{"id":"https://openalex.org/W2073671344","doi":"https://doi.org/10.1111/j.1476-5381.1990.tb12115.x","title":"Evidence for the presynaptic action of 5\u2010hydroxytryptamine and the involvement of purinergic innervation in the rabbit lower urinary tract","display_name":"Evidence for the presynaptic action of 5\u2010hydroxytryptamine and the involvement of purinergic innervation in the rabbit lower urinary tract","publication_year":1990,"publication_date":"1990-09-01","ids":{"openalex":"https://openalex.org/W2073671344","doi":"https://doi.org/10.1111/j.1476-5381.1990.tb12115.x","mag":"2073671344","pmid":"https://pubmed.ncbi.nlm.nih.gov/2178017","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1917638"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.1990.tb12115.x","doi":"https://doi.org/10.1111/j.1476-5381.1990.tb12115.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1990.tb12115.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1990.tb12115.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1990.tb12115.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111812873","display_name":"Hong\u2010I Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Hong\u2010I Chen","raw_affiliation_strings":["University Department of Pharmacology, University of Oxford","University Department of Pharmacology, University of Oxford, South Parks Road, Oxford, OX1 3QT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Pharmacology, University of Oxford","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"University Department of Pharmacology, University of Oxford, South Parks Road, Oxford, OX1 3QT","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111812873"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":3.038,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.90338876,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"101","issue":"1","first_page":"212","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/presynaptic-action","display_name":"presynaptic action","score":0.7160000205039978},{"id":"https://openalex.org/keywords/lower-urinary-tract","display_name":"lower urinary tract","score":0.8619999885559082},{"id":"https://openalex.org/keywords/detrusor-contraction","display_name":"detrusor contraction","score":0.800000011920929},{"id":"https://openalex.org/keywords/urethral-smooth-muscle","display_name":"urethral smooth muscle","score":0.9200000166893005},{"id":"https://openalex.org/keywords/5-ht3-receptor","display_name":"5-HT3 receptor","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mdl-72222","display_name":"MDL 72222","score":0.8539999723434448},{"id":"https://openalex.org/keywords/tropisetron","display_name":"tropisetron","score":0.9240000247955322},{"id":"https://openalex.org/keywords/ketanserin","display_name":"ketanserin","score":0.7630000114440918},{"id":"https://openalex.org/keywords/methysergide","display_name":"methysergide","score":0.9539999961853027},{"id":"https://openalex.org/keywords/atropine","display_name":"atropine","score":0.8050000071525574},{"id":"https://openalex.org/keywords/alpha-beta-methylene-atp","display_name":"alpha,beta-methylene ATP","score":0.9490000009536743},{"id":"https://openalex.org/keywords/non-adrenergic-non-cholinergic-neurotransmission","display_name":"non-adrenergic non-cholinergic neurotransmission","score":0.9070000052452087},{"id":"https://openalex.org/keywords/electrical-field-stimulation","display_name":"electrical field stimulation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C2781005078","wikidata":"https://www.wikidata.org/wiki/Q424442","display_name":"Methysergide","level":4,"score":0.9139320850372314},{"id":"https://openalex.org/C2777785214","wikidata":"https://www.wikidata.org/wiki/Q415997","display_name":"Ketanserin","level":5,"score":0.7319613695144653},{"id":"https://openalex.org/C2780648677","wikidata":"https://www.wikidata.org/wiki/Q425296","display_name":"Prazosin","level":4,"score":0.6712243556976318},{"id":"https://openalex.org/C2780253649","wikidata":"https://www.wikidata.org/wiki/Q420360","display_name":"Phentolamine","level":3,"score":0.6440027952194214},{"id":"https://openalex.org/C2780019924","wikidata":"https://www.wikidata.org/wiki/Q7120083","display_name":"PPADS","level":4,"score":0.6060909628868103},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6028580069541931},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6016008853912354},{"id":"https://openalex.org/C57306754","wikidata":"https://www.wikidata.org/wiki/Q1010629","display_name":"Purinergic receptor","level":3,"score":0.5813926458358765},{"id":"https://openalex.org/C2775893369","wikidata":"https://www.wikidata.org/wiki/Q410557","display_name":"Hexamethonium","level":3,"score":0.5451298952102661},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5266793966293335},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.4679397940635681},{"id":"https://openalex.org/C2775859210","wikidata":"https://www.wikidata.org/wiki/Q26272","display_name":"Atropine","level":2,"score":0.4654339849948883},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.4617573916912079},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.4615139961242676},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3916819989681244},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3615177273750305},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3559522032737732},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.3298770785331726},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.29628729820251465},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2556624114513397},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.24987265467643738},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19223913550376892},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.11605396866798401}],"mesh":[{"descriptor_ui":"D000077526","descriptor_name":"Tropisetron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001285","descriptor_name":"Atropine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014326","descriptor_name":"Tropanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014521","descriptor_name":"Urethra","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014551","descriptor_name":"Urinary Tract","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D017829","descriptor_name":"Granisetron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1476-5381.1990.tb12115.x","doi":"https://doi.org/10.1111/j.1476-5381.1990.tb12115.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1990.tb12115.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1990.tb12115.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1917638","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1917638","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmid:2178017","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2178017","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1476-5381.1990.tb12115.x","doi":"https://doi.org/10.1111/j.1476-5381.1990.tb12115.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1990.tb12115.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1990.tb12115.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2073671344.pdf","grobid_xml":"https://content.openalex.org/works/W2073671344.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W75653604","https://openalex.org/W84078659","https://openalex.org/W1521210328","https://openalex.org/W1595292389","https://openalex.org/W1926506503","https://openalex.org/W1968708631","https://openalex.org/W1979370204","https://openalex.org/W1981492725","https://openalex.org/W1983739679","https://openalex.org/W1987668393","https://openalex.org/W1991410513","https://openalex.org/W1995604771","https://openalex.org/W1995909187","https://openalex.org/W1998615691","https://openalex.org/W2003700491","https://openalex.org/W2005395166","https://openalex.org/W2007399047","https://openalex.org/W2012141492","https://openalex.org/W2016527469","https://openalex.org/W2019547393","https://openalex.org/W2041262227","https://openalex.org/W2049015612","https://openalex.org/W2052699760","https://openalex.org/W2081874031","https://openalex.org/W2086898945","https://openalex.org/W2094089660","https://openalex.org/W2115623279","https://openalex.org/W2141641013","https://openalex.org/W2142367588","https://openalex.org/W2149099917","https://openalex.org/W2149454735","https://openalex.org/W2243059796","https://openalex.org/W2271225187","https://openalex.org/W2287013486","https://openalex.org/W2408913717","https://openalex.org/W4407044630"],"related_works":["https://openalex.org/W1973480285","https://openalex.org/W1999479024","https://openalex.org/W2772674046","https://openalex.org/W2016527469","https://openalex.org/W2078248414","https://openalex.org/W2141641013","https://openalex.org/W2044805947","https://openalex.org/W1922249991","https://openalex.org/W2775180670","https://openalex.org/W1961883180"],"abstract_inverted_index":{"1.":[0],"The":[1,29,99,114],"effects":[2],"of":[3,49,121],"5-hydroxytryptamine":[4],"(5-HT)":[5],"were":[6,124],"studied":[7],"in":[8,23,169],"vitro":[9],"on":[10,56,107,158],"bladder":[11],"and":[12,26,44,64,86,116,136,146,153],"urethral":[13],"muscle":[14],"strips":[15],"from":[16],"the":[17,24,37,57,71,92,108,128,132,139,159,170,181],"rabbit.":[18],"5-HT":[19,185],"produced":[20],"dose-dependent":[21],"contraction":[22,31,109,123],"detrusor":[25],"urethra.":[27],"2.":[28],"5-HT-induced":[30,122],"could":[32],"be":[33],"dose-dependently":[34],"inhibited":[35,91],"by":[36,127,188],"5-HT3":[38,100,140,178],"antagonists":[39,130,134,141],"MDL":[40,102,142],"72222,":[41,143],"ICS":[42,144],"205-930":[43,145],"BRL":[45,147],"43694.":[46,148],"No":[47],"effect":[48,106,157],"ketanserin,":[50],"methysergide":[51,137],"or":[52,138],"metitepine":[53],"was":[54],"observed":[55],"contractile":[58,72,93,160,182],"response":[59,73,94,161,183],"to":[60,74,95,110,162,184],"5-HT.":[61,75,163],"3.":[62],"Atropine":[63,85],"alpha,":[65,87,117],"beta-methylene":[66,88,118],"ATP":[67,89],"both":[68],"partially":[69],"blocked":[70],"Together":[76],"they":[77],"caused":[78],"more":[79],"inhibition":[80],"than":[81],"either":[82],"alone.":[83],"4.":[84],"also":[90],"electrical":[96],"field":[97,111],"stimulation.":[98,112],"antagonist":[101],"72222":[103],"had":[104,155],"no":[105,156],"5.":[113],"atropine-":[115],"ATP-resistant":[119],"components":[120],"not":[125],"affected":[126],"5-HT1":[129],"metitepine,":[131],"5-HT2":[133],"ketanserin":[135],"6.":[149],"Tetrodotoxin,":[150],"hexamethonium,":[151],"phentolamine":[152],"prazosin":[154],"7.":[164],"These":[165],"results":[166],"suggest":[167],"that":[168],"rabbit":[171],"lower":[172],"urinary":[173],"tract":[174],"(i)":[175],"there":[176,192],"are":[177],"receptors,":[179],"(ii)":[180],"is":[186,193],"mediated":[187],"presynaptic":[189],"stimulation,":[190],"(iii)":[191],"non-adrenergic,":[194],"non-cholinergic":[195],"excitatory":[196],"neurotransmission.":[197]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
