{"id":"https://openalex.org/W2073676252","doi":"https://doi.org/10.1126/science.280.5367.1274","title":"Distinct WNT Pathways Regulating AER Formation and Dorsoventral Polarity in the Chick Limb Bud","display_name":"Distinct WNT Pathways Regulating AER Formation and Dorsoventral Polarity in the Chick Limb Bud","publication_year":1998,"publication_date":"1998-05-22","ids":{"openalex":"https://openalex.org/W2073676252","doi":"https://doi.org/10.1126/science.280.5367.1274","mag":"2073676252","pmid":"https://pubmed.ncbi.nlm.nih.gov/9596583"},"language":"en","primary_location":{"id":"doi:10.1126/science.280.5367.1274","doi":"https://doi.org/10.1126/science.280.5367.1274","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.280.5367.1274","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044295729","display_name":"Mineko Kengaku","orcid":"https://orcid.org/0000-0002-1666-3648","observed_orcids":["https://orcid.org/0000-0002-1666-3648"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mineko Kengaku","raw_affiliation_strings":["J. Capdevila, C. Rodriguez-Esteban, J. De La Pen\u0303a, J. C. I. Belmonte, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA","M. Kengaku and C. J. Tabin, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","R. L. Johnson, Department of Biochemistry and Molecular Biology, M.D. Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. Capdevila, C. Rodriguez-Esteban, J. De La Pen\u0303a, J. C. I. Belmonte, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"M. Kengaku and C. J. Tabin, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"R. L. Johnson, Department of Biochemistry and Molecular Biology, M.D. Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109918410","display_name":"Javier Capdevila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Javier Capdevila","raw_affiliation_strings":["J. Capdevila, C. Rodriguez-Esteban, J. De La Pen\u0303a, J. C. I. Belmonte, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA","M. Kengaku and C. J. Tabin, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","R. L. Johnson, Department of Biochemistry and Molecular Biology, M.D. Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. Capdevila, C. Rodriguez-Esteban, J. De La Pen\u0303a, J. C. I. Belmonte, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"M. Kengaku and C. J. Tabin, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"R. L. Johnson, Department of Biochemistry and Molecular Biology, M.D. Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008875501","display_name":"Concepci\u00f3n Rodr\u0131\u0301guez-Esteban","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Concepcio\u0301n Rodriguez-Esteban","raw_affiliation_strings":["J. Capdevila, C. Rodriguez-Esteban, J. De La Pen\u0303a, J. C. I. Belmonte, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA","M. Kengaku and C. J. Tabin, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","R. L. Johnson, Department of Biochemistry and Molecular Biology, M.D. Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. Capdevila, C. Rodriguez-Esteban, J. De La Pen\u0303a, J. C. I. Belmonte, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"M. Kengaku and C. J. Tabin, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"R. L. Johnson, Department of Biochemistry and Molecular Biology, M.D. Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111929640","display_name":"Jennifer De La Pe\u00f1a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer De La Pen\u0303a","raw_affiliation_strings":["J. Capdevila, C. Rodriguez-Esteban, J. De La Pen\u0303a, J. C. I. Belmonte, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA","M. Kengaku and C. J. Tabin, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","R. L. Johnson, Department of Biochemistry and Molecular Biology, M.D. Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. Capdevila, C. Rodriguez-Esteban, J. De La Pen\u0303a, J. C. I. Belmonte, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"M. Kengaku and C. J. Tabin, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"R. L. Johnson, Department of Biochemistry and Molecular Biology, M.D. Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069957994","display_name":"Randy L. Johnson","orcid":"https://orcid.org/0000-0003-4549-3593","observed_orcids":["https://orcid.org/0000-0003-4549-3593"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randy L. Johnson","raw_affiliation_strings":["J. Capdevila, C. Rodriguez-Esteban, J. De La Pen\u0303a, J. C. I. Belmonte, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA","M. Kengaku and C. J. Tabin, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","R. L. Johnson, Department of Biochemistry and Molecular Biology, M.D. Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. Capdevila, C. Rodriguez-Esteban, J. De La Pen\u0303a, J. C. I. Belmonte, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"M. Kengaku and C. J. Tabin, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"R. L. Johnson, Department of Biochemistry and Molecular Biology, M.D. Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050690657","display_name":"Juan Carlos Izpis\u00faa Belmonte","orcid":"https://orcid.org/0000-0003-0557-8875","observed_orcids":["https://orcid.org/0000-0003-0557-8875"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Juan Carlos Izpisu\u0301a Belmonte","raw_affiliation_strings":["J. Capdevila, C. Rodriguez-Esteban, J. De La Pen\u0303a, J. C. I. Belmonte, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA","M. Kengaku and C. J. Tabin, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","R. L. Johnson, Department of Biochemistry and Molecular Biology, M.D. Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. Capdevila, C. Rodriguez-Esteban, J. De La Pen\u0303a, J. C. I. Belmonte, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"M. Kengaku and C. J. Tabin, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"R. L. Johnson, Department of Biochemistry and Molecular Biology, M.D. Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014300544","display_name":"Clifford James Tabin","orcid":"https://orcid.org/0000-0002-2957-4871","observed_orcids":["https://orcid.org/0000-0002-2957-4871"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Clifford J. Tabin","raw_affiliation_strings":["J. Capdevila, C. Rodriguez-Esteban, J. De La Pen\u0303a, J. C. I. Belmonte, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA","M. Kengaku and C. J. Tabin, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","R. L. Johnson, Department of Biochemistry and Molecular Biology, M.D. Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. Capdevila, C. Rodriguez-Esteban, J. De La Pen\u0303a, J. C. I. Belmonte, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"M. Kengaku and C. J. Tabin, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"R. L. Johnson, Department of Biochemistry and Molecular Biology, M.D. Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008875501","https://openalex.org/A5014300544","https://openalex.org/A5044295729","https://openalex.org/A5050690657","https://openalex.org/A5109918410"],"corresponding_institution_ids":["https://openalex.org/I1307098950","https://openalex.org/I1343551460","https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":10.8083,"has_fulltext":false,"cited_by_count":411,"citation_normalized_percentile":{"value":0.99083854,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"280","issue":"5367","first_page":"1274","last_page":"1277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.06289999932050705,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13107","display_name":"Congenital limb and hand anomalies","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1309","display_name":"Developmental Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apical-ectodermal-ridge","display_name":"apical ectodermal ridge","score":0.968999981880188},{"id":"https://openalex.org/keywords/wnt3a","display_name":"Wnt3a","score":0.9309999942779541},{"id":"https://openalex.org/keywords/wnt7a","display_name":"Wnt7a","score":0.9990000128746033},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.7829999923706055},{"id":"https://openalex.org/keywords/lef1","display_name":"LEF1","score":0.8130000233650208},{"id":"https://openalex.org/keywords/dorsoventral-polarity","display_name":"dorsoventral polarity","score":0.8399999737739563},{"id":"https://openalex.org/keywords/chick-limb-bud","display_name":"chick limb bud","score":0.8370000123977661},{"id":"https://openalex.org/keywords/limb-development","display_name":"limb development","score":0.9589999914169312}],"concepts":[{"id":"https://openalex.org/C84013057","wikidata":"https://www.wikidata.org/wiki/Q2919735","display_name":"Zone of polarizing activity","level":5,"score":0.8268284201622009},{"id":"https://openalex.org/C102309675","wikidata":"https://www.wikidata.org/wiki/Q4779801","display_name":"Apical ectodermal ridge","level":5,"score":0.8210037350654602},{"id":"https://openalex.org/C25770073","wikidata":"https://www.wikidata.org/wiki/Q6548937","display_name":"Limb bud","level":3,"score":0.8167726397514343},{"id":"https://openalex.org/C2779329299","wikidata":"https://www.wikidata.org/wiki/Q272474","display_name":"Ectoderm","level":4,"score":0.812130868434906},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.7864233255386353},{"id":"https://openalex.org/C2779131293","wikidata":"https://www.wikidata.org/wiki/Q18048098","display_name":"WNT3A","level":4,"score":0.7603275775909424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7005033493041992},{"id":"https://openalex.org/C86370654","wikidata":"https://www.wikidata.org/wiki/Q2277862","display_name":"Limb development","level":3,"score":0.6667559742927551},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6173022389411926},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.5971259474754333},{"id":"https://openalex.org/C2777361361","wikidata":"https://www.wikidata.org/wiki/Q1112585","display_name":"Polarity (international relations)","level":3,"score":0.5649511814117432},{"id":"https://openalex.org/C49353375","wikidata":"https://www.wikidata.org/wiki/Q189100","display_name":"Cell polarity","level":3,"score":0.4161972999572754},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.4106498956680298},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39041662216186523},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.34158143401145935},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3052740693092346},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1995832920074463},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.1517728865146637},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.1477038860321045},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.09577915072441101}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004475","descriptor_name":"Ectoderm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005964","descriptor_name":"Glucosyltransferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018878","descriptor_name":"Limb Buds","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D018878","descriptor_name":"Limb Buds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030161","descriptor_name":"Avian Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051519","descriptor_name":"Fibroblast Growth Factor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051524","descriptor_name":"Fibroblast Growth Factor 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051821","descriptor_name":"Lymphoid Enhancer-Binding Factor 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060508","descriptor_name":"Wnt3 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060509","descriptor_name":"Wnt3A Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.280.5367.1274","doi":"https://doi.org/10.1126/science.280.5367.1274","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.280.5367.1274","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:9596583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9596583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1489145497","https://openalex.org/W1520481055","https://openalex.org/W1549691444","https://openalex.org/W1940197179","https://openalex.org/W1963463566","https://openalex.org/W1967137553","https://openalex.org/W1980955976","https://openalex.org/W1981792027","https://openalex.org/W1984398635","https://openalex.org/W2007215839","https://openalex.org/W2010909290","https://openalex.org/W2022154218","https://openalex.org/W2026533505","https://openalex.org/W2034030391","https://openalex.org/W2038763845","https://openalex.org/W2046813157","https://openalex.org/W2047004075","https://openalex.org/W2073908723","https://openalex.org/W2075639475","https://openalex.org/W2081362596","https://openalex.org/W2081704147","https://openalex.org/W2090636859","https://openalex.org/W2099002558","https://openalex.org/W2111334408","https://openalex.org/W2125635238","https://openalex.org/W2142728087","https://openalex.org/W2144300167","https://openalex.org/W2152678597","https://openalex.org/W4246928882","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2002989908","https://openalex.org/W1539885560","https://openalex.org/W7073579895","https://openalex.org/W2039282080","https://openalex.org/W2188828301","https://openalex.org/W2005615064","https://openalex.org/W2010909290","https://openalex.org/W6981385783","https://openalex.org/W2005956784","https://openalex.org/W1964975973"],"abstract_inverted_index":{"The":[0,37],"apical":[1],"ectodermal":[2],"ridge":[3],"(AER)":[4],"is":[5,14],"an":[6],"essential":[7],"structure":[8],"for":[9],"vertebrate":[10],"limb":[11,35],"development.":[12],"Wnt3a":[13,26,58],"expressed":[15],"during":[16],"the":[17,20,34,44,50,64,74,79,90],"induction":[18],"of":[19,25,30,46,78],"chick":[21],"AER,":[22],"and":[23,40,48],"misexpression":[24],"induces":[27],"ectopic":[28],"expression":[29],"AER-specific":[31],"genes":[32,38,85],"in":[33,60,89],"ectoderm.":[36],"beta-catenin":[39,70],"Lef1":[41,52,72],"can":[42],"mimic":[43],"effect":[45],"Wnt3a,":[47],"blocking":[49],"intrinsic":[51],"activity":[53],"disrupts":[54],"AER":[55,61],"formation.":[56],"Hence,":[57],"functions":[59],"formation":[62],"through":[63],"beta-catenin/LEF1":[65],"pathway.":[66],"In":[67],"contrast,":[68],"neither":[69],"nor":[71],"affects":[73],"Wnt7a-regulated":[75],"dorsoventral":[76],"polarity":[77],"limb.":[80],"Thus,":[81],"two":[82],"related":[83],"Wnt":[84],"elicit":[86],"distinct":[87],"responses":[88],"same":[91],"tissues":[92],"by":[93],"using":[94],"different":[95],"intracellular":[96],"pathways.":[97]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":12}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}