{"id":"https://openalex.org/W20737365","doi":null,"title":"Injury to cultured endothelial cells by thrombin-stimulated platelets.","display_name":"Injury to cultured endothelial cells by thrombin-stimulated platelets.","publication_year":1986,"publication_date":"1986-04-01","ids":{"openalex":"https://openalex.org/W20737365","mag":"20737365","pmid":"https://pubmed.ncbi.nlm.nih.gov/3959543"},"language":"en","primary_location":{"id":"pmid:3959543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3959543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111651091","display_name":"L. J\u00f6rgensen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L J\u00f8rgensen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109216999","display_name":"Ann Grothe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A G Gr\u00f8the","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Larsen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Larsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112758965","display_name":"RL Kinlough-Rathbone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R L Kinlough-Rathbone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103380870","display_name":"J. Fraser Mustard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J F Mustard","raw_affiliation_strings":["McMaster University, Hamilton, Ontario"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McMaster University, Hamilton, Ontario","institution_ids":["https://openalex.org/I98251732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9472,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.8537367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"54","issue":"4","first_page":"408","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.6826000213623047,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.6826000213623047,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.27730000019073486,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.8659999966621399},{"id":"https://openalex.org/keywords/thrombin-stimulated-platelets","display_name":"thrombin-stimulated platelets","score":0.878000020980835},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/platelet-endothelial-interaction","display_name":"platelet-endothelium interaction","score":0.8389999866485596},{"id":"https://openalex.org/keywords/endothelial-cell-detachment","display_name":"endothelial cell detachment","score":0.8560000061988831},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.8939999938011169}],"concepts":[{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.9091707468032837},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.8817666172981262},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.6492058038711548},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5650638937950134},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5057065486907959},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4570361375808716},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3971218764781952},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3306288719177246},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3304564356803894},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31989210844039917},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24684029817581177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23313862085342407}],"mesh":[{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001808","descriptor_name":"Blood Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001808","descriptor_name":"Blood Vessels","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002860","descriptor_name":"Chromium Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010973","descriptor_name":"Platelet Adhesiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3959543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3959543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:20737365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3959543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W2069339398","https://openalex.org/W2057453966","https://openalex.org/W2078445898","https://openalex.org/W2113560809","https://openalex.org/W2054390928","https://openalex.org/W2002126357","https://openalex.org/W2043834487","https://openalex.org/W2057983254"],"related_works":["https://openalex.org/W2883091035","https://openalex.org/W1979197865","https://openalex.org/W2946321171","https://openalex.org/W148516322","https://openalex.org/W2270313534","https://openalex.org/W1995627333","https://openalex.org/W1965497404","https://openalex.org/W2013617978","https://openalex.org/W1977692584","https://openalex.org/W2020851802"],"abstract_inverted_index":{"In":[0],"vivo,":[1],"stimulated":[2,286],"platelets":[3,46,149,193,235],"may":[4],"injure":[5],"the":[6,60,63,77,81,87,91,95,114,148,154,164,169,192,199,202,212,215,220,237,244,258,270,283],"endothelium.":[7],"We":[8],"have":[9],"used":[10,100],"cultured":[11,28,229,259],"endothelial":[12,16,88,230,245,260],"cells":[13,26,74,89,110,231],"to":[14,59,125,172,198,233,243,278],"assess":[15],"cell":[17,104],"damage":[18],"caused":[19,178,265],"by":[20,266],"platelet":[21,120,129,137,248],"stimulation":[22,249],"with":[23,37,119,127,135,150,194,250],"thrombin.":[24,140],"Endothelial":[25],"were":[27,35,57,97,117],"from":[29,76,86,269],"umbilical":[30],"veins":[31],"and":[32,51,62,80,99,111,122,133,224,241],"semiconfluent":[33],"cultures":[34],"labeled":[36],"Na2":[38],"51CrO4.":[39],"Twenty":[40],"four":[41],"hours":[42],"later":[43],"washed":[44],"human":[45],"(final":[47,53],"concentration":[48,54],"200,000":[49],"platelets/microliters)":[50],"thrombin":[52,123,132,151,251],"4":[55],"units/ml)":[56],"added":[58],"medium":[61],"culture":[64,78],"dish":[65,79],"was":[66],"shaken":[67],"for":[68],"15":[69],"minutes.":[70],"The":[71,141],"percentage":[72,82,155,165],"of":[73,83,103,108,147,156,166,182,188,191,205,217,228,239,285],"detached":[75],"51Cr":[84,112,167,218],"lost":[85],"into":[90,219],"ambient":[92,115,170,221],"fluid":[93,116,171],"during":[94],"shaking":[96],"determined":[98],"as":[101],"indicators":[102],"injury.":[105],"Increased":[106],"percentages":[107],"loosened":[109,157],"in":[113,168,276],"observed":[118],"suspension":[121,130,138],"compared":[124],"controls":[126,134],"neither":[128],"nor":[131],"either":[136],"or":[139],"platelet-free":[142],"supernatant":[143],"obtained":[144],"after":[145],"reaction":[146],"also":[152],"increased":[153,186],"cells,":[158],"but":[159,184,208],"it":[160],"did":[161,209],"not":[162,210],"increase":[163],"a":[173,179,262],"significant":[174],"degree.":[175],"Thrombin":[176],"alone":[177],"moderate":[180],"loss":[181],"51Cr,":[183],"no":[185],"loosening":[187,240,263],"cells.":[189,246],"Treatment":[190],"acetylsalicylic":[195],"acid":[196],"prior":[197],"experiment":[200],"depressed":[201],"detachment":[203],"effect":[204,213,264,274],"thrombin-stimulated":[206,234],"platelets,":[207],"alter":[211],"on":[214,257],"release":[216],"fluid.":[222],"Scanning":[223],"transmission":[225],"electron":[226],"microscopy":[227],"exposed":[232],"confirmed":[236],"presence":[238,284],"injury":[242,273],"Thus,":[247],"had":[252],"at":[253],"least":[254],"two":[255],"effects":[256],"cells:":[261],"material":[267],"released":[268],"platelets;":[271],"an":[272],"which,":[275],"order":[277],"reach":[279],"its":[280],"maximum,":[281],"required":[282],"platelets.":[287]},"counts_by_year":[{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
