{"id":"https://openalex.org/W2073674559","doi":"https://doi.org/10.12659/msm.892768","title":"Effectiveness and Safety of Tranexamic Acid for Total Knee Arthroplasty: A Prospective Randomized Controlled Trial","display_name":"Effectiveness and Safety of Tranexamic Acid for Total Knee Arthroplasty: A Prospective Randomized Controlled Trial","publication_year":2015,"publication_date":"2015-02-22","ids":{"openalex":"https://openalex.org/W2073674559","doi":"https://doi.org/10.12659/msm.892768","mag":"2073674559","pmid":"https://pubmed.ncbi.nlm.nih.gov/25702095","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4347720"},"language":"en","primary_location":{"id":"doi:10.12659/msm.892768","doi":"https://doi.org/10.12659/msm.892768","is_oa":true,"landing_page_url":"https://doi.org/10.12659/msm.892768","pdf_url":"https://medscimonit.com/download/index/idArt/892768","source":{"id":"https://openalex.org/S156858864","display_name":"Medical Science Monitor","issn_l":"1234-1010","issn":["1234-1010","1643-3750"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320062","host_organization_name":"International Scientific Information Inc.","host_organization_lineage":["https://openalex.org/P4310320062"],"host_organization_lineage_names":["International Scientific Information Inc."],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Science Monitor","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://medscimonit.com/download/index/idArt/892768","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030820662","display_name":"Shen Peng-fei","orcid":"https://orcid.org/0000-0002-2360-5737","observed_orcids":["https://orcid.org/0000-0002-2360-5737"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peng-Fei Shen","raw_affiliation_strings":["Department of Orthopedics, Changzhou Traditional Chinese Medicine Hospital, Changzhou, Jiangsu, China (mainland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changzhou Traditional Chinese Medicine Hospital, Changzhou, Jiangsu, China (mainland)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008025769","display_name":"Wei-lin Hou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei-Lin Hou","raw_affiliation_strings":["Department of Orthopedics, Changzhou Traditional Chinese Medicine Hospital, Changzhou, Jiangsu, China (mainland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changzhou Traditional Chinese Medicine Hospital, Changzhou, Jiangsu, China (mainland)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079392782","display_name":"Jianbo Chen","orcid":"https://orcid.org/0000-0001-6491-6577","observed_orcids":["https://orcid.org/0000-0001-6491-6577"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian-Bo Chen","raw_affiliation_strings":["Department of Orthopedics, Changzhou Traditional Chinese Medicine Hospital, Changzhou, Jiangsu, China (mainland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changzhou Traditional Chinese Medicine Hospital, Changzhou, Jiangsu, China (mainland)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100382519","display_name":"Bing Wang","orcid":"https://orcid.org/0000-0002-7028-389X","observed_orcids":["https://orcid.org/0000-0002-7028-389X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bing Wang","raw_affiliation_strings":["Department of Orthopedics, Changzhou Traditional Chinese Medicine Hospital, Changzhou, Jiangsu, China (mainland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changzhou Traditional Chinese Medicine Hospital, Changzhou, Jiangsu, China (mainland)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109304505","display_name":"Yuxing Qu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yu-Xing Qu","raw_affiliation_strings":["Department of Orthopedics, Changzhou Traditional Chinese Medicine Hospital, Changzhou, Jiangsu, China (mainland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Changzhou Traditional Chinese Medicine Hospital, Changzhou, Jiangsu, China (mainland)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109304505"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.8411,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.97227465,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"21","issue":null,"first_page":"576","last_page":"581"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tranexamic-acid","display_name":"tranexamic acid","score":1.0},{"id":"https://openalex.org/keywords/total-knee-arthroplasty","display_name":"total knee arthroplasty","score":1.0},{"id":"https://openalex.org/keywords/perioperative-blood-loss","display_name":"perioperative blood loss","score":0.9919999837875366},{"id":"https://openalex.org/keywords/blood-transfusion","display_name":"blood transfusion","score":0.6639999747276306},{"id":"https://openalex.org/keywords/postoperative-hemoglobin","display_name":"postoperative hemoglobin","score":0.6370000243186951},{"id":"https://openalex.org/keywords/deep-vein-thrombosis","display_name":"deep vein thrombosis","score":0.859000027179718},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.906000018119812},{"id":"https://openalex.org/keywords/postoperative-ecchymosis","display_name":"postoperative ecchymosis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/hidden-blood-loss","display_name":"hidden blood loss","score":0.6759999990463257},{"id":"https://openalex.org/keywords/tourniquet","display_name":"tourniquet","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2779637338","wikidata":"https://www.wikidata.org/wiki/Q418666","display_name":"Tranexamic acid","level":3,"score":0.9585732221603394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6777663230895996},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6157604455947876},{"id":"https://openalex.org/C3017871827","wikidata":"https://www.wikidata.org/wiki/Q1693864","display_name":"Total knee arthroplasty","level":2,"score":0.612695574760437},{"id":"https://openalex.org/C2778336525","wikidata":"https://www.wikidata.org/wiki/Q708178","display_name":"Arthroplasty","level":2,"score":0.5723465085029602},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4533488154411316},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39013224840164185},{"id":"https://openalex.org/C2991743468","wikidata":"https://www.wikidata.org/wiki/Q166019","display_name":"Blood loss","level":2,"score":0.15115892887115479}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003710","descriptor_name":"Demography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016063","descriptor_name":"Blood Loss, Surgical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019645","descriptor_name":"Arthroplasty, Replacement, Knee","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.12659/msm.892768","doi":"https://doi.org/10.12659/msm.892768","is_oa":true,"landing_page_url":"https://doi.org/10.12659/msm.892768","pdf_url":"https://medscimonit.com/download/index/idArt/892768","source":{"id":"https://openalex.org/S156858864","display_name":"Medical Science Monitor","issn_l":"1234-1010","issn":["1234-1010","1643-3750"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320062","host_organization_name":"International Scientific Information Inc.","host_organization_lineage":["https://openalex.org/P4310320062"],"host_organization_lineage_names":["International Scientific Information Inc."],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Science Monitor","raw_type":"journal-article"},{"id":"pmid:25702095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25702095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical science monitor : international medical journal of experimental and clinical research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4347720","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4347720/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Med Sci Monit","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.790.382","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.790.382","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c7/f7/medscimonit-21-576.PMC4347720.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.12659/msm.892768","doi":"https://doi.org/10.12659/msm.892768","is_oa":true,"landing_page_url":"https://doi.org/10.12659/msm.892768","pdf_url":"https://medscimonit.com/download/index/idArt/892768","source":{"id":"https://openalex.org/S156858864","display_name":"Medical Science Monitor","issn_l":"1234-1010","issn":["1234-1010","1643-3750"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320062","host_organization_name":"International Scientific Information Inc.","host_organization_lineage":["https://openalex.org/P4310320062"],"host_organization_lineage_names":["International Scientific Information Inc."],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Science Monitor","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2073674559.pdf","grobid_xml":"https://content.openalex.org/works/W2073674559.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W119895313","https://openalex.org/W1776155950","https://openalex.org/W1981196689","https://openalex.org/W2027207979","https://openalex.org/W2039547663","https://openalex.org/W2043912620","https://openalex.org/W2059777330","https://openalex.org/W2073007365","https://openalex.org/W2090919089","https://openalex.org/W2098149785","https://openalex.org/W2098686310","https://openalex.org/W2105488797","https://openalex.org/W2111373463","https://openalex.org/W2120619631","https://openalex.org/W2135367472","https://openalex.org/W2187967006","https://openalex.org/W2287002285","https://openalex.org/W2324437595","https://openalex.org/W2605806871","https://openalex.org/W4297066808"],"related_works":["https://openalex.org/W3029863333","https://openalex.org/W3037897147","https://openalex.org/W4407255893","https://openalex.org/W2193192378","https://openalex.org/W3029146956","https://openalex.org/W2413190427","https://openalex.org/W2524368225","https://openalex.org/W2400465632","https://openalex.org/W153964685","https://openalex.org/W2034434540"],"abstract_inverted_index":{"BACKGROUND:":[0],"Total":[1],"knee":[2],"arthroplasty":[3],"(TKA)":[4],"is":[5,240],"associated":[6,242],"with":[7,243],"significant":[8],"perioperative":[9,31],"blood":[10,32,96,107,110,162,165,215],"loss":[11,33,216],"and":[12,23,122,131,167,205],"need":[13],"for":[14,144],"transfusion.":[15],"This":[16],"study":[17],"aimed":[18],"to":[19,29,53],"evaluate":[20],"the":[21,72,86,168,176,181,192,197,232],"effectiveness":[22],"safety":[24],"of":[25,43,75,115,127,139,170,203,238,246],"tranexamic":[26],"acid":[27],"(TXA)":[28],"reduce":[30],"in":[34,62,175,180,191,196,209],"patients":[35,45,141],"receiving":[36],"TKA.":[37],"MATERIAL":[38],"AND":[39],"METHODS:":[40],"A":[41,137],"total":[42,103,109,138,158,164],"92":[44],"who":[46],"accepted":[47],"unilateral":[48],"TKA":[49,221],"from":[50],"May":[51,54],"2012":[52],"2013":[55],"randomly":[56],"received":[57],"either":[58],"15":[59,83,225,229],"mg/kg":[60,226],"TXA":[61,177,193,227,239],"100":[63],"mL":[64],"normal":[65,76],"saline":[66,77],"solution":[67,78],"(TXA":[68,146],"group,":[69,80,147,150],"n=46)":[70,81],"or":[71],"same":[73],"amount":[74],"(placebo":[79],"at":[82,100,119,228],"min":[84,230],"before":[85,231],"tourniquet":[87,233],"was":[88,189,207,234],"loosened.":[89,235],"The":[90,185,201,236],"following":[91],"data":[92],"were":[93,142,173],"recorded:":[94],"intraoperative":[95],"loss;":[97,108,111],"post-operative":[98,117,154,186],"drainage":[99,104,159],"12":[101],"h;":[102],"amount;":[105],"hidden":[106,161],"transfusion":[112,204],"volumes;":[113],"number":[114,126],"transfusions;":[116],"hemoglobin":[118],"1,":[120],"3,":[121],"5":[123],"days;":[124],"D-dimer;":[125],"lower":[128,174],"limb":[129],"ecchymoses;":[130],"deep":[132],"vein":[133],"thrombosis":[134],"(DVT).":[135],"RESULTS:":[136],"81":[140],"available":[143],"analysis":[145],"n=41;":[148],"placebo":[149,182,198],"n=40).":[151],"Post-operative12-h":[152],"drainage,":[153],"24-h":[155],"D-dimer":[156],"values,":[157],"volume,":[160],"loss,":[163,166],"rate":[169,202],"postoperative":[171],"ecchymosis":[172],"group":[178,183,194,199],"than":[179,195],"(p<0.05).":[184],"3-day":[187],"Hgb":[188],"higher":[190],"(p=0.000).":[200],"DVT":[206],"similar":[208],"both":[210],"groups":[211],"(n.s.).":[212],"CONCLUSIONS:":[213],"Perioperative":[214],"could":[217],"be":[218],"reduced":[219],"after":[220],"by":[222],"intravenously":[223],"injecting":[224],"application":[237],"not":[241],"increased":[244],"risk":[245],"DVT.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}