{"id":"https://openalex.org/W2073861040","doi":"https://doi.org/10.1371/journal.pone.0052868","title":"p62/SQSTM1-Dependent Autophagy of Lewy Body-Like \u03b1-Synuclein Inclusions","display_name":"p62/SQSTM1-Dependent Autophagy of Lewy Body-Like \u03b1-Synuclein Inclusions","publication_year":2012,"publication_date":"2012-12-31","ids":{"openalex":"https://openalex.org/W2073861040","doi":"https://doi.org/10.1371/journal.pone.0052868","mag":"2073861040","pmid":"https://pubmed.ncbi.nlm.nih.gov/23300799","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3534125"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0052868","doi":"https://doi.org/10.1371/journal.pone.0052868","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0052868","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0052868&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0052868&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103376778","display_name":"Yoshihisa Watanabe","orcid":"https://orcid.org/0000-0002-9499-2914","observed_orcids":["https://orcid.org/0000-0002-9499-2914"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihisa Watanabe","raw_affiliation_strings":["Department of Basic Geriatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Geriatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073327869","display_name":"Harutsugu Tatebe","orcid":"https://orcid.org/0009-0006-3780-2308","observed_orcids":["https://orcid.org/0009-0006-3780-2308"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Harutsugu Tatebe","raw_affiliation_strings":["Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071868046","display_name":"Katsutoshi Taguchi","orcid":"https://orcid.org/0000-0001-5511-3975","observed_orcids":["https://orcid.org/0000-0001-5511-3975"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsutoshi Taguchi","raw_affiliation_strings":["Department of Basic Geriatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Geriatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014504805","display_name":"Yasuhisa Endo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27429435","display_name":"Kyoto Institute of Technology","ror":"https://ror.org/00965ax52","country_code":"JP","type":"education","lineage":["https://openalex.org/I27429435"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhisa Endo","raw_affiliation_strings":["Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Kyoto, Japan","institution_ids":["https://openalex.org/I27429435"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102887436","display_name":"Takahiko Tokuda","orcid":"https://orcid.org/0000-0002-7411-4911","observed_orcids":["https://orcid.org/0000-0002-7411-4911"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiko Tokuda","raw_affiliation_strings":["Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010300845","display_name":"Toshiki Mizuno","orcid":"https://orcid.org/0000-0002-7907-8243","observed_orcids":["https://orcid.org/0000-0002-7907-8243"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiki Mizuno","raw_affiliation_strings":["Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109063002","display_name":"Masanori Nakagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanori Nakagawa","raw_affiliation_strings":["Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032113813","display_name":"Masaki Tanaka","orcid":"https://orcid.org/0000-0001-6143-9197","observed_orcids":["https://orcid.org/0000-0001-6143-9197"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masaki Tanaka","raw_affiliation_strings":["Department of Basic Geriatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Geriatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032113813"],"corresponding_institution_ids":["https://openalex.org/I40677808"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":4.7849,"has_fulltext":true,"cited_by_count":104,"citation_normalized_percentile":{"value":0.95446148,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"7","issue":"12","first_page":"e52868","last_page":"e52868"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.06769999861717224,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9129999876022339},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.9459999799728394},{"id":"https://openalex.org/keywords/p62","display_name":"p62","score":0.8980000019073486},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9350000023841858},{"id":"https://openalex.org/keywords/autophagy-lysosome-pathway","display_name":"autophagy-lysosome pathway","score":0.9139999747276306},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9629999995231628},{"id":"https://openalex.org/keywords/alpha-synuclein-phosphorylation","display_name":"alpha-synuclein phosphorylation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.9570000171661377},{"id":"https://openalex.org/keywords/autophagosome-biogenesis","display_name":"autophagosome formation","score":0.7329999804496765},{"id":"https://openalex.org/keywords/lysosomal-dysfunction","display_name":"lysosomal dysfunction","score":0.7599999904632568},{"id":"https://openalex.org/keywords/mitochondrial-clearance","display_name":"mitochondrial clearance","score":0.7910000085830688},{"id":"https://openalex.org/keywords/mitochondrial-uncoupling","display_name":"mitochondrial uncoupling","score":0.9300000071525574},{"id":"https://openalex.org/keywords/atg5","display_name":"ATG5","score":0.6150000095367432},{"id":"https://openalex.org/keywords/bafilomycin-a1","display_name":"bafilomycin A1","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9430708289146423},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.711054265499115},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.6478493213653564},{"id":"https://openalex.org/C2777722557","wikidata":"https://www.wikidata.org/wiki/Q4841341","display_name":"Bafilomycin","level":4,"score":0.6074510216712952},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.5968985557556152},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5660094022750854},{"id":"https://openalex.org/C2779097696","wikidata":"https://www.wikidata.org/wiki/Q1822234","display_name":"Lewy body","level":4,"score":0.5598383545875549},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.5384812951087952},{"id":"https://openalex.org/C203750385","wikidata":"https://www.wikidata.org/wiki/Q1308970","display_name":"Inclusion bodies","level":4,"score":0.4861595332622528},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.445669025182724},{"id":"https://openalex.org/C2908656506","wikidata":"https://www.wikidata.org/wiki/Q18033497","display_name":"Sequestosome 1","level":4,"score":0.4375263452529907},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.4235679507255554},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4088406562805176},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3777022957801819},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.3147507309913635},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17583832144737244},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.12831270694732666},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11455374956130981},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10540959239006042},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071456","descriptor_name":"Sequestosome-1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010588","descriptor_name":"Phagosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016631","descriptor_name":"Lewy Bodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063306","descriptor_name":"Mitophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0052868","doi":"https://doi.org/10.1371/journal.pone.0052868","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0052868","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0052868&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3534125","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3534125","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23300799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23300799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.780.9129","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.780.9129","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ec/10/pone.0052868.PMC3534125.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a3ab914464db47c2aa37187f85b9fb0c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a3ab914464db47c2aa37187f85b9fb0c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 12, p e52868 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/115101","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/p62_SQSTM1_Dependent_Autophagy_of_Lewy_Body_Like_Synuclein_Inclusions__/115101","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0052868","doi":"https://doi.org/10.1371/journal.pone.0052868","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0052868","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0052868&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G452945505","display_name":"The role of BAG3/HSP70 complex in selective autophagic degradation of alpha-synuclein","funder_award_id":"24591272","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7975078901","display_name":"Elucidation of characters and neurotoxic mechanisms of alpha-synuclein oligomers and its application to molecular targeted therapy","funder_award_id":"23591252","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320321945","display_name":"Ministry of Health, Labour and Welfare","ror":"https://ror.org/03mwa7s65"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2073861040.pdf","grobid_xml":"https://content.openalex.org/works/W2073861040.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1590336161","https://openalex.org/W1964057486","https://openalex.org/W1967111894","https://openalex.org/W1971483465","https://openalex.org/W1986625112","https://openalex.org/W1990294498","https://openalex.org/W2006840724","https://openalex.org/W2014268728","https://openalex.org/W2021242983","https://openalex.org/W2021400058","https://openalex.org/W2022527632","https://openalex.org/W2025116212","https://openalex.org/W2026175550","https://openalex.org/W2027649342","https://openalex.org/W2037948191","https://openalex.org/W2038976751","https://openalex.org/W2051097977","https://openalex.org/W2055432326","https://openalex.org/W2057358353","https://openalex.org/W2058629097","https://openalex.org/W2061441903","https://openalex.org/W2068288454","https://openalex.org/W2072427499","https://openalex.org/W2074239221","https://openalex.org/W2076874931","https://openalex.org/W2078207717","https://openalex.org/W2106444069","https://openalex.org/W2117626437","https://openalex.org/W2129321855","https://openalex.org/W2133789233","https://openalex.org/W2135686999","https://openalex.org/W2138311396","https://openalex.org/W2142047537","https://openalex.org/W2144522321","https://openalex.org/W2155015733","https://openalex.org/W2157535220","https://openalex.org/W2573367782"],"related_works":["https://openalex.org/W7100988207","https://openalex.org/W2017642230","https://openalex.org/W2948242406","https://openalex.org/W2047333119","https://openalex.org/W2066304458","https://openalex.org/W2157535220","https://openalex.org/W1853528758","https://openalex.org/W2052029497","https://openalex.org/W1578537711","https://openalex.org/W4378952349"],"abstract_inverted_index":{"\u03b1-Synuclein":[0],"is":[1,19,32,187],"the":[2,8,27,61,90,124,135,157,178],"main":[3],"component":[4],"of":[5,13,23,29,36,63,117,126,137,160,180],"Lewy":[6,37],"bodies,":[7],"intraneuronal":[9],"inclusion":[10],"bodies":[11],"characteristic":[12],"Parkinson's":[14],"disease.":[15],"Although":[16],"\u03b1-synuclein":[17,30,48,64,71,127,140,146,164,181,191],"accumulation":[18],"caused":[20],"by":[21,46,82,119,190],"inhibition":[22,116],"proteasome":[24],"and":[25,66,76,87],"autophagy-lysosome,":[26],"degradation":[28],"inclusions":[31,39,65,72,99,128,147,192],"still":[33],"unknown.":[34],"Formation":[35],"body-like":[38],"can":[40],"be":[41],"replicated":[42],"in":[43,51,93,102,163,177,193],"cultured":[44],"cells":[45],"introducing":[47],"fibrils":[49],"generated":[50],"vitro.":[52],"We":[53],"used":[54],"this":[55],"cell":[56,95],"culture":[57],"model":[58],"to":[59,89],"investigate":[60],"autophagy":[62,118],"impaired":[67,161],"mitochondria.":[68],"The":[69],"intracellular":[70],"immediately":[73],"underwent":[74],"phosphorylation":[75],"ubiquitination.":[77],"Simultaneously":[78],"they":[79],"were":[80,100,169],"encircled":[81],"an":[83],"adaptor":[84],"protein":[85],"p62/SQSTM1":[86],"directed":[88],"autophagy-lysosome":[91],"pathway":[92],"HEK293":[94,194],"line.":[96],"Most":[97],"phospho-\u03b1-synuclein-positive":[98],"degraded":[101],"24":[103],"h,":[104],"however,":[105],"lysosomal":[106],"dysfunction":[107],"with":[108],"bafilomycin":[109],"A1":[110],"significantly":[111],"affected":[112],"their":[113],"clearance.":[114],"Moreover,":[115],"Atg-5":[120],"siRNA":[121],"treatment":[122],"reduced":[123],"incorporation":[125],"into":[129],"LC3-positive":[130],"autophagosomes.":[131],"Knockdown":[132],"experiments":[133],"demonstrated":[134],"requirement":[136],"p62":[138],"for":[139,151],"autophagy.":[141,153],"These":[142],"results":[143],"demonstrate":[144],"that":[145,184],"are":[148],"preferred":[149],"targets":[150],"p62-dependent":[152],"Next,":[154],"we":[155],"investigated":[156],"autophagic":[158],"clearance":[159,186],"mitochondria":[162,168],"inclusion-containing":[165],"cells.":[166,195],"Impaired":[167],"almost":[170],"completely":[171],"eliminated":[172],"after":[173],"mitochondrial":[174,185],"uncoupling":[175],"even":[176],"presence":[179],"inclusions,":[182],"suggesting":[183],"not":[188],"prevented":[189]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}