{"id":"https://openalex.org/W2073638852","doi":"https://doi.org/10.1083/jcb.109.3.1207","title":"Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro.","display_name":"Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro.","publication_year":1989,"publication_date":"1989-09-01","ids":{"openalex":"https://openalex.org/W2073638852","doi":"https://doi.org/10.1083/jcb.109.3.1207","mag":"2073638852","pmid":"https://pubmed.ncbi.nlm.nih.gov/2475508","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115750"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.109.3.1207","doi":"https://doi.org/10.1083/jcb.109.3.1207","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.109.3.1207","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115750","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045531616","display_name":"Stuart H. Yuspa","orcid":"https://orcid.org/0000-0003-4785-337X","observed_orcids":["https://orcid.org/0000-0003-4785-337X"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S H Yuspa","raw_affiliation_strings":["Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006792778","display_name":"Anne Kilkenny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A E Kilkenny","raw_affiliation_strings":["Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090122914","display_name":"Peter M. Steinert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P M Steinert","raw_affiliation_strings":["Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071625723","display_name":"Dennis R. Roop","orcid":"https://orcid.org/0000-0001-5868-5880","observed_orcids":["https://orcid.org/0000-0001-5868-5880"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D R Roop","raw_affiliation_strings":["Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":9.6263,"has_fulltext":false,"cited_by_count":572,"citation_normalized_percentile":{"value":0.98652882,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"109","issue":"3","first_page":"1207","last_page":"1217"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12355","display_name":"Genetic and rare skin diseases.","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-differentiation","display_name":"epidermal differentiation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/extracellular-calcium","display_name":"extracellular calcium","score":0.8700000047683716},{"id":"https://openalex.org/keywords/calcium-gradient","display_name":"calcium gradient","score":0.7649999856948853},{"id":"https://openalex.org/keywords/keratin-1","display_name":"keratin 1","score":0.9620000123977661},{"id":"https://openalex.org/keywords/keratin-10","display_name":"keratin 10","score":1.0},{"id":"https://openalex.org/keywords/filaggrin","display_name":"filaggrin","score":0.996999979019165},{"id":"https://openalex.org/keywords/basal-cells","display_name":"basal cells","score":0.5210000276565552},{"id":"https://openalex.org/keywords/spinous-cells","display_name":"spinous cells","score":0.7200000286102295},{"id":"https://openalex.org/keywords/granular-cells","display_name":"granular cells","score":0.8529999852180481},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.38100001215934753},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.7720000147819519},{"id":"https://openalex.org/keywords/mrna-levels","display_name":"mRNA levels","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8502293825149536},{"id":"https://openalex.org/C190684412","wikidata":"https://www.wikidata.org/wiki/Q21201832","display_name":"Filaggrin","level":3,"score":0.8373035192489624},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.7093058824539185},{"id":"https://openalex.org/C2777577635","wikidata":"https://www.wikidata.org/wiki/Q18028085","display_name":"Involucrin","level":4,"score":0.6359727382659912},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5043514966964722},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4992368221282959},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4957452714443207},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48849284648895264},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.480023056268692},{"id":"https://openalex.org/C2909546088","wikidata":"https://www.wikidata.org/wiki/Q7249605","display_name":"Proliferation Marker","level":3,"score":0.45368021726608276},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.45015189051628113},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.4394170343875885},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4293268024921417},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2580304741859436},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.23648712038993835},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.17717155814170837},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15078023076057434},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1406066119670868},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08947834372520447},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07630005478858948},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000078404","descriptor_name":"Epidermal Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000091344","descriptor_name":"Filaggrin Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007381","descriptor_name":"Intermediate Filament Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007381","descriptor_name":"Intermediate Filament Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007381","descriptor_name":"Intermediate Filament Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013462","descriptor_name":"Sulfur Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1083/jcb.109.3.1207","doi":"https://doi.org/10.1083/jcb.109.3.1207","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.109.3.1207","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:915401","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115750","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2115750","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115750","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:2475508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2475508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.277.7130","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.277.7130","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/56/ae/J_Cell_Biol_1989_Sep_1_109(3)_1207-1217.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:915401","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115750","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.5799999833106995,"id":"https://metadata.un.org/sdg/15","display_name":"Life on land"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1206935348","https://openalex.org/W1519455435","https://openalex.org/W1557398645","https://openalex.org/W1559678336","https://openalex.org/W1571327651","https://openalex.org/W1584008028","https://openalex.org/W1591071605","https://openalex.org/W1599670156","https://openalex.org/W1969928750","https://openalex.org/W1973869185","https://openalex.org/W1974469880","https://openalex.org/W1974725462","https://openalex.org/W1978370418","https://openalex.org/W1979211697","https://openalex.org/W1982235561","https://openalex.org/W1985103299","https://openalex.org/W1987986127","https://openalex.org/W1989468162","https://openalex.org/W1991856499","https://openalex.org/W1992165963","https://openalex.org/W1993169352","https://openalex.org/W1997118518","https://openalex.org/W1998464125","https://openalex.org/W2010390522","https://openalex.org/W2014798096","https://openalex.org/W2016435958","https://openalex.org/W2016613744","https://openalex.org/W2018267354","https://openalex.org/W2018429484","https://openalex.org/W2026023235","https://openalex.org/W2027250767","https://openalex.org/W2037666059","https://openalex.org/W2038085058","https://openalex.org/W2040051442","https://openalex.org/W2044695645","https://openalex.org/W2051665279","https://openalex.org/W2052140292","https://openalex.org/W2060333964","https://openalex.org/W2070909725","https://openalex.org/W2071761976","https://openalex.org/W2072798835","https://openalex.org/W2077547402","https://openalex.org/W2082076255","https://openalex.org/W2083012075","https://openalex.org/W2083045895","https://openalex.org/W2085296969","https://openalex.org/W2087803718","https://openalex.org/W2089101401","https://openalex.org/W2091649522","https://openalex.org/W2119297613","https://openalex.org/W2126625988","https://openalex.org/W2134691008","https://openalex.org/W2138818809","https://openalex.org/W2141728368","https://openalex.org/W2149218470","https://openalex.org/W2158246711","https://openalex.org/W2406359249"],"related_works":["https://openalex.org/W35840514","https://openalex.org/W2134352492","https://openalex.org/W2042431428","https://openalex.org/W2086673242","https://openalex.org/W3087912005","https://openalex.org/W2086650253","https://openalex.org/W268676397","https://openalex.org/W2339954610","https://openalex.org/W1997445704","https://openalex.org/W2042371906"],"abstract_inverted_index":{"Epidermal":[0],"differentiation":[1,75,329],"is":[2,76,82,321],"characterized":[3],"by":[4,208,274],"a":[5,16,55,89,151,288,304,322],"series":[6],"of":[7,92,140,154,159,191,214,231,241,271,325,327,338],"coordinated":[8],"morphological":[9],"and":[10,41,44,46,54,73,125,132,168,221,236,251,261,299,331],"biochemical":[11],"changes":[12],"which":[13],"result":[14],"in":[15,29,68,103,156,201,243,255,265,293,303,313,342],"highly":[17,19],"specialized,":[18],"organized,":[20],"stratified":[21],"squamous":[22],"epithelium.":[23],"Among":[24],"the":[25,79,93,96,104,110,137,157,202,226,232,239,256,266,296,318,336,339],"specific":[26,130],"markers":[27,97,139,233,330],"expressed":[28,247,254,264],"differentiating":[30],"epidermis":[31],"are":[32,65,302],"(a)":[33],"two":[34,48],"early":[35],"spinous":[36,300],"cell":[37,51],"proteins,":[38,52],"keratins":[39],"1":[40,85],"10":[42],"(K1":[43],"K10);":[45],"(b)":[47],"later":[49],"granular":[50],"filaggrin":[53,102,262],"cornified":[56],"envelope":[57],"precursor":[58],"(CE).":[59],"In":[60],"vitro,":[61],"epidermal":[62,117,328],"basal":[63,297],"cells":[64,94,118,192,298,301],"selectively":[66],"cultured":[67,116],"0.05":[69],"mM":[70],"Ca2+":[71,80,106,123,155,164,182,204,215,228,290,305,310,319,340],"medium,":[72],"terminal":[74],"induced":[77],"when":[78],"concentration":[81,153],"increased":[83,197],"to":[84,121,199,219,238],"mM.":[86,161],"However,":[87],"only":[88],"small":[90],"fraction":[91],"express":[95],"K1,":[98],"K10,":[99],"CE,":[100],"or":[101,180,187],"higher":[105,179],"medium.":[107],"To":[108],"explore":[109],"factors":[111],"required":[112,217],"for":[113,136,171,335],"marker":[114,146,173,195,223],"expression,":[115],"were":[119,127,174,185,263],"exposed":[120],"intermediate":[122],"concentrations":[124,183],"extracts":[126],"analyzed":[128],"using":[129],"antibody":[131],"nucleic":[133],"acid":[134],"probes":[135],"four":[138],"interest.":[141],"These":[142,312],"studies":[143],"revealed":[144],"that":[145,277,287,317],"expression":[147,230,273,326],"was":[148,196,216,234,246,253,281],"enhanced":[149],"at":[150,178],"restricted":[152],"medium":[158,205],"0.10-0.16":[160],"At":[162,225],"this":[163],"concentration,":[165,229],"both":[166,218],"protein":[167,280],"mRNA":[169],"levels":[170],"each":[172,194],"substantially":[175,307],"increased,":[176],"whereas":[177],"lower":[181],"they":[184],"diminished":[186],"undetected.":[188],"The":[189],"percentage":[190],"expressing":[193],"two-":[198],"threefold":[200],"permissive":[203,227],"as":[206],"determined":[207,286],"immunofluorescence":[209],"analysis.":[210],"This":[211],"optimal":[212],"level":[213],"initiate":[220],"sustain":[222],"expression.":[224],"sequential":[235],"similar":[237],"order":[240],"appearance":[242],"vivo.":[244,343],"K1":[245,272],"within":[248],"8-12":[249],"h":[250],"K10":[252],"ensuing":[257],"12-24-h":[258],"period.":[259],"CE":[260],"subsequent":[267],"24":[268],"h.":[269],"Inhibition":[270],"cycloheximide":[275],"suggested":[276],"an":[278,333],"inducible":[279],"involved.":[282],"Other":[283],"investigators":[284],"have":[285],"shallow":[289],"gradient":[291,341],"exists":[292],"epidermis,":[294],"where":[295],"environment":[306,320],"below":[308],"serum":[309],"levels.":[311],"vitro":[314],"results":[315],"suggest":[316],"fundamental":[323],"regulator":[324],"provide":[332],"explanation":[334],"existence":[337]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":15}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}