{"id":"https://openalex.org/W2073668720","doi":"https://doi.org/10.1007/bf01534730","title":"Chinese hamster cells deficient in ornithine decarboxylase activity: Reversion by gene amplification and by azacytidine treatment","display_name":"Chinese hamster cells deficient in ornithine decarboxylase activity: Reversion by gene amplification and by azacytidine treatment","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W2073668720","doi":"https://doi.org/10.1007/bf01534730","mag":"2073668720","pmid":"https://pubmed.ncbi.nlm.nih.gov/2579446"},"language":"en","primary_location":{"id":"doi:10.1007/bf01534730","doi":"https://doi.org/10.1007/bf01534730","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01534730","pdf_url":null,"source":{"id":"https://openalex.org/S198917220","display_name":"Somatic Cell and Molecular Genetics","issn_l":"0098-0366","issn":["0098-0366","0740-7750","1572-9931"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Somatic Cell and Molecular Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023033903","display_name":"Carolyn S. Steglich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn Steglich","raw_affiliation_strings":["Department of Biology, University of California San Diego, B-022, 92093, La Jolla, California","Department of Biology, University of California San Diego La Jolla"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of California San Diego, B-022, 92093, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Biology, University of California San Diego La Jolla","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068072988","display_name":"Ann Grens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Grens","raw_affiliation_strings":["Department of Biology, University of California San Diego, B-022, 92093, La Jolla, California","Department of Biology, University of California San Diego La Jolla"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of California San Diego, B-022, 92093, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Biology, University of California San Diego La Jolla","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024361021","display_name":"Immo E. Scheffler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Immo E. Scheffler","raw_affiliation_strings":["Department of Biology, University of California San Diego, B-022, 92093, La Jolla, California","Department of Biology, University of California San Diego La Jolla"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of California San Diego, B-022, 92093, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Biology, University of California San Diego La Jolla","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":2.5679,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.90834027,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"11","issue":"1","first_page":"11","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ornithine-decarboxylase","display_name":"ornithine decarboxylase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/gene-amplification","display_name":"gene amplification","score":0.7419999837875366},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.9390000104904175},{"id":"https://openalex.org/keywords/reversion","display_name":"reversion","score":0.6389999985694885},{"id":"https://openalex.org/keywords/complementation-groups","display_name":"complementation groups","score":0.7400000095367432},{"id":"https://openalex.org/keywords/knockout-mutants","display_name":"knockout mutants","score":0.6819999814033508},{"id":"https://openalex.org/keywords/ethyl-methanesulfonate","display_name":"ethyl methanesulfonate","score":0.718999981880188},{"id":"https://openalex.org/keywords/gene-dosage","display_name":"gene dosage","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C3018250846","wikidata":"https://www.wikidata.org/wiki/Q903441","display_name":"Methane sulfonate","level":4,"score":0.8994626402854919},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.8032538890838623},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7713722586631775},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.7577297687530518},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6626939177513123},{"id":"https://openalex.org/C70883133","wikidata":"https://www.wikidata.org/wiki/Q7318316","display_name":"Reversion","level":4,"score":0.6356028318405151},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.6011871099472046},{"id":"https://openalex.org/C121289238","wikidata":"https://www.wikidata.org/wiki/Q931579","display_name":"Ornithine decarboxylase","level":3,"score":0.5988174676895142},{"id":"https://openalex.org/C20950039","wikidata":"https://www.wikidata.org/wiki/Q578111","display_name":"Auxotrophy","level":4,"score":0.5902103185653687},{"id":"https://openalex.org/C2776796294","wikidata":"https://www.wikidata.org/wiki/Q410198","display_name":"Ornithine","level":4,"score":0.5613954067230225},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5170862674713135},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4692062735557556},{"id":"https://openalex.org/C108905728","wikidata":"https://www.wikidata.org/wiki/Q24727228","display_name":"Ornithine decarboxylase antizyme","level":4,"score":0.43504977226257324},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.4211072623729706},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3092377781867981},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.12595057487487793},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.08204537630081177},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.06144031882286072},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009952","descriptor_name":"Ornithine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D009952","descriptor_name":"Ornithine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009955","descriptor_name":"Ornithine Decarboxylase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D009955","descriptor_name":"Ornithine Decarboxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009955","descriptor_name":"Ornithine Decarboxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf01534730","doi":"https://doi.org/10.1007/bf01534730","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01534730","pdf_url":null,"source":{"id":"https://openalex.org/S198917220","display_name":"Somatic Cell and Molecular Genetics","issn_l":"0098-0366","issn":["0098-0366","0740-7750","1572-9931"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Somatic Cell and Molecular Genetics","raw_type":"journal-article"},{"id":"pmid:2579446","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2579446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Somatic cell and molecular genetics","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1484018552","display_name":null,"funder_award_id":"GM07471","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2994518206","display_name":null,"funder_award_id":"GM 18835","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W260686678","https://openalex.org/W1029204746","https://openalex.org/W1494632330","https://openalex.org/W1510871275","https://openalex.org/W1512565762","https://openalex.org/W1513994171","https://openalex.org/W1529202366","https://openalex.org/W1606965185","https://openalex.org/W1632490275","https://openalex.org/W1650774872","https://openalex.org/W1663235327","https://openalex.org/W1679966592","https://openalex.org/W1841156322","https://openalex.org/W1867400316","https://openalex.org/W1964556049","https://openalex.org/W1968137605","https://openalex.org/W1971735319","https://openalex.org/W1983582864","https://openalex.org/W2008563472","https://openalex.org/W2011836510","https://openalex.org/W2021960562","https://openalex.org/W2023295893","https://openalex.org/W2030632897","https://openalex.org/W2036303296","https://openalex.org/W2040278824","https://openalex.org/W2040381235","https://openalex.org/W2042230780","https://openalex.org/W2043508927","https://openalex.org/W2045553639","https://openalex.org/W2052915168","https://openalex.org/W2059333614","https://openalex.org/W2060262724","https://openalex.org/W2060333964","https://openalex.org/W2060987454","https://openalex.org/W2066160869","https://openalex.org/W2066646864","https://openalex.org/W2071489383","https://openalex.org/W2078987244","https://openalex.org/W2080937251","https://openalex.org/W2095594022","https://openalex.org/W2121349955","https://openalex.org/W2145750252","https://openalex.org/W2154594469","https://openalex.org/W2161445160","https://openalex.org/W2170343590","https://openalex.org/W2281124822","https://openalex.org/W2346284756","https://openalex.org/W2442121487","https://openalex.org/W4211138283"],"related_works":["https://openalex.org/W1560508154","https://openalex.org/W2080937251","https://openalex.org/W1529202366","https://openalex.org/W1505011996","https://openalex.org/W4235869820","https://openalex.org/W2218554046","https://openalex.org/W1976097640","https://openalex.org/W1525833306","https://openalex.org/W1821922395","https://openalex.org/W2002442168"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}