{"id":"https://openalex.org/W2073645208","doi":"https://doi.org/10.1073/pnas.2237000100","title":"Molecular determinants of Ca 2+ /calmodulin-dependent regulation of Ca v 2.1 channels","display_name":"Molecular determinants of Ca 2+ /calmodulin-dependent regulation of Ca v 2.1 channels","publication_year":2003,"publication_date":"2003-12-12","ids":{"openalex":"https://openalex.org/W2073645208","doi":"https://doi.org/10.1073/pnas.2237000100","mag":"2073645208","pmid":"https://pubmed.ncbi.nlm.nih.gov/14673106","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/307692"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2237000100","doi":"https://doi.org/10.1073/pnas.2237000100","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.2237000100","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/307692","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100686477","display_name":"Amy Lee","orcid":"https://orcid.org/0000-0001-8021-0443","observed_orcids":["https://orcid.org/0000-0001-8021-0443"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Lee","raw_affiliation_strings":["Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195-7280; and Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322-3090"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195-7280; and Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322-3090","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101995229","display_name":"Hong Zhou","orcid":"https://orcid.org/0000-0002-2998-0490","observed_orcids":["https://orcid.org/0000-0002-2998-0490"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Zhou","raw_affiliation_strings":["Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195-7280; and Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322-3090"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195-7280; and Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322-3090","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002307585","display_name":"Todd Scheuer","orcid":"https://orcid.org/0000-0003-3655-0816","observed_orcids":["https://orcid.org/0000-0003-3655-0816"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Scheuer","raw_affiliation_strings":["Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195-7280; and Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322-3090"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195-7280; and Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322-3090","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078941732","display_name":"William A. Catterall","orcid":"https://orcid.org/0000-0001-5509-3580","observed_orcids":["https://orcid.org/0000-0001-5509-3580"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Catterall","raw_affiliation_strings":["Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195-7280; and Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322-3090"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195-7280; and Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322-3090","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1444,"has_fulltext":false,"cited_by_count":148,"citation_normalized_percentile":{"value":0.8726667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"100","issue":"26","first_page":"16059","last_page":"16064"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-q-type-calcium-channels","display_name":"P/Q-type calcium channels","score":0.9120000004768372},{"id":"https://openalex.org/keywords/calmodulin","display_name":"calmodulin","score":0.9490000009536743},{"id":"https://openalex.org/keywords/alpha1-subunit","display_name":"alpha1 subunit","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cam-binding-domain","display_name":"CaM-binding domain","score":0.8849999904632568},{"id":"https://openalex.org/keywords/ef-hand-calcium-binding","display_name":"EF-hand calcium binding","score":0.7440000176429749},{"id":"https://openalex.org/keywords/presynaptic-calcium-currents","display_name":"presynaptic calcium currents","score":0.871999979019165},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.9580000042915344},{"id":"https://openalex.org/keywords/channel-regulation","display_name":"channel regulation","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.812978982925415},{"id":"https://openalex.org/C25166345","wikidata":"https://www.wikidata.org/wiki/Q4914012","display_name":"Binding domain","level":3,"score":0.5192553997039795},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5184968709945679},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5018250942230225},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.48568686842918396},{"id":"https://openalex.org/C2776972302","wikidata":"https://www.wikidata.org/wiki/Q14905744","display_name":"Cav1.2","level":4,"score":0.4853574335575104},{"id":"https://openalex.org/C42086223","wikidata":"https://www.wikidata.org/wiki/Q24723907","display_name":"EF hand","level":4,"score":0.4739280343055725},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4711674153804779},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34892672300338745},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3041874170303345},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10972282290458679},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0990317165851593}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020864","descriptor_name":"Calcium Channels, N-Type","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020864","descriptor_name":"Calcium Channels, N-Type","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.2237000100","doi":"https://doi.org/10.1073/pnas.2237000100","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.2237000100","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:307692","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/307692","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:14673106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14673106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:307692","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/307692","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1551046554","display_name":"MODULATION  PRESYNAPTIC CA2+ CHANNELS BY CA2+/CALMODULIN","funder_award_id":"F32NS010645","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1946653559","display_name":null,"funder_award_id":"NS10645","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5825393552","display_name":"Molecular Properties of Voltage-Sensitive Calcium Channels","funder_award_id":"R01NS022625","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5868556272","display_name":null,"funder_award_id":"NS 22625","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G720738863","display_name":null,"funder_award_id":"NS044922","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8023288960","display_name":"Regulation of neuronal calcium channels by CaBP1","funder_award_id":"R01NS044922","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1523938232","https://openalex.org/W1628979938","https://openalex.org/W1639584526","https://openalex.org/W1965661118","https://openalex.org/W1971844027","https://openalex.org/W1975356564","https://openalex.org/W1980430647","https://openalex.org/W1983326785","https://openalex.org/W1996587443","https://openalex.org/W1997413420","https://openalex.org/W2002152970","https://openalex.org/W2008864455","https://openalex.org/W2009987643","https://openalex.org/W2025853041","https://openalex.org/W2035491306","https://openalex.org/W2036145275","https://openalex.org/W2050825441","https://openalex.org/W2053330127","https://openalex.org/W2055098453","https://openalex.org/W2055923860","https://openalex.org/W2075654108","https://openalex.org/W2076801049","https://openalex.org/W2085287462","https://openalex.org/W2086871275","https://openalex.org/W2087062865","https://openalex.org/W2087902062","https://openalex.org/W2092924576","https://openalex.org/W2096264533","https://openalex.org/W2096942328","https://openalex.org/W2118906494","https://openalex.org/W2124595526","https://openalex.org/W2130151244","https://openalex.org/W2141479114","https://openalex.org/W2146411874","https://openalex.org/W2151769410","https://openalex.org/W2159348191"],"related_works":["https://openalex.org/W2774133391","https://openalex.org/W2585424355","https://openalex.org/W2125318318","https://openalex.org/W2916753079","https://openalex.org/W6999140668","https://openalex.org/W1963539924","https://openalex.org/W1936533736","https://openalex.org/W2031835902","https://openalex.org/W2035912021","https://openalex.org/W2096264533"],"abstract_inverted_index":{"Ca2+-dependent":[0,40,169],"facilitation":[1,214],"and":[2,5,15,48,63,72,104,131,156,215,238],"inactivation":[3,111],"(CDF":[4],"CDI)":[6],"of":[7,42,57,79,85,90,119,124,134,141,188,229],"Cav2.1":[8,43,230],"channels":[9,44],"modulate":[10],"presynaptic":[11],"P/Q-type":[12],"Ca2+":[13,26,121,182,200,235,244],"currents":[14],"contribute":[16],"to":[17,31,160,171,184,202,233],"activity-dependent":[18],"synaptic":[19],"plasticity.":[20],"This":[21,223],"dual":[22],"feedback":[23],"regulation":[24,228,240],"by":[25,77],"involves":[27],"calmodulin":[28],"(CaM)":[29],"binding":[30,122,170,183,201],"the":[32,54,59,64,86,91,120,129,145,172,185,196,203],"alpha1":[33],"subunit":[34],"(alpha12.1).":[35],"The":[36],"molecular":[37],"determinants":[38],"for":[39,138,150],"modulation":[41],"reside":[45],"in":[46,49,53,180,231],"CaM":[47,125,135,190,208],"two":[50,88],"CaM-binding":[51,60],"sites":[52,123],"C-terminal":[55,132,186],"domain":[56,61,93],"alpha12.1,":[58],"(CBD)":[62],"IQ-like":[65,92,173,197],"domain.":[66,174,198],"In":[67,81,152],"transfected":[68],"tsA-201":[69],"cells,":[70],"CDF":[71,97,192],"CDI":[73],"were":[74,136,158],"both":[75,128],"reduced":[76],"deletion":[78],"CBD.":[80],"contrast,":[82],"alanine":[83],"substitution":[84],"first":[87],"residues":[89],"(IM-AA)":[94],"completely":[95],"prevented":[96],"but":[98,112,143,165],"had":[99],"little":[100],"effect":[101],"on":[102],"CDI,":[103],"glutamate":[105],"substitutions":[106],"(IM-EE)":[107],"greatly":[108],"accelerated":[109],"voltage-dependent":[110],"did":[113],"not":[114,166],"prevent":[115],"CDI.":[116,151,222],"Mutational":[117],"analyses":[118],"showed":[126],"that":[127,220],"N-":[130],"lobes":[133],"required":[137],"full":[139],"development":[140],"facilitation,":[142],"only":[144],"N-terminal":[146,204],"lobe":[147],"was":[148],"essential":[149],"biochemical":[153],"assays,":[154],"CaM12":[155,167],"CaM34":[157,164],"unable":[159],"bind":[161],"CBD,":[162,211],"whereas":[163],"retained":[168],"These":[175],"findings":[176],"support":[177],"a":[178,217],"model":[179],"which":[181,212],"EF-hands":[187,205],"preassociated":[189],"initiates":[191,221],"via":[193],"interaction":[194],"with":[195,210],"Further":[199],"promotes":[206],"secondary":[207],"interactions":[209],"enhance":[213],"cause":[216],"conformational":[218],"change":[219],"multifaceted":[224],"mechanism":[225],"allows":[226],"positive":[227],"response":[232],"local":[234],"increases":[236,245],"(CDF)":[237],"negative":[239],"during":[241],"more":[242],"global":[243],"(CDI).":[246]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}