{"id":"https://openalex.org/W2073986643","doi":"https://doi.org/10.1158/0008-5472.can-06-4497","title":"Homologous Recombination Is the Principal Pathway for the Repair of DNA Damage Induced by Tirapazamine in Mammalian Cells","display_name":"Homologous Recombination Is the Principal Pathway for the Repair of DNA Damage Induced by Tirapazamine in Mammalian Cells","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2073986643","doi":"https://doi.org/10.1158/0008-5472.can-06-4497","mag":"2073986643","pmid":"https://pubmed.ncbi.nlm.nih.gov/18172318"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-06-4497","doi":"https://doi.org/10.1158/0008-5472.can-06-4497","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-06-4497","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029071777","display_name":"James Evans","orcid":"https://orcid.org/0009-0005-0401-6397","observed_orcids":["https://orcid.org/0009-0005-0401-6397"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James W. Evans","raw_affiliation_strings":["1Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University, Stanford, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University, Stanford, California;","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079966273","display_name":"Sophia B. Chernikova","orcid":"https://orcid.org/0000-0002-0605-3520","observed_orcids":["https://orcid.org/0000-0002-0605-3520"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophia B. Chernikova","raw_affiliation_strings":["1Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University, Stanford, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University, Stanford, California;","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083156203","display_name":"Lisa Ann Kachnic","orcid":"https://orcid.org/0000-0001-8239-9147","observed_orcids":["https://orcid.org/0000-0001-8239-9147"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa A. Kachnic","raw_affiliation_strings":["2Department of Radiation Oncology, Boston University Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Radiation Oncology, Boston University Medical Center;","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054306473","display_name":"Judit P. Ban\u00e1th","orcid":"https://orcid.org/0009-0003-5788-4679","observed_orcids":["https://orcid.org/0009-0003-5788-4679"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Judit P. Banath","raw_affiliation_strings":["4Medical Biophysics Department, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Medical Biophysics Department, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006775012","display_name":"Olivier Sordet","orcid":"https://orcid.org/0000-0001-6027-4925","observed_orcids":["https://orcid.org/0000-0001-6027-4925"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivier Sordet","raw_affiliation_strings":["5Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland; and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056956946","display_name":"Yvette M. Delahoussaye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yvette M. Delahoussaye","raw_affiliation_strings":["1Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University, Stanford, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University, Stanford, California;","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009747952","display_name":"Alejandro D. Treszezamsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandro Treszezamsky","raw_affiliation_strings":["3Department of Radiation Oncology, Massachusetts General Hospital, Harvard University School of Medicine, Boston, Massachusetts;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Radiation Oncology, Massachusetts General Hospital, Harvard University School of Medicine, Boston, Massachusetts;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009490529","display_name":"Brian H. Chon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian H. Chon","raw_affiliation_strings":["3Department of Radiation Oncology, Massachusetts General Hospital, Harvard University School of Medicine, Boston, Massachusetts;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Radiation Oncology, Massachusetts General Hospital, Harvard University School of Medicine, Boston, Massachusetts;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054763410","display_name":"Zhihui Feng","orcid":"https://orcid.org/0000-0001-5746-0241","observed_orcids":["https://orcid.org/0000-0001-5746-0241"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhihui Feng","raw_affiliation_strings":["3Department of Radiation Oncology, Massachusetts General Hospital, Harvard University School of Medicine, Boston, Massachusetts;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Radiation Oncology, Massachusetts General Hospital, Harvard University School of Medicine, Boston, Massachusetts;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041236682","display_name":"Yongchuan Gu","orcid":"https://orcid.org/0000-0001-5679-168X","observed_orcids":["https://orcid.org/0000-0001-5679-168X"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Yongchuan Gu","raw_affiliation_strings":["6Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087508568","display_name":"William Robert Wilson","orcid":"https://orcid.org/0000-0002-9939-8738","observed_orcids":["https://orcid.org/0000-0002-9939-8738"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"William R. Wilson","raw_affiliation_strings":["6Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042114293","display_name":"Yves G. Pommier","orcid":"https://orcid.org/0000-0002-3108-0758","observed_orcids":["https://orcid.org/0000-0002-3108-0758"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yves Pommier","raw_affiliation_strings":["5Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland; and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111889006","display_name":"Peggy L. Olive","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peggy L. Olive","raw_affiliation_strings":["4Medical Biophysics Department, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Medical Biophysics Department, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056895130","display_name":"Simon N. Powell","orcid":"https://orcid.org/0000-0002-8183-4765","observed_orcids":["https://orcid.org/0000-0002-8183-4765"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon N. Powell","raw_affiliation_strings":["3Department of Radiation Oncology, Massachusetts General Hospital, Harvard University School of Medicine, Boston, Massachusetts;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Radiation Oncology, Massachusetts General Hospital, Harvard University School of Medicine, Boston, Massachusetts;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103419611","display_name":"J. Martin Brown","orcid":"https://orcid.org/0000-0001-7636-4554","observed_orcids":["https://orcid.org/0000-0001-7636-4554","https://orcid.org/0000-0001-9288-1113"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Martin Brown","raw_affiliation_strings":["1Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University, Stanford, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University, Stanford, California;","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1018,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.92116667,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"68","issue":"1","first_page":"257","last_page":"265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tirapazamine","display_name":"tirapazamine","score":1.0},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9679999947547913},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8230000138282776},{"id":"https://openalex.org/keywords/sister-chromatid-exchange","display_name":"sister chromatid exchange","score":0.8119999766349792},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":0.8330000042915344},{"id":"https://openalex.org/keywords/base-excision-repair","display_name":"base excision repair","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dna-protein-cross-links","display_name":"DNA-protein crosslinks","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gamma-h2ax","display_name":"\u03b3H2AX","score":0.8140000104904175},{"id":"https://openalex.org/keywords/replication-fork-collapse","display_name":"replication fork collapse","score":0.652999997138977},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.7409999966621399},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.7239999771118164},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.9860000014305115},{"id":"https://openalex.org/keywords/xrcc2","display_name":"XRCC2","score":0.8149999976158142},{"id":"https://openalex.org/keywords/xrcc3","display_name":"XRCC3","score":0.9760000109672546},{"id":"https://openalex.org/keywords/rad51d","display_name":"RAD51D","score":0.8769999742507935},{"id":"https://openalex.org/keywords/radiosensitizers","display_name":"radiosensitizers","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2776313096","wikidata":"https://www.wikidata.org/wiki/Q3529346","display_name":"Tirapazamine","level":4,"score":0.949614405632019},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.7844830751419067},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.7641599178314209},{"id":"https://openalex.org/C2779309665","wikidata":"https://www.wikidata.org/wiki/Q17917256","display_name":"ERCC1","level":5,"score":0.7408562302589417},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6293942928314209},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.580482542514801},{"id":"https://openalex.org/C74054111","wikidata":"https://www.wikidata.org/wiki/Q5891445","display_name":"Homology directed repair","level":5,"score":0.4947309195995331},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4447858929634094},{"id":"https://openalex.org/C187206112","wikidata":"https://www.wikidata.org/wiki/Q3113091","display_name":"Base excision repair","level":4,"score":0.4307727813720703},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.43041807413101196},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3834120035171509},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38147157430648804},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3743758201599121},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3097493648529053},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.0838819146156311},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07223770022392273}],"mesh":[{"descriptor_ui":"D000077704","descriptor_name":"Tirapazamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077704","descriptor_name":"Tirapazamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077704","descriptor_name":"Tirapazamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004720","descriptor_name":"Endonucleases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004720","descriptor_name":"Endonucleases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004720","descriptor_name":"Endonucleases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004720","descriptor_name":"Endonucleases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004720","descriptor_name":"Endonucleases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004720","descriptor_name":"Endonucleases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.can-06-4497","doi":"https://doi.org/10.1158/0008-5472.can-06-4497","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-06-4497","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:18172318","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18172318","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.4300000071525574,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1231024394","display_name":"Roles of BRCA1, BRCA2 in Homologous Recombination","funder_award_id":"7r01ca107640-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1295147849","display_name":null,"funder_award_id":"CA 89393","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3009939169","display_name":null,"funder_award_id":"CA82566","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5661117367","display_name":"Development of New Hypoxic Cytotoxins for Cancer Therapy","funder_award_id":"P01CA082566","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7880683311","display_name":"Dana-Farber/Harvard SPORE in Breast Cancer","funder_award_id":"5p50ca089393-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8346930592","display_name":null,"funder_award_id":"CA107640","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W32666931","https://openalex.org/W1606456984","https://openalex.org/W1635718836","https://openalex.org/W1682474579","https://openalex.org/W1809407380","https://openalex.org/W1831022961","https://openalex.org/W1868704956","https://openalex.org/W1966092175","https://openalex.org/W1973268287","https://openalex.org/W1983270572","https://openalex.org/W1987814047","https://openalex.org/W1988970366","https://openalex.org/W1989548466","https://openalex.org/W1990819415","https://openalex.org/W1992688638","https://openalex.org/W1996830477","https://openalex.org/W2009007206","https://openalex.org/W2011896398","https://openalex.org/W2012452328","https://openalex.org/W2018520585","https://openalex.org/W2020840616","https://openalex.org/W2031819924","https://openalex.org/W2036611623","https://openalex.org/W2046463062","https://openalex.org/W2050291003","https://openalex.org/W2052483270","https://openalex.org/W2064163762","https://openalex.org/W2069565619","https://openalex.org/W2072957347","https://openalex.org/W2074552403","https://openalex.org/W2083378326","https://openalex.org/W2083902090","https://openalex.org/W2088228208","https://openalex.org/W2091894720","https://openalex.org/W2099949852","https://openalex.org/W2105280154","https://openalex.org/W2109468970","https://openalex.org/W2112653402","https://openalex.org/W2115808409","https://openalex.org/W2119325996","https://openalex.org/W2121999441","https://openalex.org/W2127504799","https://openalex.org/W2130730147","https://openalex.org/W2134200987","https://openalex.org/W2136367213","https://openalex.org/W2142416380","https://openalex.org/W2152364010","https://openalex.org/W2155143684","https://openalex.org/W2167541208","https://openalex.org/W2271870719","https://openalex.org/W2320580623"],"related_works":["https://openalex.org/W4234191197","https://openalex.org/W20978967","https://openalex.org/W2113467423","https://openalex.org/W1992129085","https://openalex.org/W1977382129","https://openalex.org/W1592611932","https://openalex.org/W1978228357","https://openalex.org/W2099082193","https://openalex.org/W1973849035","https://openalex.org/W2253377172"],"abstract_inverted_index":{"Tirapazamine":[0,144],"(3-amino-1,2,4-benzotriazine-1,4-dioxide)":[1],"is":[2,106,167],"a":[3,46],"promising":[4],"hypoxia-selective":[5],"cytotoxin":[6],"that":[7,42,93,119,159],"has":[8],"shown":[9],"significant":[10],"activity":[11],"in":[12,16,37,49,57,109,127,131,140,170,172,191,220],"advanced":[13],"clinical":[14],"trials":[15],"combination":[17],"with":[18,73,88,101,125,138],"radiotherapy":[19],"and":[20,33,137,198,204,210,226],"cisplatin.":[21],"The":[22],"current":[23],"study":[24],"aimed":[25],"to":[26,70,184],"advance":[27],"our":[28],"understanding":[29],"of":[30,51,76,112,164,176,188,212,217],"tirapazamine-induced":[31,52,113],"lesions":[32],"the":[34,74,94,110,173,177,215],"pathways":[35],"involved":[36,108],"their":[38,229],"repair.":[39,143,230],"We":[40,90,156],"show":[41,92,118,158],"homologous":[43,58,77,224],"recombination":[44,59,78,225],"plays":[45],"critical":[47],"role":[48],"repair":[50,111,135],"damage":[53,190],"because":[54],"cells":[55,171],"defective":[56],"proteins":[60],"XRCC2,":[61],"XRCC3,":[62],"Rad51D,":[63],"BRCA1,":[64],"or":[65],"BRCA2":[66],"are":[67],"particularly":[68],"sensitive":[69],"tirapazamine.":[71,89],"Consistent":[72],"involvement":[75],"repair,":[79],"we":[80,117],"observed":[81],"extensive":[82],"sister":[83],"chromatid":[84],"exchanges":[85],"after":[86],"treatment":[87],"also":[91,145],"nonhomologous":[95],"end-joining":[96],"pathway,":[97],"which":[98,149,192,218],"predominantly":[99],"deals":[100],"frank":[102],"double-strand":[103],"breaks":[104],"(DSB),":[105],"not":[107,130],"DSBs.":[114],"In":[115],"addition,":[116],"tirapazamine":[120,189],"preferentially":[121,169],"kills":[122],"mutants":[123],"both":[124],"defects":[126,139],"XPF/ERCC1":[128,227],"(but":[129],"other":[132],"nucleotide":[133],"excision":[134,142],"factors)":[136],"base":[141,196],"induces":[146],"DNA-protein":[147,199],"cross-links,":[148],"include":[150],"stable":[151],"DNA-topoisomerase":[152],"I":[153,203],"cleavable":[154,206],"complexes.":[155],"further":[157],"gamma":[160],"H2AX,":[161],"an":[162,185],"indicator":[163],"DNA":[165,193],"DSBs,":[166],"induced":[168],"S":[174],"phase":[175],"cell":[178],"cycle.":[179],"These":[180],"observations":[181],"lead":[182],"us":[183],"overall":[186],"model":[187],"single-strand":[194],"breaks,":[195],"damage,":[197],"cross-links":[200],"(including":[201],"topoisomerase":[202],"II":[205],"complexes)":[207],"produce":[208],"stalling":[209],"collapse":[211],"replication":[213],"forks,":[214],"resolution":[216],"results":[219],"DSB":[221],"intermediates,":[222],"requiring":[223],"for":[228]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
