{"id":"https://openalex.org/W2073663513","doi":"https://doi.org/10.1677/joe.0.1500113","title":"Beta-cell markers and autoantigen expression by a human insulinoma cell line: similarities to native beta cells","display_name":"Beta-cell markers and autoantigen expression by a human insulinoma cell line: similarities to native beta cells","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W2073663513","doi":"https://doi.org/10.1677/joe.0.1500113","mag":"2073663513","pmid":"https://pubmed.ncbi.nlm.nih.gov/8708552"},"language":"en","primary_location":{"id":"doi:10.1677/joe.0.1500113","doi":"https://doi.org/10.1677/joe.0.1500113","is_oa":false,"landing_page_url":"https://doi.org/10.1677/joe.0.1500113","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068601139","display_name":"Maria Gisella Cavallo","orcid":"https://orcid.org/0000-0001-6630-8049","observed_orcids":["https://orcid.org/0000-0001-6630-8049"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M G Cavallo","raw_affiliation_strings":["Istituto Clinica Medica II, University of Rome La Sapienza, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Clinica Medica II, University of Rome La Sapienza, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069364785","display_name":"Francesco Dotta","orcid":"https://orcid.org/0000-0003-4947-7478","observed_orcids":["https://orcid.org/0000-0003-4947-7478"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Dotta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091268493","display_name":"Laura Monetini","orcid":"https://orcid.org/0000-0001-6948-796X","observed_orcids":["https://orcid.org/0000-0001-6948-796X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Monetini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111978322","display_name":"S. Dionisi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Dionisi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108448037","display_name":"M. Previti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Previti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"L Valente","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Valente","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Toto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Toto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056539409","display_name":"Umberto Di Mario","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Di Mario","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087265840","display_name":"Paolo Pozzilli","orcid":"https://orcid.org/0000-0001-5090-636X","observed_orcids":["https://orcid.org/0000-0001-5090-636X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Pozzilli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8324,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.68680387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"150","issue":"1","first_page":"113","last_page":"120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulinoma-cell-lines","display_name":"insulinoma cell lines","score":0.8360000252723694},{"id":"https://openalex.org/keywords/beta-cell-autoantigens","display_name":"beta cell autoantigens","score":0.9559999704360962},{"id":"https://openalex.org/keywords/type-1-diabetes-autoimmunity","display_name":"type 1 diabetes autoimmunity","score":0.8790000081062317},{"id":"https://openalex.org/keywords/glutamic-acid-decarboxylase","display_name":"glutamic acid decarboxylase","score":0.9800000190734863},{"id":"https://openalex.org/keywords/islet-cell-antibodies","display_name":"islet cell antibodies","score":0.8450000286102295},{"id":"https://openalex.org/keywords/a2b5","display_name":"A2B5","score":0.6790000200271606},{"id":"https://openalex.org/keywords/neuroendocrine-markers","display_name":"neuroendocrine markers","score":0.7630000114440918},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.7291855812072754},{"id":"https://openalex.org/C2777331542","wikidata":"https://www.wikidata.org/wiki/Q419287","display_name":"Ganglioside","level":2,"score":0.7175458073616028},{"id":"https://openalex.org/C2780053029","wikidata":"https://www.wikidata.org/wiki/Q1501239","display_name":"Insulinoma","level":3,"score":0.6843723654747009},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.5673373937606812},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.560187578201294},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5557759404182434},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.533551037311554},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5223090052604675},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5027890205383301},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49854183197021484},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4586887061595917},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.42864981293678284},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4128470718860626},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.4124906659126282},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41101253032684326},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3957803249359131},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30387139320373535},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1987931728363037},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.15863242745399475},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.15668189525604248},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15507307648658752},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005732","descriptor_name":"Gangliosides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007340","descriptor_name":"Insulinoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007340","descriptor_name":"Insulinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1677/joe.0.1500113","doi":"https://doi.org/10.1677/joe.0.1500113","is_oa":false,"landing_page_url":"https://doi.org/10.1677/joe.0.1500113","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:8708552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8708552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of endocrinology","raw_type":"Comparative Study"},{"id":"pmh:oai:iris.uniroma1.it:11573/103101","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/103101","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:usiena-air.unisi.it:11365/33831","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11365/33831","pdf_url":null,"source":{"id":"https://openalex.org/S4377196319","display_name":"Use Siena air (University of Siena)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102064193","host_organization_name":"University of Siena","host_organization_lineage":["https://openalex.org/I102064193"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2094281259","https://openalex.org/W2121871924","https://openalex.org/W4252800000","https://openalex.org/W2037089082","https://openalex.org/W2035534626","https://openalex.org/W2064064573","https://openalex.org/W2356505589","https://openalex.org/W2052388580","https://openalex.org/W1960601565","https://openalex.org/W1997222580"],"abstract_inverted_index":{"In":[0],"the":[1,7,59,62,100,132,153,217,276],"present":[2,205,240],"study":[3,175],"we":[4],"have":[5],"evaluated":[6],"expression":[8,101,140,220,277],"of":[9,54,61,69,76,104,110,138,145,155,173,219,221,278],"different":[10,80],"beta-cell":[11],"markers,":[12,280],"islet":[13,90,97,117,163,196,242],"molecules":[14,197],"and":[15,38,86,92,102,109,122,188,201,206,293],"auto-antigens":[16],"relevant":[17,281],"in":[18,28,119,131,141,213,241,256,285,316],"diabetes":[19,120,288],"autoimmunity":[20,121],"by":[21,74,124,169,182,192,224,250],"a":[22,47],"human":[23,125,231],"insulinoma":[24,258,298],"cell":[25,64,134,179,235,243,259,283,299],"line":[26,65,300],"(CM)":[27],"order":[29],"to":[30,39,95,115,143,158,210,230,269,275],"define":[31],"its":[32],"similarities":[33,268],"with":[34,89,162,238,273],"native":[35,126,146,214,270],"beta":[36,127,147,178,215,234,271,282],"cells":[37,148,160,226,265,272],"discover":[40],"whether":[41],"it":[42],"could":[43],"be":[44,116,302],"considered":[45,303],"as":[46,199,304],"model":[48,307],"for":[49,66,308],"studies":[50,309],"on":[51],"immunological":[52],"aspects":[53],"Type":[55,286,317],"1":[56,287,318],"diabetes.":[57,319],"First,":[58],"positivity":[60],"CM":[63,133,159,193,225,264],"known":[67,114],"markers":[68,180],"neuroendocrine":[70],"derivation":[71],"was":[72,149,167],"determined":[73],"means":[75],"immunocytochemical":[77],"analysis":[78],"using":[79],"anti-islet":[81,183],"monoclonal":[82,184],"antibodies":[83,185,239,244],"including":[84],"A2B5":[85],"3G5":[87,187],"reacting":[88,161,237],"gangliosides,":[91],"HISL19":[93],"binding":[94,154,252],"an":[96,305],"glycoprotein.":[98],"Secondly,":[99],"characteristics":[103,209],"glutamic":[105],"acid":[106],"decarboxylase":[107],"(GAD)":[108],"GM2-1":[111,202],"ganglioside,":[112],"both":[113],"autoantigens":[118,284],"expressed":[123,191],"cells,":[128],"were":[129],"investigated":[130],"line.":[135,260],"The":[136,171],"pattern":[137,218],"ganglioside":[139,203],"comparison":[142],"that":[144,177,263],"also":[150,228,254],"evaluated.":[151],"Thirdly,":[152],"diabetic":[156,247],"sera":[157,248],"cytoplasmic":[164],"antigens":[165],"(ICA)":[166,245],"studied":[168],"immunohistochemistry.":[170],"results":[172],"this":[174,257,297],"showed":[176],"identified":[181,249],"A2B5,":[186],"HISL-19":[189],"are":[190,204,253],"cells;":[194,216],"similarly,":[195],"such":[198],"GAD":[200],"possess":[207],"similar":[208],"those":[211],"found":[212],"other":[222,294],"gangliosides":[223],"is":[227],"identical":[229],"pancreatic":[232],"islets;":[233],"autoantigen(s)":[236],"positive":[246],"ICA":[251,291],"detectable":[255],"We":[261],"conclude":[262],"show":[266],"close":[267],"respect":[274],"neuro-endocrine":[279],"(GAD,":[289],"GM2-1,":[290],"antigen),":[292],"gangliosides.":[295],"Therefore,":[296],"may":[301],"ideal":[306],"aimed":[310],"at":[311],"investigating":[312],"autoimmune":[313],"phenomena":[314],"occurring":[315]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}