athens University School of Medicine, Athens, Greece","Department of Histology and Embryology,4 Athens University School of Medicine, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 4-->Department of Histology and Embryology,4 Athens University School of Medicine, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Department of Histology and Embryology,4 Athens University School of Medicine, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110143868","display_name":"I. Donta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ismini Donta","raw_affiliation_strings":["<!--label omitted: 3-->Laboratory of Experimental Surgery and Surgical Research, Second Department of Propaedeutic Surgery, Laikon General Hospital,3 and","Laboratory of Experimental Surgery and Surgical Research, Second Department of Propaedeutic Surgery, Laikon General Hospital,3 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 3-->Laboratory of Experimental Surgery and Surgical Research, Second Department of Propaedeutic Surgery, Laikon General Hospital,3 and","institution_ids":["https://openalex.org/I4210114623"]},{"raw_affiliation_string":"Laboratory of Experimental Surgery and Surgical Research, Second Department of Propaedeutic Surgery, Laikon General Hospital,3 and","institution_ids":["https://openalex.org/I4210114623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019763374","display_name":"Panayiotis Karayiannakos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panayiotis Karayiannakos","raw_affiliation_strings":["<!--label omitted: 3-->Laboratory of Experimental Surgery and Surgical Research, Second Department of Propaedeutic Surgery, Laikon General Hospital,3 and","Laboratory of Experimental Surgery and Surgical Research, Second Department of Propaedeutic Surgery, Laikon General Hospital,3 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 3-->Laboratory of Experimental Surgery and Surgical Research, Second Department of Propaedeutic Surgery, Laikon General Hospital,3 and","institution_ids":["https://openalex.org/I4210114623"]},{"raw_affiliation_string":"Laboratory of Experimental Surgery and Surgical Research, Second Department of Propaedeutic Surgery, Laikon General Hospital,3 and","institution_ids":["https://openalex.org/I4210114623"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052146006","display_name":"Helen Giamarellou","orcid":"https://orcid.org/0000-0002-7387-5065","observed_orcids":["https://orcid.org/0000-0002-7387-5065"]},"institutions":[{"id":"https://openalex.org/I2800888565","display_name":"Sismanoglio General Hospital","ror":"https://ror.org/057cm0m66","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800888565"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Helen Giamarellou","raw_affiliation_strings":["<!--label omitted: 1-->Fourth Department of Medicine, Sismanoglion General Hospital,1","Fourth Department of Medicine, Sismanoglion General Hospital,1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Fourth Department of Medicine, Sismanoglion General Hospital,1","institution_ids":["https://openalex.org/I2800888565"]},{"raw_affiliation_string":"Fourth Department of Medicine, Sismanoglion General Hospital,1","institution_ids":["https://openalex.org/I2800888565"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2277,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.63667039,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"45","issue":"12","first_page":"3531","last_page":"3537"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcal-endocarditis","display_name":"staphylococcal endocarditis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/aortic-valve-endocarditis","display_name":"aortic valve endocarditis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.9100000262260437},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":1.0},{"id":"https://openalex.org/keywords/combination-antibiotic-therapy","display_name":"combination antibiotic therapy","score":0.5429999828338623},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9649999737739563},{"id":"https://openalex.org/keywords/polymorphonuclear-leukocytes","display_name":"polymorphonuclear leukocytes","score":0.8320000171661377},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.8728666305541992},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8349043130874634},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.7612883448600769},{"id":"https://openalex.org/C2775872228","wikidata":"https://www.wikidata.org/wiki/Q82504","display_name":"Endocarditis","level":2,"score":0.6673733592033386},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.5157395005226135},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.48821404576301575},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4644268751144409},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43214017152786255},{"id":"https://openalex.org/C2779443120","wikidata":"https://www.wikidata.org/wiki/Q650912","display_name":"Bacteremia","level":3,"score":0.4308810830116272},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.33865875005722046},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.14806726574897766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08553481101989746},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.06653952598571777},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016106","descriptor_name":"Methicillin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.45.12.3531-3537.2001","doi":"https://doi.org/10.1128/aac.45.12.3531-3537.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.45.12.3531-3537.2001","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:192798","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC90864","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:90864","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/90864","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:11709335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11709335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:192798","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC90864","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1595457782","https://openalex.org/W1945697359","https://openalex.org/W1978980453","https://openalex.org/W1989863691","https://openalex.org/W1990800327","https://openalex.org/W2001243199","https://openalex.org/W2011665774","https://openalex.org/W2025126559","https://openalex.org/W2025253518","https://openalex.org/W2030680958","https://openalex.org/W2045304101","https://openalex.org/W2062540437","https://openalex.org/W2063724714","https://openalex.org/W2067941465","https://openalex.org/W2070335793","https://openalex.org/W2073619436","https://openalex.org/W2075823595","https://openalex.org/W2077630310","https://openalex.org/W2086831407","https://openalex.org/W2089827209","https://openalex.org/W2095772895","https://openalex.org/W2105817410","https://openalex.org/W2115240141","https://openalex.org/W2127011406","https://openalex.org/W2133760184","https://openalex.org/W2150085320","https://openalex.org/W2152821330","https://openalex.org/W2160982442","https://openalex.org/W2162555253","https://openalex.org/W2164619382","https://openalex.org/W2170180383","https://openalex.org/W2171491673","https://openalex.org/W2175516266","https://openalex.org/W2228534199","https://openalex.org/W2400259623","https://openalex.org/W2418694184"],"related_works":["https://openalex.org/W2108163490","https://openalex.org/W2121659243","https://openalex.org/W2164619382","https://openalex.org/W7100126248","https://openalex.org/W2169388619","https://openalex.org/W2150358456","https://openalex.org/W2914911847","https://openalex.org/W2101526042","https://openalex.org/W2011800499","https://openalex.org/W2149181697"],"abstract_inverted_index":{"The":[0,135,162],"beneficial":[1,59],"effects":[2],"of":[3,37,44,53,64,71,81,104,125,137,153,164,201,218,228,247],"therapy":[4],"combining":[5],"an":[6],"antibiotic":[7],"and":[8,18,26,39,97,189,220,250],"dexamethasone":[9,54,101,119,149,221],"have":[10,241],"been":[11],"reported":[12],"in":[13,19,144,176,193,209,232,244,254],"human":[14],"studies":[15,21],"on":[16,22],"meningitis":[17],"experimental":[20,72,233],"septic":[23],"arthritis,":[24],"nephritis,":[25],"endophthalmitis.":[27],"Since":[28],"most":[29],"patients":[30],"with":[31,85,151,170,215],"staphylococcal":[32,234,248],"endocarditis":[33,75,249],"need":[34],"a":[35,78,94,110,123,216],"combination":[36,217],"medical":[38],"surgical":[40],"treatment,":[41],"the":[42,51,62,69,154,171,186,190,202,226,245],"purpose":[43],"this":[45],"study":[46],"was":[47,141,167],"to":[48,55,93,98],"determine":[49],"whether":[50],"addition":[52],"vancomycin":[56,113,147,157,219],"has":[57],"any":[58],"effect":[60],"regarding":[61],"degree":[63],"valve":[65,74,88,138,177,229,236],"tissue":[66,139,165,230],"damage":[67,140,166,231],"or":[68,118,199],"course":[70],"aortic":[73,87,235],"caused":[76],"by":[77],"methicillin-resistant":[79],"strain":[80],"Staphylococcus":[82],"aureus.":[83],"Rabbits":[84],"catheter-induced":[86],"vegetations":[89],"were":[90,183],"randomly":[91],"assigned":[92],"control":[95],"group":[96,155,188,192],"groups":[99,145],"receiving":[100,146,156],"(0.5":[102],"mg/kg":[103],"body":[105],"weight,":[106],"intravenously":[107],"[i.v.],":[108],"twice":[109],"day":[111,131],"[b.i.d]),":[112],"(30":[114],"mg/kg,":[115],"i.v.,":[116],"b.i.d),":[117],"plus":[120,148],"vancomycin,":[121],"for":[122,132,222],"total":[124],"10":[126],"doses":[127,129],"(two":[128],"per":[130,207],"5":[133,223],"days).":[134],"severity":[136,163,227],"significantly":[142],"less":[143],"compared":[150],"that":[152],"alone":[158],"(P":[159],"<":[160],"0.001).":[161],"inversely":[168],"correlated":[169],"mean":[172],"polymorphonuclear":[173],"leukocyte":[174],"number":[175],"tissue.":[178,211],"No":[179],"statistically":[180],"significant":[181,242],"differences":[182],"observed":[184],"between":[185],"vancomycin-treated":[187],"vancomycin-plus-dexamethasone-treated":[191],"survival,":[194],"blood":[195],"culture":[196],"sterilization":[197],"rate,":[198],"reduction":[200],"microbial":[203],"burden":[204],"(in":[205],"CFU":[206],"gram)":[208],"valvular":[210],"In":[212],"conclusion,":[213],"treatment":[214,246],"days":[224],"reduces":[225],"endocarditis.":[237],"These":[238],"findings":[239],"could":[240],"implications":[243],"deserve":[251],"further":[252],"confirmation":[253],"clinical":[255],"trials.":[256]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}