{"id":"https://openalex.org/W2073666490","doi":"https://doi.org/10.1074/jbc.m111.224345","title":"Pattern Recognition Scavenger Receptor CD204 Attenuates Toll-like Receptor 4-induced NF-\u03baB Activation by Directly Inhibiting Ubiquitination of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6","display_name":"Pattern Recognition Scavenger Receptor CD204 Attenuates Toll-like Receptor 4-induced NF-\u03baB Activation by Directly Inhibiting Ubiquitination of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6","publication_year":2011,"publication_date":"2011-04-02","ids":{"openalex":"https://openalex.org/W2073666490","doi":"https://doi.org/10.1074/jbc.m111.224345","mag":"2073666490","pmid":"https://pubmed.ncbi.nlm.nih.gov/21460221","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3099696"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m111.224345","doi":"https://doi.org/10.1074/jbc.m111.224345","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.224345","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m111.224345","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026949506","display_name":"Xiaofei Yu","orcid":"https://orcid.org/0000-0003-3119-4920","observed_orcids":["https://orcid.org/0000-0003-3119-4920"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4210146488","display_name":"Institute of Molecular Medicine","ror":"https://ror.org/04eb14s37","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210146488"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"Xiaofei Yu","raw_affiliation_strings":["Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA","From the Department of Human and Molecular Genetics,","the Institute of Molecular Medicine, and","the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"From the Department of Human and Molecular Genetics,","institution_ids":[]},{"raw_affiliation_string":"the Institute of Molecular Medicine, and","institution_ids":["https://openalex.org/I4210146488"]},{"raw_affiliation_string":"the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298,","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102011509","display_name":"Huanfa Yi","orcid":"https://orcid.org/0000-0003-3785-3691","observed_orcids":["https://orcid.org/0000-0003-3785-3691"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4210146488","display_name":"Institute of Molecular Medicine","ror":"https://ror.org/04eb14s37","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210146488"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"Huanfa Yi","raw_affiliation_strings":["From the Department of Human and Molecular Genetics,","the Institute of Molecular Medicine, and","the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Human and Molecular Genetics,","institution_ids":[]},{"raw_affiliation_string":"the Institute of Molecular Medicine, and","institution_ids":["https://openalex.org/I4210146488"]},{"raw_affiliation_string":"the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298,","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042783365","display_name":"Chunqing Guo","orcid":"https://orcid.org/0000-0002-3148-8542","observed_orcids":["https://orcid.org/0000-0002-3148-8542"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4210146488","display_name":"Institute of Molecular Medicine","ror":"https://ror.org/04eb14s37","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210146488"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"Chunqing Guo","raw_affiliation_strings":["From the Department of Human and Molecular Genetics,","the Institute of Molecular Medicine, and","the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Human and Molecular Genetics,","institution_ids":[]},{"raw_affiliation_string":"the Institute of Molecular Medicine, and","institution_ids":["https://openalex.org/I4210146488"]},{"raw_affiliation_string":"the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298,","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087749038","display_name":"Daming Zuo","orcid":"https://orcid.org/0000-0003-2003-9474","observed_orcids":["https://orcid.org/0000-0003-2003-9474"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4210146488","display_name":"Institute of Molecular Medicine","ror":"https://ror.org/04eb14s37","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210146488"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"Daming Zuo","raw_affiliation_strings":["From the Department of Human and Molecular Genetics,","the Institute of Molecular Medicine, and","the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Human and Molecular Genetics,","institution_ids":[]},{"raw_affiliation_string":"the Institute of Molecular Medicine, and","institution_ids":["https://openalex.org/I4210146488"]},{"raw_affiliation_string":"the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298,","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100325747","display_name":"Yanping Wang","orcid":"https://orcid.org/0009-0009-9498-2124","observed_orcids":["https://orcid.org/0009-0009-9498-2124"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanping Wang","raw_affiliation_strings":["the Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California 90048, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California 90048, and","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100668992","display_name":"Hyung Lae Kim","orcid":"https://orcid.org/0000-0003-2085-6140","observed_orcids":["https://orcid.org/0000-0003-2085-6140"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyung L. Kim","raw_affiliation_strings":["the Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California 90048, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California 90048, and","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016166287","display_name":"John R. Subjeck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Subjeck","raw_affiliation_strings":["the Department of Cellar Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Cellar Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100755827","display_name":"Xiang\u2010Yang Wang","orcid":"https://orcid.org/0000-0003-2421-5367","observed_orcids":["https://orcid.org/0000-0003-2421-5367"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4210146488","display_name":"Institute of Molecular Medicine","ror":"https://ror.org/04eb14s37","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210146488"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["IN","US"],"is_corresponding":true,"raw_author_name":"Xiang-Yang Wang","raw_affiliation_strings":["From the Department of Human and Molecular Genetics,","the Institute of Molecular Medicine, and","the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Human and Molecular Genetics,","institution_ids":[]},{"raw_affiliation_string":"the Institute of Molecular Medicine, and","institution_ids":["https://openalex.org/I4210146488"]},{"raw_affiliation_string":"the Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298,","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100755827"],"corresponding_institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4210146488","https://openalex.org/I4390039382"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.999,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.96056842,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"286","issue":"21","first_page":"18795","last_page":"18806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd204","display_name":"CD204","score":0.8790000081062317},{"id":"https://openalex.org/keywords/scavenger-receptor-a","display_name":"scavenger receptor A","score":0.9620000123977661},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9449999928474426},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/traf6","display_name":"TRAF6","score":0.9440000057220459},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.9710000157356262},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.4399999976158142},{"id":"https://openalex.org/keywords/pattern-recognition-receptors","display_name":"pattern recognition receptors","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.6799225807189941},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6106308102607727},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5852187275886536},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.5331119298934937},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5327057242393494},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5081446170806885},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4801763594150543},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.47020918130874634},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.436037540435791},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.31885826587677},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2267031967639923},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1623266041278839},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09525817632675171}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048029","descriptor_name":"TNF Receptor-Associated Factor 6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048029","descriptor_name":"TNF Receptor-Associated Factor 6","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D048029","descriptor_name":"TNF Receptor-Associated Factor 6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051117","descriptor_name":"Scavenger Receptors, Class A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051117","descriptor_name":"Scavenger Receptors, Class A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051117","descriptor_name":"Scavenger Receptors, Class A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m111.224345","doi":"https://doi.org/10.1074/jbc.m111.224345","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.224345","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2364393","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3099696","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:21460221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21460221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3099696","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3099696/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m111.224345","doi":"https://doi.org/10.1074/jbc.m111.224345","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.224345","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4918485225","display_name":"Scavenger Receptor-A and Immune Regulation","funder_award_id":"R01CA129111","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5509001875","display_name":"Large Stress Proteins in Biology and Medicine","funder_award_id":"R01CA154708","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6895797584","display_name":null,"funder_award_id":"CA099362","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1586921439","https://openalex.org/W1600472471","https://openalex.org/W1669694727","https://openalex.org/W1903287340","https://openalex.org/W1932157053","https://openalex.org/W1966312417","https://openalex.org/W1979582699","https://openalex.org/W1980213997","https://openalex.org/W2001756328","https://openalex.org/W2007331685","https://openalex.org/W2010453472","https://openalex.org/W2011405026","https://openalex.org/W2020831499","https://openalex.org/W2037454778","https://openalex.org/W2044115042","https://openalex.org/W2044451441","https://openalex.org/W2044964980","https://openalex.org/W2054968614","https://openalex.org/W2069663822","https://openalex.org/W2074799449","https://openalex.org/W2082263327","https://openalex.org/W2105731567","https://openalex.org/W2107277218","https://openalex.org/W2107611361","https://openalex.org/W2109491705","https://openalex.org/W2110068304","https://openalex.org/W2110522379","https://openalex.org/W2114216755","https://openalex.org/W2114563504","https://openalex.org/W2131392583","https://openalex.org/W2143498880","https://openalex.org/W2149807755","https://openalex.org/W2152714704","https://openalex.org/W2163018106","https://openalex.org/W2168514491","https://openalex.org/W2170948660","https://openalex.org/W4238609105"],"related_works":["https://openalex.org/W2054968614","https://openalex.org/W2036596999","https://openalex.org/W2092101871","https://openalex.org/W2118762274","https://openalex.org/W806705003","https://openalex.org/W2950852830","https://openalex.org/W2124045397","https://openalex.org/W2147755001","https://openalex.org/W3087889094","https://openalex.org/W4313354822"],"abstract_inverted_index":{"The":[0,115],"collaboration":[1],"and":[2,20,113,152,157,174],"cross-talk":[3],"between":[4,150],"different":[5],"classes":[6],"of":[7,30,46,77,101,110,117,124,133],"innate":[8],"pattern":[9,168],"recognition":[10,169],"receptors":[11],"are":[12],"crucial":[13],"for":[14],"a":[15,26,40,161,166],"well":[16],"coordinated":[17],"inflammatory":[18,67,176],"response":[19],"host":[21],"defense.":[22],"Here":[23],"we":[24,86,144],"report":[25],"previously":[27],"unrecognized":[28],"role":[29],"scavenger":[31],"receptor":[32,48,170],"A":[33],"(SRA;":[34],"also":[35],"known":[36],"as":[37,39],"CD204)":[38],"signaling":[41,155],"regulator":[42],"in":[43,70,108],"the":[44,78,83,98,130,147,153],"context":[45],"Toll-like":[47],"4":[49],"(TLR4)":[50],"activation.":[51],"We":[52],"show":[53],"that":[54,88,129],"SRA/CD204":[55,65,89,121,134,151],"deficiency":[56],"leads":[57],"to":[58,61],"greater":[59],"sensitivity":[60],"LPS-induced":[62],"endotoxic":[63],"shock.":[64],"down-regulates":[66],"gene":[68],"expression":[69],"dendritic":[71],"cells":[72],"by":[73,94,120,164],"suppressing":[74],"TLR4-induced":[75],"activation":[76,173],"transcription":[79],"factor":[80,104],"NF-\u03baB.":[81],"For":[82],"first":[84],"time,":[85],"demonstrate":[87],"executes":[90],"its":[91,125,139],"regulatory":[92],"functions":[93],"directly":[95],"interacting":[96],"with":[97],"TRAF-C":[99],"domain":[100],"TNF":[102],"receptor-associated":[103],"6":[105],"(TRAF6),":[106],"resulting":[107],"inhibition":[109],"TRAF6":[111],"dimerization":[112],"ubiquitination.":[114],"attenuation":[116],"NF-\u03baB":[118],"activity":[119],"is":[122],"independent":[123],"ligand-binding":[126],"domain,":[127],"indicating":[128],"signaling-regulatory":[131],"feature":[132],"can":[135],"be":[136],"uncoupled":[137],"from":[138],"conventional":[140],"endocytic":[141],"functions.":[142],"Collectively,":[143],"have":[145],"identified":[146],"molecular":[148],"linkage":[149],"TLR4":[154,172],"pathways,":[156],"our":[158],"results":[159],"reveal":[160],"novel":[162],"mechanism":[163],"which":[165],"non-TLR":[167],"restricts":[171],"consequent":[175],"response.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
