{"id":"https://openalex.org/W2073883679","doi":"https://doi.org/10.1186/1479-5876-10-s2-a49","title":"A quaternary equation for interdisciplinary medical research (IMR)","display_name":"A quaternary equation for interdisciplinary medical research (IMR)","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2073883679","doi":"https://doi.org/10.1186/1479-5876-10-s2-a49","mag":"2073883679"},"language":"en","primary_location":{"id":"doi:10.1186/1479-5876-10-s2-a49","doi":"https://doi.org/10.1186/1479-5876-10-s2-a49","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1479-5876-10-s2-a49","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/1479-5876-10-S2-A49","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/1479-5876-10-S2-A49","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111627233","display_name":"Marc Shuman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marc Shuman","raw_affiliation_strings":["Departments of Medicine, Univ. of California Schools of Medicine & Pharmacy, San Francisco, CA, USA","Departments of Medicine, Univ. of California Schools of Medicine & Pharmacy, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Univ. of California Schools of Medicine & Pharmacy, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Departments of Medicine, Univ. of California Schools of Medicine & Pharmacy, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103911025","display_name":"Jim Wells","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jim Wells","raw_affiliation_strings":["Departments of Pharmaceutical Chemistry, Univ. of California Schools of Medicine & Pharmacy, San Francisco, CA, USA","Departments of Pharmaceutical Chemistry, Univ. of California Schools of Medicine & Pharmacy, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmaceutical Chemistry, Univ. of California Schools of Medicine & Pharmacy, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Departments of Pharmaceutical Chemistry, Univ. of California Schools of Medicine & Pharmacy, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079376363","display_name":"Kevan M. Shokat","orcid":"https://orcid.org/0000-0001-8590-7741","observed_orcids":["https://orcid.org/0000-0001-8590-7741"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Shokat","raw_affiliation_strings":["Department of Cellular and Molecular Pharmacology, Univ. of California Schools of Medicine & Pharmacy, San Francisco, CA, USA","Department of Cellular and Molecular Pharmacology, Univ. of California Schools of Medicine & Pharmacy, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Pharmacology, Univ. of California Schools of Medicine & Pharmacy, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Cellular and Molecular Pharmacology, Univ. of California Schools of Medicine & Pharmacy, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091752977","display_name":"Sebasti\u00e1n Bernales","orcid":"https://orcid.org/0000-0002-8971-4995","observed_orcids":["https://orcid.org/0000-0002-8971-4995"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Bernales","raw_affiliation_strings":["Departments of Biochemistry & Biophysics, Univ. of California Schools of Medicine & Pharmacy, San Francisco, CA, USA","Departments of Biochemistry & Biophysics, Univ. of California Schools of Medicine & Pharmacy, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry & Biophysics, Univ. of California Schools of Medicine & Pharmacy, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Departments of Biochemistry & Biophysics, Univ. of California Schools of Medicine & Pharmacy, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087493059","display_name":"Peter Walter","orcid":"https://orcid.org/0000-0002-6849-708X","observed_orcids":["https://orcid.org/0000-0002-6849-708X","https://orcid.org/0000-0001-8745-6593"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Walter","raw_affiliation_strings":["Departments of Biochemistry & Biophysics, Univ. of California Schools of Medicine & Pharmacy, San Francisco, CA, USA","Departments of Biochemistry & Biophysics, Univ. of California Schools of Medicine & Pharmacy, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry & Biophysics, Univ. of California Schools of Medicine & Pharmacy, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Departments of Biochemistry & Biophysics, Univ. of California Schools of Medicine & Pharmacy, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036394378","display_name":"Leonard D. Shultz","orcid":"https://orcid.org/0000-0002-4868-1031","observed_orcids":["https://orcid.org/0000-0002-4868-1031"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard Shultz","raw_affiliation_strings":["The Jackson Laboratory, Sacramento, CA, USA","The Jackson Laboratory, Sacramento, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Sacramento, CA, USA","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"The Jackson Laboratory, Sacramento, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078103055","display_name":"Neal C. Goodwin","orcid":"https://orcid.org/0000-0002-1117-1740","observed_orcids":["https://orcid.org/0000-0002-1117-1740"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neal Goodwin","raw_affiliation_strings":["The Jackson Laboratory, Sacramento, CA, USA","The Jackson Laboratory, Sacramento, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Sacramento, CA, USA","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"The Jackson Laboratory, Sacramento, USA","institution_ids":["https://openalex.org/I4210115256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111627233"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13552042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"S2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.8619999885559082},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.8100000023841858},{"id":"https://openalex.org/keywords/ire1","display_name":"IRE1","score":0.7860000133514404},{"id":"https://openalex.org/keywords/perk","display_name":"PERK","score":0.9940000176429749},{"id":"https://openalex.org/keywords/atf6","display_name":"ATF6","score":0.996999979019165},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.6439999938011169},{"id":"https://openalex.org/keywords/high-throughput-drug-screening","display_name":"high-throughput drug screening","score":0.746999979019165},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.6809999942779541},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.335999995470047},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9789999723434448}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5874284505844116},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.5561010837554932},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5539947748184204},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.510753870010376},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5102360248565674},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4540189504623413},{"id":"https://openalex.org/C178855305","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmaceutical sciences","level":2,"score":0.4474492073059082},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4400607943534851},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.42941349744796753},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.4289555549621582},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4009953737258911},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.38368484377861023},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.37104249000549316},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36970236897468567},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31534343957901},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13527822494506836}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/1479-5876-10-s2-a49","doi":"https://doi.org/10.1186/1479-5876-10-s2-a49","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1479-5876-10-s2-a49","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/1479-5876-10-S2-A49","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3479976","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3479976","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Transl Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1479-5876-10-s2-a49","doi":"https://doi.org/10.1186/1479-5876-10-s2-a49","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1479-5876-10-s2-a49","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/1479-5876-10-S2-A49","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2073883679.pdf","grobid_xml":"https://content.openalex.org/works/W2073883679.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3083466538","https://openalex.org/W2387802174","https://openalex.org/W2616867479","https://openalex.org/W2958158208","https://openalex.org/W3120628984","https://openalex.org/W3135810880","https://openalex.org/W801830832","https://openalex.org/W1619133210","https://openalex.org/W625755886","https://openalex.org/W2072714194"],"abstract_inverted_index":{"A":[0],"popular":[1],"model":[2],"for":[3,30,61,95,201],"developmental":[4],"therapeutics":[5],"is":[6,197],"one":[7],"in":[8,46,55,83,110,124,129,138,149,194,225],"which":[9,195],"drugs":[10],"are":[11,19,44,53,72,81,91],"developed":[12,73],"by":[13],"biotechnology":[14],"and":[15,25,57,86,136,140,158,168,179,183],"pharma.":[16],"Candidate":[17],"molecules":[18],"then":[20],"handed":[21],"off":[22],"to":[23,74,219,222,233],"academia":[24],"Clinical":[26],"Research":[27],"Organizations":[28],"(CRO's)":[29],"clinical":[31,159],"testing.":[32],"We":[33,98],"have":[34,99,163,191],"embarked":[35],"on":[36],"a":[37,47],"different":[38],"approach":[39,102],"whereby":[40],"1.":[41],"Potential":[42],"targets":[43,71],"identified":[45],"candidate":[48],"pathway,":[49,118,127],"2.":[50],"Gene":[51],"expression/genomics":[52],"interrogated":[54],"normal":[56],"diseased":[58],"human":[59],"tissues":[60],"their":[62,76],"relevance,":[63],"3.":[64],"Highly":[65],"specific":[66],"chemical":[67,182],"reagents":[68],"against":[69,170],"putative":[70],"determine":[75],"importance,":[77],"4.":[78],"Model":[79],"compounds":[80,162],"tested":[82,169],"pre-clinical":[84],"cell":[85,156],"mouse":[87],"models,":[88],"5.":[89],"Collaborations":[90],"established":[92,193],"with":[93,103,147,214],"biotechnology/pharma":[94],"drug":[96,108,152],"development.":[97],"taken":[100],"this":[101,125,215],"the":[104,119,175,198,203],"goal":[105],"of":[106,174],"stimulating":[107],"development":[109],"an":[111],"as":[112],"yet":[113],"relatively":[114],"unexplored":[115],"important":[116],"survival":[117],"Unfolded":[120],"Protein":[121],"Response.":[122],"Interest":[123],"complex":[126],"expressed":[128],"all":[130,171],"eukaryotic":[131],"organisms,":[132],"has":[133],"recently":[134],"surfaced,":[135],"particularly":[137],"cancer":[139],"neurodegenerative":[141],"diseases.":[142],"Our":[143],"team":[144],"includes":[145],"faculty":[146],"expertise":[148],"high":[150],"throughput":[151],"screening,":[153],"kinase":[154],"chemistry,":[155],"biology,":[157],"research.":[160],"Specific":[161],"been":[164,192],"identified,":[165],"further":[166],"modified":[167],"3":[172],"branches":[173],"UPR:":[176],"Ire1,":[177],"PERK":[178],"ATF6":[180],"using":[181],"cellbased":[184],"assays.":[185],"In":[186],"addition,":[187],"novel":[188],"transgenic":[189],"animals":[190],"there":[196],"exciting":[199],"potential":[200],"recreating":[202],"orphan":[204],"disease,":[205,216],"Multiple":[206],"Myeloma.":[207],"Using":[208],"primary":[209],"bone":[210],"marrow":[211],"from":[212],"patients":[213],"we":[217],"hope":[218],"be":[220],"able":[221],"screen":[223],"drugs,":[224],"vivo,":[226],"that":[227],"will":[228],"predict":[229],"individual":[230],"patients'":[231],"response":[232],"treatment.":[234]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}